rRNA adenine N(6)-methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

rRNA dimethyltransferase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X8W9_LEIDO

TriTrypDb:

LdBPK_350790.1 , LdCL_350012500 , LDHU3_35.0940

Length:

463

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X8W9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8W9

Function

Biological processes
Term	Name	Level	Count
GO:0000154	rRNA modification	6	1
GO:0001510	RNA methylation	4	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0031167	rRNA methylation	5	1
GO:0032259	methylation	2	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000179	rRNA (adenine-N6,N6-)-dimethyltransferase activity	6	11
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0008168	methyltransferase activity	4	11
GO:0008170	N-methyltransferase activity	5	11
GO:0008173	RNA methyltransferase activity	4	11
GO:0008649	rRNA methyltransferase activity	5	11
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	11
GO:0016433	rRNA (adenine) methyltransferase activity	6	11
GO:0016740	transferase activity	2	11
GO:0016741	transferase activity, transferring one-carbon groups	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140102	catalytic activity, acting on a rRNA	4	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	106	112	PF00089	0.206
CLV_NRD_NRD_1	154	156	PF00675	0.471
CLV_NRD_NRD_1	212	214	PF00675	0.600
CLV_NRD_NRD_1	453	455	PF00675	0.536
CLV_PCSK_FUR_1	210	214	PF00082	0.683
CLV_PCSK_KEX2_1	154	156	PF00082	0.471
CLV_PCSK_KEX2_1	212	214	PF00082	0.598
CLV_PCSK_SKI1_1	142	146	PF00082	0.482
CLV_PCSK_SKI1_1	285	289	PF00082	0.367
CLV_PCSK_SKI1_1	382	386	PF00082	0.269
CLV_PCSK_SKI1_1	52	56	PF00082	0.323
CLV_PCSK_SKI1_1	91	95	PF00082	0.281
DEG_ODPH_VHL_1	308	321	PF01847	0.469
DOC_ANK_TNKS_1	225	232	PF00023	0.573
DOC_ANK_TNKS_1	27	34	PF00023	0.416
DOC_ANK_TNKS_1	342	349	PF00023	0.546
DOC_CKS1_1	72	77	PF01111	0.511
DOC_CYCLIN_RxL_1	88	95	PF00134	0.455
DOC_MAPK_MEF2A_6	52	59	PF00069	0.455
DOC_MAPK_NFAT4_5	52	60	PF00069	0.455
DOC_PP1_RVXF_1	178	184	PF00149	0.639
DOC_USP7_MATH_1	165	169	PF00917	0.658
DOC_USP7_MATH_1	199	203	PF00917	0.694
DOC_USP7_MATH_1	310	314	PF00917	0.456
DOC_USP7_MATH_1	4	8	PF00917	0.721
DOC_USP7_UBL2_3	35	39	PF12436	0.390
DOC_WW_Pin1_4	108	113	PF00397	0.406
DOC_WW_Pin1_4	155	160	PF00397	0.634
DOC_WW_Pin1_4	170	175	PF00397	0.513
DOC_WW_Pin1_4	237	242	PF00397	0.717
DOC_WW_Pin1_4	455	460	PF00397	0.683
DOC_WW_Pin1_4	6	11	PF00397	0.629
DOC_WW_Pin1_4	71	76	PF00397	0.514
LIG_14-3-3_CanoR_1	118	127	PF00244	0.412
LIG_14-3-3_CanoR_1	180	184	PF00244	0.594
LIG_14-3-3_CanoR_1	318	322	PF00244	0.455
LIG_14-3-3_CanoR_1	330	336	PF00244	0.455
LIG_14-3-3_CanoR_1	382	387	PF00244	0.455
LIG_14-3-3_CanoR_1	69	75	PF00244	0.455
LIG_Actin_WH2_2	128	144	PF00022	0.509
LIG_Actin_WH2_2	368	384	PF00022	0.531
LIG_APCC_ABBA_1	110	115	PF00400	0.546
LIG_BIR_III_4	191	195	PF00653	0.655
LIG_BRCT_BRCA1_1	121	125	PF00533	0.482
LIG_BRCT_BRCA1_1	312	316	PF00533	0.455
LIG_FHA_1	127	133	PF00498	0.580
LIG_FHA_1	269	275	PF00498	0.475
LIG_FHA_1	371	377	PF00498	0.456
LIG_FHA_1	58	64	PF00498	0.455
LIG_FHA_1	88	94	PF00498	0.460
LIG_FHA_2	180	186	PF00498	0.640
LIG_FHA_2	297	303	PF00498	0.438
LIG_FHA_2	332	338	PF00498	0.455
LIG_FHA_2	342	348	PF00498	0.455
LIG_FHA_2	411	417	PF00498	0.455
LIG_FHA_2	71	77	PF00498	0.546
LIG_LIR_Gen_1	122	133	PF02991	0.418
LIG_LIR_Gen_1	313	322	PF02991	0.455
LIG_LIR_Nem_3	122	128	PF02991	0.442
LIG_LIR_Nem_3	143	148	PF02991	0.414
LIG_LIR_Nem_3	313	319	PF02991	0.455
LIG_PTB_Apo_2	261	268	PF02174	0.455
LIG_REV1ctd_RIR_1	324	334	PF16727	0.531
LIG_SH2_CRK	38	42	PF00017	0.515
LIG_SH2_SRC	218	221	PF00017	0.733
LIG_SH2_STAP1	49	53	PF00017	0.469
LIG_SH2_STAT3	401	404	PF00017	0.455
LIG_SH2_STAT5	120	123	PF00017	0.459
LIG_SH2_STAT5	66	69	PF00017	0.556
LIG_SH3_3	13	19	PF00018	0.575
LIG_SH3_3	153	159	PF00018	0.589
LIG_SH3_3	21	27	PF00018	0.427
LIG_SUMO_SIM_anti_2	136	143	PF11976	0.472
LIG_SUMO_SIM_anti_2	317	323	PF11976	0.455
LIG_SUMO_SIM_anti_2	416	421	PF11976	0.531
LIG_SUMO_SIM_par_1	349	354	PF11976	0.546
LIG_SUMO_SIM_par_1	413	418	PF11976	0.469
LIG_TRAF2_1	159	162	PF00917	0.685
LIG_TRAF2_2	217	222	PF00917	0.635
LIG_UBA3_1	54	58	PF00899	0.455
MOD_CDK_SPxK_1	71	77	PF00069	0.511
MOD_CK1_1	119	125	PF00069	0.429
MOD_CK1_1	173	179	PF00069	0.693
MOD_CK1_1	221	227	PF00069	0.753
MOD_CK1_1	317	323	PF00069	0.455
MOD_CK1_1	5	11	PF00069	0.707
MOD_CK1_1	65	71	PF00069	0.490
MOD_CK1_1	92	98	PF00069	0.462
MOD_CK2_1	296	302	PF00069	0.449
MOD_CK2_1	341	347	PF00069	0.495
MOD_CK2_1	415	421	PF00069	0.455
MOD_DYRK1A_RPxSP_1	155	159	PF00069	0.623
MOD_GlcNHglycan	142	145	PF01048	0.481
MOD_GlcNHglycan	167	170	PF01048	0.692
MOD_GlcNHglycan	175	178	PF01048	0.697
MOD_GlcNHglycan	201	204	PF01048	0.656
MOD_GlcNHglycan	4	7	PF01048	0.708
MOD_GSK3_1	175	182	PF00069	0.746
MOD_GSK3_1	2	9	PF00069	0.617
MOD_GSK3_1	310	317	PF00069	0.455
MOD_GSK3_1	382	389	PF00069	0.519
MOD_GSK3_1	67	74	PF00069	0.472
MOD_GSK3_1	85	92	PF00069	0.491
MOD_NEK2_1	140	145	PF00069	0.582
MOD_NEK2_1	245	250	PF00069	0.608
MOD_NEK2_1	331	336	PF00069	0.500
MOD_NEK2_1	364	369	PF00069	0.531
MOD_NEK2_1	415	420	PF00069	0.530
MOD_NEK2_1	57	62	PF00069	0.463
MOD_NEK2_1	67	72	PF00069	0.485
MOD_NEK2_1	89	94	PF00069	0.455
MOD_PIKK_1	175	181	PF00454	0.766
MOD_PIKK_1	279	285	PF00454	0.546
MOD_PIKK_1	296	302	PF00454	0.368
MOD_PIKK_1	433	439	PF00454	0.440
MOD_PKA_2	179	185	PF00069	0.773
MOD_PKA_2	317	323	PF00069	0.461
MOD_PKA_2	68	74	PF00069	0.455
MOD_Plk_1	336	342	PF00069	0.455
MOD_Plk_1	364	370	PF00069	0.475
MOD_Plk_1	415	421	PF00069	0.546
MOD_Plk_4	317	323	PF00069	0.465
MOD_Plk_4	331	337	PF00069	0.478
MOD_Plk_4	365	371	PF00069	0.480
MOD_Plk_4	410	416	PF00069	0.455
MOD_Plk_4	62	68	PF00069	0.546
MOD_ProDKin_1	108	114	PF00069	0.406
MOD_ProDKin_1	155	161	PF00069	0.640
MOD_ProDKin_1	170	176	PF00069	0.514
MOD_ProDKin_1	237	243	PF00069	0.713
MOD_ProDKin_1	455	461	PF00069	0.643
MOD_ProDKin_1	6	12	PF00069	0.627
MOD_ProDKin_1	71	77	PF00069	0.514
MOD_SUMO_for_1	257	260	PF00179	0.455
MOD_SUMO_for_1	29	32	PF00179	0.391
TRG_DiLeu_BaLyEn_6	204	209	PF01217	0.677
TRG_ER_diArg_1	153	155	PF00400	0.462
TRG_ER_diArg_1	209	212	PF00400	0.566
TRG_NES_CRM1_1	397	409	PF08389	0.546
TRG_Pf-PMV_PEXEL_1	207	211	PF00026	0.664
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.255

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXZ3	Leptomonas seymouri	78%	86%
A0A1X0NJH8	Trypanosomatidae	56%	87%
A0A3R7NNC2	Trypanosoma rangeli	58%	96%
A4HMA9	Leishmania braziliensis	88%	100%
A4IAX5	Leishmania infantum	100%	100%
D0A280	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	99%
E9AEQ2	Leishmania major	94%	100%
E9B5V7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BN79	Trypanosoma cruzi	61%	97%