Thioredoxin, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

thioredoxin, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X8S7_LEIDO

TriTrypDb:

LdBPK_350380.1 , LdCL_350008800 , LDHU3_35.0510

Length:

615

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X8S7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8S7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	246	250	PF00656	0.708
CLV_NRD_NRD_1	554	556	PF00675	0.385
CLV_PCSK_KEX2_1	16	18	PF00082	0.698
CLV_PCSK_KEX2_1	237	239	PF00082	0.718
CLV_PCSK_KEX2_1	554	556	PF00082	0.385
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.698
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.693
CLV_PCSK_SKI1_1	13	17	PF00082	0.753
CLV_PCSK_SKI1_1	217	221	PF00082	0.476
CLV_PCSK_SKI1_1	435	439	PF00082	0.528
CLV_PCSK_SKI1_1	450	454	PF00082	0.411
CLV_PCSK_SKI1_1	480	484	PF00082	0.417
DEG_Nend_Nbox_1	1	3	PF02207	0.686
DEG_SCF_FBW7_1	122	129	PF00400	0.801
DEG_SPOP_SBC_1	298	302	PF00917	0.718
DOC_CKS1_1	414	419	PF01111	0.658
DOC_CKS1_1	54	59	PF01111	0.731
DOC_CYCLIN_yCln2_LP_2	283	289	PF00134	0.730
DOC_CYCLIN_yCln2_LP_2	383	389	PF00134	0.467
DOC_MAPK_gen_1	176	185	PF00069	0.593
DOC_MAPK_gen_1	379	385	PF00069	0.544
DOC_MAPK_gen_1	478	485	PF00069	0.430
DOC_MAPK_HePTP_8	183	195	PF00069	0.517
DOC_MAPK_MEF2A_6	176	185	PF00069	0.686
DOC_MAPK_MEF2A_6	186	195	PF00069	0.294
DOC_USP7_MATH_1	126	130	PF00917	0.795
DOC_USP7_MATH_1	23	27	PF00917	0.736
DOC_USP7_MATH_1	248	252	PF00917	0.782
DOC_USP7_MATH_1	298	302	PF00917	0.727
DOC_USP7_MATH_1	310	314	PF00917	0.706
DOC_USP7_MATH_1	326	330	PF00917	0.723
DOC_USP7_MATH_1	358	362	PF00917	0.772
DOC_USP7_MATH_1	49	53	PF00917	0.833
DOC_USP7_MATH_1	561	565	PF00917	0.675
DOC_USP7_MATH_1	569	573	PF00917	0.512
DOC_USP7_MATH_1	80	84	PF00917	0.728
DOC_USP7_MATH_2	417	423	PF00917	0.598
DOC_WW_Pin1_4	106	111	PF00397	0.667
DOC_WW_Pin1_4	122	127	PF00397	0.817
DOC_WW_Pin1_4	19	24	PF00397	0.697
DOC_WW_Pin1_4	244	249	PF00397	0.712
DOC_WW_Pin1_4	259	264	PF00397	0.701
DOC_WW_Pin1_4	413	418	PF00397	0.598
DOC_WW_Pin1_4	53	58	PF00397	0.732
DOC_WW_Pin1_4	62	67	PF00397	0.686
DOC_WW_Pin1_4	72	77	PF00397	0.634
LIG_14-3-3_CanoR_1	217	222	PF00244	0.495
LIG_14-3-3_CanoR_1	311	320	PF00244	0.718
LIG_14-3-3_CanoR_1	424	432	PF00244	0.535
LIG_14-3-3_CanoR_1	450	456	PF00244	0.465
LIG_APCC_ABBA_1	193	198	PF00400	0.504
LIG_CAP-Gly_1	612	615	PF01302	0.604
LIG_Clathr_ClatBox_1	194	198	PF01394	0.507
LIG_EVH1_1	401	405	PF00568	0.577
LIG_FHA_1	117	123	PF00498	0.773
LIG_FHA_1	132	138	PF00498	0.742
LIG_FHA_1	188	194	PF00498	0.496
LIG_FHA_1	208	214	PF00498	0.256
LIG_FHA_1	218	224	PF00498	0.454
LIG_FHA_1	298	304	PF00498	0.795
LIG_FHA_1	535	541	PF00498	0.430
LIG_FHA_1	54	60	PF00498	0.720
LIG_FHA_1	66	72	PF00498	0.705
LIG_FHA_2	269	275	PF00498	0.779
LIG_FHA_2	300	306	PF00498	0.809
LIG_FHA_2	414	420	PF00498	0.648
LIG_FHA_2	436	442	PF00498	0.467
LIG_FHA_2	5	11	PF00498	0.797
LIG_GBD_Chelix_1	512	520	PF00786	0.501
LIG_LIR_Apic_2	488	492	PF02991	0.376
LIG_LIR_Gen_1	537	546	PF02991	0.408
LIG_LIR_Nem_3	447	452	PF02991	0.414
LIG_LIR_Nem_3	456	462	PF02991	0.409
LIG_LIR_Nem_3	528	532	PF02991	0.385
LIG_LIR_Nem_3	537	541	PF02991	0.392
LIG_MYND_1	382	386	PF01753	0.561
LIG_PDZ_Class_3	610	615	PF00595	0.594
LIG_Pex14_2	449	453	PF04695	0.538
LIG_Pex14_2	611	615	PF04695	0.599
LIG_SH2_NCK_1	231	235	PF00017	0.613
LIG_SH2_STAP1	574	578	PF00017	0.581
LIG_SH2_STAT3	409	412	PF00017	0.698
LIG_SH2_STAT5	484	487	PF00017	0.376
LIG_SH2_STAT5	529	532	PF00017	0.430
LIG_SH3_3	140	146	PF00018	0.648
LIG_SH3_3	17	23	PF00018	0.720
LIG_SH3_3	399	405	PF00018	0.579
LIG_SH3_3	411	417	PF00018	0.690
LIG_SH3_5	227	231	PF00018	0.595
LIG_SH3_5	525	529	PF00018	0.430
LIG_SUMO_SIM_anti_2	189	195	PF11976	0.440
LIG_SUMO_SIM_par_1	348	354	PF11976	0.633
LIG_SUMO_SIM_par_1	430	436	PF11976	0.530
LIG_TRAF2_1	397	400	PF00917	0.622
LIG_TRAF2_1	577	580	PF00917	0.579
LIG_TRAF2_1	9	12	PF00917	0.792
LIG_WRC_WIRS_1	535	540	PF05994	0.376
LIG_WRC_WIRS_1	598	603	PF05994	0.507
MOD_CDK_SPxxK_3	106	113	PF00069	0.760
MOD_CK1_1	169	175	PF00069	0.639
MOD_CK1_1	201	207	PF00069	0.567
MOD_CK1_1	259	265	PF00069	0.733
MOD_CK1_1	313	319	PF00069	0.740
MOD_CK1_1	329	335	PF00069	0.605
MOD_CK1_1	36	42	PF00069	0.751
MOD_CK1_1	603	609	PF00069	0.549
MOD_CK1_1	83	89	PF00069	0.777
MOD_CK2_1	272	278	PF00069	0.755
MOD_CK2_1	299	305	PF00069	0.806
MOD_CK2_1	4	10	PF00069	0.808
MOD_CK2_1	413	419	PF00069	0.660
MOD_CK2_1	580	586	PF00069	0.483
MOD_CK2_1	607	613	PF00069	0.594
MOD_Cter_Amidation	377	380	PF01082	0.644
MOD_GlcNHglycan	128	131	PF01048	0.771
MOD_GlcNHglycan	173	176	PF01048	0.636
MOD_GlcNHglycan	23	26	PF01048	0.808
MOD_GlcNHglycan	239	242	PF01048	0.701
MOD_GlcNHglycan	331	334	PF01048	0.629
MOD_GlcNHglycan	368	371	PF01048	0.706
MOD_GlcNHglycan	425	428	PF01048	0.526
MOD_GlcNHglycan	51	54	PF01048	0.731
MOD_GlcNHglycan	558	561	PF01048	0.631
MOD_GlcNHglycan	563	566	PF01048	0.719
MOD_GSK3_1	116	123	PF00069	0.808
MOD_GSK3_1	131	138	PF00069	0.683
MOD_GSK3_1	152	159	PF00069	0.503
MOD_GSK3_1	162	169	PF00069	0.495
MOD_GSK3_1	19	26	PF00069	0.598
MOD_GSK3_1	2	9	PF00069	0.801
MOD_GSK3_1	207	214	PF00069	0.423
MOD_GSK3_1	244	251	PF00069	0.638
MOD_GSK3_1	268	275	PF00069	0.812
MOD_GSK3_1	336	343	PF00069	0.664
MOD_GSK3_1	408	415	PF00069	0.637
MOD_GSK3_1	419	426	PF00069	0.567
MOD_GSK3_1	458	465	PF00069	0.448
MOD_GSK3_1	472	479	PF00069	0.510
MOD_GSK3_1	49	56	PF00069	0.750
MOD_GSK3_1	508	515	PF00069	0.430
MOD_GSK3_1	596	603	PF00069	0.521
MOD_GSK3_1	72	79	PF00069	0.753
MOD_GSK3_1	83	90	PF00069	0.738
MOD_N-GLC_1	170	175	PF02516	0.594
MOD_N-GLC_1	81	86	PF02516	0.781
MOD_N-GLC_2	35	37	PF02516	0.721
MOD_NEK2_1	166	171	PF00069	0.577
MOD_NEK2_1	2	7	PF00069	0.800
MOD_NEK2_1	256	261	PF00069	0.696
MOD_NEK2_1	458	463	PF00069	0.409
MOD_NEK2_1	485	490	PF00069	0.423
MOD_NEK2_1	590	595	PF00069	0.528
MOD_NEK2_1	597	602	PF00069	0.514
MOD_NEK2_2	153	158	PF00069	0.462
MOD_NEK2_2	549	554	PF00069	0.385
MOD_PIKK_1	211	217	PF00454	0.461
MOD_PIKK_1	265	271	PF00454	0.690
MOD_PIKK_1	358	364	PF00454	0.726
MOD_PIKK_1	408	414	PF00454	0.692
MOD_PIKK_1	567	573	PF00454	0.590
MOD_PIKK_1	603	609	PF00454	0.527
MOD_PKA_1	237	243	PF00069	0.653
MOD_PKA_2	120	126	PF00069	0.727
MOD_PKA_2	237	243	PF00069	0.653
MOD_PKA_2	310	316	PF00069	0.699
MOD_PKA_2	423	429	PF00069	0.550
MOD_PKA_2	472	478	PF00069	0.648
MOD_PKA_2	86	92	PF00069	0.784
MOD_PKB_1	85	93	PF00069	0.832
MOD_Plk_1	11	17	PF00069	0.732
MOD_Plk_1	198	204	PF00069	0.533
MOD_Plk_1	211	217	PF00069	0.434
MOD_Plk_1	265	271	PF00069	0.606
MOD_Plk_4	162	168	PF00069	0.492
MOD_Plk_4	187	193	PF00069	0.433
MOD_Plk_4	351	357	PF00069	0.662
MOD_Plk_4	444	450	PF00069	0.419
MOD_Plk_4	508	514	PF00069	0.430
MOD_Plk_4	534	540	PF00069	0.376
MOD_Plk_4	597	603	PF00069	0.513
MOD_ProDKin_1	106	112	PF00069	0.665
MOD_ProDKin_1	122	128	PF00069	0.815
MOD_ProDKin_1	19	25	PF00069	0.697
MOD_ProDKin_1	244	250	PF00069	0.712
MOD_ProDKin_1	259	265	PF00069	0.702
MOD_ProDKin_1	413	419	PF00069	0.597
MOD_ProDKin_1	53	59	PF00069	0.732
MOD_ProDKin_1	62	68	PF00069	0.687
MOD_ProDKin_1	72	78	PF00069	0.634
MOD_SUMO_for_1	530	533	PF00179	0.430
MOD_SUMO_rev_2	92	102	PF00179	0.705
TRG_DiLeu_BaEn_1	189	194	PF01217	0.494
TRG_DiLeu_BaEn_1	499	504	PF01217	0.462
TRG_DiLeu_BaLyEn_6	379	384	PF01217	0.627
TRG_ENDOCYTIC_2	527	530	PF00928	0.430
TRG_ENDOCYTIC_2	550	553	PF00928	0.430
TRG_ER_diArg_1	553	555	PF00400	0.385
TRG_NES_CRM1_1	340	353	PF08389	0.703
TRG_NES_CRM1_1	521	533	PF08389	0.376
TRG_NLS_MonoExtC_3	15	21	PF00514	0.690
TRG_NLS_MonoExtN_4	13	20	PF00514	0.742
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	576	580	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA84	Leptomonas seymouri	59%	98%
A0A1X0NIY2	Trypanosomatidae	35%	100%
A4HM75	Leishmania braziliensis	79%	100%
A4IAT8	Leishmania infantum	99%	100%
E9AEL5	Leishmania major	92%	100%
E9B5S6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	99%