Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X8W4_LEIDO

TriTrypDb:

LdBPK_351080.1 , LdCL_350015600 , LDHU3_35.1390

Length:

580

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X8W4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8W4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	289	293	PF00656	0.696
CLV_C14_Caspase3-7	96	100	PF00656	0.701
CLV_NRD_NRD_1	116	118	PF00675	0.684
CLV_NRD_NRD_1	122	124	PF00675	0.622
CLV_NRD_NRD_1	136	138	PF00675	0.668
CLV_NRD_NRD_1	139	141	PF00675	0.631
CLV_NRD_NRD_1	16	18	PF00675	0.707
CLV_NRD_NRD_1	162	164	PF00675	0.702
CLV_NRD_NRD_1	166	168	PF00675	0.668
CLV_NRD_NRD_1	21	23	PF00675	0.739
CLV_NRD_NRD_1	220	222	PF00675	0.666
CLV_NRD_NRD_1	235	237	PF00675	0.497
CLV_NRD_NRD_1	25	27	PF00675	0.684
CLV_NRD_NRD_1	278	280	PF00675	0.701
CLV_NRD_NRD_1	308	310	PF00675	0.699
CLV_NRD_NRD_1	393	395	PF00675	0.514
CLV_NRD_NRD_1	43	45	PF00675	0.699
CLV_NRD_NRD_1	574	576	PF00675	0.501
CLV_NRD_NRD_1	67	69	PF00675	0.701
CLV_PCSK_FUR_1	114	118	PF00082	0.646
CLV_PCSK_FUR_1	137	141	PF00082	0.784
CLV_PCSK_FUR_1	19	23	PF00082	0.593
CLV_PCSK_FUR_1	306	310	PF00082	0.684
CLV_PCSK_FUR_1	38	42	PF00082	0.597
CLV_PCSK_FUR_1	391	395	PF00082	0.508
CLV_PCSK_KEX2_1	114	116	PF00082	0.694
CLV_PCSK_KEX2_1	122	124	PF00082	0.636
CLV_PCSK_KEX2_1	136	138	PF00082	0.622
CLV_PCSK_KEX2_1	139	141	PF00082	0.573
CLV_PCSK_KEX2_1	144	146	PF00082	0.646
CLV_PCSK_KEX2_1	16	18	PF00082	0.709
CLV_PCSK_KEX2_1	166	168	PF00082	0.671
CLV_PCSK_KEX2_1	21	23	PF00082	0.763
CLV_PCSK_KEX2_1	220	222	PF00082	0.666
CLV_PCSK_KEX2_1	237	239	PF00082	0.480
CLV_PCSK_KEX2_1	25	27	PF00082	0.697
CLV_PCSK_KEX2_1	278	280	PF00082	0.701
CLV_PCSK_KEX2_1	3	5	PF00082	0.732
CLV_PCSK_KEX2_1	306	308	PF00082	0.708
CLV_PCSK_KEX2_1	393	395	PF00082	0.514
CLV_PCSK_KEX2_1	40	42	PF00082	0.664
CLV_PCSK_KEX2_1	43	45	PF00082	0.698
CLV_PCSK_KEX2_1	574	576	PF00082	0.501
CLV_PCSK_KEX2_1	67	69	PF00082	0.701
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.712
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.630
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.732
CLV_PCSK_PC7_1	111	117	PF00082	0.641
CLV_PCSK_PC7_1	140	146	PF00082	0.817
CLV_PCSK_PC7_1	17	23	PF00082	0.659
CLV_PCSK_PC7_1	38	44	PF00082	0.593
CLV_PCSK_SKI1_1	237	241	PF00082	0.632
CLV_PCSK_SKI1_1	360	364	PF00082	0.467
CLV_PCSK_SKI1_1	397	401	PF00082	0.544
CLV_PCSK_SKI1_1	469	473	PF00082	0.655
CLV_PCSK_SKI1_1	507	511	PF00082	0.646
DEG_APCC_DBOX_1	359	367	PF00400	0.473
DEG_APCC_KENBOX_2	509	513	PF00400	0.645
DEG_SPOP_SBC_1	204	208	PF00917	0.573
DEG_SPOP_SBC_1	430	434	PF00917	0.596
DOC_ANK_TNKS_1	67	74	PF00023	0.634
DOC_CKS1_1	529	534	PF01111	0.664
DOC_CYCLIN_RxL_1	235	244	PF00134	0.638
DOC_MAPK_gen_1	236	242	PF00069	0.523
DOC_PP1_RVXF_1	236	243	PF00149	0.639
DOC_PP4_FxxP_1	534	537	PF00568	0.597
DOC_PP4_MxPP_1	270	273	PF00568	0.668
DOC_USP7_MATH_1	176	180	PF00917	0.644
DOC_USP7_MATH_1	200	204	PF00917	0.589
DOC_USP7_MATH_1	402	406	PF00917	0.554
DOC_USP7_MATH_1	419	423	PF00917	0.546
DOC_USP7_MATH_1	430	434	PF00917	0.650
DOC_USP7_MATH_1	442	446	PF00917	0.569
DOC_USP7_MATH_1	475	479	PF00917	0.638
DOC_USP7_MATH_1	559	563	PF00917	0.473
DOC_WW_Pin1_4	518	523	PF00397	0.682
DOC_WW_Pin1_4	528	533	PF00397	0.594
LIG_14-3-3_CanoR_1	125	133	PF00244	0.702
LIG_14-3-3_CanoR_1	170	174	PF00244	0.635
LIG_14-3-3_CanoR_1	309	315	PF00244	0.706
LIG_14-3-3_CanoR_1	85	95	PF00244	0.702
LIG_14-3-3_CterR_2	575	580	PF00244	0.489
LIG_BIR_III_2	519	523	PF00653	0.587
LIG_BIR_III_4	247	251	PF00653	0.650
LIG_BIR_III_4	474	478	PF00653	0.616
LIG_EVH1_1	523	527	PF00568	0.644
LIG_FHA_1	451	457	PF00498	0.645
LIG_FHA_1	555	561	PF00498	0.402
LIG_FHA_2	206	212	PF00498	0.609
LIG_FHA_2	79	85	PF00498	0.659
LIG_Integrin_isoDGR_2	572	574	PF01839	0.541
LIG_LIR_Apic_2	335	341	PF02991	0.640
LIG_LIR_Apic_2	531	537	PF02991	0.602
LIG_LIR_Gen_1	405	414	PF02991	0.480
LIG_LIR_Nem_3	101	107	PF02991	0.688
LIG_LIR_Nem_3	405	409	PF02991	0.460
LIG_MAD2	85	93	PF02301	0.669
LIG_PTB_Apo_2	564	571	PF02174	0.499
LIG_PTB_Phospho_1	564	570	PF10480	0.502
LIG_SH2_GRB2like	570	573	PF00017	0.528
LIG_SH2_NCK_1	338	342	PF00017	0.630
LIG_SH2_NCK_1	406	410	PF00017	0.513
LIG_SH2_SRC	535	538	PF00017	0.628
LIG_SH2_SRC	570	573	PF00017	0.528
LIG_SH2_STAT5	209	212	PF00017	0.579
LIG_SH2_STAT5	535	538	PF00017	0.650
LIG_SH2_STAT5	570	573	PF00017	0.528
LIG_SH3_3	265	271	PF00018	0.647
LIG_SH3_3	389	395	PF00018	0.506
LIG_SH3_3	521	527	PF00018	0.677
LIG_SH3_3	539	545	PF00018	0.418
LIG_SUMO_SIM_anti_2	452	460	PF11976	0.548
LIG_SUMO_SIM_par_1	452	460	PF11976	0.548
LIG_SUMO_SIM_par_1	547	552	PF11976	0.486
LIG_TYR_ITIM	404	409	PF00017	0.456
MOD_CK1_1	20	26	PF00069	0.695
MOD_CK1_1	203	209	PF00069	0.652
MOD_CK1_1	330	336	PF00069	0.667
MOD_CK1_1	373	379	PF00069	0.489
MOD_CK1_1	429	435	PF00069	0.614
MOD_CK1_1	445	451	PF00069	0.545
MOD_CK1_1	78	84	PF00069	0.608
MOD_CK2_1	123	129	PF00069	0.684
MOD_CK2_1	169	175	PF00069	0.636
MOD_CK2_1	205	211	PF00069	0.610
MOD_CK2_1	78	84	PF00069	0.660
MOD_CK2_1	97	103	PF00069	0.597
MOD_Cter_Amidation	1	4	PF01082	0.647
MOD_Cter_Amidation	137	140	PF01082	0.693
MOD_Cter_Amidation	142	145	PF01082	0.623
MOD_Cter_Amidation	161	164	PF01082	0.670
MOD_Cter_Amidation	572	575	PF01082	0.538
MOD_GlcNHglycan	202	205	PF01048	0.617
MOD_GlcNHglycan	247	251	PF01048	0.701
MOD_GlcNHglycan	295	298	PF01048	0.681
MOD_GlcNHglycan	428	431	PF01048	0.582
MOD_GlcNHglycan	433	436	PF01048	0.551
MOD_GlcNHglycan	481	484	PF01048	0.660
MOD_GlcNHglycan	492	495	PF01048	0.585
MOD_GlcNHglycan	6	9	PF01048	0.707
MOD_GlcNHglycan	69	72	PF01048	0.710
MOD_GSK3_1	200	207	PF00069	0.659
MOD_GSK3_1	211	218	PF00069	0.609
MOD_GSK3_1	326	333	PF00069	0.636
MOD_GSK3_1	366	373	PF00069	0.502
MOD_GSK3_1	425	432	PF00069	0.613
MOD_GSK3_1	440	447	PF00069	0.664
MOD_GSK3_1	457	464	PF00069	0.505
MOD_GSK3_1	475	482	PF00069	0.641
MOD_GSK3_1	74	81	PF00069	0.674
MOD_LATS_1	57	63	PF00433	0.680
MOD_LATS_1	65	71	PF00433	0.540
MOD_N-GLC_1	186	191	PF02516	0.559
MOD_N-GLC_1	280	285	PF02516	0.670
MOD_N-GLC_1	293	298	PF02516	0.582
MOD_N-GLC_1	327	332	PF02516	0.686
MOD_N-GLC_1	4	9	PF02516	0.706
MOD_N-GLC_1	445	450	PF02516	0.661
MOD_N-GLC_2	423	425	PF02516	0.574
MOD_NEK2_1	368	373	PF00069	0.511
MOD_NEK2_1	444	449	PF00069	0.622
MOD_PKA_1	43	49	PF00069	0.652
MOD_PKA_1	67	73	PF00069	0.658
MOD_PKA_2	110	116	PF00069	0.697
MOD_PKA_2	146	152	PF00069	0.653
MOD_PKA_2	169	175	PF00069	0.653
MOD_PKA_2	20	26	PF00069	0.690
MOD_PKA_2	43	49	PF00069	0.708
MOD_PKA_2	60	66	PF00069	0.610
MOD_PKA_2	67	73	PF00069	0.748
MOD_PKB_1	123	131	PF00069	0.645
MOD_PKB_1	41	49	PF00069	0.650
MOD_Plk_1	10	16	PF00069	0.651
MOD_Plk_1	210	216	PF00069	0.619
MOD_Plk_1	280	286	PF00069	0.670
MOD_Plk_1	326	332	PF00069	0.689
MOD_Plk_1	366	372	PF00069	0.498
MOD_Plk_1	451	457	PF00069	0.658
MOD_Plk_2-3	211	217	PF00069	0.609
MOD_Plk_2-3	45	51	PF00069	0.710
MOD_Plk_4	272	278	PF00069	0.574
MOD_Plk_4	333	339	PF00069	0.652
MOD_Plk_4	374	380	PF00069	0.465
MOD_Plk_4	451	457	PF00069	0.632
MOD_Plk_4	461	467	PF00069	0.544
MOD_ProDKin_1	518	524	PF00069	0.680
MOD_ProDKin_1	528	534	PF00069	0.591
TRG_ENDOCYTIC_2	104	107	PF00928	0.691
TRG_ENDOCYTIC_2	406	409	PF00928	0.465
TRG_ER_diArg_1	114	117	PF00400	0.716
TRG_ER_diArg_1	136	139	PF00400	0.729
TRG_ER_diArg_1	15	17	PF00400	0.803
TRG_ER_diArg_1	19	22	PF00400	0.746
TRG_ER_diArg_1	220	223	PF00400	0.672
TRG_ER_diArg_1	236	239	PF00400	0.490
TRG_ER_diArg_1	277	279	PF00400	0.692
TRG_ER_diArg_1	282	285	PF00400	0.665
TRG_ER_diArg_1	306	309	PF00400	0.706
TRG_ER_diArg_1	38	41	PF00400	0.611
TRG_ER_diArg_1	390	393	PF00400	0.512
TRG_ER_diArg_1	42	44	PF00400	0.664
TRG_ER_diArg_1	574	576	PF00400	0.501
TRG_ER_diArg_1	92	95	PF00400	0.697
TRG_NLS_Bipartite_1	220	240	PF00514	0.546
TRG_NLS_MonoExtC_3	162	167	PF00514	0.704
TRG_Pf-PMV_PEXEL_1	227	232	PF00026	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HFF4	Leishmania braziliensis	66%	100%
A4IB03	Leishmania infantum	99%	100%
E9AET1	Leishmania major	86%	100%
E9B5Y6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%