Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X8Y2_LEIDO

TriTrypDb:

LdBPK_350900.1 , LdCL_350013800 , LDHU3_35.1090

Length:

520

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X8Y2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8Y2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	242	246	PF00656	0.781
CLV_C14_Caspase3-7	64	68	PF00656	0.652
CLV_C14_Caspase3-7	92	96	PF00656	0.599
CLV_NRD_NRD_1	116	118	PF00675	0.612
CLV_NRD_NRD_1	126	128	PF00675	0.519
CLV_NRD_NRD_1	25	27	PF00675	0.537
CLV_NRD_NRD_1	304	306	PF00675	0.641
CLV_NRD_NRD_1	379	381	PF00675	0.613
CLV_NRD_NRD_1	443	445	PF00675	0.697
CLV_NRD_NRD_1	510	512	PF00675	0.604
CLV_PCSK_FUR_1	387	391	PF00082	0.539
CLV_PCSK_FUR_1	449	453	PF00082	0.708
CLV_PCSK_FUR_1	506	510	PF00082	0.645
CLV_PCSK_KEX2_1	107	109	PF00082	0.554
CLV_PCSK_KEX2_1	126	128	PF00082	0.630
CLV_PCSK_KEX2_1	148	150	PF00082	0.600
CLV_PCSK_KEX2_1	25	27	PF00082	0.603
CLV_PCSK_KEX2_1	302	304	PF00082	0.626
CLV_PCSK_KEX2_1	379	381	PF00082	0.582
CLV_PCSK_KEX2_1	389	391	PF00082	0.470
CLV_PCSK_KEX2_1	443	445	PF00082	0.691
CLV_PCSK_KEX2_1	448	450	PF00082	0.650
CLV_PCSK_KEX2_1	451	453	PF00082	0.631
CLV_PCSK_KEX2_1	508	510	PF00082	0.603
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.599
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.600
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.655
CLV_PCSK_PC1ET2_1	389	391	PF00082	0.529
CLV_PCSK_PC1ET2_1	448	450	PF00082	0.732
CLV_PCSK_PC1ET2_1	451	453	PF00082	0.719
CLV_PCSK_PC7_1	21	27	PF00082	0.529
CLV_PCSK_PC7_1	444	450	PF00082	0.735
CLV_PCSK_PC7_1	506	512	PF00082	0.695
CLV_PCSK_SKI1_1	100	104	PF00082	0.668
CLV_PCSK_SKI1_1	107	111	PF00082	0.510
CLV_PCSK_SKI1_1	341	345	PF00082	0.650
CLV_PCSK_SKI1_1	359	363	PF00082	0.478
CLV_PCSK_SKI1_1	42	46	PF00082	0.666
CLV_PCSK_SKI1_1	502	506	PF00082	0.644
DEG_APCC_DBOX_1	13	21	PF00400	0.596
DEG_APCC_DBOX_1	139	147	PF00400	0.617
DEG_APCC_DBOX_1	378	386	PF00400	0.609
DOC_CYCLIN_RxL_1	356	364	PF00134	0.604
DOC_MAPK_gen_1	12	20	PF00069	0.561
DOC_MAPK_gen_1	126	133	PF00069	0.617
DOC_MAPK_gen_1	45	55	PF00069	0.603
DOC_MAPK_MEF2A_6	126	133	PF00069	0.617
DOC_MAPK_MEF2A_6	48	57	PF00069	0.650
DOC_MAPK_NFAT4_5	126	134	PF00069	0.594
DOC_MAPK_RevD_3	290	303	PF00069	0.634
DOC_PP1_RVXF_1	187	193	PF00149	0.421
DOC_PP4_FxxP_1	490	493	PF00568	0.664
DOC_USP7_MATH_1	167	171	PF00917	0.746
DOC_USP7_MATH_1	182	186	PF00917	0.356
DOC_USP7_MATH_1	333	337	PF00917	0.740
DOC_USP7_MATH_1	453	457	PF00917	0.667
DOC_USP7_MATH_1	6	10	PF00917	0.569
DOC_USP7_MATH_1	98	102	PF00917	0.686
DOC_WW_Pin1_4	133	138	PF00397	0.636
DOC_WW_Pin1_4	228	233	PF00397	0.786
DOC_WW_Pin1_4	463	468	PF00397	0.678
LIG_14-3-3_CanoR_1	120	129	PF00244	0.474
LIG_14-3-3_CanoR_1	163	167	PF00244	0.646
LIG_14-3-3_CanoR_1	25	29	PF00244	0.569
LIG_14-3-3_CanoR_1	379	383	PF00244	0.570
LIG_14-3-3_CanoR_1	443	447	PF00244	0.687
LIG_14-3-3_CanoR_1	452	462	PF00244	0.595
LIG_14-3-3_CanoR_1	54	60	PF00244	0.555
LIG_14-3-3_CterR_2	517	520	PF00244	0.725
LIG_Actin_WH2_2	364	381	PF00022	0.543
LIG_BRCT_BRCA1_1	226	230	PF00533	0.506
LIG_BRCT_BRCA1_1	363	367	PF00533	0.534
LIG_CtBP_PxDLS_1	291	295	PF00389	0.694
LIG_DLG_GKlike_1	65	72	PF00625	0.701
LIG_FHA_1	276	282	PF00498	0.551
LIG_FHA_1	345	351	PF00498	0.657
LIG_FHA_1	68	74	PF00498	0.658
LIG_FHA_2	192	198	PF00498	0.593
LIG_FHA_2	240	246	PF00498	0.794
LIG_FHA_2	248	254	PF00498	0.747
LIG_FHA_2	278	284	PF00498	0.593
LIG_FHA_2	308	314	PF00498	0.610
LIG_FHA_2	390	396	PF00498	0.636
LIG_FHA_2	496	502	PF00498	0.708
LIG_FHA_2	6	12	PF00498	0.532
LIG_FHA_2	62	68	PF00498	0.671
LIG_Integrin_RGD_1	65	67	PF01839	0.590
LIG_LIR_Gen_1	125	133	PF02991	0.529
LIG_LIR_Gen_1	75	83	PF02991	0.573
LIG_LIR_Nem_3	125	131	PF02991	0.528
LIG_LIR_Nem_3	75	80	PF02991	0.595
LIG_NBox_RRM_1	398	408	PF00076	0.626
LIG_NRBOX	217	223	PF00104	0.552
LIG_RPA_C_Fungi	115	127	PF08784	0.469
LIG_SH2_CRK	128	132	PF00017	0.598
LIG_SH2_CRK	77	81	PF00017	0.654
LIG_SH2_SRC	320	323	PF00017	0.623
LIG_SH2_STAP1	320	324	PF00017	0.682
LIG_SH2_STAT3	267	270	PF00017	0.613
LIG_SH2_STAT5	273	276	PF00017	0.575
LIG_SH2_STAT5	475	478	PF00017	0.665
LIG_SH3_3	347	353	PF00018	0.693
LIG_SH3_3	464	470	PF00018	0.664
LIG_SUMO_SIM_anti_2	216	224	PF11976	0.466
LIG_SUMO_SIM_par_1	216	224	PF11976	0.636
LIG_TRAF2_1	27	30	PF00917	0.582
LIG_TRAF2_1	407	410	PF00917	0.563
LIG_TRAF2_1	431	434	PF00917	0.736
LIG_WW_3	437	441	PF00397	0.588
MOD_CDK_SPxxK_3	133	140	PF00069	0.627
MOD_CDK_SPxxK_3	228	235	PF00069	0.660
MOD_CK1_1	165	171	PF00069	0.624
MOD_CK1_1	185	191	PF00069	0.540
MOD_CK1_1	220	226	PF00069	0.642
MOD_CK1_1	236	242	PF00069	0.662
MOD_CK1_1	466	472	PF00069	0.699
MOD_CK1_1	75	81	PF00069	0.689
MOD_CK2_1	132	138	PF00069	0.630
MOD_CK2_1	191	197	PF00069	0.530
MOD_CK2_1	228	234	PF00069	0.695
MOD_CK2_1	24	30	PF00069	0.546
MOD_CK2_1	247	253	PF00069	0.764
MOD_CK2_1	277	283	PF00069	0.540
MOD_CK2_1	307	313	PF00069	0.517
MOD_CK2_1	428	434	PF00069	0.731
MOD_CK2_1	444	450	PF00069	0.445
MOD_CK2_1	495	501	PF00069	0.598
MOD_Cter_Amidation	506	509	PF01082	0.690
MOD_GlcNHglycan	184	187	PF01048	0.541
MOD_GlcNHglycan	234	238	PF01048	0.779
MOD_GlcNHglycan	321	325	PF01048	0.630
MOD_GlcNHglycan	429	433	PF01048	0.697
MOD_GSK3_1	116	123	PF00069	0.595
MOD_GSK3_1	129	136	PF00069	0.584
MOD_GSK3_1	165	172	PF00069	0.648
MOD_GSK3_1	176	183	PF00069	0.634
MOD_GSK3_1	220	227	PF00069	0.588
MOD_GSK3_1	277	284	PF00069	0.600
MOD_GSK3_1	333	340	PF00069	0.633
MOD_GSK3_1	57	64	PF00069	0.678
MOD_N-GLC_1	120	125	PF02516	0.624
MOD_N-GLC_1	176	181	PF02516	0.647
MOD_N-GLC_2	349	351	PF02516	0.655
MOD_NEK2_1	116	121	PF00069	0.483
MOD_NEK2_1	129	134	PF00069	0.636
MOD_NEK2_1	171	176	PF00069	0.536
MOD_NEK2_1	226	231	PF00069	0.712
MOD_PIKK_1	165	171	PF00454	0.686
MOD_PKA_1	389	395	PF00069	0.608
MOD_PKA_1	513	519	PF00069	0.643
MOD_PKA_2	116	122	PF00069	0.498
MOD_PKA_2	162	168	PF00069	0.665
MOD_PKA_2	24	30	PF00069	0.518
MOD_PKA_2	281	287	PF00069	0.679
MOD_PKA_2	378	384	PF00069	0.558
MOD_PKA_2	389	395	PF00069	0.508
MOD_PKA_2	439	445	PF00069	0.787
MOD_PKB_1	511	519	PF00069	0.635
MOD_Plk_1	176	182	PF00069	0.614
MOD_Plk_1	233	239	PF00069	0.665
MOD_Plk_1	409	415	PF00069	0.567
MOD_Plk_1	75	81	PF00069	0.608
MOD_Plk_2-3	307	313	PF00069	0.571
MOD_Plk_4	191	197	PF00069	0.587
MOD_Plk_4	214	220	PF00069	0.553
MOD_Plk_4	389	395	PF00069	0.637
MOD_ProDKin_1	133	139	PF00069	0.635
MOD_ProDKin_1	228	234	PF00069	0.787
MOD_ProDKin_1	463	469	PF00069	0.669
MOD_SUMO_for_1	343	346	PF00179	0.751
MOD_SUMO_for_1	388	391	PF00179	0.638
MOD_SUMO_rev_2	27	34	PF00179	0.636
MOD_SUMO_rev_2	427	437	PF00179	0.728
TRG_ENDOCYTIC_2	128	131	PF00928	0.549
TRG_ENDOCYTIC_2	477	480	PF00928	0.602
TRG_ENDOCYTIC_2	77	80	PF00928	0.599
TRG_ER_diArg_1	126	128	PF00400	0.575
TRG_ER_diArg_1	303	305	PF00400	0.544
TRG_ER_diArg_1	378	380	PF00400	0.663
TRG_ER_diArg_1	505	508	PF00400	0.653
TRG_ER_diArg_1	509	511	PF00400	0.591
TRG_NLS_Bipartite_1	107	121	PF00514	0.593
TRG_NLS_MonoCore_2	301	306	PF00514	0.471
TRG_NLS_MonoExtC_3	301	307	PF00514	0.609
TRG_NLS_MonoExtN_4	300	306	PF00514	0.597
TRG_Pf-PMV_PEXEL_1	205	209	PF00026	0.566
TRG_Pf-PMV_PEXEL_1	315	319	PF00026	0.595

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0N1	Leptomonas seymouri	52%	90%
A0A1X0NJ03	Trypanosomatidae	30%	89%
A0A422NI80	Trypanosoma rangeli	30%	92%
A4HMB9	Leishmania braziliensis	78%	100%
A4IAY5	Leishmania infantum	99%	100%
C9ZNI2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	89%
E9AER3	Leishmania major	91%	100%
E9B5W8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%