Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X8N2_LEIDO

TriTrypDb:

LdBPK_344240.1 , LdCL_340052500 , LDHU3_34.6630

Length:

555

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X8N2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8N2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	411	415	PF00656	0.534
CLV_C14_Caspase3-7	79	83	PF00656	0.583
CLV_NRD_NRD_1	104	106	PF00675	0.515
CLV_NRD_NRD_1	256	258	PF00675	0.595
CLV_NRD_NRD_1	299	301	PF00675	0.621
CLV_NRD_NRD_1	347	349	PF00675	0.613
CLV_NRD_NRD_1	391	393	PF00675	0.555
CLV_NRD_NRD_1	477	479	PF00675	0.577
CLV_NRD_NRD_1	505	507	PF00675	0.469
CLV_NRD_NRD_1	552	554	PF00675	0.624
CLV_PCSK_FUR_1	102	106	PF00082	0.634
CLV_PCSK_FUR_1	502	506	PF00082	0.476
CLV_PCSK_KEX2_1	104	106	PF00082	0.511
CLV_PCSK_KEX2_1	153	155	PF00082	0.577
CLV_PCSK_KEX2_1	256	258	PF00082	0.595
CLV_PCSK_KEX2_1	299	301	PF00082	0.610
CLV_PCSK_KEX2_1	347	349	PF00082	0.613
CLV_PCSK_KEX2_1	370	372	PF00082	0.697
CLV_PCSK_KEX2_1	391	393	PF00082	0.555
CLV_PCSK_KEX2_1	479	481	PF00082	0.608
CLV_PCSK_KEX2_1	504	506	PF00082	0.497
CLV_PCSK_PC1ET2_1	153	155	PF00082	0.577
CLV_PCSK_PC1ET2_1	370	372	PF00082	0.636
CLV_PCSK_PC1ET2_1	479	481	PF00082	0.608
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.487
CLV_PCSK_PC7_1	100	106	PF00082	0.528
CLV_PCSK_PC7_1	343	349	PF00082	0.640
CLV_PCSK_SKI1_1	104	108	PF00082	0.613
CLV_PCSK_SKI1_1	265	269	PF00082	0.498
CLV_PCSK_SKI1_1	505	509	PF00082	0.439
CLV_PCSK_SKI1_1	543	547	PF00082	0.535
CLV_PCSK_SKI1_1	65	69	PF00082	0.559
CLV_Separin_Metazoa	344	348	PF03568	0.672
DEG_APCC_DBOX_1	504	512	PF00400	0.454
DEG_Nend_Nbox_1	1	3	PF02207	0.611
DOC_CYCLIN_RxL_1	262	269	PF00134	0.495
DOC_CYCLIN_RxL_1	502	513	PF00134	0.368
DOC_CYCLIN_yCln2_LP_2	311	317	PF00134	0.634
DOC_MAPK_gen_1	502	511	PF00069	0.459
DOC_MAPK_MEF2A_6	444	453	PF00069	0.703
DOC_MAPK_RevD_3	285	300	PF00069	0.576
DOC_PP1_RVXF_1	152	159	PF00149	0.508
DOC_PP2B_LxvP_1	226	229	PF13499	0.580
DOC_USP7_MATH_1	113	117	PF00917	0.523
DOC_USP7_MATH_1	137	141	PF00917	0.566
DOC_USP7_MATH_1	412	416	PF00917	0.547
DOC_USP7_MATH_1	435	439	PF00917	0.604
DOC_USP7_UBL2_3	450	454	PF12436	0.562
DOC_WW_Pin1_4	185	190	PF00397	0.547
DOC_WW_Pin1_4	276	281	PF00397	0.520
DOC_WW_Pin1_4	335	340	PF00397	0.647
LIG_14-3-3_CanoR_1	123	132	PF00244	0.489
LIG_14-3-3_CanoR_1	170	175	PF00244	0.674
LIG_14-3-3_CanoR_1	237	244	PF00244	0.523
LIG_14-3-3_CanoR_1	28	36	PF00244	0.608
LIG_14-3-3_CterR_2	553	555	PF00244	0.627
LIG_DLG_GKlike_1	170	177	PF00625	0.595
LIG_EH1_1	46	54	PF00400	0.595
LIG_FHA_1	1	7	PF00498	0.696
LIG_FHA_1	105	111	PF00498	0.595
LIG_FHA_1	282	288	PF00498	0.507
LIG_FHA_1	35	41	PF00498	0.545
LIG_FHA_1	544	550	PF00498	0.593
LIG_FHA_1	64	70	PF00498	0.663
LIG_FHA_1	75	81	PF00498	0.497
LIG_FHA_2	230	236	PF00498	0.640
LIG_FHA_2	246	252	PF00498	0.434
LIG_FHA_2	28	34	PF00498	0.604
LIG_FHA_2	409	415	PF00498	0.562
LIG_FHA_2	492	498	PF00498	0.431
LIG_Integrin_RGD_1	70	72	PF01839	0.611
LIG_LIR_Gen_1	544	549	PF02991	0.494
LIG_LIR_Nem_3	178	184	PF02991	0.473
LIG_LIR_Nem_3	544	548	PF02991	0.500
LIG_MYND_1	314	318	PF01753	0.631
LIG_NRBOX	263	269	PF00104	0.563
LIG_RPA_C_Fungi	252	264	PF08784	0.582
LIG_SH2_STAP1	2	6	PF00017	0.682
LIG_SH2_STAT3	531	534	PF00017	0.573
LIG_SH2_STAT5	2	5	PF00017	0.697
LIG_SH2_STAT5	315	318	PF00017	0.570
LIG_SH2_STAT5	531	534	PF00017	0.573
LIG_Sin3_3	285	292	PF02671	0.562
LIG_Sin3_3	353	360	PF02671	0.560
LIG_SUMO_SIM_par_1	21	26	PF11976	0.638
LIG_SUMO_SIM_par_1	283	290	PF11976	0.479
LIG_TRAF2_1	233	236	PF00917	0.630
LIG_TRAF2_1	248	251	PF00917	0.447
LIG_UBA3_1	470	479	PF00899	0.593
LIG_WRC_WIRS_1	160	165	PF05994	0.521
LIG_WW_3	62	66	PF00397	0.631
MOD_CDK_SPK_2	185	190	PF00069	0.532
MOD_CDK_SPxxK_3	185	192	PF00069	0.529
MOD_CK1_1	11	17	PF00069	0.556
MOD_CK1_1	145	151	PF00069	0.521
MOD_CK1_1	222	228	PF00069	0.622
MOD_CK1_1	333	339	PF00069	0.587
MOD_CK1_1	405	411	PF00069	0.599
MOD_CK1_1	440	446	PF00069	0.555
MOD_CK1_1	78	84	PF00069	0.641
MOD_CK2_1	185	191	PF00069	0.534
MOD_CK2_1	229	235	PF00069	0.537
MOD_CK2_1	245	251	PF00069	0.523
MOD_CK2_1	334	340	PF00069	0.616
MOD_CK2_1	440	446	PF00069	0.587
MOD_CK2_1	491	497	PF00069	0.429
MOD_GlcNHglycan	10	13	PF01048	0.584
MOD_GlcNHglycan	111	114	PF01048	0.445
MOD_GlcNHglycan	221	224	PF01048	0.664
MOD_GlcNHglycan	238	241	PF01048	0.457
MOD_GlcNHglycan	24	28	PF01048	0.548
MOD_GlcNHglycan	382	385	PF01048	0.700
MOD_GlcNHglycan	407	410	PF01048	0.615
MOD_GlcNHglycan	414	417	PF01048	0.568
MOD_GlcNHglycan	49	52	PF01048	0.568
MOD_GSK3_1	104	111	PF00069	0.604
MOD_GSK3_1	142	149	PF00069	0.608
MOD_GSK3_1	23	30	PF00069	0.497
MOD_GSK3_1	276	283	PF00069	0.521
MOD_GSK3_1	330	337	PF00069	0.570
MOD_GSK3_1	34	41	PF00069	0.574
MOD_GSK3_1	376	383	PF00069	0.554
MOD_GSK3_1	398	405	PF00069	0.604
MOD_GSK3_1	4	11	PF00069	0.622
MOD_GSK3_1	408	415	PF00069	0.514
MOD_GSK3_1	543	550	PF00069	0.455
MOD_GSK3_1	74	81	PF00069	0.586
MOD_N-GLC_1	170	175	PF02516	0.497
MOD_NEK2_1	219	224	PF00069	0.527
MOD_NEK2_1	244	249	PF00069	0.490
MOD_NEK2_1	287	292	PF00069	0.519
MOD_NEK2_1	331	336	PF00069	0.500
MOD_NEK2_1	36	41	PF00069	0.609
MOD_NEK2_1	363	368	PF00069	0.579
MOD_NEK2_1	474	479	PF00069	0.537
MOD_NEK2_1	547	552	PF00069	0.577
MOD_NEK2_1	76	81	PF00069	0.557
MOD_NEK2_1	98	103	PF00069	0.595
MOD_PIKK_1	38	44	PF00454	0.590
MOD_PKA_1	104	110	PF00069	0.605
MOD_PKA_1	370	376	PF00069	0.555
MOD_PKA_1	391	397	PF00069	0.560
MOD_PKA_2	104	110	PF00069	0.605
MOD_PKA_2	236	242	PF00069	0.629
MOD_PKA_2	27	33	PF00069	0.459
MOD_PKA_2	346	352	PF00069	0.534
MOD_PKA_2	370	376	PF00069	0.555
MOD_PKA_2	391	397	PF00069	0.697
MOD_PKA_2	8	14	PF00069	0.667
MOD_PKB_1	102	110	PF00069	0.620
MOD_Plk_1	142	148	PF00069	0.648
MOD_Plk_1	170	176	PF00069	0.492
MOD_Plk_1	376	382	PF00069	0.570
MOD_Plk_1	543	549	PF00069	0.500
MOD_Plk_1	81	87	PF00069	0.593
MOD_Plk_4	142	148	PF00069	0.675
MOD_Plk_4	204	210	PF00069	0.493
MOD_Plk_4	283	289	PF00069	0.542
MOD_Plk_4	391	397	PF00069	0.667
MOD_ProDKin_1	185	191	PF00069	0.549
MOD_ProDKin_1	276	282	PF00069	0.510
MOD_ProDKin_1	335	341	PF00069	0.653
MOD_SUMO_rev_2	443	451	PF00179	0.559
MOD_SUMO_rev_2	50	59	PF00179	0.595
TRG_DiLeu_BaEn_1	191	196	PF01217	0.587
TRG_DiLeu_BaLyEn_6	164	169	PF01217	0.537
TRG_DiLeu_BaLyEn_6	226	231	PF01217	0.525
TRG_DiLeu_BaLyEn_6	419	424	PF01217	0.529
TRG_ER_diArg_1	102	105	PF00400	0.548
TRG_ER_diArg_1	346	348	PF00400	0.631
TRG_ER_diArg_1	390	392	PF00400	0.559
TRG_ER_diArg_1	420	423	PF00400	0.537
TRG_NLS_MonoExtC_3	477	482	PF00514	0.603
TRG_NLS_MonoExtN_4	476	483	PF00514	0.618
TRG_NLS_MonoExtN_4	502	508	PF00514	0.456
TRG_Pf-PMV_PEXEL_1	265	269	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	506	510	PF00026	0.396

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2P1	Leptomonas seymouri	43%	99%
A4HBG7	Leishmania braziliensis	74%	100%
A4IAL3	Leishmania infantum	99%	100%
E9B5N8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q280	Leishmania major	87%	100%