Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X8V4_LEIDO

TriTrypDb:

LdBPK_350980.1 , LdCL_350014600 , LDHU3_35.1190

Length:

792

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X8V4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8V4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	241	245	PF00656	0.670
CLV_C14_Caspase3-7	689	693	PF00656	0.484
CLV_MEL_PAP_1	317	323	PF00089	0.421
CLV_NRD_NRD_1	11	13	PF00675	0.490
CLV_NRD_NRD_1	129	131	PF00675	0.679
CLV_NRD_NRD_1	183	185	PF00675	0.433
CLV_NRD_NRD_1	198	200	PF00675	0.592
CLV_NRD_NRD_1	307	309	PF00675	0.462
CLV_NRD_NRD_1	577	579	PF00675	0.528
CLV_NRD_NRD_1	605	607	PF00675	0.603
CLV_NRD_NRD_1	686	688	PF00675	0.703
CLV_NRD_NRD_1	714	716	PF00675	0.802
CLV_PCSK_FUR_1	575	579	PF00082	0.473
CLV_PCSK_KEX2_1	10	12	PF00082	0.514
CLV_PCSK_KEX2_1	129	131	PF00082	0.679
CLV_PCSK_KEX2_1	183	185	PF00082	0.454
CLV_PCSK_KEX2_1	198	200	PF00082	0.613
CLV_PCSK_KEX2_1	209	211	PF00082	0.634
CLV_PCSK_KEX2_1	307	309	PF00082	0.551
CLV_PCSK_KEX2_1	577	579	PF00082	0.504
CLV_PCSK_KEX2_1	605	607	PF00082	0.603
CLV_PCSK_KEX2_1	714	716	PF00082	0.817
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.634
CLV_PCSK_SKI1_1	104	108	PF00082	0.720
CLV_PCSK_SKI1_1	224	228	PF00082	0.510
CLV_PCSK_SKI1_1	265	269	PF00082	0.493
CLV_PCSK_SKI1_1	407	411	PF00082	0.446
CLV_PCSK_SKI1_1	552	556	PF00082	0.372
DEG_APCC_DBOX_1	551	559	PF00400	0.486
DEG_Nend_Nbox_1	1	3	PF02207	0.534
DEG_SCF_FBW7_1	408	414	PF00400	0.493
DEG_SIAH_1	119	127	PF03145	0.612
DEG_SPOP_SBC_1	146	150	PF00917	0.767
DOC_CDC14_PxL_1	752	760	PF14671	0.358
DOC_CKS1_1	24	29	PF01111	0.550
DOC_CKS1_1	408	413	PF01111	0.581
DOC_CYCLIN_RxL_1	262	270	PF00134	0.419
DOC_CYCLIN_RxL_1	549	557	PF00134	0.349
DOC_CYCLIN_yCln2_LP_2	276	282	PF00134	0.418
DOC_MAPK_gen_1	129	136	PF00069	0.672
DOC_MAPK_gen_1	575	582	PF00069	0.580
DOC_MAPK_gen_1	59	68	PF00069	0.408
DOC_MAPK_gen_1	687	698	PF00069	0.541
DOC_MAPK_MEF2A_6	481	489	PF00069	0.490
DOC_MAPK_MEF2A_6	552	560	PF00069	0.488
DOC_PP1_RVXF_1	63	69	PF00149	0.369
DOC_PP1_RVXF_1	693	699	PF00149	0.553
DOC_PP2B_LxvP_1	134	137	PF13499	0.729
DOC_PP2B_LxvP_1	276	279	PF13499	0.488
DOC_PP2B_LxvP_1	558	561	PF13499	0.501
DOC_USP7_MATH_1	135	139	PF00917	0.811
DOC_USP7_MATH_1	146	150	PF00917	0.735
DOC_USP7_MATH_1	172	176	PF00917	0.665
DOC_USP7_MATH_1	250	254	PF00917	0.594
DOC_USP7_MATH_1	280	284	PF00917	0.557
DOC_USP7_MATH_1	399	403	PF00917	0.376
DOC_USP7_MATH_1	419	423	PF00917	0.496
DOC_USP7_MATH_1	453	457	PF00917	0.646
DOC_USP7_MATH_1	504	508	PF00917	0.619
DOC_USP7_MATH_1	588	592	PF00917	0.680
DOC_USP7_MATH_1	638	642	PF00917	0.698
DOC_USP7_MATH_1	719	723	PF00917	0.740
DOC_USP7_MATH_1	92	96	PF00917	0.494
DOC_WW_Pin1_4	142	147	PF00397	0.731
DOC_WW_Pin1_4	188	193	PF00397	0.697
DOC_WW_Pin1_4	23	28	PF00397	0.551
DOC_WW_Pin1_4	267	272	PF00397	0.524
DOC_WW_Pin1_4	407	412	PF00397	0.600
DOC_WW_Pin1_4	417	422	PF00397	0.605
DOC_WW_Pin1_4	444	449	PF00397	0.658
DOC_WW_Pin1_4	471	476	PF00397	0.673
DOC_WW_Pin1_4	631	636	PF00397	0.694
LIG_14-3-3_CanoR_1	184	192	PF00244	0.591
LIG_14-3-3_CanoR_1	198	205	PF00244	0.611
LIG_14-3-3_CanoR_1	307	317	PF00244	0.378
LIG_14-3-3_CanoR_1	320	328	PF00244	0.602
LIG_14-3-3_CanoR_1	584	590	PF00244	0.539
LIG_14-3-3_CanoR_1	91	101	PF00244	0.466
LIG_APCC_ABBA_1	379	384	PF00400	0.610
LIG_CSL_BTD_1	276	279	PF09270	0.488
LIG_EH1_1	668	676	PF00400	0.343
LIG_FHA_1	1	7	PF00498	0.618
LIG_FHA_1	119	125	PF00498	0.683
LIG_FHA_1	12	18	PF00498	0.516
LIG_FHA_1	165	171	PF00498	0.748
LIG_FHA_1	244	250	PF00498	0.716
LIG_FHA_1	26	32	PF00498	0.558
LIG_FHA_1	323	329	PF00498	0.642
LIG_FHA_1	355	361	PF00498	0.473
LIG_FHA_1	520	526	PF00498	0.712
LIG_FHA_1	544	550	PF00498	0.327
LIG_FHA_1	555	561	PF00498	0.364
LIG_FHA_1	631	637	PF00498	0.668
LIG_FHA_1	675	681	PF00498	0.482
LIG_FHA_1	733	739	PF00498	0.608
LIG_FHA_1	96	102	PF00498	0.589
LIG_FHA_2	254	260	PF00498	0.517
LIG_FHA_2	288	294	PF00498	0.745
LIG_FHA_2	373	379	PF00498	0.732
LIG_FHA_2	495	501	PF00498	0.452
LIG_FHA_2	540	546	PF00498	0.446
LIG_FHA_2	560	566	PF00498	0.275
LIG_FHA_2	647	653	PF00498	0.497
LIG_FHA_2	739	745	PF00498	0.434
LIG_GBD_Chelix_1	389	397	PF00786	0.401
LIG_Integrin_isoDGR_2	511	513	PF01839	0.628
LIG_LIR_Apic_2	228	234	PF02991	0.360
LIG_LIR_Apic_2	3	7	PF02991	0.434
LIG_LIR_Apic_2	545	550	PF02991	0.334
LIG_LIR_Gen_1	175	182	PF02991	0.606
LIG_LIR_Gen_1	423	432	PF02991	0.494
LIG_LIR_Nem_3	175	179	PF02991	0.585
LIG_LIR_Nem_3	423	429	PF02991	0.515
LIG_LIR_Nem_3	786	791	PF02991	0.412
LIG_LYPXL_yS_3	755	758	PF13949	0.335
LIG_SH2_CRK	82	86	PF00017	0.354
LIG_SH2_GRB2like	611	614	PF00017	0.556
LIG_SH2_PTP2	54	57	PF00017	0.473
LIG_SH2_PTP2	547	550	PF00017	0.411
LIG_SH2_SRC	20	23	PF00017	0.569
LIG_SH2_SRC	537	540	PF00017	0.453
LIG_SH2_SRC	54	57	PF00017	0.491
LIG_SH2_SRC	611	614	PF00017	0.428
LIG_SH2_SRC	771	774	PF00017	0.414
LIG_SH2_STAP1	611	615	PF00017	0.504
LIG_SH2_STAP1	699	703	PF00017	0.446
LIG_SH2_STAT5	186	189	PF00017	0.579
LIG_SH2_STAT5	20	23	PF00017	0.484
LIG_SH2_STAT5	347	350	PF00017	0.376
LIG_SH2_STAT5	368	371	PF00017	0.545
LIG_SH2_STAT5	537	540	PF00017	0.408
LIG_SH2_STAT5	54	57	PF00017	0.360
LIG_SH2_STAT5	547	550	PF00017	0.297
LIG_SH2_STAT5	662	665	PF00017	0.467
LIG_SH2_STAT5	67	70	PF00017	0.334
LIG_SH2_STAT5	766	769	PF00017	0.367
LIG_SH2_STAT5	771	774	PF00017	0.384
LIG_SH3_2	716	721	PF14604	0.643
LIG_SH3_3	120	126	PF00018	0.719
LIG_SH3_3	140	146	PF00018	0.476
LIG_SH3_3	21	27	PF00018	0.583
LIG_SH3_3	355	361	PF00018	0.488
LIG_SH3_3	402	408	PF00018	0.391
LIG_SH3_3	455	461	PF00018	0.790
LIG_SH3_3	500	506	PF00018	0.622
LIG_SH3_3	637	643	PF00018	0.580
LIG_SH3_3	658	664	PF00018	0.327
LIG_SH3_3	68	74	PF00018	0.433
LIG_SH3_3	713	719	PF00018	0.702
LIG_SUMO_SIM_par_1	132	139	PF11976	0.669
LIG_SUMO_SIM_par_1	641	647	PF11976	0.573
LIG_TRAF2_1	290	293	PF00917	0.731
LIG_TYR_ITIM	80	85	PF00017	0.410
LIG_WRC_WIRS_1	400	405	PF05994	0.377
MOD_CDK_SPK_2	188	193	PF00069	0.552
MOD_CDK_SPxK_1	23	29	PF00069	0.551
MOD_CDK_SPxxK_3	417	424	PF00069	0.471
MOD_CK1_1	145	151	PF00069	0.749
MOD_CK1_1	188	194	PF00069	0.630
MOD_CK1_1	253	259	PF00069	0.441
MOD_CK1_1	299	305	PF00069	0.619
MOD_CK1_1	322	328	PF00069	0.689
MOD_CK1_1	372	378	PF00069	0.618
MOD_CK1_1	456	462	PF00069	0.664
MOD_CK1_1	507	513	PF00069	0.651
MOD_CK1_1	647	653	PF00069	0.540
MOD_CK1_1	734	740	PF00069	0.489
MOD_CK1_1	95	101	PF00069	0.589
MOD_CK2_1	253	259	PF00069	0.606
MOD_CK2_1	287	293	PF00069	0.727
MOD_CK2_1	494	500	PF00069	0.428
MOD_CK2_1	539	545	PF00069	0.506
MOD_CK2_1	559	565	PF00069	0.262
MOD_CK2_1	646	652	PF00069	0.589
MOD_CK2_1	723	729	PF00069	0.632
MOD_CK2_1	738	744	PF00069	0.410
MOD_Cter_Amidation	685	688	PF01082	0.558
MOD_Cter_Amidation	712	715	PF01082	0.805
MOD_DYRK1A_RPxSP_1	407	411	PF00069	0.446
MOD_GlcNHglycan	187	190	PF01048	0.645
MOD_GlcNHglycan	210	213	PF01048	0.687
MOD_GlcNHglycan	246	249	PF01048	0.742
MOD_GlcNHglycan	280	283	PF01048	0.548
MOD_GlcNHglycan	321	324	PF01048	0.552
MOD_GlcNHglycan	354	357	PF01048	0.416
MOD_GlcNHglycan	41	44	PF01048	0.565
MOD_GlcNHglycan	440	443	PF01048	0.625
MOD_GlcNHglycan	475	478	PF01048	0.565
MOD_GlcNHglycan	506	509	PF01048	0.646
MOD_GlcNHglycan	530	533	PF01048	0.617
MOD_GlcNHglycan	586	589	PF01048	0.571
MOD_GlcNHglycan	590	593	PF01048	0.613
MOD_GlcNHglycan	615	618	PF01048	0.557
MOD_GlcNHglycan	711	714	PF01048	0.721
MOD_GlcNHglycan	773	776	PF01048	0.456
MOD_GSK3_1	141	148	PF00069	0.774
MOD_GSK3_1	157	164	PF00069	0.759
MOD_GSK3_1	234	241	PF00069	0.666
MOD_GSK3_1	244	251	PF00069	0.590
MOD_GSK3_1	280	287	PF00069	0.655
MOD_GSK3_1	291	298	PF00069	0.682
MOD_GSK3_1	407	414	PF00069	0.567
MOD_GSK3_1	466	473	PF00069	0.699
MOD_GSK3_1	515	522	PF00069	0.577
MOD_GSK3_1	539	546	PF00069	0.496
MOD_GSK3_1	584	591	PF00069	0.548
MOD_GSK3_1	596	603	PF00069	0.636
MOD_GSK3_1	613	620	PF00069	0.607
MOD_GSK3_1	719	726	PF00069	0.648
MOD_GSK3_1	727	734	PF00069	0.733
MOD_GSK3_1	783	790	PF00069	0.421
MOD_LATS_1	468	474	PF00433	0.586
MOD_N-GLC_1	238	243	PF02516	0.679
MOD_N-GLC_1	471	476	PF02516	0.495
MOD_N-GLC_1	519	524	PF02516	0.742
MOD_N-GLC_1	617	622	PF02516	0.595
MOD_N-GLC_1	681	686	PF02516	0.544
MOD_N-GLC_2	436	438	PF02516	0.286
MOD_NEK2_1	159	164	PF00069	0.692
MOD_NEK2_1	2	7	PF00069	0.518
MOD_NEK2_1	47	52	PF00069	0.391
MOD_NEK2_1	489	494	PF00069	0.500
MOD_NEK2_1	554	559	PF00069	0.356
MOD_NEK2_1	601	606	PF00069	0.469
MOD_NEK2_1	629	634	PF00069	0.533
MOD_NEK2_1	644	649	PF00069	0.602
MOD_NEK2_2	377	382	PF00069	0.620
MOD_NEK2_2	783	788	PF00069	0.411
MOD_PIKK_1	136	142	PF00454	0.730
MOD_PIKK_1	239	245	PF00454	0.739
MOD_PK_1	454	460	PF00069	0.685
MOD_PKA_1	104	110	PF00069	0.657
MOD_PKA_1	11	17	PF00069	0.566
MOD_PKA_1	198	204	PF00069	0.612
MOD_PKA_2	11	17	PF00069	0.574
MOD_PKA_2	197	203	PF00069	0.594
MOD_PKA_2	237	243	PF00069	0.679
MOD_PKA_2	299	305	PF00069	0.683
MOD_PKA_2	319	325	PF00069	0.594
MOD_PKA_2	583	589	PF00069	0.617
MOD_PKA_2	599	605	PF00069	0.623
MOD_PKA_2	61	67	PF00069	0.400
MOD_PKA_2	93	99	PF00069	0.588
MOD_Plk_1	215	221	PF00069	0.421
MOD_Plk_1	377	383	PF00069	0.619
MOD_Plk_1	596	602	PF00069	0.452
MOD_Plk_4	543	549	PF00069	0.353
MOD_Plk_4	783	789	PF00069	0.412
MOD_ProDKin_1	142	148	PF00069	0.732
MOD_ProDKin_1	188	194	PF00069	0.702
MOD_ProDKin_1	23	29	PF00069	0.551
MOD_ProDKin_1	267	273	PF00069	0.521
MOD_ProDKin_1	407	413	PF00069	0.611
MOD_ProDKin_1	417	423	PF00069	0.600
MOD_ProDKin_1	444	450	PF00069	0.663
MOD_ProDKin_1	471	477	PF00069	0.659
MOD_ProDKin_1	631	637	PF00069	0.691
MOD_SUMO_rev_2	201	211	PF00179	0.594
MOD_SUMO_rev_2	228	237	PF00179	0.470
MOD_SUMO_rev_2	292	297	PF00179	0.658
MOD_SUMO_rev_2	332	338	PF00179	0.583
MOD_SUMO_rev_2	367	375	PF00179	0.745
TRG_DiLeu_BaLyEn_6	26	31	PF01217	0.378
TRG_DiLeu_BaLyEn_6	4	9	PF01217	0.556
TRG_DiLeu_BaLyEn_6	640	645	PF01217	0.599
TRG_ENDOCYTIC_2	54	57	PF00928	0.388
TRG_ENDOCYTIC_2	755	758	PF00928	0.335
TRG_ENDOCYTIC_2	82	85	PF00928	0.355
TRG_ER_diArg_1	183	185	PF00400	0.450
TRG_ER_diArg_1	307	309	PF00400	0.461
TRG_ER_diArg_1	575	578	PF00400	0.505
TRG_ER_diArg_1	714	716	PF00400	0.555
TRG_ER_diArg_1	9	12	PF00400	0.519
TRG_Pf-PMV_PEXEL_1	654	659	PF00026	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Q0	Leptomonas seymouri	47%	95%
A0A1X0NJG4	Trypanosomatidae	28%	97%
A0A422N118	Trypanosoma rangeli	30%	100%
A4HMC7	Leishmania braziliensis	73%	100%
A4IAZ3	Leishmania infantum	99%	100%
C9ZNJ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AES1	Leishmania major	89%	100%
E9B5X6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5B090	Trypanosoma cruzi	30%	100%