TPR repeat family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peroxisome targeting signal 1 receptor, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X906_LEIDO

TriTrypDb:

LdBPK_351430.1 , LdCL_350019200 , LDHU3_35.1870

Length:

625

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005778	peroxisomal membrane	6	1
GO:0005829	cytosol	2	1
GO:0031090	organelle membrane	3	1
GO:0031903	microbody membrane	5	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

A0A3S7X906

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X906

Function

Biological processes
Term	Name	Level	Count
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0016560	protein import into peroxisome matrix, docking	5	1
GO:0033036	macromolecule localization	2	2
GO:0051179	localization	1	2
GO:0051641	cellular localization	2	2
GO:0070727	cellular macromolecule localization	3	2
GO:0006810	transport	3	1
GO:0015031	protein transport	4	1
GO:0045184	establishment of protein localization	3	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0000268	peroxisome targeting sequence binding	5	1
GO:0005048	signal sequence binding	4	1
GO:0005052	peroxisome matrix targeting signal-1 binding	6	1
GO:0005488	binding	1	1
GO:0033218	amide binding	2	1
GO:0042277	peptide binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	31	35	PF00656	0.665
CLV_NRD_NRD_1	384	386	PF00675	0.456
CLV_NRD_NRD_1	494	496	PF00675	0.345
CLV_PCSK_SKI1_1	15	19	PF00082	0.575
CLV_PCSK_SKI1_1	215	219	PF00082	0.507
CLV_PCSK_SKI1_1	90	94	PF00082	0.703
DEG_APCC_DBOX_1	591	599	PF00400	0.372
DEG_Nend_UBRbox_2	1	3	PF02207	0.577
DOC_CDC14_PxL_1	138	146	PF14671	0.644
DOC_PP2B_LxvP_1	252	255	PF13499	0.542
DOC_PP4_FxxP_1	186	189	PF00568	0.627
DOC_PP4_FxxP_1	259	262	PF00568	0.629
DOC_PP4_FxxP_1	447	450	PF00568	0.462
DOC_USP7_MATH_1	116	120	PF00917	0.714
DOC_USP7_MATH_1	162	166	PF00917	0.699
DOC_USP7_MATH_1	411	415	PF00917	0.395
DOC_USP7_MATH_1	429	433	PF00917	0.437
DOC_USP7_MATH_1	448	452	PF00917	0.476
DOC_USP7_MATH_1	468	472	PF00917	0.207
DOC_USP7_MATH_1	565	569	PF00917	0.490
DOC_USP7_MATH_1	86	90	PF00917	0.613
DOC_USP7_UBL2_3	506	510	PF12436	0.356
DOC_WW_Pin1_4	258	263	PF00397	0.619
DOC_WW_Pin1_4	267	272	PF00397	0.718
LIG_14-3-3_CanoR_1	592	596	PF00244	0.392
LIG_APCC_ABBA_1	498	503	PF00400	0.329
LIG_BRCT_BRCA1_1	470	474	PF00533	0.480
LIG_FHA_1	592	598	PF00498	0.415
LIG_FHA_2	193	199	PF00498	0.530
LIG_FHA_2	267	273	PF00498	0.699
LIG_FHA_2	365	371	PF00498	0.370
LIG_FHA_2	456	462	PF00498	0.529
LIG_FHA_2	605	611	PF00498	0.561
LIG_FXI_DFP_1	323	327	PF00024	0.491
LIG_IBAR_NPY_1	319	321	PF08397	0.386
LIG_LIR_Apic_2	185	189	PF02991	0.666
LIG_LIR_Apic_2	256	262	PF02991	0.622
LIG_LIR_Apic_2	444	450	PF02991	0.531
LIG_LIR_Gen_1	177	188	PF02991	0.647
LIG_LIR_Gen_1	296	304	PF02991	0.539
LIG_LIR_Gen_1	358	369	PF02991	0.501
LIG_LIR_Gen_1	424	433	PF02991	0.552
LIG_LIR_Gen_1	471	480	PF02991	0.502
LIG_LIR_Nem_3	136	141	PF02991	0.751
LIG_LIR_Nem_3	177	183	PF02991	0.628
LIG_LIR_Nem_3	202	208	PF02991	0.497
LIG_LIR_Nem_3	358	364	PF02991	0.387
LIG_LIR_Nem_3	424	428	PF02991	0.520
LIG_LIR_Nem_3	471	477	PF02991	0.505
LIG_Pex14_1	176	180	PF04695	0.568
LIG_Pex14_1	293	297	PF04695	0.524
LIG_Pex14_1	53	57	PF04695	0.539
LIG_Pex14_2	615	619	PF04695	0.374
LIG_PTB_Apo_2	532	539	PF02174	0.298
LIG_PTB_Phospho_1	532	538	PF10480	0.298
LIG_SH2_CRK	138	142	PF00017	0.756
LIG_SH2_CRK	180	184	PF00017	0.684
LIG_SH2_GRB2like	549	552	PF00017	0.382
LIG_SH2_NCK_1	180	184	PF00017	0.598
LIG_SH2_NCK_1	555	559	PF00017	0.444
LIG_SH2_STAP1	425	429	PF00017	0.529
LIG_SH2_STAP1	460	464	PF00017	0.536
LIG_SH2_STAT3	608	611	PF00017	0.495
LIG_SH2_STAT5	242	245	PF00017	0.533
LIG_SH2_STAT5	279	282	PF00017	0.728
LIG_SH2_STAT5	538	541	PF00017	0.322
LIG_SH3_3	224	230	PF00018	0.541
LIG_SH3_3	231	237	PF00018	0.571
LIG_SH3_3	311	317	PF00018	0.449
LIG_SH3_3	417	423	PF00018	0.482
LIG_SH3_3	428	434	PF00018	0.528
LIG_SH3_3	499	505	PF00018	0.419
LIG_SUMO_SIM_anti_2	374	380	PF11976	0.395
LIG_TRAF2_1	195	198	PF00917	0.509
LIG_TYR_ITSM	176	183	PF00017	0.687
LIG_UBA3_1	378	386	PF00899	0.477
LIG_WRC_WIRS_1	183	188	PF05994	0.659
MOD_CK1_1	266	272	PF00069	0.777
MOD_CK1_1	550	556	PF00069	0.464
MOD_CK2_1	192	198	PF00069	0.521
MOD_CK2_1	266	272	PF00069	0.729
MOD_CK2_1	352	358	PF00069	0.496
MOD_CK2_1	364	370	PF00069	0.374
MOD_CK2_1	455	461	PF00069	0.493
MOD_CK2_1	604	610	PF00069	0.525
MOD_GlcNHglycan	144	147	PF01048	0.701
MOD_GlcNHglycan	164	167	PF01048	0.627
MOD_GlcNHglycan	186	189	PF01048	0.704
MOD_GlcNHglycan	26	29	PF01048	0.716
MOD_GlcNHglycan	265	268	PF01048	0.763
MOD_GlcNHglycan	575	578	PF01048	0.540
MOD_GSK3_1	11	18	PF00069	0.668
MOD_GSK3_1	174	181	PF00069	0.648
MOD_GSK3_1	24	31	PF00069	0.734
MOD_GSK3_1	254	261	PF00069	0.656
MOD_GSK3_1	263	270	PF00069	0.772
MOD_GSK3_1	396	403	PF00069	0.492
MOD_GSK3_1	468	475	PF00069	0.522
MOD_GSK3_1	573	580	PF00069	0.484
MOD_N-GLC_1	142	147	PF02516	0.717
MOD_N-GLC_1	308	313	PF02516	0.476
MOD_N-GLC_1	550	555	PF02516	0.464
MOD_NEK2_1	364	369	PF00069	0.371
MOD_NEK2_1	398	403	PF00069	0.378
MOD_NEK2_1	511	516	PF00069	0.298
MOD_NEK2_1	591	596	PF00069	0.390
MOD_NEK2_1	76	81	PF00069	0.570
MOD_NEK2_2	411	416	PF00069	0.418
MOD_PIKK_1	116	122	PF00454	0.677
MOD_PIKK_1	133	139	PF00454	0.717
MOD_PIKK_1	169	175	PF00454	0.688
MOD_PIKK_1	178	184	PF00454	0.685
MOD_PIKK_1	364	370	PF00454	0.374
MOD_PIKK_1	468	474	PF00454	0.526
MOD_PIKK_1	550	556	PF00454	0.464
MOD_PIKK_1	565	571	PF00454	0.485
MOD_PIKK_1	76	82	PF00454	0.713
MOD_PKA_2	591	597	PF00069	0.391
MOD_Plk_1	142	148	PF00069	0.739
MOD_Plk_1	15	21	PF00069	0.616
MOD_Plk_1	178	184	PF00069	0.650
MOD_Plk_1	192	198	PF00069	0.463
MOD_Plk_1	550	556	PF00069	0.464
MOD_Plk_2-3	192	198	PF00069	0.607
MOD_Plk_2-3	455	461	PF00069	0.545
MOD_Plk_4	108	114	PF00069	0.696
MOD_Plk_4	15	21	PF00069	0.714
MOD_Plk_4	254	260	PF00069	0.638
MOD_Plk_4	441	447	PF00069	0.600
MOD_Plk_4	577	583	PF00069	0.603
MOD_ProDKin_1	258	264	PF00069	0.626
MOD_ProDKin_1	267	273	PF00069	0.717
MOD_SUMO_rev_2	187	196	PF00179	0.626
MOD_SUMO_rev_2	503	507	PF00179	0.346
TRG_DiLeu_BaEn_1	222	227	PF01217	0.613
TRG_DiLeu_BaEn_1	32	37	PF01217	0.570
TRG_DiLeu_BaEn_2	203	209	PF01217	0.548
TRG_ENDOCYTIC_2	138	141	PF00928	0.748
TRG_ENDOCYTIC_2	180	183	PF00928	0.624
TRG_ENDOCYTIC_2	206	209	PF00928	0.498
TRG_ENDOCYTIC_2	297	300	PF00928	0.539
TRG_ENDOCYTIC_2	425	428	PF00928	0.398
TRG_ENDOCYTIC_2	549	552	PF00928	0.366
TRG_NES_CRM1_1	610	622	PF08389	0.447
TRG_Pf-PMV_PEXEL_1	457	461	PF00026	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBT5	Leptomonas seymouri	82%	100%
A0A0S4KFV0	Bodo saltans	46%	99%
A0A1X0NH73	Trypanosomatidae	50%	96%
A0A422N9P3	Trypanosoma rangeli	58%	95%
A4HMG4	Leishmania braziliensis	86%	100%
A4IB35	Leishmania infantum	100%	100%
C9ZNN6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	95%
E9AEW5	Leishmania major	94%	100%
E9B621	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O70525	Cavia porcellus	32%	98%
P50542	Homo sapiens	33%	98%
Q1RMV0	Bos taurus	33%	98%
Q920N5	Cricetulus griseus	30%	98%
Q9FMA3	Arabidopsis thaliana	34%	86%
V5B7T1	Trypanosoma cruzi	49%	94%