H/ACA ribonucleoprotein complex subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleolar protein family a, putative (fragment)

Species:

Leishmania donovani

UniProt:

A0A3S7X8L6_LEIDO

TriTrypDb:

LdBPK_344120.1 , LdCL_340050600 , LDHU3_34.6450

Length:

211

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	4
GO:0032991	protein-containing complex	1	4
GO:0043226	organelle	2	4
GO:0043228	non-membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043232	intracellular non-membrane-bounded organelle	4	4
GO:0110165	cellular anatomical entity	1	4
GO:1990904	ribonucleoprotein complex	2	4

Expansion

Sequence features

A0A3S7X8L6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8L6

Function

Biological processes
Term	Name	Level	Count
GO:0001522	pseudouridine synthesis	6	4
GO:0006139	nucleobase-containing compound metabolic process	3	4
GO:0006364	rRNA processing	8	4
GO:0006396	RNA processing	6	4
GO:0006725	cellular aromatic compound metabolic process	3	4
GO:0006807	nitrogen compound metabolic process	2	4
GO:0008152	metabolic process	1	4
GO:0009451	RNA modification	5	4
GO:0009987	cellular process	1	4
GO:0016070	RNA metabolic process	5	4
GO:0016072	rRNA metabolic process	7	4
GO:0034470	ncRNA processing	7	4
GO:0034641	cellular nitrogen compound metabolic process	3	4
GO:0034660	ncRNA metabolic process	6	4
GO:0043170	macromolecule metabolic process	3	4
GO:0043412	macromolecule modification	4	4
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0046483	heterocycle metabolic process	3	4
GO:0071704	organic substance metabolic process	2	4
GO:0090304	nucleic acid metabolic process	4	4
GO:1901360	organic cyclic compound metabolic process	3	4

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	4
GO:0003723	RNA binding	4	4
GO:0005488	binding	1	4
GO:0097159	organic cyclic compound binding	2	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	133	137	PF00082	0.443
DOC_CKS1_1	128	133	PF01111	0.182
DOC_PP4_FxxP_1	135	138	PF00568	0.426
DOC_PP4_FxxP_1	20	23	PF00568	0.446
DOC_WW_Pin1_4	105	110	PF00397	0.199
DOC_WW_Pin1_4	122	127	PF00397	0.415
LIG_14-3-3_CanoR_1	133	138	PF00244	0.444
LIG_14-3-3_CanoR_1	66	74	PF00244	0.182
LIG_APCC_ABBA_1	132	137	PF00400	0.451
LIG_BRCT_BRCA1_1	16	20	PF00533	0.491
LIG_FHA_1	96	102	PF00498	0.173
LIG_LIR_Apic_2	120	126	PF02991	0.182
LIG_LIR_Apic_2	17	23	PF02991	0.448
LIG_LIR_Nem_3	127	132	PF02991	0.176
LIG_SH2_PTP2	123	126	PF00017	0.143
LIG_SH2_STAT5	123	126	PF00017	0.142
LIG_SH2_STAT5	81	84	PF00017	0.173
LIG_SH3_3	135	141	PF00018	0.450
LIG_SH3_3	40	46	PF00018	0.446
LIG_WRC_WIRS_1	52	57	PF05994	0.182
MOD_CDK_SPxK_1	127	133	PF00069	0.173
MOD_CK2_1	112	118	PF00069	0.173
MOD_GSK3_1	101	108	PF00069	0.214
MOD_N-GLC_1	96	101	PF02516	0.176
MOD_PIKK_1	124	130	PF00454	0.173
MOD_PKA_2	166	172	PF00069	0.465
MOD_PKA_2	176	182	PF00069	0.414
MOD_PKA_2	183	189	PF00069	0.471
MOD_PKA_2	191	197	PF00069	0.474
MOD_PKA_2	65	71	PF00069	0.182
MOD_Plk_4	51	57	PF00069	0.182
MOD_ProDKin_1	105	111	PF00069	0.199
MOD_ProDKin_1	122	128	PF00069	0.415
TRG_DiLeu_BaEn_3	50	56	PF01217	0.173
TRG_ER_diArg_1	141	144	PF00400	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7A8	Leptomonas seymouri	75%	96%
A4IAK0	Leishmania infantum	99%	100%
Q8VZT0	Arabidopsis thaliana	42%	100%