LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7X8U8_LEIDO
TriTrypDb:
LdBPK_350590.1 , LdCL_350010800 , LDHU3_35.0730
Length:
713

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X8U8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8U8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 146 150 PF00656 0.542
CLV_C14_Caspase3-7 451 455 PF00656 0.551
CLV_C14_Caspase3-7 513 517 PF00656 0.680
CLV_MEL_PAP_1 40 46 PF00089 0.659
CLV_NRD_NRD_1 178 180 PF00675 0.584
CLV_NRD_NRD_1 301 303 PF00675 0.614
CLV_NRD_NRD_1 306 308 PF00675 0.612
CLV_NRD_NRD_1 465 467 PF00675 0.751
CLV_NRD_NRD_1 553 555 PF00675 0.581
CLV_NRD_NRD_1 686 688 PF00675 0.681
CLV_PCSK_FUR_1 302 306 PF00082 0.611
CLV_PCSK_KEX2_1 196 198 PF00082 0.639
CLV_PCSK_KEX2_1 303 305 PF00082 0.614
CLV_PCSK_KEX2_1 306 308 PF00082 0.612
CLV_PCSK_KEX2_1 464 466 PF00082 0.760
CLV_PCSK_KEX2_1 553 555 PF00082 0.581
CLV_PCSK_KEX2_1 686 688 PF00082 0.681
CLV_PCSK_PC1ET2_1 196 198 PF00082 0.639
CLV_PCSK_PC1ET2_1 303 305 PF00082 0.609
CLV_PCSK_PC7_1 302 308 PF00082 0.662
CLV_PCSK_SKI1_1 180 184 PF00082 0.597
CLV_PCSK_SKI1_1 433 437 PF00082 0.586
CLV_PCSK_SKI1_1 465 469 PF00082 0.685
CLV_PCSK_SKI1_1 515 519 PF00082 0.517
DEG_APCC_DBOX_1 157 165 PF00400 0.642
DEG_APCC_DBOX_1 464 472 PF00400 0.684
DEG_SCF_FBW7_1 505 512 PF00400 0.679
DEG_SPOP_SBC_1 348 352 PF00917 0.623
DEG_SPOP_SBC_1 509 513 PF00917 0.712
DOC_MAPK_gen_1 464 473 PF00069 0.573
DOC_MAPK_MEF2A_6 693 702 PF00069 0.651
DOC_MAPK_NFAT4_5 693 701 PF00069 0.653
DOC_PP1_RVXF_1 608 615 PF00149 0.555
DOC_PP2B_LxvP_1 86 89 PF13499 0.636
DOC_PP4_FxxP_1 111 114 PF00568 0.538
DOC_PP4_FxxP_1 436 439 PF00568 0.529
DOC_USP7_MATH_1 107 111 PF00917 0.568
DOC_USP7_MATH_1 348 352 PF00917 0.609
DOC_USP7_MATH_1 354 358 PF00917 0.560
DOC_USP7_MATH_1 431 435 PF00917 0.675
DOC_USP7_MATH_1 652 656 PF00917 0.740
DOC_USP7_MATH_1 678 682 PF00917 0.679
DOC_WW_Pin1_4 266 271 PF00397 0.772
DOC_WW_Pin1_4 284 289 PF00397 0.550
DOC_WW_Pin1_4 35 40 PF00397 0.656
DOC_WW_Pin1_4 394 399 PF00397 0.649
DOC_WW_Pin1_4 505 510 PF00397 0.727
LIG_14-3-3_CanoR_1 130 139 PF00244 0.620
LIG_14-3-3_CanoR_1 219 228 PF00244 0.558
LIG_14-3-3_CanoR_1 232 240 PF00244 0.544
LIG_14-3-3_CanoR_1 330 340 PF00244 0.754
LIG_14-3-3_CanoR_1 43 53 PF00244 0.651
LIG_14-3-3_CanoR_1 55 61 PF00244 0.531
LIG_14-3-3_CanoR_1 603 613 PF00244 0.595
LIG_14-3-3_CanoR_1 669 678 PF00244 0.621
LIG_14-3-3_CanoR_1 679 683 PF00244 0.566
LIG_BIR_II_1 1 5 PF00653 0.548
LIG_BRCT_BRCA1_1 208 212 PF00533 0.634
LIG_Clathr_ClatBox_1 246 250 PF01394 0.497
LIG_deltaCOP1_diTrp_1 153 157 PF00928 0.594
LIG_deltaCOP1_diTrp_1 169 172 PF00928 0.518
LIG_EVH1_2 114 118 PF00568 0.615
LIG_FHA_1 120 126 PF00498 0.550
LIG_FHA_1 348 354 PF00498 0.598
LIG_FHA_1 447 453 PF00498 0.656
LIG_FHA_1 516 522 PF00498 0.680
LIG_FHA_2 269 275 PF00498 0.720
LIG_FHA_2 380 386 PF00498 0.634
LIG_LIR_Apic_2 110 114 PF02991 0.536
LIG_LIR_Apic_2 434 439 PF02991 0.523
LIG_LIR_Gen_1 122 132 PF02991 0.558
LIG_LIR_Gen_1 168 174 PF02991 0.666
LIG_LIR_Gen_1 527 537 PF02991 0.654
LIG_LIR_Nem_3 122 127 PF02991 0.556
LIG_LIR_Nem_3 168 173 PF02991 0.553
LIG_LIR_Nem_3 209 215 PF02991 0.625
LIG_LIR_Nem_3 248 254 PF02991 0.621
LIG_LIR_Nem_3 527 532 PF02991 0.531
LIG_LIR_Nem_3 538 542 PF02991 0.577
LIG_MLH1_MIPbox_1 208 212 PF16413 0.634
LIG_MYND_3 29 33 PF01753 0.659
LIG_PCNA_PIPBox_1 205 214 PF02747 0.632
LIG_Pex14_1 688 692 PF04695 0.663
LIG_SH2_NCK_1 221 225 PF00017 0.488
LIG_SH2_SRC 59 62 PF00017 0.626
LIG_SH2_STAP1 166 170 PF00017 0.657
LIG_SH2_STAP1 421 425 PF00017 0.626
LIG_SH2_STAT5 362 365 PF00017 0.588
LIG_SH2_STAT5 406 409 PF00017 0.655
LIG_SH2_STAT5 425 428 PF00017 0.503
LIG_SH2_STAT5 437 440 PF00017 0.618
LIG_SH3_3 20 26 PF00018 0.590
LIG_SH3_3 282 288 PF00018 0.741
LIG_SH3_3 395 401 PF00018 0.713
LIG_SH3_3 580 586 PF00018 0.712
LIG_SH3_3 613 619 PF00018 0.575
LIG_SH3_3 84 90 PF00018 0.591
LIG_SUMO_SIM_par_1 244 250 PF11976 0.501
LIG_SUMO_SIM_par_1 350 357 PF11976 0.525
LIG_SUMO_SIM_par_1 448 454 PF11976 0.566
LIG_TRAF2_1 150 153 PF00917 0.610
LIG_TRAF2_1 175 178 PF00917 0.648
LIG_TRAF2_1 467 470 PF00917 0.742
LIG_UBA3_1 363 367 PF00899 0.694
LIG_ULM_U2AF65_1 302 309 PF00076 0.651
LIG_WRC_WIRS_1 208 213 PF05994 0.630
LIG_WW_1 403 406 PF00397 0.606
MOD_CDK_SPxxK_3 266 273 PF00069 0.769
MOD_CK1_1 143 149 PF00069 0.602
MOD_CK1_1 284 290 PF00069 0.596
MOD_CK1_1 343 349 PF00069 0.739
MOD_CK1_1 379 385 PF00069 0.750
MOD_CK1_1 488 494 PF00069 0.619
MOD_CK1_1 543 549 PF00069 0.609
MOD_CK1_1 642 648 PF00069 0.740
MOD_CK1_1 8 14 PF00069 0.651
MOD_CK2_1 134 140 PF00069 0.671
MOD_CK2_1 172 178 PF00069 0.565
MOD_CK2_1 268 274 PF00069 0.654
MOD_CK2_1 379 385 PF00069 0.584
MOD_CK2_1 54 60 PF00069 0.704
MOD_CK2_1 678 684 PF00069 0.576
MOD_CK2_1 79 85 PF00069 0.652
MOD_CMANNOS 154 157 PF00535 0.665
MOD_GlcNHglycan 134 137 PF01048 0.636
MOD_GlcNHglycan 145 148 PF01048 0.780
MOD_GlcNHglycan 317 320 PF01048 0.635
MOD_GlcNHglycan 326 329 PF01048 0.737
MOD_GlcNHglycan 372 375 PF01048 0.743
MOD_GlcNHglycan 433 436 PF01048 0.718
MOD_GlcNHglycan 440 443 PF01048 0.684
MOD_GlcNHglycan 542 545 PF01048 0.611
MOD_GlcNHglycan 56 59 PF01048 0.685
MOD_GlcNHglycan 636 639 PF01048 0.746
MOD_GlcNHglycan 644 647 PF01048 0.639
MOD_GlcNHglycan 653 657 PF01048 0.532
MOD_GlcNHglycan 671 674 PF01048 0.485
MOD_GSK3_1 130 137 PF00069 0.696
MOD_GSK3_1 180 187 PF00069 0.615
MOD_GSK3_1 331 338 PF00069 0.627
MOD_GSK3_1 340 347 PF00069 0.635
MOD_GSK3_1 372 379 PF00069 0.643
MOD_GSK3_1 42 49 PF00069 0.584
MOD_GSK3_1 483 490 PF00069 0.564
MOD_GSK3_1 505 512 PF00069 0.695
MOD_GSK3_1 617 624 PF00069 0.587
MOD_GSK3_1 640 647 PF00069 0.718
MOD_GSK3_1 664 671 PF00069 0.660
MOD_GSK3_1 678 685 PF00069 0.549
MOD_N-GLC_1 634 639 PF02516 0.564
MOD_N-GLC_2 392 394 PF02516 0.664
MOD_N-GLC_2 556 558 PF02516 0.653
MOD_N-GLC_2 615 617 PF02516 0.576
MOD_NEK2_1 172 177 PF00069 0.556
MOD_NEK2_1 190 195 PF00069 0.643
MOD_NEK2_1 293 298 PF00069 0.711
MOD_NEK2_1 340 345 PF00069 0.787
MOD_NEK2_1 405 410 PF00069 0.656
MOD_NEK2_1 416 421 PF00069 0.566
MOD_NEK2_1 510 515 PF00069 0.730
MOD_NEK2_1 540 545 PF00069 0.573
MOD_NEK2_1 668 673 PF00069 0.632
MOD_NEK2_2 207 212 PF00069 0.638
MOD_NEK2_2 573 578 PF00069 0.616
MOD_NEK2_2 678 683 PF00069 0.634
MOD_OFUCOSY 485 492 PF10250 0.590
MOD_OFUCOSY 670 675 PF10250 0.659
MOD_PIKK_1 119 125 PF00454 0.595
MOD_PIKK_1 172 178 PF00454 0.675
MOD_PIKK_1 307 313 PF00454 0.727
MOD_PIKK_1 332 338 PF00454 0.578
MOD_PIKK_1 530 536 PF00454 0.639
MOD_PIKK_1 604 610 PF00454 0.608
MOD_PIKK_1 621 627 PF00454 0.466
MOD_PK_1 657 663 PF00069 0.639
MOD_PKA_2 231 237 PF00069 0.642
MOD_PKA_2 332 338 PF00069 0.749
MOD_PKA_2 42 48 PF00069 0.659
MOD_PKA_2 54 60 PF00069 0.516
MOD_PKA_2 640 646 PF00069 0.612
MOD_PKA_2 668 674 PF00069 0.637
MOD_PKA_2 678 684 PF00069 0.646
MOD_PKB_1 128 136 PF00069 0.597
MOD_PKB_1 158 166 PF00069 0.661
MOD_PKB_1 305 313 PF00069 0.601
MOD_Plk_1 197 203 PF00069 0.628
MOD_Plk_1 515 521 PF00069 0.687
MOD_Plk_1 8 14 PF00069 0.651
MOD_Plk_1 94 100 PF00069 0.662
MOD_Plk_4 160 166 PF00069 0.548
MOD_Plk_4 207 213 PF00069 0.695
MOD_Plk_4 281 287 PF00069 0.744
MOD_Plk_4 46 52 PF00069 0.571
MOD_Plk_4 515 521 PF00069 0.657
MOD_Plk_4 94 100 PF00069 0.664
MOD_ProDKin_1 266 272 PF00069 0.770
MOD_ProDKin_1 284 290 PF00069 0.546
MOD_ProDKin_1 35 41 PF00069 0.655
MOD_ProDKin_1 394 400 PF00069 0.650
MOD_ProDKin_1 505 511 PF00069 0.727
MOD_SUMO_for_1 195 198 PF00179 0.703
MOD_SUMO_rev_2 175 182 PF00179 0.579
TRG_DiLeu_BaEn_2 94 100 PF01217 0.582
TRG_DiLeu_LyEn_5 242 247 PF01217 0.506
TRG_ENDOCYTIC_2 425 428 PF00928 0.545
TRG_ER_diArg_1 127 130 PF00400 0.613
TRG_ER_diArg_1 157 160 PF00400 0.663
TRG_ER_diArg_1 302 305 PF00400 0.614
TRG_ER_diArg_1 306 308 PF00400 0.616
TRG_ER_diArg_1 463 466 PF00400 0.747
TRG_ER_diArg_1 553 555 PF00400 0.639
TRG_ER_diArg_1 686 688 PF00400 0.563
TRG_NLS_MonoCore_2 301 306 PF00514 0.609
TRG_NLS_MonoExtC_3 301 306 PF00514 0.614
TRG_NLS_MonoExtN_4 302 307 PF00514 0.624
TRG_Pf-PMV_PEXEL_1 307 311 PF00026 0.662
TRG_Pf-PMV_PEXEL_1 466 470 PF00026 0.680

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3A3 Leptomonas seymouri 29% 100%
A4HM92 Leishmania braziliensis 63% 100%
A4IAV6 Leishmania infantum 100% 100%
E9AEN4 Leishmania major 87% 100%
E9B5U0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS