PP28 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X8W2_LEIDO

TriTrypDb:

LdBPK_350920.1 , LdCL_350014000 , LDHU3_35.1110

Length:

235

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X8W2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8W2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	122	124	PF00675	0.556
CLV_NRD_NRD_1	129	131	PF00675	0.588
CLV_NRD_NRD_1	13	15	PF00675	0.621
CLV_NRD_NRD_1	163	165	PF00675	0.546
CLV_NRD_NRD_1	181	183	PF00675	0.511
CLV_NRD_NRD_1	185	187	PF00675	0.556
CLV_NRD_NRD_1	188	190	PF00675	0.554
CLV_NRD_NRD_1	33	35	PF00675	0.355
CLV_NRD_NRD_1	57	59	PF00675	0.556
CLV_PCSK_FUR_1	178	182	PF00082	0.585
CLV_PCSK_FUR_1	65	69	PF00082	0.397
CLV_PCSK_KEX2_1	122	124	PF00082	0.558
CLV_PCSK_KEX2_1	128	130	PF00082	0.591
CLV_PCSK_KEX2_1	13	15	PF00082	0.621
CLV_PCSK_KEX2_1	162	164	PF00082	0.559
CLV_PCSK_KEX2_1	174	176	PF00082	0.496
CLV_PCSK_KEX2_1	180	182	PF00082	0.420
CLV_PCSK_KEX2_1	185	187	PF00082	0.556
CLV_PCSK_KEX2_1	33	35	PF00082	0.355
CLV_PCSK_KEX2_1	57	59	PF00082	0.558
CLV_PCSK_KEX2_1	67	69	PF00082	0.486
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.588
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.692
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.601
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.462
CLV_PCSK_PC1ET2_1	67	69	PF00082	0.367
CLV_PCSK_PC7_1	181	187	PF00082	0.603
CLV_PCSK_PC7_1	63	69	PF00082	0.363
CLV_PCSK_SKI1_1	15	19	PF00082	0.583
CLV_PCSK_SKI1_1	150	154	PF00082	0.516
CLV_PCSK_SKI1_1	213	217	PF00082	0.712
CLV_PCSK_SKI1_1	33	37	PF00082	0.491
DOC_MAPK_gen_1	108	117	PF00069	0.663
DOC_PIKK_1	195	202	PF02985	0.673
DOC_USP7_UBL2_3	158	162	PF12436	0.636
DOC_USP7_UBL2_3	213	217	PF12436	0.718
DOC_USP7_UBL2_3	5	9	PF12436	0.675
DOC_WW_Pin1_4	25	30	PF00397	0.600
LIG_14-3-3_CanoR_1	141	146	PF00244	0.602
LIG_14-3-3_CanoR_1	85	89	PF00244	0.579
LIG_BIR_II_1	1	5	PF00653	0.677
LIG_FHA_2	16	22	PF00498	0.570
LIG_FHA_2	26	32	PF00498	0.468
LIG_FHA_2	6	12	PF00498	0.755
LIG_FHA_2	95	101	PF00498	0.710
LIG_LIR_Gen_1	93	104	PF02991	0.571
LIG_PCNA_yPIPBox_3	65	78	PF02747	0.548
LIG_TRAF2_1	170	173	PF00917	0.576
LIG_TRAF2_1	51	54	PF00917	0.585
MOD_CK2_1	202	208	PF00069	0.710
MOD_CK2_1	5	11	PF00069	0.718
MOD_CK2_1	94	100	PF00069	0.700
MOD_GSK3_1	5	12	PF00069	0.677
MOD_GSK3_1	80	87	PF00069	0.592
MOD_GSK3_1	94	101	PF00069	0.698
MOD_N-GLC_1	5	10	PF02516	0.717
MOD_PIKK_1	94	100	PF00454	0.591
MOD_PKA_1	9	15	PF00069	0.675
MOD_PKA_2	84	90	PF00069	0.566
MOD_Plk_1	94	100	PF00069	0.613
MOD_Plk_4	218	224	PF00069	0.597
MOD_Plk_4	73	79	PF00069	0.584
MOD_ProDKin_1	25	31	PF00069	0.599
MOD_SUMO_rev_2	166	176	PF00179	0.582
MOD_SUMO_rev_2	38	48	PF00179	0.676
TRG_DiLeu_BaEn_1	100	105	PF01217	0.599
TRG_DiLeu_BaLyEn_6	189	194	PF01217	0.620
TRG_ER_diArg_1	163	165	PF00400	0.552
TRG_ER_diArg_1	180	182	PF00400	0.522
TRG_ER_diArg_1	32	34	PF00400	0.611
TRG_NLS_Bipartite_1	174	190	PF00514	0.593
TRG_NLS_MonoExtC_3	127	133	PF00514	0.565
TRG_NLS_MonoExtC_3	185	190	PF00514	0.680
TRG_NLS_MonoExtN_4	185	190	PF00514	0.680
TRG_Pf-PMV_PEXEL_1	15	19	PF00026	0.579
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	192	197	PF00026	0.637
TRG_Pf-PMV_PEXEL_1	33	37	PF00026	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBR1	Leptomonas seymouri	71%	99%
A4HMC1	Leishmania braziliensis	84%	100%
A4IAY7	Leishmania infantum	100%	100%
E9AER5	Leishmania major	98%	100%
E9B5X0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
V5AL94	Trypanosoma cruzi	41%	99%