Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X8Q0_LEIDO

TriTrypDb:

LdBPK_343970.1 , LdCL_340049100 , LDHU3_34.6280

Length:

465

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X8Q0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8Q0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	324	328	PF00656	0.616
CLV_C14_Caspase3-7	84	88	PF00656	0.591
CLV_NRD_NRD_1	141	143	PF00675	0.681
CLV_NRD_NRD_1	153	155	PF00675	0.744
CLV_NRD_NRD_1	159	161	PF00675	0.682
CLV_NRD_NRD_1	205	207	PF00675	0.651
CLV_NRD_NRD_1	211	213	PF00675	0.586
CLV_NRD_NRD_1	293	295	PF00675	0.623
CLV_NRD_NRD_1	370	372	PF00675	0.685
CLV_NRD_NRD_1	38	40	PF00675	0.571
CLV_NRD_NRD_1	52	54	PF00675	0.583
CLV_NRD_NRD_1	99	101	PF00675	0.606
CLV_PCSK_FUR_1	151	155	PF00082	0.621
CLV_PCSK_FUR_1	36	40	PF00082	0.569
CLV_PCSK_FUR_1	50	54	PF00082	0.573
CLV_PCSK_KEX2_1	141	143	PF00082	0.613
CLV_PCSK_KEX2_1	153	155	PF00082	0.688
CLV_PCSK_KEX2_1	205	207	PF00082	0.568
CLV_PCSK_KEX2_1	370	372	PF00082	0.685
CLV_PCSK_KEX2_1	38	40	PF00082	0.571
CLV_PCSK_KEX2_1	456	458	PF00082	0.622
CLV_PCSK_KEX2_1	52	54	PF00082	0.583
CLV_PCSK_KEX2_1	99	101	PF00082	0.606
CLV_PCSK_PC1ET2_1	456	458	PF00082	0.644
CLV_PCSK_SKI1_1	109	113	PF00082	0.675
CLV_PCSK_SKI1_1	153	157	PF00082	0.677
CLV_PCSK_SKI1_1	191	195	PF00082	0.546
CLV_PCSK_SKI1_1	39	43	PF00082	0.529
CLV_Separin_Metazoa	110	114	PF03568	0.681
CLV_Separin_Metazoa	44	48	PF03568	0.653
DEG_APCC_DBOX_1	38	46	PF00400	0.660
DEG_SPOP_SBC_1	243	247	PF00917	0.632
DOC_ANK_TNKS_1	420	427	PF00023	0.621
DOC_CYCLIN_RxL_1	150	159	PF00134	0.645
DOC_CYCLIN_RxL_1	33	44	PF00134	0.523
DOC_CYCLIN_yCln2_LP_2	236	242	PF00134	0.585
DOC_MAPK_gen_1	104	114	PF00069	0.639
DOC_MAPK_gen_1	33	42	PF00069	0.636
DOC_PP1_RVXF_1	335	342	PF00149	0.731
DOC_PP2B_LxvP_1	155	158	PF13499	0.635
DOC_PP2B_LxvP_1	408	411	PF13499	0.681
DOC_PP4_FxxP_1	448	451	PF00568	0.697
DOC_USP7_MATH_1	10	14	PF00917	0.739
DOC_USP7_MATH_1	248	252	PF00917	0.731
DOC_USP7_MATH_1	259	263	PF00917	0.582
DOC_USP7_MATH_1	314	318	PF00917	0.716
DOC_USP7_MATH_1	352	356	PF00917	0.813
DOC_USP7_MATH_1	56	60	PF00917	0.710
DOC_USP7_MATH_1	65	69	PF00917	0.638
DOC_USP7_MATH_1	85	89	PF00917	0.698
DOC_USP7_UBL2_3	133	137	PF12436	0.783
DOC_WW_Pin1_4	142	147	PF00397	0.714
DOC_WW_Pin1_4	283	288	PF00397	0.690
DOC_WW_Pin1_4	289	294	PF00397	0.688
DOC_WW_Pin1_4	298	303	PF00397	0.742
DOC_WW_Pin1_4	308	313	PF00397	0.813
DOC_WW_Pin1_4	387	392	PF00397	0.732
DOC_WW_Pin1_4	409	414	PF00397	0.784
LIG_14-3-3_CanoR_1	20	28	PF00244	0.631
LIG_14-3-3_CanoR_1	224	229	PF00244	0.688
LIG_14-3-3_CanoR_1	232	240	PF00244	0.696
LIG_14-3-3_CanoR_1	274	283	PF00244	0.562
LIG_14-3-3_CanoR_1	294	298	PF00244	0.629
LIG_14-3-3_CanoR_1	337	342	PF00244	0.769
LIG_14-3-3_CanoR_1	351	357	PF00244	0.659
LIG_14-3-3_CanoR_1	370	374	PF00244	0.626
LIG_14-3-3_CanoR_1	405	411	PF00244	0.785
LIG_14-3-3_CanoR_1	90	96	PF00244	0.644
LIG_Actin_WH2_2	190	207	PF00022	0.538
LIG_BIR_II_1	1	5	PF00653	0.783
LIG_FHA_1	171	177	PF00498	0.631
LIG_FHA_1	298	304	PF00498	0.722
LIG_FHA_1	321	327	PF00498	0.752
LIG_FHA_1	362	368	PF00498	0.786
LIG_FHA_2	391	397	PF00498	0.811
LIG_FHA_2	92	98	PF00498	0.709
LIG_Integrin_isoDGR_2	349	351	PF01839	0.591
LIG_LIR_Nem_3	126	132	PF02991	0.595
LIG_LIR_Nem_3	282	288	PF02991	0.717
LIG_LIR_Nem_3	353	359	PF02991	0.697
LIG_LIR_Nem_3	372	376	PF02991	0.653
LIG_LIR_Nem_3	393	397	PF02991	0.805
LIG_LIR_Nem_3	458	464	PF02991	0.752
LIG_PTAP_UEV_1	383	388	PF05743	0.806
LIG_SH2_CRK	240	244	PF00017	0.725
LIG_SH2_CRK	376	380	PF00017	0.670
LIG_SH2_STAP1	276	280	PF00017	0.657
LIG_SH2_STAT5	117	120	PF00017	0.662
LIG_SH2_STAT5	130	133	PF00017	0.786
LIG_SH2_STAT5	276	279	PF00017	0.659
LIG_SH2_STAT5	297	300	PF00017	0.734
LIG_SH3_1	141	147	PF00018	0.699
LIG_SH3_2	411	416	PF14604	0.646
LIG_SH3_3	141	147	PF00018	0.682
LIG_SH3_3	336	342	PF00018	0.823
LIG_SH3_3	381	387	PF00018	0.748
LIG_SH3_3	408	414	PF00018	0.625
LIG_SH3_3	425	431	PF00018	0.688
LIG_SH3_5	414	418	PF00018	0.707
LIG_SH3_CIN85_PxpxPR_1	411	416	PF14604	0.568
LIG_SUMO_SIM_anti_2	177	183	PF11976	0.691
LIG_SUMO_SIM_par_1	177	183	PF11976	0.635
LIG_TRAF2_1	27	30	PF00917	0.671
LIG_TRAF2_1	41	44	PF00917	0.470
LIG_TRAF2_1	94	97	PF00917	0.493
LIG_WW_3	413	417	PF00397	0.817
LIG_WW_3	75	79	PF00397	0.613
MOD_CDC14_SPxK_1	286	289	PF00782	0.667
MOD_CDC14_SPxK_1	292	295	PF00782	0.679
MOD_CDC14_SPxK_1	301	304	PF00782	0.757
MOD_CDK_SPK_2	289	294	PF00069	0.683
MOD_CDK_SPxK_1	283	289	PF00069	0.672
MOD_CDK_SPxK_1	298	304	PF00069	0.761
MOD_CDK_SPxxK_3	409	416	PF00069	0.748
MOD_CK1_1	385	391	PF00069	0.704
MOD_CK1_1	429	435	PF00069	0.813
MOD_CK1_1	59	65	PF00069	0.649
MOD_CK1_1	68	74	PF00069	0.714
MOD_CK2_1	177	183	PF00069	0.672
MOD_CK2_1	31	37	PF00069	0.590
MOD_CK2_1	390	396	PF00069	0.770
MOD_CK2_1	416	422	PF00069	0.780
MOD_CK2_1	91	97	PF00069	0.716
MOD_Cter_Amidation	368	371	PF01082	0.683
MOD_DYRK1A_RPxSP_1	142	146	PF00069	0.604
MOD_DYRK1A_RPxSP_1	308	312	PF00069	0.695
MOD_GlcNHglycan	118	121	PF01048	0.658
MOD_GlcNHglycan	148	151	PF01048	0.672
MOD_GlcNHglycan	191	194	PF01048	0.619
MOD_GlcNHglycan	233	236	PF01048	0.683
MOD_GlcNHglycan	246	249	PF01048	0.753
MOD_GlcNHglycan	261	264	PF01048	0.576
MOD_GlcNHglycan	329	332	PF01048	0.604
MOD_GlcNHglycan	344	347	PF01048	0.805
MOD_GlcNHglycan	360	364	PF01048	0.531
MOD_GlcNHglycan	384	387	PF01048	0.681
MOD_GlcNHglycan	417	421	PF01048	0.717
MOD_GlcNHglycan	70	73	PF01048	0.786
MOD_GSK3_1	142	149	PF00069	0.723
MOD_GSK3_1	166	173	PF00069	0.666
MOD_GSK3_1	183	190	PF00069	0.672
MOD_GSK3_1	244	251	PF00069	0.684
MOD_GSK3_1	272	279	PF00069	0.698
MOD_GSK3_1	289	296	PF00069	0.643
MOD_GSK3_1	316	323	PF00069	0.739
MOD_GSK3_1	333	340	PF00069	0.714
MOD_GSK3_1	395	402	PF00069	0.802
MOD_GSK3_1	416	423	PF00069	0.644
MOD_GSK3_1	61	68	PF00069	0.705
MOD_N-GLC_1	65	70	PF02516	0.635
MOD_NEK2_1	320	325	PF00069	0.695
MOD_NEK2_1	333	338	PF00069	0.671
MOD_NEK2_1	359	364	PF00069	0.727
MOD_NEK2_1	397	402	PF00069	0.796
MOD_PIKK_1	166	172	PF00454	0.647
MOD_PIKK_1	395	401	PF00454	0.737
MOD_PKA_2	19	25	PF00069	0.555
MOD_PKA_2	223	229	PF00069	0.786
MOD_PKA_2	231	237	PF00069	0.671
MOD_PKA_2	293	299	PF00069	0.686
MOD_PKA_2	350	356	PF00069	0.694
MOD_PKA_2	369	375	PF00069	0.594
MOD_PKA_2	420	426	PF00069	0.700
MOD_PKA_2	59	65	PF00069	0.671
MOD_Plk_1	272	278	PF00069	0.659
MOD_Plk_2-3	177	183	PF00069	0.657
MOD_Plk_2-3	31	37	PF00069	0.668
MOD_Plk_4	293	299	PF00069	0.725
MOD_Plk_4	316	322	PF00069	0.723
MOD_Plk_4	440	446	PF00069	0.703
MOD_Plk_4	450	456	PF00069	0.665
MOD_ProDKin_1	142	148	PF00069	0.714
MOD_ProDKin_1	283	289	PF00069	0.691
MOD_ProDKin_1	298	304	PF00069	0.744
MOD_ProDKin_1	308	314	PF00069	0.812
MOD_ProDKin_1	387	393	PF00069	0.731
MOD_ProDKin_1	409	415	PF00069	0.784
MOD_SUMO_for_1	455	458	PF00179	0.750
MOD_SUMO_rev_2	208	215	PF00179	0.600
MOD_SUMO_rev_2	30	35	PF00179	0.632
TRG_DiLeu_BaLyEn_6	151	156	PF01217	0.755
TRG_ENDOCYTIC_2	376	379	PF00928	0.693
TRG_ER_diArg_1	11	14	PF00400	0.643
TRG_ER_diArg_1	151	154	PF00400	0.717
TRG_ER_diArg_1	204	206	PF00400	0.623
TRG_ER_diArg_1	288	291	PF00400	0.604
TRG_ER_diArg_1	303	306	PF00400	0.628
TRG_ER_diArg_1	38	40	PF00400	0.583
TRG_ER_diArg_1	50	53	PF00400	0.605
TRG_ER_diArg_1	98	100	PF00400	0.611
TRG_Pf-PMV_PEXEL_1	100	105	PF00026	0.588
TRG_Pf-PMV_PEXEL_1	205	209	PF00026	0.624
TRG_Pf-PMV_PEXEL_1	268	273	PF00026	0.784
TRG_Pf-PMV_PEXEL_1	38	43	PF00026	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P706	Leptomonas seymouri	35%	89%
A4HBD7	Leishmania braziliensis	57%	100%
A4IAI5	Leishmania infantum	99%	100%
E9B5K9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q2C7	Leishmania major	85%	100%