Threonine--tRNA ligase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

threonyl-tRNA synthetase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X901_LEIDO

TriTrypDb:

LdBPK_351420.1 , LdCL_350019100 , LDHU3_35.1860

Length:

788

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	12

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Expansion

Sequence features

A0A3S7X901

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X901

Function

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Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006399	tRNA metabolic process	7	12
GO:0006418	tRNA aminoacylation for protein translation	6	12
GO:0006435	threonyl-tRNA aminoacylation	7	12
GO:0006520	amino acid metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004812	aminoacyl-tRNA ligase activity	4	12
GO:0004829	threonine-tRNA ligase activity	5	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016874	ligase activity	2	12
GO:0016875	ligase activity, forming carbon-oxygen bonds	3	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.559
CLV_C14_Caspase3-7	51	55	PF00656	0.557
CLV_MEL_PAP_1	584	590	PF00089	0.346
CLV_NRD_NRD_1	326	328	PF00675	0.445
CLV_NRD_NRD_1	331	333	PF00675	0.495
CLV_NRD_NRD_1	422	424	PF00675	0.346
CLV_NRD_NRD_1	571	573	PF00675	0.346
CLV_PCSK_FUR_1	420	424	PF00082	0.346
CLV_PCSK_KEX2_1	286	288	PF00082	0.508
CLV_PCSK_KEX2_1	331	333	PF00082	0.484

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKL1	Leptomonas seymouri	82%	99%
A0A0S4KJ29	Bodo saltans	66%	97%
A0A1X0NHQ0	Trypanosomatidae	68%	94%
A0A422N9K9	Trypanosoma rangeli	70%	97%
A0AJ08	Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / CIP 8149 / NCTC 11857 / SLCC 5334 / V8)	32%	100%
A0KKP9	Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049)	33%	100%
A0KWV4	Shewanella sp. (strain ANA-3)	32%	100%
A0L4J6	Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1)	31%	100%
A0PZN1	Clostridium novyi (strain NT)	36%	100%
A0Q762	Francisella tularensis subsp. novicida (strain U112)	33%	100%

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