Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X927_LEIDO

TriTrypDb:

LdBPK_351630.1 , LdCL_350021200 , LDHU3_35.2170

Length:

478

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X927

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X927

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	130	134	PF00656	0.511
CLV_C14_Caspase3-7	19	23	PF00656	0.478
CLV_NRD_NRD_1	259	261	PF00675	0.650
CLV_NRD_NRD_1	265	267	PF00675	0.622
CLV_NRD_NRD_1	356	358	PF00675	0.605
CLV_NRD_NRD_1	418	420	PF00675	0.612
CLV_PCSK_KEX2_1	258	260	PF00082	0.698
CLV_PCSK_KEX2_1	264	266	PF00082	0.662
CLV_PCSK_KEX2_1	355	357	PF00082	0.664
CLV_PCSK_KEX2_1	418	420	PF00082	0.612
CLV_PCSK_PC7_1	260	266	PF00082	0.662
CLV_PCSK_SKI1_1	118	122	PF00082	0.398
CLV_PCSK_SKI1_1	259	263	PF00082	0.660
CLV_PCSK_SKI1_1	442	446	PF00082	0.630
DOC_CKS1_1	56	61	PF01111	0.454
DOC_MAPK_MEF2A_6	37	45	PF00069	0.473
DOC_PP2B_LxvP_1	376	379	PF13499	0.528
DOC_USP7_MATH_1	109	113	PF00917	0.441
DOC_USP7_MATH_1	145	149	PF00917	0.486
DOC_USP7_MATH_1	170	174	PF00917	0.649
DOC_USP7_MATH_1	199	203	PF00917	0.661
DOC_USP7_MATH_1	205	209	PF00917	0.708
DOC_USP7_MATH_1	295	299	PF00917	0.617
DOC_USP7_MATH_1	365	369	PF00917	0.593
DOC_USP7_MATH_1	397	401	PF00917	0.665
DOC_USP7_MATH_1	405	409	PF00917	0.636
DOC_USP7_MATH_1	413	417	PF00917	0.649
DOC_USP7_MATH_1	95	99	PF00917	0.524
DOC_USP7_UBL2_3	252	256	PF12436	0.659
DOC_WW_Pin1_4	219	224	PF00397	0.686
DOC_WW_Pin1_4	269	274	PF00397	0.692
DOC_WW_Pin1_4	314	319	PF00397	0.605
DOC_WW_Pin1_4	447	452	PF00397	0.610
DOC_WW_Pin1_4	55	60	PF00397	0.447
LIG_14-3-3_CanoR_1	152	160	PF00244	0.422
LIG_14-3-3_CanoR_1	168	175	PF00244	0.457
LIG_14-3-3_CanoR_1	320	324	PF00244	0.532
LIG_14-3-3_CanoR_1	361	370	PF00244	0.621
LIG_14-3-3_CanoR_1	8	13	PF00244	0.438
LIG_BIR_II_1	1	5	PF00653	0.461
LIG_BIR_III_4	412	416	PF00653	0.673
LIG_BIR_III_4	438	442	PF00653	0.624
LIG_Clathr_ClatBox_1	15	19	PF01394	0.440
LIG_FHA_1	211	217	PF00498	0.647
LIG_FHA_1	336	342	PF00498	0.591
LIG_FHA_1	349	355	PF00498	0.633
LIG_FHA_1	64	70	PF00498	0.462
LIG_FHA_2	128	134	PF00498	0.543
LIG_FHA_2	195	201	PF00498	0.649
LIG_FHA_2	276	282	PF00498	0.677
LIG_LIR_Gen_1	11	21	PF02991	0.412
LIG_LIR_Gen_1	119	129	PF02991	0.452
LIG_LIR_Gen_1	455	465	PF02991	0.615
LIG_LIR_Nem_3	11	16	PF02991	0.393
LIG_LIR_Nem_3	119	124	PF02991	0.427
LIG_LIR_Nem_3	38	43	PF02991	0.440
LIG_LIR_Nem_3	455	461	PF02991	0.705
LIG_LIR_Nem_3	78	82	PF02991	0.366
LIG_Pex14_2	359	363	PF04695	0.551
LIG_SH2_PTP2	40	43	PF00017	0.434
LIG_SH2_SRC	40	43	PF00017	0.358
LIG_SH2_STAT5	40	43	PF00017	0.358
LIG_SH3_1	267	273	PF00018	0.704
LIG_SH3_3	267	273	PF00018	0.704
LIG_SH3_3	36	42	PF00018	0.582
LIG_TRAF2_1	246	249	PF00917	0.595
LIG_TRAF2_2	245	250	PF00917	0.674
LIG_UBA3_1	460	468	PF00899	0.592
LIG_WRC_WIRS_1	76	81	PF05994	0.307
LIG_WW_3	377	381	PF00397	0.616
MOD_CDC14_SPxK_1	317	320	PF00782	0.531
MOD_CDK_SPxK_1	314	320	PF00069	0.577
MOD_CK1_1	173	179	PF00069	0.580
MOD_CK1_1	467	473	PF00069	0.536
MOD_CK2_1	129	135	PF00069	0.535
MOD_CK2_1	151	157	PF00069	0.414
MOD_CK2_1	194	200	PF00069	0.650
MOD_CK2_1	275	281	PF00069	0.675
MOD_CK2_1	308	314	PF00069	0.733
MOD_CK2_1	389	395	PF00069	0.560
MOD_CK2_1	396	402	PF00069	0.651
MOD_CK2_1	449	455	PF00069	0.605
MOD_GlcNHglycan	108	112	PF01048	0.548
MOD_GlcNHglycan	125	128	PF01048	0.389
MOD_GlcNHglycan	147	150	PF01048	0.461
MOD_GlcNHglycan	240	243	PF01048	0.653
MOD_GlcNHglycan	345	348	PF01048	0.505
MOD_GlcNHglycan	363	366	PF01048	0.596
MOD_GlcNHglycan	383	386	PF01048	0.594
MOD_GlcNHglycan	409	412	PF01048	0.696
MOD_GlcNHglycan	415	418	PF01048	0.654
MOD_GlcNHglycan	432	435	PF01048	0.639
MOD_GlcNHglycan	442	445	PF01048	0.638
MOD_GlcNHglycan	451	454	PF01048	0.594
MOD_GlcNHglycan	469	472	PF01048	0.476
MOD_GSK3_1	103	110	PF00069	0.625
MOD_GSK3_1	123	130	PF00069	0.473
MOD_GSK3_1	170	177	PF00069	0.547
MOD_GSK3_1	189	196	PF00069	0.615
MOD_GSK3_1	205	212	PF00069	0.658
MOD_GSK3_1	295	302	PF00069	0.732
MOD_GSK3_1	326	333	PF00069	0.592
MOD_GSK3_1	361	368	PF00069	0.618
MOD_GSK3_1	430	437	PF00069	0.657
MOD_GSK3_1	460	467	PF00069	0.590
MOD_N-GLC_1	361	366	PF02516	0.634
MOD_N-GLC_1	413	418	PF02516	0.579
MOD_NEK2_1	122	127	PF00069	0.441
MOD_NEK2_1	330	335	PF00069	0.646
MOD_NEK2_1	343	348	PF00069	0.588
MOD_NEK2_1	363	368	PF00069	0.572
MOD_NEK2_1	460	465	PF00069	0.688
MOD_NEK2_1	65	70	PF00069	0.423
MOD_PIKK_1	282	288	PF00454	0.572
MOD_PIKK_1	330	336	PF00454	0.675
MOD_PK_1	8	14	PF00069	0.368
MOD_PKA_2	151	157	PF00069	0.428
MOD_PKA_2	173	179	PF00069	0.656
MOD_PKA_2	319	325	PF00069	0.503
MOD_PKA_2	424	430	PF00069	0.619
MOD_PKB_1	166	174	PF00069	0.502
MOD_Plk_1	300	306	PF00069	0.530
MOD_Plk_4	189	195	PF00069	0.643
MOD_Plk_4	8	14	PF00069	0.368
MOD_ProDKin_1	219	225	PF00069	0.683
MOD_ProDKin_1	269	275	PF00069	0.695
MOD_ProDKin_1	314	320	PF00069	0.605
MOD_ProDKin_1	447	453	PF00069	0.608
MOD_ProDKin_1	55	61	PF00069	0.444
TRG_ENDOCYTIC_2	40	43	PF00928	0.434
TRG_ER_diArg_1	166	169	PF00400	0.447
TRG_ER_diArg_1	257	260	PF00400	0.617
TRG_ER_diArg_1	264	266	PF00400	0.622
TRG_ER_diArg_1	354	357	PF00400	0.672
TRG_ER_diArg_1	375	378	PF00400	0.541

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P595	Leptomonas seymouri	39%	95%
A4HMI4	Leishmania braziliensis	49%	88%
A4IB64	Leishmania infantum	99%	100%
E9AEY5	Leishmania major	81%	96%
E9B641	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	91%