GTP-ase activating protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GTP-ase activating protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X8N7_LEIDO

TriTrypDb:

LdBPK_350260.1 , LdCL_350007600 , LDHU3_35.0350

Length:

626

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X8N7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8N7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0003924	GTPase activity	7	5
GO:0003925	G protein activity	2	5
GO:0005096	GTPase activator activity	4	10
GO:0005488	binding	1	10
GO:0005543	phospholipid binding	3	10
GO:0008047	enzyme activator activity	3	10
GO:0008289	lipid binding	2	10
GO:0016462	pyrophosphatase activity	5	5
GO:0016787	hydrolase activity	2	5
GO:0016817	hydrolase activity, acting on acid anhydrides	3	5
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	5
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	5
GO:0030234	enzyme regulator activity	2	10
GO:0030695	GTPase regulator activity	4	10
GO:0060589	nucleoside-triphosphatase regulator activity	3	10
GO:0098772	molecular function regulator activity	1	10
GO:0140677	molecular function activator activity	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	173	177	PF00656	0.699
CLV_NRD_NRD_1	245	247	PF00675	0.679
CLV_NRD_NRD_1	265	267	PF00675	0.766
CLV_NRD_NRD_1	28	30	PF00675	0.487
CLV_NRD_NRD_1	350	352	PF00675	0.444
CLV_NRD_NRD_1	435	437	PF00675	0.627
CLV_PCSK_KEX2_1	244	246	PF00082	0.605
CLV_PCSK_KEX2_1	28	30	PF00082	0.480
CLV_PCSK_KEX2_1	434	436	PF00082	0.485
CLV_PCSK_PC1ET2_1	244	246	PF00082	0.605
CLV_PCSK_SKI1_1	138	142	PF00082	0.421
CLV_PCSK_SKI1_1	311	315	PF00082	0.418
CLV_PCSK_SKI1_1	408	412	PF00082	0.408
CLV_PCSK_SKI1_1	457	461	PF00082	0.633
CLV_PCSK_SKI1_1	533	537	PF00082	0.634
CLV_PCSK_SKI1_1	76	80	PF00082	0.533
DEG_Nend_UBRbox_2	1	3	PF02207	0.669
DEG_SPOP_SBC_1	250	254	PF00917	0.567
DOC_ANK_TNKS_1	171	178	PF00023	0.634
DOC_CKS1_1	607	612	PF01111	0.637
DOC_CYCLIN_yCln2_LP_2	447	453	PF00134	0.462
DOC_MAPK_gen_1	150	158	PF00069	0.585
DOC_MAPK_gen_1	424	432	PF00069	0.485
DOC_MAPK_gen_1	51	59	PF00069	0.512
DOC_MAPK_MEF2A_6	495	504	PF00069	0.499
DOC_PP1_RVXF_1	136	143	PF00149	0.435
DOC_PP1_RVXF_1	593	599	PF00149	0.599
DOC_PP1_RVXF_1	74	81	PF00149	0.512
DOC_PP4_FxxP_1	42	45	PF00568	0.470
DOC_USP7_MATH_1	119	123	PF00917	0.719
DOC_USP7_MATH_1	197	201	PF00917	0.809
DOC_USP7_MATH_1	204	208	PF00917	0.732
DOC_USP7_MATH_1	210	214	PF00917	0.711
DOC_USP7_MATH_1	328	332	PF00917	0.444
DOC_USP7_MATH_1	391	395	PF00917	0.430
DOC_USP7_MATH_1	45	49	PF00917	0.506
DOC_USP7_MATH_1	586	590	PF00917	0.554
DOC_USP7_MATH_1	610	614	PF00917	0.626
DOC_USP7_UBL2_3	316	320	PF12436	0.272
DOC_WW_Pin1_4	251	256	PF00397	0.774
DOC_WW_Pin1_4	303	308	PF00397	0.464
DOC_WW_Pin1_4	606	611	PF00397	0.693
LIG_14-3-3_CanoR_1	118	122	PF00244	0.672
LIG_14-3-3_CanoR_1	22	28	PF00244	0.612
LIG_14-3-3_CanoR_1	266	275	PF00244	0.616
LIG_14-3-3_CanoR_1	539	548	PF00244	0.560
LIG_APCC_ABBA_1	156	161	PF00400	0.585
LIG_APCC_ABBAyCdc20_2	54	60	PF00400	0.585
LIG_BRCT_BRCA1_1	395	399	PF00533	0.485
LIG_BRCT_BRCA1_1	588	592	PF00533	0.527
LIG_deltaCOP1_diTrp_1	364	373	PF00928	0.344
LIG_deltaCOP1_diTrp_1	576	584	PF00928	0.551
LIG_deltaCOP1_diTrp_1	612	618	PF00928	0.540
LIG_EH_1	195	199	PF12763	0.580
LIG_EVH1_1	444	448	PF00568	0.612
LIG_FHA_1	22	28	PF00498	0.506
LIG_FHA_1	439	445	PF00498	0.639
LIG_FHA_1	469	475	PF00498	0.553
LIG_FHA_1	6	12	PF00498	0.480
LIG_FHA_2	171	177	PF00498	0.631
LIG_FHA_2	267	273	PF00498	0.715
LIG_FHA_2	289	295	PF00498	0.668
LIG_FHA_2	540	546	PF00498	0.445
LIG_FHA_2	607	613	PF00498	0.671
LIG_IBAR_NPY_1	209	211	PF08397	0.667
LIG_KLC1_Yacidic_2	55	60	PF13176	0.580
LIG_LIR_Gen_1	152	160	PF02991	0.589
LIG_LIR_Gen_1	236	242	PF02991	0.684
LIG_LIR_Gen_1	331	340	PF02991	0.369
LIG_LIR_Gen_1	387	397	PF02991	0.444
LIG_LIR_Gen_1	521	531	PF02991	0.446
LIG_LIR_Gen_1	620	626	PF02991	0.543
LIG_LIR_Nem_3	152	158	PF02991	0.588
LIG_LIR_Nem_3	236	240	PF02991	0.651
LIG_LIR_Nem_3	331	335	PF02991	0.344
LIG_LIR_Nem_3	387	392	PF02991	0.349
LIG_LIR_Nem_3	521	527	PF02991	0.433
LIG_LIR_Nem_3	620	625	PF02991	0.432
LIG_LYPXL_SIV_4	69	77	PF13949	0.564
LIG_NRBOX	5	11	PF00104	0.391
LIG_Pex14_1	614	618	PF04695	0.517
LIG_PTB_Apo_2	123	130	PF02174	0.613
LIG_PTB_Apo_2	80	87	PF02174	0.627
LIG_PTB_Phospho_1	123	129	PF10480	0.629
LIG_PTB_Phospho_1	80	86	PF10480	0.622
LIG_Rb_LxCxE_1	35	48	PF01857	0.541
LIG_REV1ctd_RIR_1	429	437	PF16727	0.408
LIG_SH2_CRK	496	500	PF00017	0.517
LIG_SH2_CRK	561	565	PF00017	0.503
LIG_SH2_CRK	622	626	PF00017	0.561
LIG_SH2_NCK_1	70	74	PF00017	0.631
LIG_SH2_PTP2	389	392	PF00017	0.408
LIG_SH2_SRC	58	61	PF00017	0.581
LIG_SH2_STAP1	309	313	PF00017	0.527
LIG_SH2_STAP1	427	431	PF00017	0.444
LIG_SH2_STAP1	470	474	PF00017	0.643
LIG_SH2_STAP1	86	90	PF00017	0.672
LIG_SH2_STAT3	129	132	PF00017	0.545
LIG_SH2_STAT5	155	158	PF00017	0.570
LIG_SH2_STAT5	389	392	PF00017	0.376
LIG_SH2_STAT5	40	43	PF00017	0.421
LIG_SH2_STAT5	470	473	PF00017	0.714
LIG_SH2_STAT5	561	564	PF00017	0.407
LIG_SH2_STAT5	58	61	PF00017	0.566
LIG_SH2_STAT5	99	102	PF00017	0.687
LIG_SH3_1	442	448	PF00018	0.618
LIG_SH3_3	183	189	PF00018	0.655
LIG_SH3_3	191	197	PF00018	0.649
LIG_SH3_3	252	258	PF00018	0.716
LIG_SH3_3	387	393	PF00018	0.416
LIG_SH3_3	403	409	PF00018	0.235
LIG_SH3_3	440	446	PF00018	0.580
LIG_SH3_3	580	586	PF00018	0.490
LIG_SH3_4	316	323	PF00018	0.444
LIG_SUMO_SIM_anti_2	215	224	PF11976	0.722
LIG_SUMO_SIM_anti_2	87	94	PF11976	0.652
LIG_SUMO_SIM_par_1	29	35	PF11976	0.390
LIG_SUMO_SIM_par_1	7	12	PF11976	0.433
LIG_TRAF2_1	239	242	PF00917	0.677
LIG_UBA3_1	144	153	PF00899	0.573
LIG_UBA3_1	499	505	PF00899	0.548
LIG_UBA3_1	591	595	PF00899	0.472
LIG_WRC_WIRS_1	410	415	PF05994	0.444
LIG_WW_1	493	496	PF00397	0.465
LIG_WW_2	445	448	PF00397	0.476
LIG_WW_3	492	496	PF00397	0.470
MOD_CK1_1	120	126	PF00069	0.636
MOD_CK1_1	21	27	PF00069	0.667
MOD_CK1_1	217	223	PF00069	0.722
MOD_CK1_1	412	418	PF00069	0.444
MOD_CK1_1	472	478	PF00069	0.724
MOD_CK1_1	606	612	PF00069	0.656
MOD_CK2_1	210	216	PF00069	0.770
MOD_CK2_1	220	226	PF00069	0.660
MOD_CK2_1	288	294	PF00069	0.735
MOD_CK2_1	366	372	PF00069	0.485
MOD_CK2_1	411	417	PF00069	0.401
MOD_CK2_1	462	468	PF00069	0.720
MOD_CK2_1	606	612	PF00069	0.682
MOD_GlcNHglycan	11	14	PF01048	0.401
MOD_GlcNHglycan	168	171	PF01048	0.541
MOD_GlcNHglycan	191	194	PF01048	0.702
MOD_GlcNHglycan	206	209	PF01048	0.699
MOD_GlcNHglycan	216	219	PF01048	0.578
MOD_GlcNHglycan	359	362	PF01048	0.463
MOD_GlcNHglycan	414	417	PF01048	0.414
MOD_GlcNHglycan	471	474	PF01048	0.639
MOD_GSK3_1	113	120	PF00069	0.681
MOD_GSK3_1	166	173	PF00069	0.602
MOD_GSK3_1	210	217	PF00069	0.747
MOD_GSK3_1	23	30	PF00069	0.479
MOD_GSK3_1	290	297	PF00069	0.661
MOD_GSK3_1	453	460	PF00069	0.647
MOD_GSK3_1	468	475	PF00069	0.508
MOD_GSK3_1	5	12	PF00069	0.482
MOD_GSK3_1	606	613	PF00069	0.622
MOD_GSK3_1	614	621	PF00069	0.488
MOD_LATS_1	212	218	PF00433	0.744
MOD_LATS_1	350	356	PF00433	0.441
MOD_LATS_1	537	543	PF00433	0.586
MOD_N-GLC_2	356	358	PF02516	0.444
MOD_NEK2_1	166	171	PF00069	0.649
MOD_NEK2_1	240	245	PF00069	0.551
MOD_NEK2_1	288	293	PF00069	0.692
MOD_NEK2_1	411	416	PF00069	0.500
MOD_NEK2_1	430	435	PF00069	0.245
MOD_NEK2_1	453	458	PF00069	0.603
MOD_NEK2_1	538	543	PF00069	0.573
MOD_NEK2_1	560	565	PF00069	0.545
MOD_NEK2_1	596	601	PF00069	0.533
MOD_NEK2_1	618	623	PF00069	0.412
MOD_NEK2_2	23	28	PF00069	0.582
MOD_NEK2_2	523	528	PF00069	0.544
MOD_PIKK_1	113	119	PF00454	0.616
MOD_PIKK_1	526	532	PF00454	0.554
MOD_PIKK_1	596	602	PF00454	0.571
MOD_PIKK_1	603	609	PF00454	0.651
MOD_PKA_1	266	272	PF00069	0.622
MOD_PKA_1	603	609	PF00069	0.619
MOD_PKA_2	117	123	PF00069	0.638
MOD_PKA_2	149	155	PF00069	0.637
MOD_PKA_2	182	188	PF00069	0.751
MOD_PKA_2	204	210	PF00069	0.617
MOD_PKA_2	21	27	PF00069	0.611
MOD_PKA_2	265	271	PF00069	0.787
MOD_PKA_2	418	424	PF00069	0.444
MOD_PKA_2	538	544	PF00069	0.564
MOD_PKB_1	434	442	PF00069	0.657
MOD_PKB_1	455	463	PF00069	0.672
MOD_Plk_1	2	8	PF00069	0.520
MOD_Plk_1	453	459	PF00069	0.645
MOD_Plk_4	418	424	PF00069	0.444
MOD_Plk_4	5	11	PF00069	0.468
MOD_Plk_4	560	566	PF00069	0.509
MOD_ProDKin_1	251	257	PF00069	0.776
MOD_ProDKin_1	303	309	PF00069	0.462
MOD_ProDKin_1	606	612	PF00069	0.686
MOD_SUMO_for_1	258	261	PF00179	0.756
MOD_SUMO_rev_2	43	48	PF00179	0.541
TRG_DiLeu_BaEn_1	531	536	PF01217	0.647
TRG_DiLeu_BaEn_1	88	93	PF01217	0.657
TRG_DiLeu_BaLyEn_6	140	145	PF01217	0.494
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.592
TRG_ENDOCYTIC_2	155	158	PF00928	0.645
TRG_ENDOCYTIC_2	237	240	PF00928	0.604
TRG_ENDOCYTIC_2	389	392	PF00928	0.369
TRG_ENDOCYTIC_2	427	430	PF00928	0.485
TRG_ENDOCYTIC_2	496	499	PF00928	0.424
TRG_ENDOCYTIC_2	561	564	PF00928	0.427
TRG_ENDOCYTIC_2	622	625	PF00928	0.479
TRG_ER_diArg_1	245	247	PF00400	0.655
TRG_ER_diArg_1	27	29	PF00400	0.498
TRG_ER_diArg_1	434	436	PF00400	0.485
TRG_ER_diArg_1	455	458	PF00400	0.691
TRG_ER_diArg_1	565	568	PF00400	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYE2	Leptomonas seymouri	59%	100%
A0A1X0NIZ1	Trypanosomatidae	35%	100%
A0A3S5IRI6	Trypanosoma rangeli	34%	100%
A4HM65	Leishmania braziliensis	80%	100%
A4IAS7	Leishmania infantum	100%	100%
E9AEK3	Leishmania major	91%	100%
E9B5R4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5B380	Trypanosoma cruzi	34%	100%