Aldose_1-epimerase_putative/GeneDB:LmjF.35.0970

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aldose 1-epimerase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X8Z3_LEIDO

TriTrypDb:

LdBPK_350990.1 , LdCL_350014800 , LDHU3_35.1230

Length:

377

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 28

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X8Z3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8Z3

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	21
GO:0008152	metabolic process	1	21
GO:0044238	primary metabolic process	2	21
GO:0071704	organic substance metabolic process	2	21
GO:0005996	monosaccharide metabolic process	3	6
GO:0019318	hexose metabolic process	4	6
GO:0044281	small molecule metabolic process	2	6
GO:0006006	glucose metabolic process	5	3
GO:0006012	galactose metabolic process	5	3
GO:0009056	catabolic process	2	3
GO:0016052	carbohydrate catabolic process	4	3
GO:0019320	hexose catabolic process	5	3
GO:0019388	galactose catabolic process	6	3
GO:0033499	galactose catabolic process via UDP-galactose	7	3
GO:0044282	small molecule catabolic process	3	3
GO:0046365	monosaccharide catabolic process	4	3
GO:1901575	organic substance catabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	21
GO:0004034	aldose 1-epimerase activity	5	16
GO:0005488	binding	1	21
GO:0016853	isomerase activity	2	21
GO:0016854	racemase and epimerase activity	3	16
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	4	16
GO:0030246	carbohydrate binding	2	21

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	355	357	PF00675	0.241
CLV_PCSK_KEX2_1	355	357	PF00082	0.296
CLV_PCSK_SKI1_1	281	285	PF00082	0.296
DOC_MAPK_gen_1	19	27	PF00069	0.377
DOC_MAPK_gen_1	325	334	PF00069	0.439
DOC_MAPK_MEF2A_6	19	27	PF00069	0.463
DOC_PP1_RVXF_1	12	18	PF00149	0.429
DOC_PP2B_LxvP_1	215	218	PF13499	0.480
DOC_USP7_MATH_2	142	148	PF00917	0.493
DOC_WW_Pin1_4	131	136	PF00397	0.436
DOC_WW_Pin1_4	170	175	PF00397	0.446
DOC_WW_Pin1_4	287	292	PF00397	0.442
LIG_14-3-3_CanoR_1	360	366	PF00244	0.442
LIG_Actin_WH2_2	11	26	PF00022	0.329
LIG_APCC_ABBA_1	282	287	PF00400	0.444
LIG_APCC_ABBAyCdc20_2	281	287	PF00400	0.444
LIG_BIR_III_2	176	180	PF00653	0.482
LIG_FHA_1	148	154	PF00498	0.472
LIG_FHA_1	18	24	PF00498	0.485
LIG_FHA_1	81	87	PF00498	0.494
LIG_FHA_2	120	126	PF00498	0.389
LIG_FHA_2	161	167	PF00498	0.534
LIG_FHA_2	239	245	PF00498	0.458
LIG_FHA_2	59	65	PF00498	0.485
LIG_LIR_Apic_2	129	135	PF02991	0.476
LIG_LIR_Gen_1	232	243	PF02991	0.567
LIG_LIR_Nem_3	163	168	PF02991	0.524
LIG_LIR_Nem_3	232	238	PF02991	0.513
LIG_LIR_Nem_3	64	70	PF02991	0.557
LIG_OCRL_FandH_1	109	121	PF00620	0.460
LIG_Pex14_2	303	307	PF04695	0.453
LIG_PTB_Apo_2	181	188	PF02174	0.428
LIG_PTB_Phospho_1	181	187	PF10480	0.428
LIG_SH2_CRK	132	136	PF00017	0.482
LIG_SH2_CRK	67	71	PF00017	0.493
LIG_SH2_GRB2like	187	190	PF00017	0.428
LIG_SH2_SRC	268	271	PF00017	0.433
LIG_SH2_STAP1	165	169	PF00017	0.496
LIG_SH2_STAT5	132	135	PF00017	0.479
LIG_SH2_STAT5	168	171	PF00017	0.537
LIG_SH2_STAT5	309	312	PF00017	0.460
LIG_SH2_STAT5	338	341	PF00017	0.449
LIG_SH3_3	344	350	PF00018	0.461
LIG_SH3_3	36	42	PF00018	0.506
LIG_SUMO_SIM_anti_2	256	262	PF11976	0.529
LIG_SUMO_SIM_par_1	269	275	PF11976	0.472
LIG_TYR_ITSM	63	70	PF00017	0.389
LIG_UBA3_1	15	19	PF00899	0.210
MOD_CK1_1	147	153	PF00069	0.503
MOD_CK1_1	290	296	PF00069	0.443
MOD_CK1_1	359	365	PF00069	0.470
MOD_CK2_1	119	125	PF00069	0.455
MOD_CK2_1	54	60	PF00069	0.481
MOD_GlcNHglycan	318	321	PF01048	0.280
MOD_GlcNHglycan	56	59	PF01048	0.384
MOD_GSK3_1	126	133	PF00069	0.431
MOD_GSK3_1	149	156	PF00069	0.503
MOD_GSK3_1	160	167	PF00069	0.472
MOD_GSK3_1	234	241	PF00069	0.511
MOD_GSK3_1	367	374	PF00069	0.460
MOD_GSK3_1	54	61	PF00069	0.483
MOD_N-GLC_1	130	135	PF02516	0.293
MOD_N-GLC_2	294	296	PF02516	0.244
MOD_NEK2_1	130	135	PF00069	0.478
MOD_NEK2_1	30	35	PF00069	0.440
MOD_NEK2_1	361	366	PF00069	0.533
MOD_NEK2_1	68	73	PF00069	0.461
MOD_NEK2_2	80	85	PF00069	0.389
MOD_NEK2_2	99	104	PF00069	0.440
MOD_PKA_2	327	333	PF00069	0.462
MOD_PKA_2	359	365	PF00069	0.499
MOD_PKA_2	99	105	PF00069	0.488
MOD_Plk_1	367	373	PF00069	0.405
MOD_Plk_2-3	234	240	PF00069	0.444
MOD_Plk_4	164	170	PF00069	0.475
MOD_Plk_4	361	367	PF00069	0.459
MOD_ProDKin_1	131	137	PF00069	0.436
MOD_ProDKin_1	170	176	PF00069	0.446
MOD_ProDKin_1	287	293	PF00069	0.442
TRG_DiLeu_BaEn_1	278	283	PF01217	0.500
TRG_ENDOCYTIC_2	187	190	PF00928	0.428
TRG_ENDOCYTIC_2	300	303	PF00928	0.448
TRG_ENDOCYTIC_2	67	70	PF00928	0.389
TRG_ER_diArg_1	22	25	PF00400	0.377
TRG_ER_diArg_1	354	356	PF00400	0.496
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.262
TRG_PTS1	374	377	PF00515	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0E0RXA9	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	27%	87%
A0A0N0P441	Leptomonas seymouri	64%	100%
A0A0N0P558	Leptomonas seymouri	35%	93%
A0A0N1PBB3	Leptomonas seymouri	54%	100%
A0A1X0NJ33	Trypanosomatidae	56%	100%
A0A1X0NX70	Trypanosomatidae	39%	99%
A0A3R7MXQ5	Trypanosoma rangeli	39%	100%
A0A3S7WXI1	Leishmania donovani	35%	100%
A0A3S7X8W5	Leishmania donovani	70%	99%
A0A422N115	Trypanosoma rangeli	50%	100%
A4HCQ7	Leishmania braziliensis	37%	100%
A4I082	Leishmania infantum	35%	100%
A4IAZ4	Leishmania infantum	70%	99%
D4AMB9	Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)	28%	86%
E9AES2	Leishmania major	71%	99%
E9AES3	Leishmania major	97%	100%
E9AW46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9B5X7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	99%
E9B5X8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
P05149	Acinetobacter calcoaceticus	30%	99%
P0A9C3	Escherichia coli (strain K12)	30%	100%
P0A9C4	Shigella flexneri	30%	100%
P21955	Streptococcus thermophilus	21%	100%
P31765	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	29%	100%
P53757	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
Q03PA4	Levilactobacillus brevis (strain ATCC 367 / BCRC 12310 / CIP 105137 / JCM 1170 / LMG 11437 / NCIMB 947 / NCTC 947)	25%	100%
Q4QBD1	Leishmania major	36%	100%
Q5EA79	Bos taurus	29%	100%
Q5R8U1	Pongo abelii	29%	100%
Q66HG4	Rattus norvegicus	29%	100%
Q8K157	Mus musculus	29%	100%
Q96C23	Homo sapiens	30%	100%
Q9GKX6	Sus scrofa	29%	100%
V5B7Z0	Trypanosoma cruzi	38%	98%