Degradation arginine-rich protein for mis-folding, putative

Quick info Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Degradation arginine-rich protein for mis-folding, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X8Z2_LEIDO

TriTrypDb:

LdBPK_351220.1 , LdCL_350017000 , LDHU3_35.1620

Length:

219

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 1
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S7X8Z2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8Z2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.428
CLV_C14_Caspase3-7	184	188	PF00656	0.516
CLV_C14_Caspase3-7	211	215	PF00656	0.565
CLV_NRD_NRD_1	129	131	PF00675	0.455
CLV_NRD_NRD_1	99	101	PF00675	0.515
CLV_PCSK_KEX2_1	129	131	PF00082	0.432
CLV_PCSK_KEX2_1	73	75	PF00082	0.474
CLV_PCSK_KEX2_1	98	100	PF00082	0.488
CLV_PCSK_PC1ET2_1	73	75	PF00082	0.474
CLV_PCSK_SKI1_1	2	6	PF00082	0.637
CLV_PCSK_SKI1_1	28	32	PF00082	0.465
CLV_PCSK_SKI1_1	36	40	PF00082	0.446
DEG_MDM2_SWIB_1	81	88	PF02201	0.383
DEG_Nend_UBRbox_1	1	4	PF02207	0.675
DOC_PP1_RVXF_1	146	153	PF00149	0.477
DOC_USP7_MATH_1	119	123	PF00917	0.469
DOC_USP7_MATH_1	175	179	PF00917	0.485
DOC_USP7_MATH_1	67	71	PF00917	0.581
DOC_USP7_UBL2_3	144	148	PF12436	0.364
DOC_USP7_UBL2_3	29	33	PF12436	0.264
DOC_WW_Pin1_4	135	140	PF00397	0.548
DOC_WW_Pin1_4	166	171	PF00397	0.441
LIG_14-3-3_CanoR_1	195	203	PF00244	0.409
LIG_Actin_WH2_2	128	146	PF00022	0.509
LIG_BRCT_BRCA1_1	155	159	PF00533	0.441
LIG_FHA_1	196	202	PF00498	0.444
LIG_FHA_1	63	69	PF00498	0.474
LIG_FHA_2	109	115	PF00498	0.388
LIG_FHA_2	136	142	PF00498	0.422
LIG_FHA_2	159	165	PF00498	0.355
LIG_FHA_2	21	27	PF00498	0.438
LIG_LIR_Gen_1	106	116	PF02991	0.550
LIG_LIR_Gen_1	156	167	PF02991	0.452
LIG_LIR_Gen_1	53	60	PF02991	0.289
LIG_LIR_Nem_3	106	112	PF02991	0.512
LIG_LIR_Nem_3	145	150	PF02991	0.406
LIG_LIR_Nem_3	156	162	PF02991	0.451
LIG_LIR_Nem_3	83	88	PF02991	0.375
LIG_PDZ_Class_3	214	219	PF00595	0.505
LIG_Pex14_2	81	85	PF04695	0.358
LIG_PTB_Apo_2	204	211	PF02174	0.453
LIG_PTB_Apo_2	75	82	PF02174	0.503
LIG_PTB_Phospho_1	204	210	PF10480	0.450
LIG_SH2_NCK_1	210	214	PF00017	0.584
LIG_SH2_SRC	210	213	PF00017	0.576
LIG_SH2_STAT3	123	126	PF00017	0.506
LIG_SH2_STAT5	123	126	PF00017	0.453
LIG_SH2_STAT5	151	154	PF00017	0.464
LIG_SH2_STAT5	165	168	PF00017	0.404
MOD_CK1_1	178	184	PF00069	0.383
MOD_CMANNOS	82	85	PF00535	0.342
MOD_Cter_Amidation	127	130	PF01082	0.403
MOD_GlcNHglycan	117	120	PF01048	0.413
MOD_GlcNHglycan	18	21	PF01048	0.636
MOD_GlcNHglycan	183	186	PF01048	0.488
MOD_GlcNHglycan	189	192	PF01048	0.533
MOD_GlcNHglycan	69	72	PF01048	0.634
MOD_GSK3_1	103	110	PF00069	0.429
MOD_GSK3_1	115	122	PF00069	0.364
MOD_GSK3_1	16	23	PF00069	0.617
MOD_N-GLC_2	91	93	PF02516	0.383
MOD_NEK2_1	13	18	PF00069	0.492
MOD_NEK2_1	142	147	PF00069	0.353
MOD_NEK2_1	158	163	PF00069	0.408
MOD_NEK2_1	186	191	PF00069	0.531
MOD_PKA_2	62	68	PF00069	0.459
MOD_Plk_4	119	125	PF00069	0.393
MOD_Plk_4	13	19	PF00069	0.512
MOD_Plk_4	178	184	PF00069	0.440
MOD_ProDKin_1	135	141	PF00069	0.544
MOD_ProDKin_1	166	172	PF00069	0.440
MOD_SUMO_for_1	72	75	PF00179	0.498
MOD_SUMO_for_1	89	92	PF00179	0.301
MOD_SUMO_rev_2	24	30	PF00179	0.308
TRG_DiLeu_BaEn_2	50	56	PF01217	0.284
TRG_ENDOCYTIC_2	210	213	PF00928	0.462
TRG_ER_diArg_1	129	131	PF00400	0.478
TRG_ER_diArg_1	97	100	PF00400	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYS8	Leptomonas seymouri	74%	100%
A0A0S4IZ22	Bodo saltans	38%	100%
A0A1X0NHR2	Trypanosomatidae	56%	97%
A0A422N9T4	Trypanosoma rangeli	50%	95%
A4HME3	Leishmania braziliensis	81%	100%
A4IB15	Leishmania infantum	100%	100%
C9ZNP7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	96%
E9AEU4	Leishmania major	98%	100%
E9B600	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%