WAPL domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X8L9_LEIDO

TriTrypDb:

LdBPK_344080.1 , LdCL_340050200 , LDHU3_34.6390

Length:

592

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X8L9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8L9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.552
CLV_C14_Caspase3-7	87	91	PF00656	0.696
CLV_NRD_NRD_1	101	103	PF00675	0.567
CLV_NRD_NRD_1	170	172	PF00675	0.423
CLV_NRD_NRD_1	225	227	PF00675	0.676
CLV_PCSK_KEX2_1	101	103	PF00082	0.594
CLV_PCSK_KEX2_1	147	149	PF00082	0.397
CLV_PCSK_KEX2_1	170	172	PF00082	0.423
CLV_PCSK_KEX2_1	225	227	PF00082	0.616
CLV_PCSK_KEX2_1	4	6	PF00082	0.587
CLV_PCSK_KEX2_1	61	63	PF00082	0.734
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.397
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.587
CLV_PCSK_PC1ET2_1	61	63	PF00082	0.666
CLV_PCSK_SKI1_1	141	145	PF00082	0.480
CLV_PCSK_SKI1_1	200	204	PF00082	0.367
CLV_PCSK_SKI1_1	276	280	PF00082	0.364
CLV_PCSK_SKI1_1	367	371	PF00082	0.370
CLV_PCSK_SKI1_1	387	391	PF00082	0.227
DEG_APCC_DBOX_1	123	131	PF00400	0.415
DEG_APCC_DBOX_1	275	283	PF00400	0.459
DEG_SCF_FBW7_1	403	409	PF00400	0.403
DEG_SPOP_SBC_1	85	89	PF00917	0.545
DOC_CDC14_PxL_1	346	354	PF14671	0.410
DOC_CKS1_1	403	408	PF01111	0.504
DOC_CYCLIN_RxL_1	197	206	PF00134	0.304
DOC_CYCLIN_RxL_1	273	280	PF00134	0.389
DOC_CYCLIN_yCln2_LP_2	297	303	PF00134	0.408
DOC_CYCLIN_yCln2_LP_2	348	354	PF00134	0.331
DOC_MAPK_DCC_7	136	144	PF00069	0.409
DOC_MAPK_gen_1	170	176	PF00069	0.419
DOC_MAPK_gen_1	4	12	PF00069	0.707
DOC_MAPK_MEF2A_6	136	144	PF00069	0.409
DOC_MAPK_MEF2A_6	276	283	PF00069	0.374
DOC_MAPK_MEF2A_6	295	303	PF00069	0.383
DOC_MAPK_MEF2A_6	357	365	PF00069	0.532
DOC_PP2B_LxvP_1	20	23	PF13499	0.587
DOC_PP2B_LxvP_1	297	300	PF13499	0.405
DOC_PP2B_LxvP_1	492	495	PF13499	0.368
DOC_USP7_MATH_1	259	263	PF00917	0.699
DOC_USP7_MATH_1	274	278	PF00917	0.267
DOC_USP7_MATH_1	501	505	PF00917	0.553
DOC_USP7_MATH_1	70	74	PF00917	0.679
DOC_USP7_MATH_1	80	84	PF00917	0.552
DOC_USP7_UBL2_3	422	426	PF12436	0.477
DOC_WW_Pin1_4	208	213	PF00397	0.558
DOC_WW_Pin1_4	23	28	PF00397	0.734
DOC_WW_Pin1_4	285	290	PF00397	0.543
DOC_WW_Pin1_4	402	407	PF00397	0.564
DOC_WW_Pin1_4	427	432	PF00397	0.586
DOC_WW_Pin1_4	73	78	PF00397	0.670
DOC_WW_Pin1_4	81	86	PF00397	0.636
LIG_14-3-3_CanoR_1	124	128	PF00244	0.477
LIG_14-3-3_CanoR_1	295	300	PF00244	0.517
LIG_14-3-3_CanoR_1	357	365	PF00244	0.509
LIG_14-3-3_CanoR_1	401	406	PF00244	0.581
LIG_14-3-3_CanoR_1	458	466	PF00244	0.478
LIG_14-3-3_CanoR_1	48	55	PF00244	0.702
LIG_14-3-3_CanoR_1	502	509	PF00244	0.492
LIG_14-3-3_CanoR_1	567	575	PF00244	0.535
LIG_14-3-3_CanoR_1	62	72	PF00244	0.651
LIG_14-3-3_CanoR_1	75	85	PF00244	0.707
LIG_14-3-3_CanoR_1	86	92	PF00244	0.636
LIG_Actin_WH2_2	132	149	PF00022	0.363
LIG_Actin_WH2_2	341	359	PF00022	0.554
LIG_BIR_II_1	1	5	PF00653	0.668
LIG_CaM_IQ_9	306	321	PF13499	0.384
LIG_FHA_1	151	157	PF00498	0.499
LIG_FHA_1	194	200	PF00498	0.397
LIG_FHA_1	333	339	PF00498	0.479
LIG_FHA_1	356	362	PF00498	0.511
LIG_FHA_1	371	377	PF00498	0.335
LIG_FHA_1	381	387	PF00498	0.375
LIG_FHA_1	460	466	PF00498	0.445
LIG_FHA_1	489	495	PF00498	0.522
LIG_FHA_2	115	121	PF00498	0.406
LIG_FHA_2	164	170	PF00498	0.539
LIG_FHA_2	180	186	PF00498	0.351
LIG_FHA_2	201	207	PF00498	0.344
LIG_FHA_2	331	337	PF00498	0.392
LIG_FHA_2	403	409	PF00498	0.534
LIG_FHA_2	48	54	PF00498	0.799
LIG_FHA_2	568	574	PF00498	0.772
LIG_FHA_2	578	584	PF00498	0.636
LIG_FHA_2	85	91	PF00498	0.733
LIG_GBD_Chelix_1	12	20	PF00786	0.677
LIG_GBD_Chelix_1	172	180	PF00786	0.419
LIG_GBD_Chelix_1	194	202	PF00786	0.390
LIG_GBD_Chelix_1	521	529	PF00786	0.339
LIG_HP1_1	140	144	PF01393	0.407
LIG_LIR_Gen_1	45	53	PF02991	0.528
LIG_LIR_Gen_1	468	478	PF02991	0.376
LIG_LIR_Gen_1	527	535	PF02991	0.353
LIG_LIR_Nem_3	45	49	PF02991	0.528
LIG_LIR_Nem_3	468	474	PF02991	0.376
LIG_LIR_Nem_3	527	531	PF02991	0.341
LIG_NRBOX	129	135	PF00104	0.377
LIG_NRBOX	274	280	PF00104	0.323
LIG_NRBOX	311	317	PF00104	0.433
LIG_PCNA_PIPBox_1	191	200	PF02747	0.405
LIG_PCNA_yPIPBox_3	191	200	PF02747	0.393
LIG_SH2_CRK	471	475	PF00017	0.293
LIG_SH2_STAP1	471	475	PF00017	0.293
LIG_SH3_3	21	27	PF00018	0.667
LIG_SH3_3	358	364	PF00018	0.439
LIG_SH3_3	79	85	PF00018	0.716
LIG_SH3_4	387	394	PF00018	0.289
LIG_SUMO_SIM_anti_2	277	283	PF11976	0.399
LIG_SUMO_SIM_anti_2	8	14	PF11976	0.634
LIG_SUMO_SIM_anti_2	95	101	PF11976	0.608
LIG_SUMO_SIM_par_1	327	333	PF11976	0.387
LIG_TRAF2_1	334	337	PF00917	0.555
LIG_TRAF2_1	484	487	PF00917	0.587
LIG_WRC_WIRS_1	194	199	PF05994	0.419
MOD_CDK_SPK_2	81	86	PF00069	0.700
MOD_CK1_1	123	129	PF00069	0.418
MOD_CK1_1	179	185	PF00069	0.504
MOD_CK1_1	220	226	PF00069	0.600
MOD_CK1_1	237	243	PF00069	0.561
MOD_CK1_1	261	267	PF00069	0.501
MOD_CK1_1	269	275	PF00069	0.328
MOD_CK1_1	277	283	PF00069	0.299
MOD_CK1_1	442	448	PF00069	0.428
MOD_CK1_1	534	540	PF00069	0.475
MOD_CK1_1	66	72	PF00069	0.780
MOD_CK1_1	73	79	PF00069	0.690
MOD_CK1_1	81	87	PF00069	0.592
MOD_CK2_1	114	120	PF00069	0.536
MOD_CK2_1	123	129	PF00069	0.520
MOD_CK2_1	163	169	PF00069	0.576
MOD_CK2_1	314	320	PF00069	0.410
MOD_CK2_1	330	336	PF00069	0.379
MOD_CK2_1	356	362	PF00069	0.433
MOD_CK2_1	402	408	PF00069	0.551
MOD_CK2_1	457	463	PF00069	0.501
MOD_CK2_1	567	573	PF00069	0.669
MOD_GlcNHglycan	136	139	PF01048	0.447
MOD_GlcNHglycan	222	225	PF01048	0.641
MOD_GlcNHglycan	236	239	PF01048	0.705
MOD_GlcNHglycan	260	264	PF01048	0.616
MOD_GlcNHglycan	358	361	PF01048	0.411
MOD_GlcNHglycan	380	383	PF01048	0.347
MOD_GlcNHglycan	436	439	PF01048	0.570
MOD_GlcNHglycan	467	470	PF01048	0.388
MOD_GlcNHglycan	533	536	PF01048	0.434
MOD_GlcNHglycan	57	60	PF01048	0.564
MOD_GlcNHglycan	67	71	PF01048	0.661
MOD_GlcNHglycan	78	81	PF01048	0.580
MOD_GSK3_1	114	121	PF00069	0.389
MOD_GSK3_1	175	182	PF00069	0.535
MOD_GSK3_1	291	298	PF00069	0.465
MOD_GSK3_1	33	40	PF00069	0.665
MOD_GSK3_1	332	339	PF00069	0.421
MOD_GSK3_1	378	385	PF00069	0.426
MOD_GSK3_1	393	400	PF00069	0.528
MOD_GSK3_1	402	409	PF00069	0.469
MOD_GSK3_1	453	460	PF00069	0.508
MOD_GSK3_1	501	508	PF00069	0.541
MOD_GSK3_1	530	537	PF00069	0.415
MOD_GSK3_1	567	574	PF00069	0.662
MOD_GSK3_1	62	69	PF00069	0.708
MOD_GSK3_1	71	78	PF00069	0.661
MOD_GSK3_1	80	87	PF00069	0.556
MOD_N-GLC_1	285	290	PF02516	0.497
MOD_N-GLC_1	370	375	PF02516	0.321
MOD_N-GLC_2	239	241	PF02516	0.504
MOD_NEK2_1	114	119	PF00069	0.344
MOD_NEK2_1	134	139	PF00069	0.484
MOD_NEK2_1	176	181	PF00069	0.553
MOD_NEK2_1	198	203	PF00069	0.457
MOD_NEK2_1	34	39	PF00069	0.612
MOD_NEK2_1	356	361	PF00069	0.520
MOD_NEK2_1	380	385	PF00069	0.443
MOD_NEK2_1	397	402	PF00069	0.554
MOD_NEK2_1	453	458	PF00069	0.448
MOD_NEK2_1	465	470	PF00069	0.449
MOD_NEK2_1	530	535	PF00069	0.365
MOD_NEK2_2	382	387	PF00069	0.299
MOD_NEK2_2	488	493	PF00069	0.502
MOD_PIKK_1	246	252	PF00454	0.579
MOD_PIKK_1	387	393	PF00454	0.418
MOD_PIKK_1	439	445	PF00454	0.571
MOD_PK_1	295	301	PF00069	0.394
MOD_PK_1	552	558	PF00069	0.237
MOD_PKA_2	123	129	PF00069	0.526
MOD_PKA_2	356	362	PF00069	0.454
MOD_PKA_2	457	463	PF00069	0.420
MOD_PKA_2	47	53	PF00069	0.543
MOD_PKA_2	501	507	PF00069	0.467
MOD_PKA_2	55	61	PF00069	0.553
MOD_PKA_2	566	572	PF00069	0.637
MOD_PKA_2	63	69	PF00069	0.593
MOD_PKA_2	85	91	PF00069	0.694
MOD_PKB_1	399	407	PF00069	0.481
MOD_Plk_1	336	342	PF00069	0.377
MOD_Plk_1	34	40	PF00069	0.653
MOD_Plk_4	151	157	PF00069	0.535
MOD_Plk_4	176	182	PF00069	0.487
MOD_Plk_4	193	199	PF00069	0.224
MOD_Plk_4	277	283	PF00069	0.489
MOD_Plk_4	42	48	PF00069	0.520
MOD_Plk_4	442	448	PF00069	0.434
MOD_Plk_4	476	482	PF00069	0.393
MOD_ProDKin_1	208	214	PF00069	0.559
MOD_ProDKin_1	23	29	PF00069	0.734
MOD_ProDKin_1	285	291	PF00069	0.543
MOD_ProDKin_1	402	408	PF00069	0.558
MOD_ProDKin_1	427	433	PF00069	0.573
MOD_ProDKin_1	73	79	PF00069	0.670
MOD_ProDKin_1	81	87	PF00069	0.635
MOD_SUMO_for_1	421	424	PF00179	0.324
MOD_SUMO_rev_2	260	269	PF00179	0.576
MOD_SUMO_rev_2	541	549	PF00179	0.444
TRG_DiLeu_BaEn_1	129	134	PF01217	0.371
TRG_DiLeu_BaEn_1	545	550	PF01217	0.455
TRG_DiLeu_BaLyEn_6	297	302	PF01217	0.412
TRG_ENDOCYTIC_2	470	473	PF00928	0.300
TRG_ER_diArg_1	100	102	PF00400	0.579
TRG_ER_diArg_1	170	172	PF00400	0.423
TRG_NES_CRM1_1	444	455	PF08389	0.382
TRG_NES_CRM1_1	545	560	PF08389	0.242
TRG_NLS_MonoExtN_4	225	230	PF00514	0.620

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P709	Leptomonas seymouri	40%	99%
A0A1X0PAI7	Trypanosomatidae	31%	100%
A0A3R7M5G0	Trypanosoma rangeli	31%	100%
A4HBE8	Leishmania braziliensis	72%	100%
A4IAJ6	Leishmania infantum	100%	100%
C9ZLP4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B5M0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q2B6	Leishmania major	86%	100%
V5BRD9	Trypanosoma cruzi	32%	100%