Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X8X6_LEIDO

TriTrypDb:

LdBPK_351010.1 , LdCL_350014900 , LDHU3_35.1250

Length:

836

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X8X6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8X6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	303	307	PF00656	0.683
CLV_C14_Caspase3-7	328	332	PF00656	0.675
CLV_C14_Caspase3-7	601	605	PF00656	0.657
CLV_C14_Caspase3-7	81	85	PF00656	0.701
CLV_NRD_NRD_1	569	571	PF00675	0.542
CLV_NRD_NRD_1	663	665	PF00675	0.695
CLV_NRD_NRD_1	773	775	PF00675	0.736
CLV_NRD_NRD_1	797	799	PF00675	0.785
CLV_NRD_NRD_1	810	812	PF00675	0.689
CLV_PCSK_FUR_1	771	775	PF00082	0.696
CLV_PCSK_KEX2_1	569	571	PF00082	0.523
CLV_PCSK_KEX2_1	663	665	PF00082	0.681
CLV_PCSK_KEX2_1	745	747	PF00082	0.740
CLV_PCSK_KEX2_1	773	775	PF00082	0.708
CLV_PCSK_KEX2_1	797	799	PF00082	0.711
CLV_PCSK_KEX2_1	810	812	PF00082	0.648
CLV_PCSK_PC1ET2_1	745	747	PF00082	0.679
CLV_PCSK_SKI1_1	152	156	PF00082	0.422
CLV_PCSK_SKI1_1	359	363	PF00082	0.562
CLV_PCSK_SKI1_1	620	624	PF00082	0.709
DEG_COP1_1	130	140	PF00400	0.572
DEG_Nend_Nbox_1	1	3	PF02207	0.547
DEG_SPOP_SBC_1	467	471	PF00917	0.719
DEG_SPOP_SBC_1	699	703	PF00917	0.629
DOC_CYCLIN_yCln2_LP_2	107	113	PF00134	0.541
DOC_CYCLIN_yCln2_LP_2	18	24	PF00134	0.527
DOC_MAPK_HePTP_8	160	172	PF00069	0.450
DOC_MAPK_MEF2A_6	152	159	PF00069	0.448
DOC_MAPK_MEF2A_6	163	172	PF00069	0.464
DOC_PP1_RVXF_1	376	383	PF00149	0.536
DOC_PP4_FxxP_1	204	207	PF00568	0.520
DOC_USP7_MATH_1	100	104	PF00917	0.604
DOC_USP7_MATH_1	119	123	PF00917	0.383
DOC_USP7_MATH_1	14	18	PF00917	0.484
DOC_USP7_MATH_1	244	248	PF00917	0.699
DOC_USP7_MATH_1	468	472	PF00917	0.680
DOC_USP7_MATH_1	603	607	PF00917	0.735
DOC_USP7_MATH_1	626	630	PF00917	0.661
DOC_USP7_MATH_1	699	703	PF00917	0.629
DOC_USP7_MATH_1	80	84	PF00917	0.717
DOC_USP7_UBL2_3	403	407	PF12436	0.610
DOC_WW_Pin1_4	174	179	PF00397	0.532
DOC_WW_Pin1_4	219	224	PF00397	0.397
DOC_WW_Pin1_4	239	244	PF00397	0.424
DOC_WW_Pin1_4	276	281	PF00397	0.647
DOC_WW_Pin1_4	397	402	PF00397	0.618
DOC_WW_Pin1_4	414	419	PF00397	0.670
DOC_WW_Pin1_4	454	459	PF00397	0.574
DOC_WW_Pin1_4	490	495	PF00397	0.692
DOC_WW_Pin1_4	512	517	PF00397	0.575
DOC_WW_Pin1_4	599	604	PF00397	0.716
DOC_WW_Pin1_4	650	655	PF00397	0.780
DOC_WW_Pin1_4	750	755	PF00397	0.680
DOC_WW_Pin1_4	825	830	PF00397	0.765
LIG_14-3-3_CanoR_1	274	281	PF00244	0.642
LIG_14-3-3_CanoR_1	293	297	PF00244	0.544
LIG_14-3-3_CanoR_1	442	446	PF00244	0.516
LIG_14-3-3_CanoR_1	520	526	PF00244	0.474
LIG_14-3-3_CanoR_1	588	595	PF00244	0.530
LIG_14-3-3_CanoR_1	663	667	PF00244	0.629
LIG_14-3-3_CanoR_1	681	688	PF00244	0.503
LIG_Actin_WH2_2	577	595	PF00022	0.458
LIG_APCC_ABBA_1	446	451	PF00400	0.569
LIG_BIR_III_2	815	819	PF00653	0.683
LIG_BIR_III_4	553	557	PF00653	0.544
LIG_BRCT_BRCA1_1	725	729	PF00533	0.739
LIG_BRCT_BRCA1_1	75	79	PF00533	0.727
LIG_FHA_1	248	254	PF00498	0.645
LIG_FHA_1	284	290	PF00498	0.610
LIG_FHA_1	311	317	PF00498	0.699
LIG_FHA_1	407	413	PF00498	0.503
LIG_FHA_1	468	474	PF00498	0.698
LIG_FHA_1	528	534	PF00498	0.435
LIG_FHA_1	725	731	PF00498	0.724
LIG_FHA_2	156	162	PF00498	0.530
LIG_FHA_2	301	307	PF00498	0.739
LIG_FHA_2	415	421	PF00498	0.678
LIG_FHA_2	425	431	PF00498	0.337
LIG_FHA_2	540	546	PF00498	0.556
LIG_FHA_2	599	605	PF00498	0.647
LIG_FHA_2	681	687	PF00498	0.597
LIG_FHA_2	89	95	PF00498	0.684
LIG_GBD_Chelix_1	156	164	PF00786	0.532
LIG_LIR_Gen_1	177	188	PF02991	0.556
LIG_LIR_Gen_1	225	235	PF02991	0.535
LIG_LIR_Gen_1	558	568	PF02991	0.521
LIG_LIR_Gen_1	59	64	PF02991	0.632
LIG_LIR_Gen_1	665	674	PF02991	0.667
LIG_LIR_Nem_3	17	23	PF02991	0.533
LIG_LIR_Nem_3	177	183	PF02991	0.542
LIG_LIR_Nem_3	225	230	PF02991	0.515
LIG_LIR_Nem_3	371	376	PF02991	0.429
LIG_LIR_Nem_3	394	399	PF02991	0.615
LIG_LIR_Nem_3	558	563	PF02991	0.485
LIG_LIR_Nem_3	59	63	PF02991	0.658
LIG_LIR_Nem_3	800	805	PF02991	0.675
LIG_LYPXL_yS_3	20	23	PF13949	0.493
LIG_MLH1_MIPbox_1	75	79	PF16413	0.691
LIG_NBox_RRM_1	183	193	PF00076	0.437
LIG_Pex14_2	446	450	PF04695	0.387
LIG_PTB_Apo_2	556	563	PF02174	0.445
LIG_RPA_C_Fungi	158	170	PF08784	0.520
LIG_RPA_C_Fungi	261	273	PF08784	0.476
LIG_SH2_CRK	227	231	PF00017	0.512
LIG_SH2_GRB2like	557	560	PF00017	0.507
LIG_SH2_NCK_1	227	231	PF00017	0.512
LIG_SH2_NCK_1	5	9	PF00017	0.589
LIG_SH2_STAP1	557	561	PF00017	0.500
LIG_SH2_STAT5	106	109	PF00017	0.465
LIG_SH2_STAT5	721	724	PF00017	0.654
LIG_SH3_3	185	191	PF00018	0.602
LIG_SH3_3	314	320	PF00018	0.738
LIG_SH3_3	396	402	PF00018	0.579
LIG_SH3_3	450	456	PF00018	0.629
LIG_SH3_3	457	463	PF00018	0.631
LIG_SH3_3	502	508	PF00018	0.720
LIG_SH3_3	597	603	PF00018	0.680
LIG_SH3_3	648	654	PF00018	0.674
LIG_SH3_3	828	834	PF00018	0.736
LIG_SH3_4	403	410	PF00018	0.583
LIG_SUMO_SIM_anti_2	132	139	PF11976	0.548
LIG_SUMO_SIM_anti_2	166	171	PF11976	0.434
LIG_SUMO_SIM_par_1	212	217	PF11976	0.557
LIG_SUMO_SIM_par_1	22	28	PF11976	0.489
LIG_SUMO_SIM_par_1	593	598	PF11976	0.594
LIG_TRAF2_1	428	431	PF00917	0.514
LIG_TRAF2_1	675	678	PF00917	0.579
LIG_TRAF2_1	787	790	PF00917	0.600
LIG_TYR_ITIM	18	23	PF00017	0.534
LIG_UBA3_1	22	29	PF00899	0.490
LIG_UBA3_1	234	238	PF00899	0.415
LIG_WRC_WIRS_1	156	161	PF05994	0.531
LIG_WRC_WIRS_1	253	258	PF05994	0.615
LIG_WRC_WIRS_1	30	35	PF05994	0.639
LIG_WW_3	566	570	PF00397	0.589
MOD_CDK_SPxK_1	397	403	PF00069	0.597
MOD_CDK_SPxxK_3	650	657	PF00069	0.659
MOD_CK1_1	217	223	PF00069	0.495
MOD_CK1_1	242	248	PF00069	0.682
MOD_CK1_1	255	261	PF00069	0.621
MOD_CK1_1	279	285	PF00069	0.692
MOD_CK1_1	347	353	PF00069	0.691
MOD_CK1_1	365	371	PF00069	0.621
MOD_CK1_1	414	420	PF00069	0.696
MOD_CK1_1	44	50	PF00069	0.745
MOD_CK1_1	512	518	PF00069	0.673
MOD_CK1_1	539	545	PF00069	0.614
MOD_CK1_1	572	578	PF00069	0.541
MOD_CK1_1	607	613	PF00069	0.628
MOD_CK1_1	653	659	PF00069	0.698
MOD_CK1_1	700	706	PF00069	0.758
MOD_CK1_1	74	80	PF00069	0.749
MOD_CK1_1	820	826	PF00069	0.745
MOD_CK2_1	155	161	PF00069	0.527
MOD_CK2_1	246	252	PF00069	0.494
MOD_CK2_1	414	420	PF00069	0.631
MOD_CK2_1	424	430	PF00069	0.343
MOD_CK2_1	665	671	PF00069	0.584
MOD_CK2_1	680	686	PF00069	0.575
MOD_Cter_Amidation	714	717	PF01082	0.732
MOD_Cter_Amidation	743	746	PF01082	0.762
MOD_Cter_Amidation	808	811	PF01082	0.740
MOD_GlcNHglycan	207	210	PF01048	0.559
MOD_GlcNHglycan	216	219	PF01048	0.497
MOD_GlcNHglycan	246	249	PF01048	0.655
MOD_GlcNHglycan	276	279	PF01048	0.605
MOD_GlcNHglycan	350	353	PF01048	0.631
MOD_GlcNHglycan	413	417	PF01048	0.560
MOD_GlcNHglycan	43	46	PF01048	0.731
MOD_GlcNHglycan	470	473	PF01048	0.670
MOD_GlcNHglycan	511	514	PF01048	0.665
MOD_GlcNHglycan	53	56	PF01048	0.654
MOD_GlcNHglycan	589	592	PF01048	0.554
MOD_GlcNHglycan	775	778	PF01048	0.773
MOD_GlcNHglycan	819	822	PF01048	0.766
MOD_GSK3_1	155	162	PF00069	0.470
MOD_GSK3_1	238	245	PF00069	0.661
MOD_GSK3_1	252	259	PF00069	0.647
MOD_GSK3_1	279	286	PF00069	0.711
MOD_GSK3_1	344	351	PF00069	0.709
MOD_GSK3_1	357	364	PF00069	0.339
MOD_GSK3_1	408	415	PF00069	0.467
MOD_GSK3_1	58	65	PF00069	0.691
MOD_GSK3_1	599	606	PF00069	0.688
MOD_GSK3_1	817	824	PF00069	0.739
MOD_GSK3_1	82	89	PF00069	0.692
MOD_LATS_1	27	33	PF00433	0.558
MOD_N-GLC_1	100	105	PF02516	0.596
MOD_N-GLC_1	111	116	PF02516	0.538
MOD_N-GLC_1	119	124	PF02516	0.403
MOD_N-GLC_1	74	79	PF02516	0.552
MOD_NEK2_1	155	160	PF00069	0.431
MOD_NEK2_1	216	221	PF00069	0.495
MOD_NEK2_1	256	261	PF00069	0.606
MOD_NEK2_1	346	351	PF00069	0.649
MOD_NEK2_1	362	367	PF00069	0.508
MOD_NEK2_1	521	526	PF00069	0.520
MOD_NEK2_1	58	63	PF00069	0.616
MOD_NEK2_1	586	591	PF00069	0.481
MOD_NEK2_1	71	76	PF00069	0.549
MOD_NEK2_2	441	446	PF00069	0.409
MOD_PIKK_1	607	613	PF00454	0.599
MOD_PIKK_1	656	662	PF00454	0.694
MOD_PK_1	163	169	PF00069	0.472
MOD_PK_1	569	575	PF00069	0.507
MOD_PKA_1	569	575	PF00069	0.552
MOD_PKA_1	773	779	PF00069	0.771
MOD_PKA_2	292	298	PF00069	0.713
MOD_PKA_2	41	47	PF00069	0.636
MOD_PKA_2	441	447	PF00069	0.559
MOD_PKA_2	521	527	PF00069	0.467
MOD_PKA_2	569	575	PF00069	0.459
MOD_PKA_2	587	593	PF00069	0.472
MOD_PKA_2	607	613	PF00069	0.508
MOD_PKA_2	656	662	PF00069	0.712
MOD_PKA_2	680	686	PF00069	0.725
MOD_PKA_2	773	779	PF00069	0.726
MOD_PKB_1	272	280	PF00069	0.601
MOD_PKB_1	771	779	PF00069	0.707
MOD_Plk_1	100	106	PF00069	0.613
MOD_Plk_1	119	125	PF00069	0.383
MOD_Plk_1	74	80	PF00069	0.683
MOD_Plk_4	119	125	PF00069	0.650
MOD_Plk_4	155	161	PF00069	0.509
MOD_Plk_4	163	169	PF00069	0.437
MOD_Plk_4	222	228	PF00069	0.489
MOD_Plk_4	252	258	PF00069	0.668
MOD_Plk_4	29	35	PF00069	0.630
MOD_Plk_4	357	363	PF00069	0.580
MOD_Plk_4	368	374	PF00069	0.518
MOD_Plk_4	441	447	PF00069	0.471
MOD_Plk_4	626	632	PF00069	0.567
MOD_Plk_4	74	80	PF00069	0.655
MOD_ProDKin_1	174	180	PF00069	0.531
MOD_ProDKin_1	219	225	PF00069	0.395
MOD_ProDKin_1	239	245	PF00069	0.426
MOD_ProDKin_1	276	282	PF00069	0.648
MOD_ProDKin_1	397	403	PF00069	0.617
MOD_ProDKin_1	414	420	PF00069	0.675
MOD_ProDKin_1	454	460	PF00069	0.576
MOD_ProDKin_1	490	496	PF00069	0.695
MOD_ProDKin_1	512	518	PF00069	0.563
MOD_ProDKin_1	599	605	PF00069	0.721
MOD_ProDKin_1	650	656	PF00069	0.781
MOD_ProDKin_1	750	756	PF00069	0.676
MOD_ProDKin_1	825	831	PF00069	0.757
MOD_SUMO_for_1	508	511	PF00179	0.653
MOD_SUMO_rev_2	737	747	PF00179	0.727
TRG_DiLeu_BaEn_1	132	137	PF01217	0.545
TRG_DiLeu_BaEn_1	334	339	PF01217	0.489
TRG_DiLeu_BaLyEn_6	18	23	PF01217	0.424
TRG_DiLeu_BaLyEn_6	285	290	PF01217	0.704
TRG_DiLeu_BaLyEn_6	828	833	PF01217	0.579
TRG_ENDOCYTIC_2	180	183	PF00928	0.539
TRG_ENDOCYTIC_2	20	23	PF00928	0.493
TRG_ENDOCYTIC_2	227	230	PF00928	0.505
TRG_ENDOCYTIC_2	5	8	PF00928	0.586
TRG_ENDOCYTIC_2	557	560	PF00928	0.507
TRG_ENDOCYTIC_2	802	805	PF00928	0.674
TRG_ER_diArg_1	434	437	PF00400	0.478
TRG_ER_diArg_1	519	522	PF00400	0.483
TRG_ER_diArg_1	568	570	PF00400	0.573
TRG_ER_diArg_1	771	774	PF00400	0.692
TRG_ER_diArg_1	797	799	PF00400	0.785
TRG_ER_diArg_1	810	812	PF00400	0.689
TRG_NES_CRM1_1	6	19	PF08389	0.584
TRG_Pf-PMV_PEXEL_1	810	815	PF00026	0.745

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P319	Leptomonas seymouri	51%	92%
A0A1X0NIZ7	Trypanosomatidae	29%	100%
A0A3R7KEZ9	Trypanosoma rangeli	30%	100%
A4HMC9	Leishmania braziliensis	76%	100%
A4IAZ6	Leishmania infantum	100%	100%
E9AES4	Leishmania major	90%	100%
E9B5X9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%