Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoporin NUP82

Species:

Leishmania donovani

UniProt:

A0A3S7X934_LEIDO

TriTrypDb:

LdBPK_351600.1 , LdCL_350020900 , LDHU3_35.2140

Length:

780

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	1
GO:0031080	nuclear pore outer ring	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A0A3S7X934

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X934

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.589
CLV_C14_Caspase3-7	174	178	PF00656	0.517
CLV_C14_Caspase3-7	226	230	PF00656	0.580
CLV_C14_Caspase3-7	243	247	PF00656	0.483
CLV_C14_Caspase3-7	327	331	PF00656	0.534
CLV_C14_Caspase3-7	550	554	PF00656	0.451
CLV_C14_Caspase3-7	643	647	PF00656	0.500
CLV_C14_Caspase3-7	81	85	PF00656	0.550
CLV_C14_Caspase3-7	9	13	PF00656	0.582
CLV_NRD_NRD_1	184	186	PF00675	0.522
CLV_NRD_NRD_1	414	416	PF00675	0.444
CLV_NRD_NRD_1	589	591	PF00675	0.583
CLV_NRD_NRD_1	667	669	PF00675	0.567
CLV_PCSK_KEX2_1	184	186	PF00082	0.522
CLV_PCSK_KEX2_1	203	205	PF00082	0.523
CLV_PCSK_KEX2_1	282	284	PF00082	0.549
CLV_PCSK_KEX2_1	414	416	PF00082	0.444
CLV_PCSK_KEX2_1	589	591	PF00082	0.583
CLV_PCSK_PC1ET2_1	203	205	PF00082	0.555
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.549
CLV_PCSK_SKI1_1	203	207	PF00082	0.431
CLV_PCSK_SKI1_1	23	27	PF00082	0.517
CLV_PCSK_SKI1_1	279	283	PF00082	0.536
CLV_PCSK_SKI1_1	293	297	PF00082	0.363
CLV_PCSK_SKI1_1	415	419	PF00082	0.447
CLV_PCSK_SKI1_1	505	509	PF00082	0.479
CLV_PCSK_SKI1_1	590	594	PF00082	0.548
CLV_PCSK_SKI1_1	595	599	PF00082	0.558
DEG_APCC_DBOX_1	39	47	PF00400	0.494
DEG_APCC_DBOX_1	414	422	PF00400	0.411
DEG_Nend_UBRbox_3	1	3	PF02207	0.742
DEG_SPOP_SBC_1	371	375	PF00917	0.545
DOC_CYCLIN_yCln2_LP_2	428	434	PF00134	0.496
DOC_CYCLIN_yCln2_LP_2	477	483	PF00134	0.435
DOC_MAPK_gen_1	203	210	PF00069	0.564
DOC_MAPK_MEF2A_6	203	210	PF00069	0.564
DOC_PP2B_LxvP_1	428	431	PF13499	0.444
DOC_PP4_FxxP_1	210	213	PF00568	0.585
DOC_USP7_MATH_1	171	175	PF00917	0.512
DOC_USP7_MATH_1	370	374	PF00917	0.696
DOC_USP7_MATH_1	432	436	PF00917	0.500
DOC_USP7_MATH_1	645	649	PF00917	0.483
DOC_USP7_MATH_1	687	691	PF00917	0.551
DOC_USP7_MATH_1	733	737	PF00917	0.618
DOC_USP7_MATH_1	762	766	PF00917	0.590
DOC_WW_Pin1_4	472	477	PF00397	0.372
DOC_WW_Pin1_4	662	667	PF00397	0.583
LIG_14-3-3_CanoR_1	204	209	PF00244	0.507
LIG_14-3-3_CanoR_1	231	235	PF00244	0.499
LIG_14-3-3_CanoR_1	293	302	PF00244	0.509
LIG_14-3-3_CanoR_1	314	319	PF00244	0.529
LIG_14-3-3_CanoR_1	415	425	PF00244	0.350
LIG_14-3-3_CanoR_1	639	649	PF00244	0.508
LIG_Actin_WH2_2	86	101	PF00022	0.432
LIG_BIR_III_4	596	600	PF00653	0.364
LIG_BRCT_BRCA1_1	21	25	PF00533	0.461
LIG_BRCT_BRCA1_1	666	670	PF00533	0.585
LIG_BRCT_BRCA1_1	700	704	PF00533	0.505
LIG_deltaCOP1_diTrp_1	117	122	PF00928	0.460
LIG_EH1_1	355	363	PF00400	0.316
LIG_FHA_1	190	196	PF00498	0.540
LIG_FHA_1	294	300	PF00498	0.474
LIG_FHA_1	393	399	PF00498	0.691
LIG_FHA_1	420	426	PF00498	0.443
LIG_FHA_1	462	468	PF00498	0.466
LIG_FHA_1	50	56	PF00498	0.674
LIG_FHA_1	579	585	PF00498	0.464
LIG_FHA_1	709	715	PF00498	0.468
LIG_FHA_2	207	213	PF00498	0.574
LIG_FHA_2	220	226	PF00498	0.325
LIG_FHA_2	255	261	PF00498	0.597
LIG_FHA_2	292	298	PF00498	0.501
LIG_FHA_2	373	379	PF00498	0.522
LIG_FHA_2	512	518	PF00498	0.481
LIG_FHA_2	641	647	PF00498	0.485
LIG_FHA_2	703	709	PF00498	0.505
LIG_LIR_Apic_2	207	213	PF02991	0.588
LIG_LIR_Gen_1	42	50	PF02991	0.697
LIG_LIR_Gen_1	452	462	PF02991	0.452
LIG_LIR_Gen_1	570	580	PF02991	0.378
LIG_LIR_Gen_1	69	79	PF02991	0.416
LIG_LIR_Gen_1	701	708	PF02991	0.467
LIG_LIR_Nem_3	22	28	PF02991	0.395
LIG_LIR_Nem_3	307	312	PF02991	0.460
LIG_LIR_Nem_3	317	322	PF02991	0.443
LIG_LIR_Nem_3	42	48	PF02991	0.705
LIG_LIR_Nem_3	452	457	PF02991	0.445
LIG_LIR_Nem_3	498	504	PF02991	0.417
LIG_LIR_Nem_3	570	576	PF02991	0.370
LIG_LIR_Nem_3	69	74	PF02991	0.418
LIG_LIR_Nem_3	701	707	PF02991	0.465
LIG_LIR_Nem_3	89	94	PF02991	0.397
LIG_NRBOX	270	276	PF00104	0.389
LIG_PCNA_yPIPBox_3	577	590	PF02747	0.465
LIG_PDZ_Class_1	775	780	PF00595	0.641
LIG_Pex14_1	118	122	PF04695	0.476
LIG_Pex14_1	71	75	PF04695	0.465
LIG_Pex14_2	508	512	PF04695	0.517
LIG_RPA_C_Fungi	761	773	PF08784	0.614
LIG_SH2_CRK	309	313	PF00017	0.435
LIG_SH2_CRK	454	458	PF00017	0.449
LIG_SH2_CRK	474	478	PF00017	0.189
LIG_SH2_CRK	501	505	PF00017	0.502
LIG_SH2_NCK_1	747	751	PF00017	0.581
LIG_SH2_STAP1	316	320	PF00017	0.453
LIG_SH2_STAP1	33	37	PF00017	0.617
LIG_SH2_STAP1	336	340	PF00017	0.522
LIG_SH2_STAP1	454	458	PF00017	0.480
LIG_SH2_STAP1	547	551	PF00017	0.459
LIG_SH2_STAT3	546	549	PF00017	0.324
LIG_SH2_STAT5	182	185	PF00017	0.432
LIG_SH2_STAT5	322	325	PF00017	0.482
LIG_SH2_STAT5	604	607	PF00017	0.434
LIG_SH2_STAT5	628	631	PF00017	0.476
LIG_SH3_4	23	30	PF00018	0.478
LIG_SUMO_SIM_anti_2	229	236	PF11976	0.528
LIG_SUMO_SIM_anti_2	270	275	PF11976	0.377
LIG_SUMO_SIM_par_1	204	209	PF11976	0.568
LIG_SUMO_SIM_par_1	272	278	PF11976	0.383
LIG_SUMO_SIM_par_1	393	399	PF11976	0.689
LIG_SUMO_SIM_par_1	740	746	PF11976	0.530
LIG_UBA3_1	273	282	PF00899	0.488
MOD_CDC14_SPxK_1	665	668	PF00782	0.473
MOD_CDK_SPxK_1	662	668	PF00069	0.507
MOD_CDK_SPxxK_3	662	669	PF00069	0.487
MOD_CK1_1	230	236	PF00069	0.577
MOD_CK1_1	238	244	PF00069	0.696
MOD_CK1_1	249	255	PF00069	0.734
MOD_CK1_1	291	297	PF00069	0.503
MOD_CK1_1	374	380	PF00069	0.655
MOD_CK1_1	409	415	PF00069	0.556
MOD_CK1_1	513	519	PF00069	0.524
MOD_CK1_1	69	75	PF00069	0.445
MOD_CK1_1	729	735	PF00069	0.669
MOD_CK2_1	538	544	PF00069	0.507
MOD_CK2_1	687	693	PF00069	0.578
MOD_CK2_1	702	708	PF00069	0.412
MOD_CMANNOS	118	121	PF00535	0.466
MOD_GlcNHglycan	111	114	PF01048	0.410
MOD_GlcNHglycan	187	190	PF01048	0.517
MOD_GlcNHglycan	242	245	PF01048	0.732
MOD_GlcNHglycan	248	251	PF01048	0.751
MOD_GlcNHglycan	408	411	PF01048	0.589
MOD_GlcNHglycan	434	437	PF01048	0.585
MOD_GlcNHglycan	540	543	PF01048	0.494
MOD_GlcNHglycan	564	567	PF01048	0.501
MOD_GlcNHglycan	569	572	PF01048	0.427
MOD_GlcNHglycan	607	610	PF01048	0.523
MOD_GlcNHglycan	635	638	PF01048	0.437
MOD_GlcNHglycan	68	71	PF01048	0.508
MOD_GlcNHglycan	685	688	PF01048	0.332
MOD_GlcNHglycan	731	734	PF01048	0.640
MOD_GSK3_1	185	192	PF00069	0.532
MOD_GSK3_1	2	9	PF00069	0.649
MOD_GSK3_1	370	377	PF00069	0.597
MOD_GSK3_1	390	397	PF00069	0.675
MOD_GSK3_1	406	413	PF00069	0.621
MOD_GSK3_1	496	503	PF00069	0.437
MOD_GSK3_1	507	514	PF00069	0.394
MOD_GSK3_1	558	565	PF00069	0.498
MOD_GSK3_1	656	663	PF00069	0.694
MOD_GSK3_1	676	683	PF00069	0.550
MOD_GSK3_1	698	705	PF00069	0.512
MOD_GSK3_1	709	716	PF00069	0.517
MOD_GSK3_1	723	730	PF00069	0.632
MOD_N-GLC_1	109	114	PF02516	0.462
MOD_N-GLC_1	246	251	PF02516	0.746
MOD_NEK2_1	1	6	PF00069	0.670
MOD_NEK2_1	206	211	PF00069	0.577
MOD_NEK2_1	227	232	PF00069	0.567
MOD_NEK2_1	235	240	PF00069	0.604
MOD_NEK2_1	416	421	PF00069	0.408
MOD_NEK2_1	507	512	PF00069	0.413
MOD_NEK2_1	61	66	PF00069	0.616
MOD_NEK2_1	713	718	PF00069	0.535
MOD_NEK2_1	74	79	PF00069	0.334
MOD_NEK2_2	496	501	PF00069	0.454
MOD_PIKK_1	238	244	PF00454	0.703
MOD_PIKK_1	545	551	PF00454	0.395
MOD_PIKK_1	558	564	PF00454	0.557
MOD_PIKK_1	575	581	PF00454	0.365
MOD_PKA_2	230	236	PF00069	0.506
MOD_PKA_2	238	244	PF00069	0.615
MOD_Plk_1	496	502	PF00069	0.478
MOD_Plk_1	61	67	PF00069	0.642
MOD_Plk_1	645	651	PF00069	0.588
MOD_Plk_2-3	117	123	PF00069	0.511
MOD_Plk_2-3	394	400	PF00069	0.626
MOD_Plk_4	117	123	PF00069	0.511
MOD_Plk_4	171	177	PF00069	0.364
MOD_Plk_4	254	260	PF00069	0.623
MOD_Plk_4	314	320	PF00069	0.489
MOD_Plk_4	344	350	PF00069	0.333
MOD_Plk_4	44	50	PF00069	0.673
MOD_Plk_4	496	502	PF00069	0.446
MOD_Plk_4	687	693	PF00069	0.475
MOD_Plk_4	699	705	PF00069	0.390
MOD_Plk_4	709	715	PF00069	0.414
MOD_Plk_4	92	98	PF00069	0.337
MOD_ProDKin_1	472	478	PF00069	0.373
MOD_ProDKin_1	662	668	PF00069	0.578
MOD_SUMO_for_1	524	527	PF00179	0.594
MOD_SUMO_rev_2	81	90	PF00179	0.369
TRG_DiLeu_BaEn_1	89	94	PF01217	0.497
TRG_DiLeu_BaLyEn_6	201	206	PF01217	0.540
TRG_DiLeu_BaLyEn_6	738	743	PF01217	0.470
TRG_ENDOCYTIC_2	309	312	PF00928	0.414
TRG_ENDOCYTIC_2	316	319	PF00928	0.426
TRG_ENDOCYTIC_2	336	339	PF00928	0.369
TRG_ENDOCYTIC_2	454	457	PF00928	0.474
TRG_ENDOCYTIC_2	474	477	PF00928	0.187
TRG_ENDOCYTIC_2	501	504	PF00928	0.442
TRG_ER_diArg_1	183	185	PF00400	0.443
TRG_ER_diArg_1	414	416	PF00400	0.448
TRG_ER_diArg_1	588	590	PF00400	0.585
TRG_NES_CRM1_1	350	364	PF08389	0.319
TRG_NES_CRM1_1	89	102	PF08389	0.478
TRG_Pf-PMV_PEXEL_1	134	139	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	766	770	PF00026	0.621

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P593	Leptomonas seymouri	52%	98%
A0A0S4J4X2	Bodo saltans	25%	100%
A0A422NQA4	Trypanosoma rangeli	30%	100%
A4HMI1	Leishmania braziliensis	79%	100%
A4IB61	Leishmania infantum	100%	100%
C9ZZH0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AEY2	Leishmania major	94%	100%
E9B638	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	99%
V5B3W9	Trypanosoma cruzi	30%	100%