LeishMANIAdb
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Tc-38 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Tc-38 domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7X8M8_LEIDO
TriTrypDb:
LdBPK_350160.1 , LdCL_350006600 , LDHU3_35.0230
Length:
315

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X8M8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8M8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 138 142 PF00656 0.305
CLV_NRD_NRD_1 205 207 PF00675 0.554
CLV_NRD_NRD_1 266 268 PF00675 0.413
CLV_NRD_NRD_1 4 6 PF00675 0.581
CLV_PCSK_KEX2_1 266 268 PF00082 0.660
CLV_PCSK_KEX2_1 4 6 PF00082 0.581
CLV_PCSK_SKI1_1 103 107 PF00082 0.554
CLV_PCSK_SKI1_1 11 15 PF00082 0.545
CLV_PCSK_SKI1_1 207 211 PF00082 0.522
CLV_PCSK_SKI1_1 266 270 PF00082 0.527
CLV_PCSK_SKI1_1 273 277 PF00082 0.592
CLV_PCSK_SKI1_1 57 61 PF00082 0.514
DOC_CYCLIN_RxL_1 245 255 PF00134 0.545
DOC_MAPK_gen_1 126 134 PF00069 0.567
DOC_PP2B_LxvP_1 291 294 PF13499 0.533
DOC_PP2B_LxvP_1 84 87 PF13499 0.521
DOC_PP4_FxxP_1 152 155 PF00568 0.326
DOC_USP7_MATH_1 85 89 PF00917 0.643
DOC_WW_Pin1_4 11 16 PF00397 0.631
DOC_WW_Pin1_4 151 156 PF00397 0.326
DOC_WW_Pin1_4 75 80 PF00397 0.633
LIG_14-3-3_CanoR_1 266 275 PF00244 0.433
LIG_14-3-3_CanoR_1 300 304 PF00244 0.676
LIG_14-3-3_CanoR_1 71 79 PF00244 0.571
LIG_14-3-3_CanoR_1 81 85 PF00244 0.524
LIG_BIR_II_1 1 5 PF00653 0.599
LIG_BRCT_BRCA1_1 129 133 PF00533 0.649
LIG_BRCT_BRCA1_1 152 156 PF00533 0.437
LIG_Clathr_ClatBox_1 277 281 PF01394 0.575
LIG_deltaCOP1_diTrp_1 281 286 PF00928 0.679
LIG_EH_1 238 242 PF12763 0.474
LIG_FHA_1 182 188 PF00498 0.490
LIG_FHA_1 231 237 PF00498 0.526
LIG_FHA_1 81 87 PF00498 0.504
LIG_FHA_2 274 280 PF00498 0.666
LIG_FHA_2 70 76 PF00498 0.615
LIG_LIR_Apic_2 149 155 PF02991 0.330
LIG_LIR_Apic_2 80 85 PF02991 0.568
LIG_LIR_Gen_1 166 174 PF02991 0.664
LIG_LIR_Gen_1 281 291 PF02991 0.635
LIG_LIR_Nem_3 166 172 PF02991 0.613
LIG_LIR_Nem_3 281 286 PF02991 0.640
LIG_LIR_Nem_3 309 315 PF02991 0.722
LIG_LYPXL_S_1 201 205 PF13949 0.327
LIG_LYPXL_yS_3 202 205 PF13949 0.335
LIG_PCNA_yPIPBox_3 57 65 PF02747 0.607
LIG_Pex14_2 152 156 PF04695 0.310
LIG_Pex14_2 64 68 PF04695 0.576
LIG_REV1ctd_RIR_1 103 113 PF16727 0.572
LIG_REV1ctd_RIR_1 131 140 PF16727 0.305
LIG_SH2_CRK 82 86 PF00017 0.447
LIG_SH2_STAP1 52 56 PF00017 0.628
LIG_SH2_STAT3 51 54 PF00017 0.557
LIG_SH2_STAT5 169 172 PF00017 0.655
LIG_SH2_STAT5 82 85 PF00017 0.495
LIG_SH3_3 119 125 PF00018 0.603
LIG_SH3_3 308 314 PF00018 0.696
LIG_SUMO_SIM_par_1 179 184 PF11976 0.632
LIG_SUMO_SIM_par_1 276 281 PF11976 0.573
LIG_TRAF2_1 135 138 PF00917 0.321
LIG_TRAF2_1 72 75 PF00917 0.687
LIG_UBA3_1 40 46 PF00899 0.482
MOD_CDK_SPxK_1 75 81 PF00069 0.546
MOD_CK1_1 217 223 PF00069 0.570
MOD_CK2_1 273 279 PF00069 0.664
MOD_CK2_1 69 75 PF00069 0.651
MOD_GlcNHglycan 111 114 PF01048 0.389
MOD_GlcNHglycan 129 132 PF01048 0.664
MOD_GlcNHglycan 166 169 PF01048 0.650
MOD_GlcNHglycan 214 217 PF01048 0.666
MOD_GlcNHglycan 26 29 PF01048 0.561
MOD_GlcNHglycan 95 98 PF01048 0.574
MOD_GSK3_1 179 186 PF00069 0.593
MOD_GSK3_1 208 215 PF00069 0.546
MOD_GSK3_1 230 237 PF00069 0.435
MOD_GSK3_1 262 269 PF00069 0.465
MOD_GSK3_1 7 14 PF00069 0.605
MOD_N-GLC_1 307 312 PF02516 0.709
MOD_N-GLC_1 57 62 PF02516 0.607
MOD_NEK2_1 150 155 PF00069 0.437
MOD_NEK2_1 183 188 PF00069 0.586
MOD_NEK2_1 241 246 PF00069 0.494
MOD_NEK2_1 299 304 PF00069 0.706
MOD_NEK2_2 307 312 PF00069 0.731
MOD_PIKK_1 13 19 PF00454 0.551
MOD_PIKK_1 250 256 PF00454 0.448
MOD_PIKK_1 266 272 PF00454 0.543
MOD_PIKK_1 70 76 PF00454 0.665
MOD_PKA_1 266 272 PF00069 0.450
MOD_PKA_2 262 268 PF00069 0.525
MOD_PKA_2 299 305 PF00069 0.624
MOD_PKA_2 70 76 PF00069 0.564
MOD_PKA_2 80 86 PF00069 0.523
MOD_Plk_1 307 313 PF00069 0.705
MOD_Plk_1 57 63 PF00069 0.624
MOD_Plk_2-3 192 198 PF00069 0.548
MOD_Plk_4 183 189 PF00069 0.643
MOD_Plk_4 307 313 PF00069 0.642
MOD_ProDKin_1 11 17 PF00069 0.630
MOD_ProDKin_1 151 157 PF00069 0.326
MOD_ProDKin_1 75 81 PF00069 0.632
MOD_SUMO_rev_2 112 122 PF00179 0.497
TRG_DiLeu_BaLyEn_6 200 205 PF01217 0.402
TRG_ENDOCYTIC_2 169 172 PF00928 0.655
TRG_ENDOCYTIC_2 202 205 PF00928 0.497
TRG_ENDOCYTIC_2 52 55 PF00928 0.519
TRG_ER_diArg_1 266 268 PF00400 0.413
TRG_ER_diArg_1 3 5 PF00400 0.568
TRG_Pf-PMV_PEXEL_1 266 270 PF00026 0.594

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P611 Leptomonas seymouri 64% 96%
A0A0S4JHS2 Bodo saltans 32% 81%
A0A1X0NJ57 Trypanosomatidae 44% 100%
A0A3R7LQI0 Trypanosoma rangeli 46% 100%
A4HM55 Leishmania braziliensis 86% 100%
A4IAR7 Leishmania infantum 100% 100%
D0A2E5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 100%
E9AEJ3 Leishmania major 93% 100%
E9B5Q4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
V5DJR0 Trypanosoma cruzi 48% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS