Coatomer subunit zeta

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

coatomer subunit zeta, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X8M6_LEIDO

TriTrypDb:

LdBPK_350110.1 , LdCL_350006100 , LDHU3_35.0180

Length:

184

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, coatomer zeta subunit

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	11
GO:0016020	membrane	2	11
GO:0030117	membrane coat	3	11
GO:0030120	vesicle coat	4	11
GO:0030126	COPI vesicle coat	5	11
GO:0031090	organelle membrane	3	11
GO:0032991	protein-containing complex	1	11
GO:0098588	bounding membrane of organelle	4	11
GO:0098796	membrane protein complex	2	11
GO:0110165	cellular anatomical entity	1	11

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Expansion

Sequence features

A0A3S7X8M6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8M6

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006886	intracellular protein transport	4	1
GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	6	11
GO:0006891	intra-Golgi vesicle-mediated transport	6	1
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0016192	vesicle-mediated transport	4	11
GO:0033036	macromolecule localization	2	11
GO:0045184	establishment of protein localization	3	11

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	58	60	PF00675	0.455
CLV_PCSK_KEX2_1	58	60	PF00082	0.410
CLV_PCSK_SKI1_1	123	127	PF00082	0.418
CLV_PCSK_SKI1_1	170	174	PF00082	0.577
DEG_APCC_DBOX_1	169	177	PF00400	0.569
DEG_SCF_FBW7_1	115	121	PF00400	0.554
DOC_CKS1_1	115	120	PF01111	0.554
DOC_CYCLIN_RxL_1	120	127	PF00134	0.521
DOC_USP7_MATH_1	31	35	PF00917	0.521
DOC_USP7_MATH_1	64	68	PF00917	0.392

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYF6	Leptomonas seymouri	76%	100%
A0A1X0NJF5	Trypanosomatidae	48%	100%
A0A422N7K5	Trypanosoma rangeli	43%	100%
A4HM50	Leishmania braziliensis	94%	100%
A4IAR2	Leishmania infantum	100%	100%
D0A2F0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	77%
E9AEI8	Leishmania major	98%	100%
E9B5P9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O17901	Caenorhabditis elegans	27%	100%
O74891	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	97%

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