Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X8L7_LEIDO

TriTrypDb:

LdBPK_350060.1 , LdCL_350005600 , LDHU3_35.0120

Length:

670

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3S7X8L7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8L7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	519	523	PF00656	0.561
CLV_NRD_NRD_1	172	174	PF00675	0.547
CLV_NRD_NRD_1	262	264	PF00675	0.637
CLV_NRD_NRD_1	360	362	PF00675	0.508
CLV_NRD_NRD_1	391	393	PF00675	0.528
CLV_NRD_NRD_1	470	472	PF00675	0.592
CLV_NRD_NRD_1	500	502	PF00675	0.643
CLV_NRD_NRD_1	538	540	PF00675	0.521
CLV_NRD_NRD_1	568	570	PF00675	0.482
CLV_NRD_NRD_1	625	627	PF00675	0.597
CLV_NRD_NRD_1	640	642	PF00675	0.582
CLV_NRD_NRD_1	653	655	PF00675	0.510
CLV_PCSK_FUR_1	555	559	PF00082	0.602
CLV_PCSK_FUR_1	623	627	PF00082	0.606
CLV_PCSK_KEX2_1	172	174	PF00082	0.502
CLV_PCSK_KEX2_1	249	251	PF00082	0.689
CLV_PCSK_KEX2_1	262	264	PF00082	0.606
CLV_PCSK_KEX2_1	360	362	PF00082	0.543
CLV_PCSK_KEX2_1	390	392	PF00082	0.533
CLV_PCSK_KEX2_1	470	472	PF00082	0.640
CLV_PCSK_KEX2_1	499	501	PF00082	0.652
CLV_PCSK_KEX2_1	538	540	PF00082	0.521
CLV_PCSK_KEX2_1	557	559	PF00082	0.479
CLV_PCSK_KEX2_1	568	570	PF00082	0.448
CLV_PCSK_KEX2_1	611	613	PF00082	0.537
CLV_PCSK_KEX2_1	625	627	PF00082	0.540
CLV_PCSK_KEX2_1	642	644	PF00082	0.615
CLV_PCSK_KEX2_1	653	655	PF00082	0.493
CLV_PCSK_KEX2_1	77	79	PF00082	0.477
CLV_PCSK_PC1ET2_1	249	251	PF00082	0.757
CLV_PCSK_PC1ET2_1	557	559	PF00082	0.558
CLV_PCSK_PC1ET2_1	611	613	PF00082	0.505
CLV_PCSK_PC1ET2_1	642	644	PF00082	0.659
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.547
CLV_PCSK_PC7_1	564	570	PF00082	0.477
CLV_PCSK_PC7_1	607	613	PF00082	0.598
CLV_PCSK_PC7_1	73	79	PF00082	0.580
CLV_PCSK_SKI1_1	106	110	PF00082	0.448
CLV_PCSK_SKI1_1	299	303	PF00082	0.573
CLV_PCSK_SKI1_1	445	449	PF00082	0.533
CLV_PCSK_SKI1_1	521	525	PF00082	0.538
CLV_PCSK_SKI1_1	661	665	PF00082	0.590
DEG_APCC_DBOX_1	520	528	PF00400	0.537
DEG_Nend_UBRbox_3	1	3	PF02207	0.529
DEG_SPOP_SBC_1	201	205	PF00917	0.576
DOC_ANK_TNKS_1	500	507	PF00023	0.721
DOC_CDC14_PxL_1	37	45	PF14671	0.619
DOC_CKS1_1	113	118	PF01111	0.368
DOC_MAPK_gen_1	331	340	PF00069	0.672
DOC_MAPK_gen_1	390	399	PF00069	0.611
DOC_MAPK_gen_1	470	478	PF00069	0.520
DOC_MAPK_gen_1	623	631	PF00069	0.540
DOC_MAPK_MEF2A_6	331	340	PF00069	0.651
DOC_PP4_FxxP_1	227	230	PF00568	0.720
DOC_USP7_MATH_1	155	159	PF00917	0.519
DOC_USP7_MATH_1	175	179	PF00917	0.541
DOC_USP7_MATH_1	202	206	PF00917	0.697
DOC_USP7_MATH_1	265	269	PF00917	0.697
DOC_USP7_MATH_1	443	447	PF00917	0.579
DOC_WW_Pin1_4	112	117	PF00397	0.417
DOC_WW_Pin1_4	237	242	PF00397	0.759
DOC_WW_Pin1_4	291	296	PF00397	0.652
LIG_14-3-3_CanoR_1	250	256	PF00244	0.717
LIG_14-3-3_CanoR_1	299	309	PF00244	0.668
LIG_14-3-3_CanoR_1	470	478	PF00244	0.454
LIG_14-3-3_CanoR_1	514	520	PF00244	0.627
LIG_14-3-3_CanoR_1	641	651	PF00244	0.580
LIG_14-3-3_CanoR_1	78	83	PF00244	0.468
LIG_Actin_WH2_2	445	462	PF00022	0.604
LIG_Actin_WH2_2	508	523	PF00022	0.573
LIG_BRCT_BRCA1_1	342	346	PF00533	0.538
LIG_CaM_NSCaTE_8	7	14	PF13499	0.506
LIG_eIF4E_1	87	93	PF01652	0.379
LIG_FHA_1	113	119	PF00498	0.378
LIG_FHA_1	162	168	PF00498	0.545
LIG_FHA_1	251	257	PF00498	0.624
LIG_FHA_1	46	52	PF00498	0.492
LIG_FHA_1	470	476	PF00498	0.524
LIG_FHA_2	102	108	PF00498	0.523
LIG_FHA_2	226	232	PF00498	0.611
LIG_FHA_2	284	290	PF00498	0.715
LIG_FHA_2	337	343	PF00498	0.661
LIG_LIR_Apic_2	132	137	PF02991	0.425
LIG_LIR_Apic_2	224	230	PF02991	0.666
LIG_LIR_Gen_1	120	127	PF02991	0.487
LIG_LIR_Gen_1	59	69	PF02991	0.367
LIG_LIR_Gen_1	656	663	PF02991	0.395
LIG_LIR_Nem_3	120	124	PF02991	0.356
LIG_LIR_Nem_3	5	10	PF02991	0.468
LIG_LIR_Nem_3	59	64	PF02991	0.386
LIG_LIR_Nem_3	656	660	PF02991	0.395
LIG_LIR_Nem_3	66	72	PF02991	0.379
LIG_LYPXL_yS_3	40	43	PF13949	0.614
LIG_PCNA_PIPBox_1	363	372	PF02747	0.592
LIG_Pex14_1	139	143	PF04695	0.418
LIG_PTB_Apo_2	50	57	PF02174	0.520
LIG_SH2_CRK	134	138	PF00017	0.414
LIG_SH2_CRK	97	101	PF00017	0.439
LIG_SH2_SRC	143	146	PF00017	0.556
LIG_SH2_STAP1	143	147	PF00017	0.392
LIG_SH2_STAT5	87	90	PF00017	0.384
LIG_SH2_STAT5	91	94	PF00017	0.398
LIG_SH3_3	149	155	PF00018	0.465
LIG_SH3_3	179	185	PF00018	0.641
LIG_SH3_3	226	232	PF00018	0.665
LIG_SH3_3	35	41	PF00018	0.520
LIG_SUMO_SIM_par_1	474	480	PF11976	0.539
LIG_TRAF2_1	186	189	PF00917	0.721
LIG_TRAF2_1	23	26	PF00917	0.670
LIG_TRAF2_1	44	47	PF00917	0.559
LIG_TRAF2_1	462	465	PF00917	0.505
LIG_TRAF2_1	477	480	PF00917	0.405
LIG_TYR_ITIM	38	43	PF00017	0.630
LIG_TYR_ITIM	89	94	PF00017	0.379
MOD_CDK_SPK_2	112	117	PF00069	0.432
MOD_CK1_1	112	118	PF00069	0.425
MOD_CK1_1	157	163	PF00069	0.573
MOD_CK1_1	307	313	PF00069	0.678
MOD_CK1_1	428	434	PF00069	0.545
MOD_CK1_1	45	51	PF00069	0.488
MOD_CK2_1	101	107	PF00069	0.524
MOD_CK2_1	155	161	PF00069	0.557
MOD_CK2_1	19	25	PF00069	0.624
MOD_CK2_1	225	231	PF00069	0.609
MOD_CK2_1	283	289	PF00069	0.706
MOD_CK2_1	349	355	PF00069	0.637
MOD_CK2_1	41	47	PF00069	0.479
MOD_CK2_1	513	519	PF00069	0.565
MOD_CK2_1	642	648	PF00069	0.517
MOD_GlcNHglycan	177	180	PF01048	0.661
MOD_GlcNHglycan	204	207	PF01048	0.739
MOD_GlcNHglycan	22	25	PF01048	0.658
MOD_GlcNHglycan	267	270	PF01048	0.740
MOD_GlcNHglycan	280	283	PF01048	0.694
MOD_GlcNHglycan	444	448	PF01048	0.531
MOD_GSK3_1	125	132	PF00069	0.525
MOD_GSK3_1	157	164	PF00069	0.530
MOD_GSK3_1	173	180	PF00069	0.625
MOD_GSK3_1	192	199	PF00069	0.709
MOD_GSK3_1	202	209	PF00069	0.641
MOD_GSK3_1	265	272	PF00069	0.717
MOD_GSK3_1	297	304	PF00069	0.607
MOD_GSK3_1	336	343	PF00069	0.644
MOD_GSK3_1	41	48	PF00069	0.524
MOD_GSK3_1	78	85	PF00069	0.473
MOD_N-GLC_1	284	289	PF02516	0.556
MOD_N-GLC_1	56	61	PF02516	0.536
MOD_N-GLC_1	573	578	PF02516	0.513
MOD_N-GLC_1	78	83	PF02516	0.512
MOD_NEK2_1	109	114	PF00069	0.470
MOD_NEK2_1	127	132	PF00069	0.300
MOD_NEK2_1	225	230	PF00069	0.594
MOD_NEK2_1	301	306	PF00069	0.617
MOD_NEK2_1	336	341	PF00069	0.610
MOD_NEK2_1	56	61	PF00069	0.516
MOD_NEK2_2	101	106	PF00069	0.543
MOD_PIKK_1	173	179	PF00454	0.631
MOD_PIKK_1	349	355	PF00454	0.585
MOD_PIKK_1	384	390	PF00454	0.542
MOD_PIKK_1	428	434	PF00454	0.459
MOD_PIKK_1	513	519	PF00454	0.598
MOD_PIKK_1	546	552	PF00454	0.544
MOD_PIKK_1	573	579	PF00454	0.579
MOD_PIKK_1	642	648	PF00454	0.561
MOD_PKA_1	642	648	PF00069	0.555
MOD_PKA_1	77	83	PF00069	0.506
MOD_PKA_2	349	355	PF00069	0.511
MOD_PKA_2	384	390	PF00069	0.603
MOD_PKA_2	469	475	PF00069	0.606
MOD_PKA_2	513	519	PF00069	0.637
MOD_PKA_2	642	648	PF00069	0.543
MOD_PKA_2	77	83	PF00069	0.470
MOD_Plk_1	143	149	PF00069	0.518
MOD_Plk_1	336	342	PF00069	0.595
MOD_Plk_1	443	449	PF00069	0.502
MOD_Plk_1	45	51	PF00069	0.445
MOD_Plk_1	56	62	PF00069	0.430
MOD_Plk_1	78	84	PF00069	0.551
MOD_Plk_2-3	635	641	PF00069	0.591
MOD_Plk_4	143	149	PF00069	0.458
MOD_Plk_4	251	257	PF00069	0.526
MOD_Plk_4	46	52	PF00069	0.532
MOD_Plk_4	82	88	PF00069	0.388
MOD_ProDKin_1	112	118	PF00069	0.410
MOD_ProDKin_1	237	243	PF00069	0.759
MOD_ProDKin_1	291	297	PF00069	0.648
MOD_SUMO_for_1	452	455	PF00179	0.538
MOD_SUMO_for_1	556	559	PF00179	0.570
TRG_DiLeu_BaEn_2	119	125	PF01217	0.483
TRG_DiLeu_BaEn_2	45	51	PF01217	0.566
TRG_DiLeu_BaEn_4	188	194	PF01217	0.683
TRG_DiLeu_BaLyEn_6	479	484	PF01217	0.564
TRG_ENDOCYTIC_2	40	43	PF00928	0.593
TRG_ENDOCYTIC_2	91	94	PF00928	0.348
TRG_ENDOCYTIC_2	97	100	PF00928	0.403
TRG_ER_diArg_1	171	173	PF00400	0.583
TRG_ER_diArg_1	319	322	PF00400	0.504
TRG_ER_diArg_1	390	392	PF00400	0.538
TRG_ER_diArg_1	499	501	PF00400	0.676
TRG_ER_diArg_1	538	541	PF00400	0.582
TRG_ER_diArg_1	568	571	PF00400	0.490
TRG_ER_diArg_1	594	597	PF00400	0.622
TRG_ER_diArg_1	623	626	PF00400	0.540
TRG_ER_diArg_1	641	644	PF00400	0.613
TRG_ER_diArg_1	652	654	PF00400	0.573
TRG_Pf-PMV_PEXEL_1	331	335	PF00026	0.559
TRG_Pf-PMV_PEXEL_1	482	486	PF00026	0.420
TRG_Pf-PMV_PEXEL_1	568	572	PF00026	0.631
TRG_Pf-PMV_PEXEL_1	661	665	PF00026	0.591

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P614	Leptomonas seymouri	47%	96%
A0A0S4JK29	Bodo saltans	28%	84%
A0A1X0NJ66	Trypanosomatidae	32%	100%
A0A3R7KU75	Trypanosoma rangeli	32%	100%
A4HM45	Leishmania braziliensis	74%	100%
A4IAQ7	Leishmania infantum	99%	100%
D0A2F8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AEI3	Leishmania major	91%	100%
E9B5P4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BNB8	Trypanosoma cruzi	30%	100%