Zinc finger C-x8-C-x5-C-x3-H type (And similar), putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7X8W6_LEIDO

TriTrypDb:

LdBPK_351040.1 , LdCL_350015200 , LDHU3_35.1310

Length:

432

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X8W6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8W6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0003729	mRNA binding	5	6
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.661
CLV_NRD_NRD_1	249	251	PF00675	0.571
CLV_NRD_NRD_1	25	27	PF00675	0.671
CLV_PCSK_KEX2_1	138	140	PF00082	0.304
CLV_PCSK_KEX2_1	25	27	PF00082	0.629
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.304
CLV_PCSK_SKI1_1	154	158	PF00082	0.304
CLV_PCSK_SKI1_1	364	368	PF00082	0.583
CLV_PCSK_SKI1_1	97	101	PF00082	0.606
DEG_APCC_DBOX_1	363	371	PF00400	0.577
DEG_SCF_FBW7_1	1	7	PF00400	0.600
DEG_SPOP_SBC_1	17	21	PF00917	0.648
DEG_SPOP_SBC_1	341	345	PF00917	0.626
DOC_CKS1_1	1	6	PF01111	0.597
DOC_PP4_FxxP_1	368	371	PF00568	0.531
DOC_USP7_MATH_1	107	111	PF00917	0.766
DOC_USP7_MATH_1	121	125	PF00917	0.556
DOC_USP7_MATH_1	17	21	PF00917	0.661
DOC_USP7_MATH_1	184	188	PF00917	0.587
DOC_USP7_MATH_1	210	214	PF00917	0.514
DOC_USP7_MATH_1	217	221	PF00917	0.501
DOC_USP7_MATH_1	259	263	PF00917	0.593
DOC_USP7_MATH_1	291	295	PF00917	0.614
DOC_USP7_MATH_1	303	307	PF00917	0.513
DOC_USP7_MATH_1	333	337	PF00917	0.535
DOC_USP7_MATH_1	356	360	PF00917	0.582
DOC_USP7_MATH_1	36	40	PF00917	0.466
DOC_USP7_MATH_1	410	414	PF00917	0.620
DOC_USP7_MATH_1	88	92	PF00917	0.688
DOC_USP7_MATH_1	95	99	PF00917	0.602
DOC_USP7_UBL2_3	97	101	PF12436	0.606
DOC_WW_Pin1_4	111	116	PF00397	0.742
DOC_WW_Pin1_4	250	255	PF00397	0.690
DOC_WW_Pin1_4	342	347	PF00397	0.598
DOC_WW_Pin1_4	51	56	PF00397	0.601
DOC_WW_Pin1_4	68	73	PF00397	0.678
DOC_WW_Pin1_4	86	91	PF00397	0.524
LIG_14-3-3_CanoR_1	219	226	PF00244	0.561
LIG_BRCT_BRCA1_1	364	368	PF00533	0.583
LIG_DLG_GKlike_1	25	33	PF00625	0.611
LIG_FHA_1	1	7	PF00498	0.622
LIG_FHA_1	184	190	PF00498	0.576
LIG_FHA_1	243	249	PF00498	0.735
LIG_FHA_2	17	23	PF00498	0.635
LIG_LIR_Apic_2	365	371	PF02991	0.574
LIG_LIR_Gen_1	33	40	PF02991	0.732
LIG_LIR_Gen_1	336	346	PF02991	0.563
LIG_LIR_Gen_1	395	401	PF02991	0.614
LIG_LIR_Gen_1	71	81	PF02991	0.618
LIG_LIR_Nem_3	146	151	PF02991	0.304
LIG_LIR_Nem_3	161	167	PF02991	0.450
LIG_LIR_Nem_3	33	37	PF02991	0.733
LIG_LIR_Nem_3	336	341	PF02991	0.633
LIG_LIR_Nem_3	71	77	PF02991	0.633
LIG_LYPXL_yS_3	65	68	PF13949	0.642
LIG_SH2_STAP1	205	209	PF00017	0.442
LIG_SH2_STAT3	167	170	PF00017	0.547
LIG_SH2_STAT5	167	170	PF00017	0.527
LIG_SH2_STAT5	389	392	PF00017	0.597
LIG_SH2_STAT5	415	418	PF00017	0.563
LIG_SH3_1	251	257	PF00018	0.560
LIG_SH3_3	115	121	PF00018	0.661
LIG_SH3_3	241	247	PF00018	0.670
LIG_SH3_3	251	257	PF00018	0.578
LIG_SH3_3	406	412	PF00018	0.613
LIG_SUMO_SIM_par_1	322	328	PF11976	0.627
LIG_SUMO_SIM_par_1	343	350	PF11976	0.599
LIG_TRAF2_1	78	81	PF00917	0.623
MOD_CK1_1	103	109	PF00069	0.599
MOD_CK1_1	111	117	PF00069	0.694
MOD_CK1_1	125	131	PF00069	0.487
MOD_CK1_1	21	27	PF00069	0.656
MOD_CK1_1	258	264	PF00069	0.653
MOD_CK1_1	327	333	PF00069	0.494
MOD_CK1_1	395	401	PF00069	0.499
MOD_CK1_1	413	419	PF00069	0.567
MOD_CK1_1	7	13	PF00069	0.637
MOD_CK1_1	70	76	PF00069	0.620
MOD_CK2_1	16	22	PF00069	0.607
MOD_CK2_1	7	13	PF00069	0.671
MOD_CK2_1	75	81	PF00069	0.625
MOD_GlcNHglycan	104	108	PF01048	0.543
MOD_GlcNHglycan	124	127	PF01048	0.579
MOD_GlcNHglycan	144	148	PF01048	0.238
MOD_GlcNHglycan	211	215	PF01048	0.496
MOD_GlcNHglycan	221	224	PF01048	0.564
MOD_GlcNHglycan	261	264	PF01048	0.708
MOD_GlcNHglycan	329	332	PF01048	0.593
MOD_GlcNHglycan	412	415	PF01048	0.714
MOD_GlcNHglycan	416	419	PF01048	0.709
MOD_GlcNHglycan	90	93	PF01048	0.625
MOD_GlcNHglycan	97	100	PF01048	0.612
MOD_GSK3_1	103	110	PF00069	0.641
MOD_GSK3_1	121	128	PF00069	0.593
MOD_GSK3_1	130	137	PF00069	0.454
MOD_GSK3_1	17	24	PF00069	0.723
MOD_GSK3_1	238	245	PF00069	0.719
MOD_GSK3_1	255	262	PF00069	0.615
MOD_GSK3_1	410	417	PF00069	0.550
MOD_GSK3_1	75	82	PF00069	0.601
MOD_GSK3_1	95	102	PF00069	0.620
MOD_N-GLC_1	108	113	PF02516	0.586
MOD_N-GLC_1	238	243	PF02516	0.646
MOD_N-GLC_1	7	12	PF02516	0.562
MOD_N-GLC_1	95	100	PF02516	0.589
MOD_NEK2_1	143	148	PF00069	0.304
MOD_NEK2_1	275	280	PF00069	0.650
MOD_NEK2_1	324	329	PF00069	0.588
MOD_PIKK_1	252	258	PF00454	0.620
MOD_PIKK_1	262	268	PF00454	0.616
MOD_PIKK_1	303	309	PF00454	0.655
MOD_PIKK_1	43	49	PF00454	0.613
MOD_PKA_1	25	31	PF00069	0.613
MOD_PKA_2	25	31	PF00069	0.613
MOD_Plk_1	95	101	PF00069	0.625
MOD_Plk_4	30	36	PF00069	0.686
MOD_ProDKin_1	111	117	PF00069	0.740
MOD_ProDKin_1	250	256	PF00069	0.691
MOD_ProDKin_1	342	348	PF00069	0.599
MOD_ProDKin_1	51	57	PF00069	0.601
MOD_ProDKin_1	68	74	PF00069	0.682
MOD_ProDKin_1	86	92	PF00069	0.525
TRG_DiLeu_BaLyEn_6	320	325	PF01217	0.583
TRG_ENDOCYTIC_2	396	399	PF00928	0.616
TRG_ENDOCYTIC_2	65	68	PF00928	0.642
TRG_NLS_MonoExtN_4	136	142	PF00514	0.304

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P318	Leptomonas seymouri	38%	74%
A4HMD2	Leishmania braziliensis	56%	100%
A4IAZ9	Leishmania infantum	99%	100%
E9AES7	Leishmania major	90%	100%
E9B5Y2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%