Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X8R0_LEIDO

TriTrypDb:

LdBPK_350390.1 , LdCL_350009000 , LDHU3_35.0550

Length:

548

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X8R0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8R0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.623
CLV_C14_Caspase3-7	161	165	PF00656	0.611
CLV_C14_Caspase3-7	186	190	PF00656	0.679
CLV_C14_Caspase3-7	485	489	PF00656	0.732
CLV_NRD_NRD_1	118	120	PF00675	0.533
CLV_NRD_NRD_1	174	176	PF00675	0.758
CLV_NRD_NRD_1	212	214	PF00675	0.515
CLV_NRD_NRD_1	406	408	PF00675	0.451
CLV_NRD_NRD_1	481	483	PF00675	0.749
CLV_PCSK_KEX2_1	118	120	PF00082	0.501
CLV_PCSK_KEX2_1	172	174	PF00082	0.630
CLV_PCSK_KEX2_1	212	214	PF00082	0.529
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.630
CLV_PCSK_PC7_1	208	214	PF00082	0.516
CLV_PCSK_SKI1_1	325	329	PF00082	0.687
CLV_PCSK_SKI1_1	411	415	PF00082	0.515
CLV_PCSK_SKI1_1	458	462	PF00082	0.714
CLV_PCSK_SKI1_1	466	470	PF00082	0.557
DEG_SPOP_SBC_1	126	130	PF00917	0.686
DOC_ANK_TNKS_1	44	51	PF00023	0.739
DOC_CDC14_PxL_1	363	371	PF14671	0.613
DOC_CKS1_1	191	196	PF01111	0.569
DOC_MAPK_gen_1	118	125	PF00069	0.559
DOC_MAPK_MEF2A_6	118	125	PF00069	0.495
DOC_PP2B_LxvP_1	123	126	PF13499	0.577
DOC_USP7_MATH_1	108	112	PF00917	0.547
DOC_USP7_MATH_1	113	117	PF00917	0.452
DOC_USP7_MATH_1	215	219	PF00917	0.657
DOC_USP7_MATH_1	22	26	PF00917	0.550
DOC_USP7_MATH_1	310	314	PF00917	0.597
DOC_USP7_MATH_1	33	37	PF00917	0.458
DOC_USP7_MATH_1	71	75	PF00917	0.734
DOC_WW_Pin1_4	101	106	PF00397	0.699
DOC_WW_Pin1_4	190	195	PF00397	0.578
DOC_WW_Pin1_4	350	355	PF00397	0.772
LIG_14-3-3_CanoR_1	182	191	PF00244	0.657
LIG_14-3-3_CanoR_1	197	203	PF00244	0.656
LIG_14-3-3_CanoR_1	212	220	PF00244	0.499
LIG_14-3-3_CanoR_1	269	277	PF00244	0.555
LIG_14-3-3_CanoR_1	373	379	PF00244	0.498
LIG_14-3-3_CanoR_1	411	421	PF00244	0.449
LIG_14-3-3_CanoR_1	509	515	PF00244	0.638
LIG_14-3-3_CanoR_1	95	99	PF00244	0.496
LIG_Actin_WH2_2	405	422	PF00022	0.546
LIG_APCC_ABBA_1	96	101	PF00400	0.579
LIG_APCC_ABBAyCdc20_2	95	101	PF00400	0.539
LIG_BIR_II_1	1	5	PF00653	0.731
LIG_BRCT_BRCA1_1	1	5	PF00533	0.631
LIG_BRCT_BRCA1_1	216	220	PF00533	0.720
LIG_CSL_BTD_1	123	126	PF09270	0.618
LIG_CSL_BTD_1	191	194	PF09270	0.585
LIG_EH_1	388	392	PF12763	0.543
LIG_eIF4E_1	254	260	PF01652	0.547
LIG_FHA_1	150	156	PF00498	0.544
LIG_FHA_1	373	379	PF00498	0.524
LIG_FHA_2	128	134	PF00498	0.714
LIG_FHA_2	174	180	PF00498	0.668
LIG_FHA_2	299	305	PF00498	0.448
LIG_FHA_2	61	67	PF00498	0.737
LIG_Integrin_RGD_1	47	49	PF01839	0.686
LIG_LIR_Apic_2	97	102	PF02991	0.668
LIG_LIR_Gen_1	2	13	PF02991	0.598
LIG_LIR_Gen_1	252	262	PF02991	0.540
LIG_LIR_Nem_3	189	195	PF02991	0.495
LIG_LIR_Nem_3	2	8	PF02991	0.592
LIG_LIR_Nem_3	252	257	PF02991	0.482
LIG_MAD2	119	127	PF02301	0.616
LIG_MYND_1	367	371	PF01753	0.648
LIG_NRBOX	81	87	PF00104	0.588
LIG_PCNA_PIPBox_1	117	126	PF02747	0.605
LIG_Pex14_2	156	160	PF04695	0.535
LIG_Pex14_2	409	413	PF04695	0.549
LIG_Rb_pABgroove_1	297	305	PF01858	0.455
LIG_SH2_NCK_1	99	103	PF00017	0.649
LIG_SH2_SRC	421	424	PF00017	0.426
LIG_SH2_STAT5	20	23	PF00017	0.595
LIG_SH2_STAT5	421	424	PF00017	0.553
LIG_SH3_1	99	105	PF00018	0.658
LIG_SH3_2	368	373	PF14604	0.623
LIG_SH3_3	188	194	PF00018	0.595
LIG_SH3_3	277	283	PF00018	0.560
LIG_SH3_3	302	308	PF00018	0.538
LIG_SH3_3	362	368	PF00018	0.705
LIG_SH3_3	99	105	PF00018	0.661
LIG_SH3_4	483	490	PF00018	0.660
LIG_SUMO_SIM_par_1	309	316	PF11976	0.589
LIG_UBA3_1	446	452	PF00899	0.621
LIG_Vh1_VBS_1	412	430	PF01044	0.524
LIG_Vh1_VBS_1	449	467	PF01044	0.686
MOD_CDK_SPxxK_3	190	197	PF00069	0.510
MOD_CK1_1	149	155	PF00069	0.561
MOD_CK1_1	200	206	PF00069	0.665
MOD_CK1_1	211	217	PF00069	0.594
MOD_CK1_1	4	10	PF00069	0.571
MOD_CK1_1	425	431	PF00069	0.545
MOD_CK1_1	515	521	PF00069	0.623
MOD_CK1_1	74	80	PF00069	0.669
MOD_CK2_1	127	133	PF00069	0.515
MOD_CK2_1	246	252	PF00069	0.496
MOD_CK2_1	310	316	PF00069	0.645
MOD_CK2_1	317	323	PF00069	0.649
MOD_CK2_1	338	344	PF00069	0.684
MOD_CK2_1	60	66	PF00069	0.766
MOD_CK2_1	73	79	PF00069	0.684
MOD_GlcNHglycan	110	113	PF01048	0.582
MOD_GlcNHglycan	130	133	PF01048	0.632
MOD_GlcNHglycan	160	163	PF01048	0.621
MOD_GlcNHglycan	213	216	PF01048	0.655
MOD_GlcNHglycan	241	244	PF01048	0.680
MOD_GlcNHglycan	248	251	PF01048	0.298
MOD_GlcNHglycan	308	311	PF01048	0.548
MOD_GlcNHglycan	31	34	PF01048	0.648
MOD_GlcNHglycan	357	360	PF01048	0.683
MOD_GlcNHglycan	73	76	PF01048	0.697
MOD_GlcNHglycan	91	94	PF01048	0.626
MOD_GSK3_1	173	180	PF00069	0.685
MOD_GSK3_1	197	204	PF00069	0.590
MOD_GSK3_1	211	218	PF00069	0.636
MOD_GSK3_1	235	242	PF00069	0.629
MOD_GSK3_1	267	274	PF00069	0.502
MOD_GSK3_1	29	36	PF00069	0.647
MOD_GSK3_1	306	313	PF00069	0.579
MOD_GSK3_1	450	457	PF00069	0.661
MOD_GSK3_1	505	512	PF00069	0.647
MOD_GSK3_1	70	77	PF00069	0.724
MOD_GSK3_1	85	92	PF00069	0.534
MOD_GSK3_1	97	104	PF00069	0.497
MOD_LATS_1	450	456	PF00433	0.618
MOD_N-GLC_2	139	141	PF02516	0.570
MOD_NEK2_1	1	6	PF00069	0.610
MOD_NEK2_1	220	225	PF00069	0.660
MOD_NEK2_1	235	240	PF00069	0.613
MOD_NEK2_1	29	34	PF00069	0.614
MOD_NEK2_1	374	379	PF00069	0.561
MOD_NEK2_1	412	417	PF00069	0.502
MOD_NEK2_1	486	491	PF00069	0.659
MOD_NEK2_1	510	515	PF00069	0.685
MOD_NEK2_2	215	220	PF00069	0.678
MOD_NEK2_2	298	303	PF00069	0.394
MOD_NEK2_2	502	507	PF00069	0.662
MOD_PIKK_1	113	119	PF00454	0.525
MOD_PIKK_1	13	19	PF00454	0.567
MOD_PIKK_1	317	323	PF00454	0.593
MOD_PIKK_1	39	45	PF00454	0.702
MOD_PIKK_1	466	472	PF00454	0.705
MOD_PKA_1	173	179	PF00069	0.695
MOD_PKA_2	173	179	PF00069	0.788
MOD_PKA_2	211	217	PF00069	0.541
MOD_PKA_2	22	28	PF00069	0.647
MOD_PKA_2	372	378	PF00069	0.502
MOD_PKA_2	508	514	PF00069	0.641
MOD_PKA_2	57	63	PF00069	0.701
MOD_PKA_2	94	100	PF00069	0.492
MOD_PKB_1	507	515	PF00069	0.591
MOD_Plk_4	215	221	PF00069	0.701
MOD_Plk_4	289	295	PF00069	0.414
MOD_Plk_4	298	304	PF00069	0.353
MOD_Plk_4	414	420	PF00069	0.498
MOD_Plk_4	94	100	PF00069	0.599
MOD_ProDKin_1	101	107	PF00069	0.702
MOD_ProDKin_1	190	196	PF00069	0.572
MOD_ProDKin_1	350	356	PF00069	0.769
MOD_SUMO_rev_2	485	492	PF00179	0.692
TRG_DiLeu_BaLyEn_6	255	260	PF01217	0.481
TRG_DiLeu_BaLyEn_6	365	370	PF01217	0.680
TRG_DiLeu_BaLyEn_6	442	447	PF01217	0.608
TRG_ENDOCYTIC_2	254	257	PF00928	0.539
TRG_ER_diArg_1	118	120	PF00400	0.533
TRG_ER_diArg_1	173	175	PF00400	0.759
TRG_ER_diArg_1	506	509	PF00400	0.579
TRG_NLS_MonoExtC_3	473	478	PF00514	0.728
TRG_NLS_MonoExtN_4	474	479	PF00514	0.710
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.669

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II05	Leptomonas seymouri	55%	96%
A0A0S4JU63	Bodo saltans	25%	100%
A0A1X0NIV1	Trypanosomatidae	30%	100%
A4HM76	Leishmania braziliensis	77%	100%
A4IAT9	Leishmania infantum	99%	100%
D0A2B2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AEL6	Leishmania major	93%	100%
E9B5S7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BNA1	Trypanosoma cruzi	31%	100%