Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X910_LEIDO

TriTrypDb:

LdBPK_351520.1 , LdCL_350020100 , LDHU3_35.2030

Length:

619

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 5
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X910

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X910

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	146	148	PF00675	0.547
CLV_NRD_NRD_1	246	248	PF00675	0.491
CLV_NRD_NRD_1	44	46	PF00675	0.539
CLV_NRD_NRD_1	494	496	PF00675	0.499
CLV_PCSK_KEX2_1	146	148	PF00082	0.520
CLV_PCSK_KEX2_1	246	248	PF00082	0.489
CLV_PCSK_KEX2_1	44	46	PF00082	0.539
CLV_PCSK_KEX2_1	493	495	PF00082	0.494
CLV_PCSK_KEX2_1	70	72	PF00082	0.495
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.495
CLV_PCSK_PC7_1	489	495	PF00082	0.448
CLV_PCSK_SKI1_1	139	143	PF00082	0.536
CLV_PCSK_SKI1_1	275	279	PF00082	0.466
CLV_PCSK_SKI1_1	425	429	PF00082	0.578
CLV_PCSK_SKI1_1	478	482	PF00082	0.455
CLV_PCSK_SKI1_1	526	530	PF00082	0.485
DOC_CDC14_PxL_1	324	332	PF14671	0.604
DOC_CKS1_1	432	437	PF01111	0.671
DOC_CYCLIN_yCln2_LP_2	105	108	PF00134	0.777
DOC_CYCLIN_yCln2_LP_2	252	258	PF00134	0.664
DOC_CYCLIN_yCln2_LP_2	591	597	PF00134	0.351
DOC_MAPK_DCC_7	593	601	PF00069	0.351
DOC_MAPK_MEF2A_6	593	601	PF00069	0.342
DOC_PP1_RVXF_1	273	280	PF00149	0.696
DOC_PP1_RVXF_1	524	531	PF00149	0.669
DOC_PP2B_LxvP_1	105	108	PF13499	0.777
DOC_PP2B_PxIxI_1	257	263	PF00149	0.728
DOC_PP4_FxxP_1	265	268	PF00568	0.710
DOC_PP4_MxPP_1	81	84	PF00568	0.736
DOC_USP7_MATH_1	192	196	PF00917	0.686
DOC_USP7_MATH_1	248	252	PF00917	0.740
DOC_USP7_MATH_1	31	35	PF00917	0.698
DOC_USP7_MATH_1	338	342	PF00917	0.735
DOC_USP7_MATH_1	383	387	PF00917	0.739
DOC_USP7_MATH_1	452	456	PF00917	0.667
DOC_USP7_MATH_1	559	563	PF00917	0.765
DOC_WW_Pin1_4	153	158	PF00397	0.774
DOC_WW_Pin1_4	246	251	PF00397	0.734
DOC_WW_Pin1_4	308	313	PF00397	0.649
DOC_WW_Pin1_4	343	348	PF00397	0.592
DOC_WW_Pin1_4	431	436	PF00397	0.738
DOC_WW_Pin1_4	509	514	PF00397	0.718
LIG_14-3-3_CanoR_1	337	343	PF00244	0.643
LIG_14-3-3_CanoR_1	353	360	PF00244	0.602
LIG_14-3-3_CanoR_1	408	413	PF00244	0.799
LIG_14-3-3_CanoR_1	441	449	PF00244	0.722
LIG_14-3-3_CanoR_1	74	80	PF00244	0.638
LIG_14-3-3_CanoR_1	9	14	PF00244	0.703
LIG_Actin_WH2_2	365	383	PF00022	0.659
LIG_BH_BH3_1	82	98	PF00452	0.749
LIG_BIR_III_4	384	388	PF00653	0.689
LIG_BRCT_BRCA1_1	14	18	PF00533	0.739
LIG_BRCT_BRCA1_1	192	196	PF00533	0.687
LIG_BRCT_BRCA1_1	252	256	PF00533	0.757
LIG_BRCT_BRCA1_1	275	279	PF00533	0.736
LIG_BRCT_BRCA1_1	385	389	PF00533	0.749
LIG_deltaCOP1_diTrp_1	557	564	PF00928	0.734
LIG_eIF4E_1	172	178	PF01652	0.707
LIG_FHA_1	100	106	PF00498	0.718
LIG_FHA_1	213	219	PF00498	0.693
LIG_FHA_1	229	235	PF00498	0.765
LIG_FHA_1	347	353	PF00498	0.561
LIG_FHA_2	18	24	PF00498	0.711
LIG_FHA_2	445	451	PF00498	0.656
LIG_FHA_2	527	533	PF00498	0.659
LIG_FHA_2	552	558	PF00498	0.679
LIG_LIR_Apic_2	263	268	PF02991	0.711
LIG_LIR_Apic_2	555	561	PF02991	0.651
LIG_LIR_Gen_1	15	25	PF02991	0.711
LIG_LIR_Gen_1	321	331	PF02991	0.613
LIG_LIR_Gen_1	434	443	PF02991	0.661
LIG_LIR_Gen_1	454	465	PF02991	0.541
LIG_LIR_Gen_1	521	530	PF02991	0.658
LIG_LIR_Gen_1	61	69	PF02991	0.627
LIG_LIR_Nem_3	15	21	PF02991	0.716
LIG_LIR_Nem_3	253	259	PF02991	0.737
LIG_LIR_Nem_3	321	327	PF02991	0.658
LIG_LIR_Nem_3	329	334	PF02991	0.610
LIG_LIR_Nem_3	406	412	PF02991	0.751
LIG_LIR_Nem_3	434	440	PF02991	0.690
LIG_LIR_Nem_3	454	460	PF02991	0.533
LIG_LIR_Nem_3	521	527	PF02991	0.661
LIG_LIR_Nem_3	529	533	PF02991	0.591
LIG_LIR_Nem_3	544	549	PF02991	0.669
LIG_LIR_Nem_3	568	573	PF02991	0.399
LIG_LIR_Nem_3	585	591	PF02991	0.636
LIG_LIR_Nem_3	61	65	PF02991	0.630
LIG_MLH1_MIPbox_1	275	279	PF16413	0.736
LIG_MLH1_MIPbox_1	385	389	PF16413	0.749
LIG_PCNA_yPIPBox_3	288	302	PF02747	0.798
LIG_Pex14_2	600	604	PF04695	0.424
LIG_REV1ctd_RIR_1	276	282	PF16727	0.718
LIG_SH2_CRK	369	373	PF00017	0.612
LIG_SH2_CRK	524	528	PF00017	0.671
LIG_SH2_GRB2like	56	59	PF00017	0.649
LIG_SH2_NCK_1	320	324	PF00017	0.663
LIG_SH2_NCK_1	56	60	PF00017	0.648
LIG_SH2_PTP2	437	440	PF00017	0.635
LIG_SH2_SRC	56	59	PF00017	0.645
LIG_SH2_STAP1	320	324	PF00017	0.663
LIG_SH2_STAP1	369	373	PF00017	0.651
LIG_SH2_STAP1	374	378	PF00017	0.689
LIG_SH2_STAP1	56	60	PF00017	0.662
LIG_SH2_STAT5	437	440	PF00017	0.628
LIG_SH2_STAT5	541	544	PF00017	0.638
LIG_SH3_2	283	288	PF14604	0.820
LIG_SH3_3	252	258	PF00018	0.733
LIG_SH3_3	280	286	PF00018	0.732
LIG_SH3_3	510	516	PF00018	0.760
LIG_SH3_3	591	597	PF00018	0.363
LIG_TRAF2_1	448	451	PF00917	0.647
LIG_TRAF2_1	554	557	PF00917	0.677
LIG_TRFH_1	324	328	PF08558	0.497
LIG_TRFH_1	360	364	PF08558	0.570
LIG_UBA3_1	326	332	PF00899	0.567
LIG_WRC_WIRS_1	527	532	PF05994	0.581
LIG_WW_1	83	86	PF00397	0.682
MOD_CK1_1	12	18	PF00069	0.641
MOD_CK1_1	162	168	PF00069	0.593
MOD_CK1_1	190	196	PF00069	0.603
MOD_CK1_1	290	296	PF00069	0.738
MOD_CK1_1	313	319	PF00069	0.630
MOD_CK1_1	34	40	PF00069	0.576
MOD_CK1_1	341	347	PF00069	0.506
MOD_CK1_1	391	397	PF00069	0.761
MOD_CK1_1	411	417	PF00069	0.753
MOD_CK1_1	444	450	PF00069	0.667
MOD_CK1_1	552	558	PF00069	0.725
MOD_CK2_1	444	450	PF00069	0.598
MOD_CK2_1	551	557	PF00069	0.599
MOD_Cter_Amidation	244	247	PF01082	0.585
MOD_GlcNHglycan	189	192	PF01048	0.616
MOD_GlcNHglycan	289	292	PF01048	0.746
MOD_GlcNHglycan	33	36	PF01048	0.657
MOD_GlcNHglycan	384	388	PF01048	0.699
MOD_GlcNHglycan	390	393	PF01048	0.692
MOD_GlcNHglycan	561	564	PF01048	0.706
MOD_GlcNHglycan	604	607	PF01048	0.462
MOD_GSK3_1	149	156	PF00069	0.730
MOD_GSK3_1	246	253	PF00069	0.783
MOD_GSK3_1	30	37	PF00069	0.585
MOD_GSK3_1	379	386	PF00069	0.694
MOD_GSK3_1	411	418	PF00069	0.709
MOD_GSK3_1	441	448	PF00069	0.613
MOD_GSK3_1	537	544	PF00069	0.556
MOD_GSK3_1	559	566	PF00069	0.566
MOD_GSK3_1	9	16	PF00069	0.652
MOD_N-GLC_1	149	154	PF02516	0.733
MOD_N-GLC_1	237	242	PF02516	0.773
MOD_N-GLC_1	502	507	PF02516	0.775
MOD_N-GLC_1	75	80	PF02516	0.546
MOD_N-GLC_1	99	104	PF02516	0.646
MOD_NEK2_1	177	182	PF00069	0.617
MOD_NEK2_1	203	208	PF00069	0.536
MOD_NEK2_1	287	292	PF00069	0.738
MOD_NEK2_1	351	356	PF00069	0.446
MOD_NEK2_1	388	393	PF00069	0.755
MOD_NEK2_1	537	542	PF00069	0.523
MOD_NEK2_1	565	570	PF00069	0.461
MOD_NEK2_1	602	607	PF00069	0.422
MOD_NEK2_2	452	457	PF00069	0.489
MOD_PIKK_1	250	256	PF00454	0.547
MOD_PIKK_1	352	358	PF00454	0.477
MOD_PIKK_1	471	477	PF00454	0.606
MOD_PIKK_1	552	558	PF00454	0.602
MOD_PK_1	273	279	PF00069	0.561
MOD_PKA_2	25	31	PF00069	0.667
MOD_PKA_2	287	293	PF00069	0.712
MOD_PKA_2	352	358	PF00069	0.482
MOD_PKA_2	559	565	PF00069	0.644
MOD_Plk_1	149	155	PF00069	0.658
MOD_Plk_1	162	168	PF00069	0.593
MOD_Plk_1	228	234	PF00069	0.628
MOD_Plk_1	50	56	PF00069	0.637
MOD_Plk_1	75	81	PF00069	0.584
MOD_Plk_2-3	445	451	PF00069	0.657
MOD_Plk_4	17	23	PF00069	0.640
MOD_Plk_4	177	183	PF00069	0.540
MOD_Plk_4	326	332	PF00069	0.543
MOD_Plk_4	338	344	PF00069	0.456
MOD_Plk_4	34	40	PF00069	0.476
MOD_Plk_4	346	352	PF00069	0.234
MOD_Plk_4	452	458	PF00069	0.528
MOD_Plk_4	50	56	PF00069	0.668
MOD_Plk_4	537	543	PF00069	0.561
MOD_Plk_4	566	572	PF00069	0.408
MOD_ProDKin_1	153	159	PF00069	0.725
MOD_ProDKin_1	246	252	PF00069	0.677
MOD_ProDKin_1	308	314	PF00069	0.560
MOD_ProDKin_1	343	349	PF00069	0.473
MOD_ProDKin_1	431	437	PF00069	0.681
MOD_ProDKin_1	509	515	PF00069	0.653
MOD_SUMO_for_1	227	230	PF00179	0.615
MOD_SUMO_rev_2	66	72	PF00179	0.609
TRG_DiLeu_BaEn_2	67	73	PF01217	0.608
TRG_ENDOCYTIC_2	186	189	PF00928	0.633
TRG_ENDOCYTIC_2	369	372	PF00928	0.548
TRG_ENDOCYTIC_2	437	440	PF00928	0.531
TRG_ENDOCYTIC_2	524	527	PF00928	0.595
TRG_ENDOCYTIC_2	86	89	PF00928	0.615
TRG_ER_diArg_1	145	147	PF00400	0.696
TRG_ER_diArg_1	294	297	PF00400	0.684
TRG_ER_diArg_1	43	45	PF00400	0.668
TRG_ER_diArg_1	493	495	PF00400	0.612
TRG_Pf-PMV_PEXEL_1	441	445	PF00026	0.700
TRG_Pf-PMV_PEXEL_1	47	51	PF00026	0.656

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5N3	Leptomonas seymouri	37%	84%
A4HMH3	Leishmania braziliensis	79%	100%
A4IB53	Leishmania infantum	100%	100%
C9ZZG0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9AEX4	Leishmania major	94%	100%
E9B630	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%