LeishMANIAdb
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RNA_binding_protein_putative/GeneDB:LmjF.35.1400

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
RNA_binding_protein_putative/GeneDB:LmjF.35.1400
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7X912_LEIDO
TriTrypDb:
LdBPK_351410.1 , LdCL_350019000 , LDHU3_35.1850
Length:
232

Annotations

Annotations by Jardim et al.

Nucleic acid binding, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0005730 nucleolus 5 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3S7X912
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X912

Function

Biological processes
Term Name Level Count
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 10 1
GO:0000469 cleavage involved in rRNA processing 7 1
GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 10 1
GO:0000478 endonucleolytic cleavage involved in rRNA processing 8 1
GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 9 1
GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 10 1
GO:0000966 RNA 5'-end processing 7 1
GO:0000967 rRNA 5'-end processing 9 1
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006364 rRNA processing 8 1
GO:0006396 RNA processing 6 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0016070 RNA metabolic process 5 1
GO:0016072 rRNA metabolic process 7 1
GO:0022607 cellular component assembly 4 1
GO:0022618 ribonucleoprotein complex assembly 6 1
GO:0034462 small-subunit processome assembly 7 1
GO:0034470 ncRNA processing 7 1
GO:0034471 ncRNA 5'-end processing 8 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0034660 ncRNA metabolic process 6 1
GO:0036260 RNA capping 7 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043933 protein-containing complex organization 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0046483 heterocycle metabolic process 3 1
GO:0065003 protein-containing complex assembly 5 1
GO:0071704 organic substance metabolic process 2 1
GO:0071826 ribonucleoprotein complex subunit organization 5 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0090304 nucleic acid metabolic process 4 1
GO:0090305 nucleic acid phosphodiester bond hydrolysis 5 1
GO:0090501 RNA phosphodiester bond hydrolysis 6 1
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic 7 1
GO:1901360 organic cyclic compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 8
GO:0003723 RNA binding 4 7
GO:0005488 binding 1 8
GO:0097159 organic cyclic compound binding 2 8
GO:1901363 heterocyclic compound binding 2 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 170 174 PF00656 0.670
CLV_C14_Caspase3-7 74 78 PF00656 0.462
CLV_NRD_NRD_1 124 126 PF00675 0.453
CLV_NRD_NRD_1 127 129 PF00675 0.441
CLV_NRD_NRD_1 135 137 PF00675 0.417
CLV_NRD_NRD_1 146 148 PF00675 0.543
CLV_NRD_NRD_1 155 157 PF00675 0.378
CLV_NRD_NRD_1 160 162 PF00675 0.558
CLV_NRD_NRD_1 229 231 PF00675 0.741
CLV_NRD_NRD_1 42 44 PF00675 0.455
CLV_NRD_NRD_1 54 56 PF00675 0.522
CLV_NRD_NRD_1 96 98 PF00675 0.434
CLV_PCSK_FUR_1 125 129 PF00082 0.427
CLV_PCSK_FUR_1 94 98 PF00082 0.468
CLV_PCSK_KEX2_1 123 125 PF00082 0.460
CLV_PCSK_KEX2_1 127 129 PF00082 0.436
CLV_PCSK_KEX2_1 135 137 PF00082 0.408
CLV_PCSK_KEX2_1 146 148 PF00082 0.595
CLV_PCSK_KEX2_1 159 161 PF00082 0.595
CLV_PCSK_KEX2_1 227 229 PF00082 0.753
CLV_PCSK_KEX2_1 42 44 PF00082 0.455
CLV_PCSK_KEX2_1 54 56 PF00082 0.522
CLV_PCSK_KEX2_1 93 95 PF00082 0.476
CLV_PCSK_KEX2_1 96 98 PF00082 0.432
CLV_PCSK_PC1ET2_1 123 125 PF00082 0.526
CLV_PCSK_PC1ET2_1 159 161 PF00082 0.592
CLV_PCSK_PC1ET2_1 227 229 PF00082 0.663
CLV_PCSK_PC1ET2_1 93 95 PF00082 0.439
CLV_PCSK_PC7_1 156 162 PF00082 0.589
CLV_PCSK_SKI1_1 14 18 PF00082 0.399
CLV_PCSK_SKI1_1 156 160 PF00082 0.578
CLV_PCSK_SKI1_1 224 228 PF00082 0.627
CLV_PCSK_SKI1_1 42 46 PF00082 0.447
DEG_SPOP_SBC_1 204 208 PF00917 0.551
DOC_MAPK_gen_1 24 33 PF00069 0.582
DOC_MAPK_gen_1 42 49 PF00069 0.451
DOC_MAPK_MEF2A_6 27 35 PF00069 0.458
DOC_MAPK_MEF2A_6 54 63 PF00069 0.502
DOC_PP1_RVXF_1 30 36 PF00149 0.454
DOC_USP7_MATH_1 137 141 PF00917 0.477
DOC_USP7_MATH_1 169 173 PF00917 0.616
DOC_USP7_MATH_1 180 184 PF00917 0.592
DOC_USP7_MATH_1 186 190 PF00917 0.671
DOC_USP7_MATH_1 203 207 PF00917 0.543
DOC_USP7_MATH_1 215 219 PF00917 0.702
DOC_USP7_UBL2_3 205 209 PF12436 0.640
LIG_AP2alpha_1 107 111 PF02296 0.411
LIG_BIR_II_1 1 5 PF00653 0.594
LIG_BIR_III_4 175 179 PF00653 0.609
LIG_deltaCOP1_diTrp_1 67 72 PF00928 0.424
LIG_LIR_Apic_2 5 11 PF02991 0.430
LIG_LIR_Gen_1 112 120 PF02991 0.432
LIG_LIR_Gen_1 67 75 PF02991 0.435
LIG_LIR_Nem_3 112 116 PF02991 0.411
LIG_LIR_Nem_3 67 72 PF02991 0.424
LIG_Pex14_1 103 107 PF04695 0.344
LIG_Pex14_2 107 111 PF04695 0.434
LIG_SH2_CRK 8 12 PF00017 0.481
LIG_SH2_GRB2like 18 21 PF00017 0.468
LIG_SH2_NCK_1 8 12 PF00017 0.481
LIG_SH2_SRC 8 11 PF00017 0.389
LIG_SH2_STAT5 18 21 PF00017 0.443
LIG_SH3_3 53 59 PF00018 0.473
LIG_UBA3_1 60 66 PF00899 0.492
MOD_CK1_1 181 187 PF00069 0.700
MOD_CK1_1 189 195 PF00069 0.621
MOD_CK2_1 112 118 PF00069 0.368
MOD_CK2_1 137 143 PF00069 0.517
MOD_Cter_Amidation 121 124 PF01082 0.465
MOD_GlcNHglycan 188 191 PF01048 0.679
MOD_GlcNHglycan 213 216 PF01048 0.768
MOD_GlcNHglycan 73 76 PF01048 0.537
MOD_GSK3_1 180 187 PF00069 0.614
MOD_GSK3_1 211 218 PF00069 0.635
MOD_N-GLC_1 181 186 PF02516 0.537
MOD_NEK2_1 70 75 PF00069 0.458
MOD_PIKK_1 9 15 PF00454 0.434
MOD_PKB_1 193 201 PF00069 0.610
MOD_Plk_1 137 143 PF00069 0.517
MOD_Plk_1 181 187 PF00069 0.526
MOD_Plk_2-3 109 115 PF00069 0.443
MOD_Plk_4 112 118 PF00069 0.428
TRG_DiLeu_BaLyEn_6 56 61 PF01217 0.503
TRG_ENDOCYTIC_2 145 148 PF00928 0.543
TRG_ENDOCYTIC_2 38 41 PF00928 0.427
TRG_ENDOCYTIC_2 99 102 PF00928 0.479
TRG_ER_diArg_1 124 127 PF00400 0.424
TRG_ER_diArg_1 145 147 PF00400 0.477
TRG_ER_diArg_1 160 163 PF00400 0.617
TRG_ER_diArg_1 228 230 PF00400 0.692
TRG_ER_diArg_1 41 43 PF00400 0.358
TRG_ER_diArg_1 54 56 PF00400 0.521
TRG_ER_diArg_1 94 97 PF00400 0.426
TRG_ER_FFAT_2 67 77 PF00635 0.443
TRG_NLS_Bipartite_1 146 163 PF00514 0.539
TRG_NLS_MonoExtC_3 122 127 PF00514 0.473
TRG_NLS_MonoExtC_3 155 160 PF00514 0.530
TRG_NLS_MonoExtC_3 223 228 PF00514 0.677
TRG_NLS_MonoExtC_3 50 55 PF00514 0.581
TRG_NLS_MonoExtC_3 92 97 PF00514 0.418
TRG_NLS_MonoExtN_4 156 163 PF00514 0.641
TRG_NLS_MonoExtN_4 222 228 PF00514 0.627
TRG_NLS_MonoExtN_4 48 55 PF00514 0.579

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0NJ36 Trypanosomatidae 52% 85%
A0A3R7N8I1 Trypanosoma rangeli 56% 100%
A3LVD5 Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) 25% 67%
A4HMG2 Leishmania braziliensis 84% 100%
A4IB33 Leishmania infantum 100% 100%
E9AEW3 Leishmania major 95% 100%
E9B619 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
O74362 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 30% 69%
P53743 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 31% 73%
Q0UM32 Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) 29% 71%
Q2GZQ4 Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) 28% 70%
Q54BL2 Dictyostelium discoideum 25% 78%
Q59YL9 Candida albicans (strain SC5314 / ATCC MYA-2876) 25% 72%
Q6BSS5 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 24% 77%
Q6CSP8 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 26% 79%
Q75DA3 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 26% 74%
Q7S8W7 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 28% 68%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS