RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X8Y6_LEIDO

TriTrypDb:

LdBPK_351110.1 , LdCL_350015900 , LDHU3_35.1420

Length:

693

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X8Y6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8Y6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	211	215	PF00656	0.711
CLV_NRD_NRD_1	101	103	PF00675	0.675
CLV_NRD_NRD_1	142	144	PF00675	0.811
CLV_NRD_NRD_1	152	154	PF00675	0.617
CLV_NRD_NRD_1	234	236	PF00675	0.671
CLV_NRD_NRD_1	394	396	PF00675	0.724
CLV_NRD_NRD_1	48	50	PF00675	0.719
CLV_NRD_NRD_1	567	569	PF00675	0.503
CLV_NRD_NRD_1	608	610	PF00675	0.734
CLV_NRD_NRD_1	630	632	PF00675	0.799
CLV_NRD_NRD_1	644	646	PF00675	0.615
CLV_NRD_NRD_1	663	665	PF00675	0.660
CLV_PCSK_FUR_1	140	144	PF00082	0.816
CLV_PCSK_FUR_1	675	679	PF00082	0.559
CLV_PCSK_KEX2_1	10	12	PF00082	0.750
CLV_PCSK_KEX2_1	103	105	PF00082	0.714
CLV_PCSK_KEX2_1	142	144	PF00082	0.800
CLV_PCSK_KEX2_1	152	154	PF00082	0.607
CLV_PCSK_KEX2_1	234	236	PF00082	0.694
CLV_PCSK_KEX2_1	394	396	PF00082	0.724
CLV_PCSK_KEX2_1	48	50	PF00082	0.719
CLV_PCSK_KEX2_1	566	568	PF00082	0.517
CLV_PCSK_KEX2_1	608	610	PF00082	0.726
CLV_PCSK_KEX2_1	644	646	PF00082	0.692
CLV_PCSK_KEX2_1	663	665	PF00082	0.660
CLV_PCSK_KEX2_1	677	679	PF00082	0.578
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.750
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.714
CLV_PCSK_PC1ET2_1	677	679	PF00082	0.563
CLV_PCSK_SKI1_1	135	139	PF00082	0.650
CLV_PCSK_SKI1_1	579	583	PF00082	0.517
DEG_SCF_FBW7_1	78	85	PF00400	0.644
DEG_SIAH_1	549	557	PF03145	0.790
DEG_SPOP_SBC_1	356	360	PF00917	0.768
DEG_SPOP_SBC_1	386	390	PF00917	0.787
DEG_SPOP_SBC_1	39	43	PF00917	0.717
DEG_SPOP_SBC_1	601	605	PF00917	0.756
DOC_CKS1_1	190	195	PF01111	0.730
DOC_CKS1_1	226	231	PF01111	0.730
DOC_CKS1_1	303	308	PF01111	0.774
DOC_CKS1_1	498	503	PF01111	0.708
DOC_CYCLIN_RxL_1	410	421	PF00134	0.799
DOC_CYCLIN_yCln2_LP_2	226	232	PF00134	0.731
DOC_MAPK_gen_1	507	515	PF00069	0.609
DOC_MAPK_MEF2A_6	428	435	PF00069	0.800
DOC_PP2B_LxvP_1	408	411	PF13499	0.692
DOC_PP2B_LxvP_1	597	600	PF13499	0.796
DOC_PP4_MxPP_1	1	4	PF00568	0.823
DOC_USP7_MATH_1	105	109	PF00917	0.819
DOC_USP7_MATH_1	141	145	PF00917	0.721
DOC_USP7_MATH_1	245	249	PF00917	0.701
DOC_USP7_MATH_1	255	259	PF00917	0.546
DOC_USP7_MATH_1	262	266	PF00917	0.653
DOC_USP7_MATH_1	322	326	PF00917	0.742
DOC_USP7_MATH_1	350	354	PF00917	0.820
DOC_USP7_MATH_1	377	381	PF00917	0.764
DOC_USP7_MATH_1	402	406	PF00917	0.809
DOC_USP7_MATH_1	411	415	PF00917	0.530
DOC_USP7_MATH_1	480	484	PF00917	0.666
DOC_USP7_MATH_1	496	500	PF00917	0.676
DOC_USP7_MATH_1	509	513	PF00917	0.621
DOC_USP7_MATH_1	602	606	PF00917	0.650
DOC_USP7_MATH_1	630	634	PF00917	0.813
DOC_USP7_MATH_1	636	640	PF00917	0.766
DOC_USP7_MATH_1	662	666	PF00917	0.715
DOC_USP7_MATH_1	94	98	PF00917	0.757
DOC_USP7_MATH_2	28	34	PF00917	0.816
DOC_WW_Pin1_4	120	125	PF00397	0.734
DOC_WW_Pin1_4	154	159	PF00397	0.737
DOC_WW_Pin1_4	182	187	PF00397	0.746
DOC_WW_Pin1_4	189	194	PF00397	0.820
DOC_WW_Pin1_4	225	230	PF00397	0.728
DOC_WW_Pin1_4	24	29	PF00397	0.809
DOC_WW_Pin1_4	246	251	PF00397	0.823
DOC_WW_Pin1_4	258	263	PF00397	0.512
DOC_WW_Pin1_4	299	304	PF00397	0.671
DOC_WW_Pin1_4	497	502	PF00397	0.710
DOC_WW_Pin1_4	518	523	PF00397	0.646
DOC_WW_Pin1_4	592	597	PF00397	0.649
DOC_WW_Pin1_4	654	659	PF00397	0.742
DOC_WW_Pin1_4	76	81	PF00397	0.764
DOC_WW_Pin1_4	85	90	PF00397	0.833
LIG_14-3-3_CanoR_1	116	124	PF00244	0.826
LIG_14-3-3_CanoR_1	269	277	PF00244	0.735
LIG_14-3-3_CanoR_1	357	362	PF00244	0.717
LIG_14-3-3_CanoR_1	507	515	PF00244	0.688
LIG_14-3-3_CanoR_1	545	550	PF00244	0.623
LIG_14-3-3_CanoR_1	609	617	PF00244	0.660
LIG_14-3-3_CanoR_1	631	640	PF00244	0.756
LIG_14-3-3_CanoR_1	644	653	PF00244	0.663
LIG_14-3-3_CanoR_1	663	673	PF00244	0.614
LIG_BIR_III_2	214	218	PF00653	0.702
LIG_BIR_III_2	586	590	PF00653	0.693
LIG_BRCT_BRCA1_1	143	147	PF00533	0.828
LIG_BRCT_BRCA1_1	665	669	PF00533	0.620
LIG_FHA_1	128	134	PF00498	0.738
LIG_FHA_1	155	161	PF00498	0.674
LIG_FHA_1	192	198	PF00498	0.717
LIG_FHA_1	287	293	PF00498	0.672
LIG_FHA_1	356	362	PF00498	0.774
LIG_FHA_1	483	489	PF00498	0.791
LIG_FHA_2	387	393	PF00498	0.770
LIG_FHA_2	62	68	PF00498	0.696
LIG_LIR_Gen_1	305	313	PF02991	0.685
LIG_LIR_Gen_1	521	530	PF02991	0.605
LIG_LIR_Gen_1	666	676	PF02991	0.590
LIG_LIR_Nem_3	305	311	PF02991	0.660
LIG_LIR_Nem_3	521	526	PF02991	0.615
LIG_LIR_Nem_3	578	584	PF02991	0.532
LIG_LIR_Nem_3	666	672	PF02991	0.603
LIG_PTAP_UEV_1	123	128	PF05743	0.695
LIG_SH2_CRK	206	210	PF00017	0.720
LIG_SH2_CRK	298	302	PF00017	0.675
LIG_SH2_CRK	523	527	PF00017	0.703
LIG_SH2_NCK_1	298	302	PF00017	0.772
LIG_SH2_STAT3	611	614	PF00017	0.641
LIG_SH2_STAT5	298	301	PF00017	0.726
LIG_SH3_3	121	127	PF00018	0.826
LIG_SH3_3	158	164	PF00018	0.653
LIG_SH3_3	214	220	PF00018	0.824
LIG_SH3_3	297	303	PF00018	0.692
LIG_SH3_3	381	387	PF00018	0.796
LIG_SH3_3	593	599	PF00018	0.696
LIG_SH3_3	652	658	PF00018	0.793
LIG_SH3_3	74	80	PF00018	0.814
LIG_SUMO_SIM_par_1	21	27	PF11976	0.759
LIG_TRAF2_1	216	219	PF00917	0.825
MOD_CDC14_SPxK_1	502	505	PF00782	0.704
MOD_CDC14_SPxK_1	595	598	PF00782	0.708
MOD_CDK_SPxK_1	499	505	PF00069	0.707
MOD_CDK_SPxK_1	592	598	PF00069	0.653
MOD_CK1_1	146	152	PF00069	0.678
MOD_CK1_1	207	213	PF00069	0.849
MOD_CK1_1	248	254	PF00069	0.763
MOD_CK1_1	258	264	PF00069	0.589
MOD_CK1_1	265	271	PF00069	0.562
MOD_CK1_1	302	308	PF00069	0.673
MOD_CK1_1	372	378	PF00069	0.771
MOD_CK1_1	483	489	PF00069	0.677
MOD_CK1_1	497	503	PF00069	0.721
MOD_CK1_1	50	56	PF00069	0.714
MOD_CK1_1	521	527	PF00069	0.586
MOD_CK1_1	6	12	PF00069	0.787
MOD_CK1_1	61	67	PF00069	0.729
MOD_CK1_1	615	621	PF00069	0.750
MOD_CK1_1	624	630	PF00069	0.773
MOD_CK1_1	90	96	PF00069	0.831
MOD_CK2_1	24	30	PF00069	0.746
MOD_CK2_1	269	275	PF00069	0.674
MOD_CK2_1	386	392	PF00069	0.707
MOD_CK2_1	558	564	PF00069	0.526
MOD_CK2_1	61	67	PF00069	0.700
MOD_CK2_1	664	670	PF00069	0.721
MOD_Cter_Amidation	150	153	PF01082	0.653
MOD_Cter_Amidation	46	49	PF01082	0.719
MOD_GlcNHglycan	107	110	PF01048	0.797
MOD_GlcNHglycan	124	127	PF01048	0.681
MOD_GlcNHglycan	143	146	PF01048	0.735
MOD_GlcNHglycan	154	157	PF01048	0.586
MOD_GlcNHglycan	206	209	PF01048	0.831
MOD_GlcNHglycan	257	260	PF01048	0.840
MOD_GlcNHglycan	265	268	PF01048	0.607
MOD_GlcNHglycan	324	327	PF01048	0.849
MOD_GlcNHglycan	352	355	PF01048	0.753
MOD_GlcNHglycan	367	370	PF01048	0.566
MOD_GlcNHglycan	379	382	PF01048	0.612
MOD_GlcNHglycan	482	485	PF01048	0.704
MOD_GlcNHglycan	49	52	PF01048	0.850
MOD_GlcNHglycan	494	497	PF01048	0.650
MOD_GlcNHglycan	54	57	PF01048	0.677
MOD_GlcNHglycan	60	63	PF01048	0.723
MOD_GlcNHglycan	614	617	PF01048	0.626
MOD_GlcNHglycan	647	650	PF01048	0.691
MOD_GlcNHglycan	666	669	PF01048	0.617
MOD_GlcNHglycan	690	693	PF01048	0.701
MOD_GlcNHglycan	92	95	PF01048	0.744
MOD_GlcNHglycan	96	99	PF01048	0.754
MOD_GSK3_1	111	118	PF00069	0.701
MOD_GSK3_1	122	129	PF00069	0.638
MOD_GSK3_1	178	185	PF00069	0.689
MOD_GSK3_1	192	199	PF00069	0.808
MOD_GSK3_1	24	31	PF00069	0.741
MOD_GSK3_1	245	252	PF00069	0.756
MOD_GSK3_1	258	265	PF00069	0.708
MOD_GSK3_1	318	325	PF00069	0.772
MOD_GSK3_1	34	41	PF00069	0.694
MOD_GSK3_1	365	372	PF00069	0.681
MOD_GSK3_1	43	50	PF00069	0.587
MOD_GSK3_1	492	499	PF00069	0.758
MOD_GSK3_1	540	547	PF00069	0.655
MOD_GSK3_1	632	639	PF00069	0.709
MOD_GSK3_1	643	650	PF00069	0.677
MOD_GSK3_1	66	73	PF00069	0.771
MOD_GSK3_1	683	690	PF00069	0.668
MOD_GSK3_1	78	85	PF00069	0.626
MOD_GSK3_1	90	97	PF00069	0.628
MOD_N-GLC_1	37	42	PF02516	0.723
MOD_N-GLC_1	372	377	PF02516	0.702
MOD_N-GLC_1	402	407	PF02516	0.800
MOD_N-GLC_1	71	76	PF02516	0.692
MOD_N-GLC_2	165	167	PF02516	0.632
MOD_NEK2_1	176	181	PF00069	0.720
MOD_NEK2_1	334	339	PF00069	0.801
MOD_NEK2_1	34	39	PF00069	0.732
MOD_NEK2_1	447	452	PF00069	0.629
MOD_NEK2_1	590	595	PF00069	0.694
MOD_NEK2_1	84	89	PF00069	0.718
MOD_PIKK_1	115	121	PF00454	0.826
MOD_PIKK_1	192	198	PF00454	0.694
MOD_PIKK_1	334	340	PF00454	0.692
MOD_PIKK_1	436	442	PF00454	0.807
MOD_PIKK_1	449	455	PF00454	0.504
MOD_PIKK_1	521	527	PF00454	0.644
MOD_PIKK_1	558	564	PF00454	0.600
MOD_PIKK_1	602	608	PF00454	0.827
MOD_PIKK_1	610	616	PF00454	0.726
MOD_PKA_1	152	158	PF00069	0.650
MOD_PKA_1	663	669	PF00069	0.733
MOD_PKA_2	105	111	PF00069	0.728
MOD_PKA_2	115	121	PF00069	0.650
MOD_PKA_2	141	147	PF00069	0.721
MOD_PKA_2	152	158	PF00069	0.727
MOD_PKA_2	268	274	PF00069	0.793
MOD_PKA_2	322	328	PF00069	0.758
MOD_PKA_2	356	362	PF00069	0.699
MOD_PKA_2	47	53	PF00069	0.723
MOD_PKA_2	509	515	PF00069	0.636
MOD_PKA_2	544	550	PF00069	0.748
MOD_PKA_2	58	64	PF00069	0.718
MOD_PKA_2	621	627	PF00069	0.811
MOD_PKA_2	630	636	PF00069	0.641
MOD_PKA_2	643	649	PF00069	0.624
MOD_PKA_2	662	668	PF00069	0.643
MOD_PKA_2	687	693	PF00069	0.661
MOD_Plk_1	372	378	PF00069	0.631
MOD_Plk_1	66	72	PF00069	0.817
MOD_Plk_4	337	343	PF00069	0.803
MOD_Plk_4	357	363	PF00069	0.498
MOD_Plk_4	483	489	PF00069	0.754
MOD_Plk_4	638	644	PF00069	0.807
MOD_ProDKin_1	120	126	PF00069	0.731
MOD_ProDKin_1	154	160	PF00069	0.737
MOD_ProDKin_1	182	188	PF00069	0.747
MOD_ProDKin_1	189	195	PF00069	0.819
MOD_ProDKin_1	225	231	PF00069	0.728
MOD_ProDKin_1	24	30	PF00069	0.812
MOD_ProDKin_1	246	252	PF00069	0.822
MOD_ProDKin_1	258	264	PF00069	0.511
MOD_ProDKin_1	299	305	PF00069	0.670
MOD_ProDKin_1	497	503	PF00069	0.709
MOD_ProDKin_1	518	524	PF00069	0.639
MOD_ProDKin_1	592	598	PF00069	0.653
MOD_ProDKin_1	654	660	PF00069	0.738
MOD_ProDKin_1	76	82	PF00069	0.760
MOD_ProDKin_1	85	91	PF00069	0.834
MOD_SUMO_rev_2	346	353	PF00179	0.624
TRG_DiLeu_BaLyEn_6	329	334	PF01217	0.811
TRG_ENDOCYTIC_2	206	209	PF00928	0.720
TRG_ENDOCYTIC_2	523	526	PF00928	0.706
TRG_ER_diArg_1	140	143	PF00400	0.746
TRG_ER_diArg_1	152	154	PF00400	0.656
TRG_ER_diArg_1	234	236	PF00400	0.671
TRG_ER_diArg_1	394	396	PF00400	0.724
TRG_ER_diArg_1	469	472	PF00400	0.692
TRG_ER_diArg_1	565	568	PF00400	0.510
TRG_ER_diArg_1	607	609	PF00400	0.722
TRG_ER_diArg_1	643	645	PF00400	0.698
TRG_NLS_MonoExtC_3	101	106	PF00514	0.731
TRG_NLS_MonoExtN_4	630	635	PF00514	0.749
TRG_Pf-PMV_PEXEL_1	135	139	PF00026	0.600

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCI7	Leptomonas seymouri	44%	100%
A4IB06	Leishmania infantum	99%	100%
E9AET4	Leishmania major	88%	98%
E9B5Y9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	97%