Aldose 1-epimerase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aldose 1-epimerase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X8W5_LEIDO

TriTrypDb:

LdBPK_350990.1 , LdCL_350014700 , LDHU3_35.1200

Length:

371

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 28

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X8W5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8W5

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	21
GO:0008152	metabolic process	1	21
GO:0044238	primary metabolic process	2	21
GO:0071704	organic substance metabolic process	2	21
GO:0005996	monosaccharide metabolic process	3	6
GO:0019318	hexose metabolic process	4	6
GO:0044281	small molecule metabolic process	2	6
GO:0006006	glucose metabolic process	5	3
GO:0006012	galactose metabolic process	5	3
GO:0009056	catabolic process	2	3
GO:0016052	carbohydrate catabolic process	4	3
GO:0019320	hexose catabolic process	5	3
GO:0019388	galactose catabolic process	6	3
GO:0033499	galactose catabolic process via UDP-galactose	7	3
GO:0044282	small molecule catabolic process	3	3
GO:0046365	monosaccharide catabolic process	4	3
GO:1901575	organic substance catabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	21
GO:0004034	aldose 1-epimerase activity	5	16
GO:0005488	binding	1	21
GO:0016853	isomerase activity	2	21
GO:0016854	racemase and epimerase activity	3	16
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	4	16
GO:0030246	carbohydrate binding	2	21

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	353	355	PF00675	0.243
CLV_PCSK_KEX2_1	353	355	PF00082	0.297
CLV_PCSK_SKI1_1	279	283	PF00082	0.297
DEG_Nend_UBRbox_3	1	3	PF02207	0.310
DOC_MAPK_gen_1	111	118	PF00069	0.433
DOC_MAPK_gen_1	323	332	PF00069	0.441
DOC_PP1_RVXF_1	12	18	PF00149	0.425
DOC_PP2B_LxvP_1	213	216	PF13499	0.482
DOC_WW_Pin1_4	130	135	PF00397	0.438
DOC_WW_Pin1_4	169	174	PF00397	0.459
DOC_WW_Pin1_4	285	290	PF00397	0.444
LIG_14-3-3_CanoR_1	128	134	PF00244	0.557
LIG_14-3-3_CanoR_1	357	364	PF00244	0.446
LIG_Actin_WH2_2	11	26	PF00022	0.372
LIG_APCC_ABBA_1	280	285	PF00400	0.449
LIG_APCC_ABBAyCdc20_2	279	285	PF00400	0.449
LIG_BIR_III_2	175	179	PF00653	0.491
LIG_Clathr_ClatBox_1	15	19	PF01394	0.389
LIG_eIF4E_1	10	16	PF01652	0.354
LIG_FHA_1	119	125	PF00498	0.457
LIG_FHA_1	147	153	PF00498	0.473
LIG_FHA_1	18	24	PF00498	0.378
LIG_FHA_1	326	332	PF00498	0.395
LIG_FHA_2	160	166	PF00498	0.527
LIG_FHA_2	237	243	PF00498	0.460
LIG_FHA_2	361	367	PF00498	0.479
LIG_LIR_Apic_2	199	205	PF02991	0.504
LIG_LIR_Apic_2	59	65	PF02991	0.450
LIG_LIR_Gen_1	230	241	PF02991	0.567
LIG_LIR_Gen_1	44	55	PF02991	0.434
LIG_LIR_Nem_3	162	167	PF02991	0.506
LIG_LIR_Nem_3	230	236	PF02991	0.515
LIG_LIR_Nem_3	44	50	PF02991	0.434
LIG_Pex14_2	301	305	PF04695	0.455
LIG_SH2_CRK	12	16	PF00017	0.267
LIG_SH2_CRK	131	135	PF00017	0.484
LIG_SH2_NCK_1	62	66	PF00017	0.483
LIG_SH2_SRC	266	269	PF00017	0.435
LIG_SH2_SRC	62	65	PF00017	0.490
LIG_SH2_STAP1	12	16	PF00017	0.398
LIG_SH2_STAP1	164	168	PF00017	0.497
LIG_SH2_STAP1	30	34	PF00017	0.192
LIG_SH2_STAT3	91	94	PF00017	0.500
LIG_SH2_STAT5	131	134	PF00017	0.481
LIG_SH2_STAT5	147	150	PF00017	0.389
LIG_SH2_STAT5	167	170	PF00017	0.537
LIG_SH2_STAT5	307	310	PF00017	0.462
LIG_SH2_STAT5	92	95	PF00017	0.541
LIG_SH3_3	342	348	PF00018	0.463
LIG_SH3_3	36	42	PF00018	0.509
LIG_SH3_3	52	58	PF00018	0.500
LIG_SUMO_SIM_anti_2	254	260	PF11976	0.530
LIG_SUMO_SIM_par_1	267	273	PF11976	0.473
LIG_WRC_WIRS_1	147	152	PF05994	0.500
MOD_CK1_1	166	172	PF00069	0.523
MOD_CK1_1	183	189	PF00069	0.480
MOD_CK1_1	288	294	PF00069	0.445
MOD_CK1_1	33	39	PF00069	0.444
MOD_CK1_1	360	366	PF00069	0.456
MOD_CK2_1	360	366	PF00069	0.468
MOD_GlcNHglycan	137	140	PF01048	0.305
MOD_GlcNHglycan	316	319	PF01048	0.267
MOD_GSK3_1	148	155	PF00069	0.504
MOD_GSK3_1	159	166	PF00069	0.474
MOD_GSK3_1	232	239	PF00069	0.511
MOD_N-GLC_1	129	134	PF02516	0.295
MOD_N-GLC_1	335	340	PF02516	0.300
MOD_N-GLC_2	100	102	PF02516	0.300
MOD_N-GLC_2	146	148	PF02516	0.300
MOD_N-GLC_2	292	294	PF02516	0.249
MOD_NEK2_1	118	123	PF00069	0.467
MOD_NEK2_1	129	134	PF00069	0.480
MOD_NEK2_1	182	187	PF00069	0.480
MOD_NEK2_1	68	73	PF00069	0.457
MOD_NEK2_2	159	164	PF00069	0.500
MOD_NEK2_2	98	103	PF00069	0.407
MOD_PIKK_1	90	96	PF00454	0.500
MOD_PKA_2	325	331	PF00069	0.464
MOD_Plk_1	360	366	PF00069	0.469
MOD_Plk_2-3	232	238	PF00069	0.449
MOD_Plk_4	159	165	PF00069	0.479
MOD_ProDKin_1	130	136	PF00069	0.438
MOD_ProDKin_1	169	175	PF00069	0.459
MOD_ProDKin_1	285	291	PF00069	0.444
TRG_DiLeu_BaEn_1	276	281	PF01217	0.502
TRG_ENDOCYTIC_2	12	15	PF00928	0.275
TRG_ENDOCYTIC_2	147	150	PF00928	0.453
TRG_ENDOCYTIC_2	298	301	PF00928	0.450
TRG_ER_diArg_1	352	354	PF00400	0.497
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.264

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P441	Leptomonas seymouri	85%	100%
A0A0N0P558	Leptomonas seymouri	35%	91%
A0A0N1PBB3	Leptomonas seymouri	47%	99%
A0A1X0NJ33	Trypanosomatidae	47%	98%
A0A1X0NX70	Trypanosomatidae	38%	97%
A0A3R7MXQ5	Trypanosoma rangeli	36%	98%
A0A3S7WXI1	Leishmania donovani	33%	100%
A0A3S7X8Z3	Leishmania donovani	70%	98%
A0A422N115	Trypanosoma rangeli	44%	98%
A4HCQ7	Leishmania braziliensis	34%	100%
A4I082	Leishmania infantum	33%	100%
A4IAZ4	Leishmania infantum	99%	100%
D4AMB9	Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)	28%	84%
E9AES2	Leishmania major	98%	100%
E9AES3	Leishmania major	70%	100%
E9AW46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9B5X7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9B5X8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
P05149	Acinetobacter calcoaceticus	29%	97%
P0A9C3	Escherichia coli (strain K12)	28%	100%
P0A9C4	Shigella flexneri	28%	100%
P31765	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	27%	100%
P38893	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
P53757	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
Q03PA4	Levilactobacillus brevis (strain ATCC 367 / BCRC 12310 / CIP 105137 / JCM 1170 / LMG 11437 / NCIMB 947 / NCTC 947)	26%	100%
Q4QBD1	Leishmania major	35%	100%
Q5EA79	Bos taurus	27%	100%
Q5R8U1	Pongo abelii	27%	100%
Q66HG4	Rattus norvegicus	28%	100%
Q8K157	Mus musculus	28%	100%
Q96C23	Homo sapiens	27%	100%
Q9GKX6	Sus scrofa	27%	100%
V5B7Z0	Trypanosoma cruzi	35%	96%