Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X8N4_LEIDO

TriTrypDb:

LdBPK_343870.1 , LdCL_340048100 , LDHU3_34.6170

Length:

339

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X8N4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8N4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	4	8	PF00656	0.628
CLV_C14_Caspase3-7	50	54	PF00656	0.719
CLV_NRD_NRD_1	21	23	PF00675	0.577
CLV_NRD_NRD_1	210	212	PF00675	0.427
CLV_NRD_NRD_1	275	277	PF00675	0.552
CLV_NRD_NRD_1	40	42	PF00675	0.332
CLV_NRD_NRD_1	63	65	PF00675	0.784
CLV_PCSK_KEX2_1	160	162	PF00082	0.395
CLV_PCSK_KEX2_1	21	23	PF00082	0.599
CLV_PCSK_KEX2_1	210	212	PF00082	0.399
CLV_PCSK_KEX2_1	275	277	PF00082	0.539
CLV_PCSK_KEX2_1	63	65	PF00082	0.741
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.395
CLV_PCSK_SKI1_1	110	114	PF00082	0.517
CLV_PCSK_SKI1_1	211	215	PF00082	0.474
CLV_PCSK_SKI1_1	289	293	PF00082	0.398
CLV_PCSK_SKI1_1	312	316	PF00082	0.410
DEG_APCC_DBOX_1	183	191	PF00400	0.335
DEG_APCC_DBOX_1	25	33	PF00400	0.518
DEG_APCC_DBOX_1	288	296	PF00400	0.397
DEG_Nend_UBRbox_2	1	3	PF02207	0.666
DEG_SCF_FBW7_2	332	337	PF00400	0.550
DEG_SPOP_SBC_1	133	137	PF00917	0.414
DOC_MAPK_DCC_7	286	296	PF00069	0.507
DOC_MAPK_gen_1	160	166	PF00069	0.401
DOC_MAPK_gen_1	286	296	PF00069	0.471
DOC_MAPK_gen_1	319	329	PF00069	0.503
DOC_MAPK_MEF2A_6	289	296	PF00069	0.459
DOC_MAPK_NFAT4_5	289	297	PF00069	0.500
DOC_PP2B_LxvP_1	16	19	PF13499	0.469
DOC_PP2B_LxvP_1	164	167	PF13499	0.470
DOC_PP4_FxxP_1	82	85	PF00568	0.537
DOC_USP7_MATH_1	12	16	PF00917	0.572
DOC_USP7_MATH_1	206	210	PF00917	0.525
DOC_USP7_MATH_1	59	63	PF00917	0.696
DOC_WW_Pin1_4	254	259	PF00397	0.512
DOC_WW_Pin1_4	330	335	PF00397	0.451
DOC_WW_Pin1_4	55	60	PF00397	0.697
DOC_WW_Pin1_4	76	81	PF00397	0.456
LIG_14-3-3_CanoR_1	141	151	PF00244	0.481
LIG_14-3-3_CanoR_1	210	219	PF00244	0.478
LIG_14-3-3_CanoR_1	275	281	PF00244	0.610
LIG_14-3-3_CanoR_1	324	328	PF00244	0.509
LIG_Actin_WH2_2	114	130	PF00022	0.518
LIG_Actin_WH2_2	32	49	PF00022	0.342
LIG_BRCT_BRCA1_1	325	329	PF00533	0.433
LIG_BRCT_BRCA1_1	78	82	PF00533	0.415
LIG_CaM_NSCaTE_8	28	35	PF13499	0.469
LIG_deltaCOP1_diTrp_1	73	82	PF00928	0.506
LIG_EVH1_1	164	168	PF00568	0.518
LIG_FHA_1	11	17	PF00498	0.552
LIG_FHA_1	297	303	PF00498	0.455
LIG_FHA_1	84	90	PF00498	0.528
LIG_FHA_2	102	108	PF00498	0.555
LIG_FHA_2	142	148	PF00498	0.503
LIG_LIR_Apic_2	79	85	PF02991	0.447
LIG_LIR_Gen_1	326	336	PF02991	0.455
LIG_LIR_LC3C_4	185	189	PF02991	0.460
LIG_LIR_Nem_3	326	332	PF02991	0.456
LIG_LIR_Nem_3	79	84	PF02991	0.472
LIG_MLH1_MIPbox_1	78	82	PF16413	0.415
LIG_NRBOX	108	114	PF00104	0.495
LIG_PCNA_yPIPBox_3	141	155	PF02747	0.371
LIG_SH2_PTP2	267	270	PF00017	0.451
LIG_SH2_STAT5	267	270	PF00017	0.365
LIG_SH2_STAT5	38	41	PF00017	0.484
LIG_SH2_STAT5	81	84	PF00017	0.441
LIG_SH3_3	162	168	PF00018	0.454
LIG_SUMO_SIM_anti_2	123	128	PF11976	0.491
LIG_SUMO_SIM_anti_2	144	153	PF11976	0.524
LIG_SUMO_SIM_anti_2	185	191	PF11976	0.384
LIG_SUMO_SIM_par_1	12	17	PF11976	0.579
LIG_SUMO_SIM_par_1	185	191	PF11976	0.438
LIG_SUMO_SIM_par_1	292	297	PF11976	0.493
LIG_WRC_WIRS_1	6	11	PF05994	0.598
MOD_CDK_SPK_2	254	259	PF00069	0.512
MOD_CDK_SPK_2	55	60	PF00069	0.697
MOD_CK1_1	330	336	PF00069	0.449
MOD_CK1_1	58	64	PF00069	0.695
MOD_CK1_1	76	82	PF00069	0.291
MOD_CK1_1	83	89	PF00069	0.413
MOD_CK2_1	141	147	PF00069	0.509
MOD_CK2_1	179	185	PF00069	0.528
MOD_CK2_1	254	260	PF00069	0.497
MOD_GlcNHglycan	181	184	PF01048	0.499
MOD_GlcNHglycan	75	78	PF01048	0.550
MOD_GSK3_1	1	8	PF00069	0.570
MOD_GSK3_1	10	17	PF00069	0.509
MOD_GSK3_1	276	283	PF00069	0.606
MOD_GSK3_1	323	330	PF00069	0.429
MOD_GSK3_1	42	49	PF00069	0.629
MOD_GSK3_1	55	62	PF00069	0.619
MOD_GSK3_1	76	83	PF00069	0.476
MOD_N-GLC_2	138	140	PF02516	0.397
MOD_NEK2_1	1	6	PF00069	0.622
MOD_NEK2_1	134	139	PF00069	0.494
MOD_NEK2_1	280	285	PF00069	0.476
MOD_NEK2_1	327	332	PF00069	0.554
MOD_PIKK_1	211	217	PF00454	0.469
MOD_PKA_1	41	47	PF00069	0.663
MOD_PKA_2	142	148	PF00069	0.492
MOD_PKA_2	323	329	PF00069	0.525
MOD_PKA_2	46	52	PF00069	0.616
MOD_PKA_2	59	65	PF00069	0.712
MOD_PKB_1	141	149	PF00069	0.491
MOD_Plk_1	1	7	PF00069	0.626
MOD_Plk_1	42	48	PF00069	0.643
MOD_Plk_4	1	7	PF00069	0.646
MOD_Plk_4	323	329	PF00069	0.435
MOD_ProDKin_1	254	260	PF00069	0.509
MOD_ProDKin_1	330	336	PF00069	0.449
MOD_ProDKin_1	55	61	PF00069	0.701
MOD_ProDKin_1	76	82	PF00069	0.446
MOD_SUMO_for_1	117	120	PF00179	0.506
TRG_DiLeu_BaEn_1	147	152	PF01217	0.490
TRG_DiLeu_BaEn_1	229	234	PF01217	0.394
TRG_DiLeu_BaEn_1	287	292	PF01217	0.381
TRG_DiLeu_BaLyEn_6	290	295	PF01217	0.456
TRG_DiLeu_BaLyEn_6	298	303	PF01217	0.453
TRG_ENDOCYTIC_2	267	270	PF00928	0.381
TRG_ENDOCYTIC_2	81	84	PF00928	0.549
TRG_ER_diArg_1	63	66	PF00400	0.733
TRG_NES_CRM1_1	107	123	PF08389	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P703	Leptomonas seymouri	60%	80%
A0A0S4KKR7	Bodo saltans	32%	66%
A0A1X0PA52	Trypanosomatidae	46%	84%
A0A422NVD0	Trypanosoma rangeli	44%	90%
A4HBC7	Leishmania braziliensis	82%	100%
A4IAH5	Leishmania infantum	100%	100%
C9ZLR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	89%
E9B5J9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q2D7	Leishmania major	91%	100%
V5BW32	Trypanosoma cruzi	44%	89%