Phosphoinositide phospholipase C

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylinositol-specific phospholipase-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7X8U7_LEIDO

TriTrypDb:

LdBPK_350040.1 , LdCL_350005400 , LDHU3_35.0080

Length:

729

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X8U7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8U7

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	16
GO:0007165	signal transduction	2	16
GO:0008152	metabolic process	1	16
GO:0009056	catabolic process	2	16
GO:0009987	cellular process	1	16
GO:0016042	lipid catabolic process	4	16
GO:0035556	intracellular signal transduction	3	16
GO:0044238	primary metabolic process	2	16
GO:0050789	regulation of biological process	2	16
GO:0050794	regulation of cellular process	3	16
GO:0065007	biological regulation	1	16
GO:0071704	organic substance metabolic process	2	16
GO:1901575	organic substance catabolic process	3	16
GO:0048015	phosphatidylinositol-mediated signaling	5	2
GO:0048017	inositol lipid-mediated signaling	4	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	16
GO:0004435	phosphatidylinositol phospholipase C activity	7	16
GO:0004620	phospholipase activity	5	16
GO:0004629	phospholipase C activity	6	16
GO:0005488	binding	1	14
GO:0005509	calcium ion binding	5	14
GO:0008081	phosphoric diester hydrolase activity	5	16
GO:0016298	lipase activity	4	16
GO:0016787	hydrolase activity	2	16
GO:0016788	hydrolase activity, acting on ester bonds	3	16
GO:0042578	phosphoric ester hydrolase activity	4	16
GO:0043167	ion binding	2	14
GO:0043169	cation binding	3	14
GO:0046872	metal ion binding	4	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	283	287	PF00656	0.441
CLV_C14_Caspase3-7	425	429	PF00656	0.363
CLV_C14_Caspase3-7	535	539	PF00656	0.323
CLV_NRD_NRD_1	129	131	PF00675	0.461
CLV_NRD_NRD_1	467	469	PF00675	0.485
CLV_PCSK_KEX2_1	128	130	PF00082	0.411
CLV_PCSK_KEX2_1	467	469	PF00082	0.485
CLV_PCSK_SKI1_1	130	134	PF00082	0.543
CLV_PCSK_SKI1_1	266	270	PF00082	0.347
CLV_PCSK_SKI1_1	328	332	PF00082	0.293
CLV_PCSK_SKI1_1	356	360	PF00082	0.398
CLV_PCSK_SKI1_1	361	365	PF00082	0.392
CLV_PCSK_SKI1_1	415	419	PF00082	0.376
CLV_PCSK_SKI1_1	421	425	PF00082	0.379
CLV_PCSK_SKI1_1	43	47	PF00082	0.476
CLV_PCSK_SKI1_1	703	707	PF00082	0.437
DEG_APCC_DBOX_1	420	428	PF00400	0.346
DEG_MDM2_SWIB_1	104	111	PF02201	0.453
DEG_SPOP_SBC_1	486	490	PF00917	0.484
DOC_CKS1_1	722	727	PF01111	0.360
DOC_MAPK_DCC_7	27	36	PF00069	0.285
DOC_MAPK_gen_1	27	36	PF00069	0.540
DOC_MAPK_gen_1	43	49	PF00069	0.417
DOC_MAPK_gen_1	436	443	PF00069	0.359
DOC_MAPK_gen_1	660	669	PF00069	0.307
DOC_MAPK_MEF2A_6	27	36	PF00069	0.453
DOC_MAPK_MEF2A_6	390	398	PF00069	0.380
DOC_MAPK_MEF2A_6	662	671	PF00069	0.443
DOC_PP1_RVXF_1	157	163	PF00149	0.432
DOC_PP1_RVXF_1	359	365	PF00149	0.312
DOC_PP4_FxxP_1	376	379	PF00568	0.359
DOC_PP4_FxxP_1	722	725	PF00568	0.451
DOC_SPAK_OSR1_1	236	240	PF12202	0.459
DOC_USP7_MATH_1	141	145	PF00917	0.458
DOC_USP7_MATH_1	213	217	PF00917	0.313
DOC_USP7_MATH_1	479	483	PF00917	0.376
DOC_USP7_MATH_1	75	79	PF00917	0.308
DOC_USP7_UBL2_3	436	440	PF12436	0.359
DOC_USP7_UBL2_3	84	88	PF12436	0.497
DOC_WW_Pin1_4	223	228	PF00397	0.343
DOC_WW_Pin1_4	245	250	PF00397	0.446
DOC_WW_Pin1_4	400	405	PF00397	0.272
DOC_WW_Pin1_4	430	435	PF00397	0.303
DOC_WW_Pin1_4	47	52	PF00397	0.488
DOC_WW_Pin1_4	512	517	PF00397	0.239
DOC_WW_Pin1_4	721	726	PF00397	0.409
LIG_14-3-3_CanoR_1	118	122	PF00244	0.388
LIG_14-3-3_CanoR_1	128	133	PF00244	0.424
LIG_14-3-3_CanoR_1	220	229	PF00244	0.582
LIG_14-3-3_CanoR_1	251	256	PF00244	0.360
LIG_14-3-3_CanoR_1	262	269	PF00244	0.490
LIG_14-3-3_CanoR_1	291	299	PF00244	0.503
LIG_14-3-3_CanoR_1	356	364	PF00244	0.413
LIG_14-3-3_CanoR_1	487	492	PF00244	0.551
LIG_Actin_WH2_2	19	37	PF00022	0.487
LIG_Actin_WH2_2	440	458	PF00022	0.378
LIG_AP2alpha_1	181	185	PF02296	0.409
LIG_APCC_ABBA_1	629	634	PF00400	0.431
LIG_APCC_ABBAyCdc20_2	628	634	PF00400	0.288
LIG_BIR_II_1	1	5	PF00653	0.585
LIG_BRCT_BRCA1_1	66	70	PF00533	0.480
LIG_deltaCOP1_diTrp_1	384	392	PF00928	0.231
LIG_DLG_GKlike_1	251	258	PF00625	0.373
LIG_EVH1_2	177	181	PF00568	0.425
LIG_FHA_1	271	277	PF00498	0.432
LIG_FHA_1	357	363	PF00498	0.277
LIG_FHA_1	472	478	PF00498	0.429
LIG_FHA_1	522	528	PF00498	0.336
LIG_FHA_1	600	606	PF00498	0.375
LIG_FHA_1	638	644	PF00498	0.430
LIG_FHA_1	662	668	PF00498	0.355
LIG_FHA_1	678	684	PF00498	0.381
LIG_FHA_1	708	714	PF00498	0.447
LIG_FHA_1	722	728	PF00498	0.358
LIG_FHA_2	112	118	PF00498	0.394
LIG_FHA_2	129	135	PF00498	0.461
LIG_FHA_2	228	234	PF00498	0.451
LIG_FHA_2	281	287	PF00498	0.477
LIG_FHA_2	368	374	PF00498	0.380
LIG_FHA_2	400	406	PF00498	0.361
LIG_FHA_2	533	539	PF00498	0.337
LIG_FHA_2	613	619	PF00498	0.586
LIG_FHA_2	677	683	PF00498	0.382
LIG_LIR_Apic_2	341	346	PF02991	0.323
LIG_LIR_Apic_2	373	379	PF02991	0.359
LIG_LIR_Apic_2	721	725	PF02991	0.320
LIG_LIR_Gen_1	107	116	PF02991	0.429
LIG_LIR_Gen_1	119	125	PF02991	0.427
LIG_LIR_Gen_1	161	169	PF02991	0.452
LIG_LIR_Gen_1	200	208	PF02991	0.394
LIG_LIR_Gen_1	232	240	PF02991	0.449
LIG_LIR_Gen_1	254	260	PF02991	0.518
LIG_LIR_Gen_1	67	76	PF02991	0.483
LIG_LIR_Nem_3	107	111	PF02991	0.387
LIG_LIR_Nem_3	119	124	PF02991	0.343
LIG_LIR_Nem_3	146	151	PF02991	0.493
LIG_LIR_Nem_3	161	165	PF02991	0.354
LIG_LIR_Nem_3	200	204	PF02991	0.392
LIG_LIR_Nem_3	232	237	PF02991	0.409
LIG_LIR_Nem_3	254	259	PF02991	0.482
LIG_LIR_Nem_3	391	395	PF02991	0.306
LIG_LIR_Nem_3	48	52	PF02991	0.349
LIG_PCNA_yPIPBox_3	135	149	PF02747	0.542
LIG_PCNA_yPIPBox_3	35	46	PF02747	0.297
LIG_Pex14_2	104	108	PF04695	0.418
LIG_Pex14_2	181	185	PF04695	0.421
LIG_Pex14_2	201	205	PF04695	0.411
LIG_Pex14_2	70	74	PF04695	0.377
LIG_Pex14_2	94	98	PF04695	0.489
LIG_PTB_Apo_2	167	174	PF02174	0.374
LIG_SH2_GRB2like	207	210	PF00017	0.382
LIG_SH2_SRC	503	506	PF00017	0.272
LIG_SH2_STAT3	218	221	PF00017	0.352
LIG_SH2_STAT3	374	377	PF00017	0.323
LIG_SH2_STAT3	96	99	PF00017	0.411
LIG_SH2_STAT5	207	210	PF00017	0.437
LIG_SH2_STAT5	303	306	PF00017	0.294
LIG_SH2_STAT5	312	315	PF00017	0.291
LIG_SH2_STAT5	432	435	PF00017	0.386
LIG_SH2_STAT5	503	506	PF00017	0.374
LIG_SH2_STAT5	582	585	PF00017	0.335
LIG_SH2_STAT5	96	99	PF00017	0.394
LIG_SH3_3	580	586	PF00018	0.337
LIG_SUMO_SIM_par_1	391	397	PF11976	0.298
LIG_SUMO_SIM_par_1	639	646	PF11976	0.343
LIG_SxIP_EBH_1	592	606	PF03271	0.255
LIG_TRAF2_1	230	233	PF00917	0.471
LIG_TRFH_1	275	279	PF08558	0.472
LIG_TRFH_1	582	586	PF08558	0.293
LIG_UBA3_1	471	476	PF00899	0.351
LIG_WRC_WIRS_1	46	51	PF05994	0.444
MOD_CDK_SPxK_1	245	251	PF00069	0.452
MOD_CDK_SPxK_1	430	436	PF00069	0.359
MOD_CK1_1	10	16	PF00069	0.568
MOD_CK1_1	223	229	PF00069	0.369
MOD_CK1_1	308	314	PF00069	0.287
MOD_CK1_1	320	326	PF00069	0.322
MOD_CK1_1	430	436	PF00069	0.380
MOD_CK1_1	482	488	PF00069	0.382
MOD_CK1_1	637	643	PF00069	0.481
MOD_CK1_1	677	683	PF00069	0.491
MOD_CK1_1	707	713	PF00069	0.528
MOD_CK1_1	721	727	PF00069	0.320
MOD_CK2_1	111	117	PF00069	0.368
MOD_CK2_1	158	164	PF00069	0.392
MOD_CK2_1	213	219	PF00069	0.508
MOD_CK2_1	227	233	PF00069	0.437
MOD_CK2_1	399	405	PF00069	0.361
MOD_CK2_1	499	505	PF00069	0.296
MOD_GlcNHglycan	460	463	PF01048	0.619
MOD_GlcNHglycan	477	480	PF01048	0.409
MOD_GlcNHglycan	596	599	PF01048	0.570
MOD_GlcNHglycan	676	679	PF01048	0.514
MOD_GlcNHglycan	706	709	PF01048	0.466
MOD_GSK3_1	187	194	PF00069	0.428
MOD_GSK3_1	219	226	PF00069	0.532
MOD_GSK3_1	3	10	PF00069	0.675
MOD_GSK3_1	304	311	PF00069	0.307
MOD_GSK3_1	400	407	PF00069	0.398
MOD_GSK3_1	471	478	PF00069	0.453
MOD_GSK3_1	482	489	PF00069	0.372
MOD_GSK3_1	521	528	PF00069	0.305
MOD_GSK3_1	532	539	PF00069	0.326
MOD_GSK3_1	59	66	PF00069	0.500
MOD_GSK3_1	608	615	PF00069	0.551
MOD_GSK3_1	672	679	PF00069	0.486
MOD_GSK3_1	75	82	PF00069	0.448
MOD_LATS_1	354	360	PF00433	0.199
MOD_LATS_1	674	680	PF00433	0.285
MOD_N-GLC_1	141	146	PF02516	0.522
MOD_N-GLC_1	245	250	PF02516	0.413
MOD_N-GLC_1	305	310	PF02516	0.370
MOD_NEK2_1	1	6	PF00069	0.571
MOD_NEK2_1	104	109	PF00069	0.424
MOD_NEK2_1	116	121	PF00069	0.390
MOD_NEK2_1	133	138	PF00069	0.505
MOD_NEK2_1	304	309	PF00069	0.324
MOD_NEK2_1	34	39	PF00069	0.455
MOD_NEK2_1	422	427	PF00069	0.364
MOD_NEK2_1	455	460	PF00069	0.587
MOD_NEK2_1	471	476	PF00069	0.593
MOD_NEK2_2	213	218	PF00069	0.465
MOD_NEK2_2	718	723	PF00069	0.321
MOD_OFUCOSY	188	195	PF10250	0.359
MOD_PIKK_1	99	105	PF00454	0.366
MOD_PKA_1	128	134	PF00069	0.335
MOD_PKA_2	117	123	PF00069	0.404
MOD_PKA_2	128	134	PF00069	0.516
MOD_PKA_2	219	225	PF00069	0.544
MOD_PKA_2	261	267	PF00069	0.541
MOD_PKA_2	290	296	PF00069	0.421
MOD_PKA_2	34	40	PF00069	0.505
MOD_PKA_2	486	492	PF00069	0.537
MOD_Plk_1	116	122	PF00069	0.448
MOD_Plk_1	141	147	PF00069	0.526
MOD_Plk_1	163	169	PF00069	0.466
MOD_Plk_1	232	238	PF00069	0.472
MOD_Plk_1	427	433	PF00069	0.304
MOD_Plk_1	620	626	PF00069	0.404
MOD_Plk_1	7	13	PF00069	0.615
MOD_Plk_2-3	117	123	PF00069	0.425
MOD_Plk_4	117	123	PF00069	0.455
MOD_Plk_4	251	257	PF00069	0.497
MOD_Plk_4	280	286	PF00069	0.408
MOD_Plk_4	308	314	PF00069	0.293
MOD_Plk_4	499	505	PF00069	0.453
MOD_Plk_4	64	70	PF00069	0.462
MOD_Plk_4	643	649	PF00069	0.454
MOD_Plk_4	712	718	PF00069	0.414
MOD_ProDKin_1	223	229	PF00069	0.328
MOD_ProDKin_1	245	251	PF00069	0.443
MOD_ProDKin_1	400	406	PF00069	0.272
MOD_ProDKin_1	430	436	PF00069	0.303
MOD_ProDKin_1	47	53	PF00069	0.498
MOD_ProDKin_1	512	518	PF00069	0.239
MOD_ProDKin_1	721	727	PF00069	0.424
MOD_SUMO_rev_2	453	458	PF00179	0.541
TRG_DiLeu_BaEn_2	145	151	PF01217	0.376
TRG_DiLeu_BaLyEn_6	29	34	PF01217	0.310
TRG_DiLeu_BaLyEn_6	467	472	PF01217	0.494
TRG_DiLeu_BaLyEn_6	603	608	PF01217	0.294
TRG_ENDOCYTIC_2	148	151	PF00928	0.406
TRG_ENDOCYTIC_2	198	201	PF00928	0.379
TRG_ENDOCYTIC_2	327	330	PF00928	0.323
TRG_ENDOCYTIC_2	542	545	PF00928	0.288
TRG_ENDOCYTIC_2	697	700	PF00928	0.371
TRG_ER_diArg_1	128	130	PF00400	0.413
TRG_NES_CRM1_1	412	428	PF08389	0.340
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.487
TRG_Pf-PMV_PEXEL_1	369	373	PF00026	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1N0	Leptomonas seymouri	31%	99%
A0A0N1IKD7	Leptomonas seymouri	62%	97%
A0A0S4ITT3	Bodo saltans	31%	84%
A0A0S4J9Y4	Bodo saltans	32%	100%
A0A0S4JUS2	Bodo saltans	32%	100%
A0A1X0P2K1	Trypanosomatidae	34%	99%
A0A3Q8IF05	Leishmania donovani	33%	100%
A0A422N571	Trypanosoma rangeli	34%	100%
A4HCK9	Leishmania braziliensis	31%	100%
A4HM43	Leishmania braziliensis	79%	100%
A4I027	Leishmania infantum	31%	100%
A4I5X4	Leishmania infantum	33%	100%
A4IAQ5	Leishmania infantum	100%	100%
A5D6R3	Danio rerio	30%	93%
E9AEI1	Leishmania major	92%	100%
E9B168	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9B5P2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
P10688	Rattus norvegicus	31%	96%
P10895	Bos taurus	30%	96%
P40977	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	81%
Q15111	Homo sapiens	30%	67%
Q1RML2	Bos taurus	28%	100%
Q2VRL0	Gallus gallus	30%	100%
Q32NH8	Xenopus laevis	29%	96%
Q39032	Arabidopsis thaliana	26%	100%
Q3USB7	Mus musculus	29%	67%
Q4Q6Z7	Leishmania major	33%	100%
Q4QBH9	Leishmania major	29%	100%
Q56W08	Arabidopsis thaliana	26%	100%
Q5RET0	Pongo abelii	29%	96%
Q62688	Rattus norvegicus	30%	67%
Q62711	Rattus norvegicus	28%	94%
Q7YRU3	Sus scrofa	28%	100%
Q86YW0	Homo sapiens	28%	100%
Q8GV43	Arabidopsis thaliana	27%	100%
Q8K2J0	Mus musculus	30%	93%
Q8K4D7	Mus musculus	28%	100%
Q8N3E9	Homo sapiens	30%	92%
Q8R3B1	Mus musculus	30%	96%
Q944C2	Arabidopsis thaliana	26%	100%
Q9BRC7	Homo sapiens	28%	96%
Q9LY51	Arabidopsis thaliana	27%	100%