ARD/ARD' family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

1,2-Dihydroxy-3-keto-5-methylthiopentene dioxygenase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X8L3_LEIDO

TriTrypDb:

LdBPK_344230.1 , LdCL_340052400 , LDHU3_34.6620

Length:

279

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 3
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S7X8L3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8L3

Function

Biological processes
Term	Name	Level	Count
GO:0000096	sulfur amino acid metabolic process	4	12
GO:0000097	sulfur amino acid biosynthetic process	5	12
GO:0006082	organic acid metabolic process	3	12
GO:0006520	amino acid metabolic process	3	12
GO:0006555	methionine metabolic process	5	12
GO:0006790	sulfur compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008652	amino acid biosynthetic process	4	12
GO:0009058	biosynthetic process	2	12
GO:0009066	aspartate family amino acid metabolic process	5	12
GO:0009067	aspartate family amino acid biosynthetic process	6	12
GO:0009086	methionine biosynthetic process	6	12
GO:0009987	cellular process	1	12
GO:0016053	organic acid biosynthetic process	4	12
GO:0019752	carboxylic acid metabolic process	5	12
GO:0043436	oxoacid metabolic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044272	sulfur compound biosynthetic process	4	12
GO:0044281	small molecule metabolic process	2	12
GO:0044283	small molecule biosynthetic process	3	12
GO:0046394	carboxylic acid biosynthetic process	5	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12
GO:1901605	alpha-amino acid metabolic process	4	12
GO:1901607	alpha-amino acid biosynthetic process	5	12
GO:0019509	L-methionine salvage from methylthioadenosine	6	1
GO:0043094	cellular metabolic compound salvage	3	1
GO:0043102	amino acid salvage	4	1
GO:0071265	L-methionine biosynthetic process	7	1
GO:0071267	L-methionine salvage	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0010309	acireductone dioxygenase [iron(II)-requiring] activity	5	12
GO:0016491	oxidoreductase activity	2	12
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	3	12
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	4	12
GO:0051213	dioxygenase activity	3	12
GO:0010308	acireductone dioxygenase (Ni2+-requiring) activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	252	256	PF00656	0.654
CLV_MEL_PAP_1	131	137	PF00089	0.398
CLV_NRD_NRD_1	112	114	PF00675	0.588
CLV_NRD_NRD_1	20	22	PF00675	0.590
CLV_NRD_NRD_1	32	34	PF00675	0.554
CLV_NRD_NRD_1	42	44	PF00675	0.580
CLV_NRD_NRD_1	45	47	PF00675	0.579
CLV_NRD_NRD_1	57	59	PF00675	0.560
CLV_PCSK_FUR_1	43	47	PF00082	0.665
CLV_PCSK_FUR_1	58	62	PF00082	0.600
CLV_PCSK_KEX2_1	22	24	PF00082	0.577
CLV_PCSK_KEX2_1	248	250	PF00082	0.649
CLV_PCSK_KEX2_1	32	34	PF00082	0.578
CLV_PCSK_KEX2_1	44	46	PF00082	0.575
CLV_PCSK_KEX2_1	57	59	PF00082	0.561
CLV_PCSK_KEX2_1	60	62	PF00082	0.541
CLV_PCSK_KEX2_1	67	69	PF00082	0.655
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.577
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.649
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.650
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.550
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.524
CLV_PCSK_PC1ET2_1	67	69	PF00082	0.659
DEG_Nend_UBRbox_2	1	3	PF02207	0.740
DOC_MAPK_gen_1	123	133	PF00069	0.582
DOC_MAPK_gen_1	150	160	PF00069	0.549
DOC_MAPK_gen_1	197	206	PF00069	0.549
DOC_MAPK_gen_1	43	53	PF00069	0.723
DOC_MAPK_HePTP_8	120	132	PF00069	0.548
DOC_MAPK_HePTP_8	196	208	PF00069	0.635
DOC_MAPK_MEF2A_6	113	122	PF00069	0.569
DOC_MAPK_MEF2A_6	123	132	PF00069	0.540
DOC_MAPK_MEF2A_6	199	208	PF00069	0.635
DOC_USP7_UBL2_3	110	114	PF12436	0.541
LIG_14-3-3_CanoR_1	134	143	PF00244	0.657
LIG_14-3-3_CanoR_1	223	227	PF00244	0.625
LIG_EVH1_1	77	81	PF00568	0.584
LIG_FHA_1	104	110	PF00498	0.576
LIG_FHA_1	153	159	PF00498	0.547
LIG_FHA_2	161	167	PF00498	0.558
LIG_FHA_2	177	183	PF00498	0.549
LIG_FHA_2	223	229	PF00498	0.549
LIG_LIR_Gen_1	138	147	PF02991	0.552
LIG_LIR_Gen_1	201	210	PF02991	0.554
LIG_LIR_Gen_1	228	238	PF02991	0.549
LIG_LIR_LC3C_4	212	215	PF02991	0.654
LIG_LIR_Nem_3	138	143	PF02991	0.560
LIG_LIR_Nem_3	181	187	PF02991	0.601
LIG_LIR_Nem_3	191	196	PF02991	0.513
LIG_LIR_Nem_3	201	206	PF02991	0.539
LIG_LIR_Nem_3	228	234	PF02991	0.560
LIG_LIR_Nem_3	63	69	PF02991	0.615
LIG_Pex14_2	169	173	PF04695	0.549
LIG_SH2_PTP2	231	234	PF00017	0.589
LIG_SH2_SRC	174	177	PF00017	0.615
LIG_SH2_STAT5	178	181	PF00017	0.619
LIG_SH2_STAT5	231	234	PF00017	0.560
LIG_SH2_STAT5	263	266	PF00017	0.475
LIG_SH2_STAT5	94	97	PF00017	0.509
LIG_SH3_3	211	217	PF00018	0.612
LIG_SH3_3	75	81	PF00018	0.607
LIG_SH3_4	110	117	PF00018	0.667
LIG_SUMO_SIM_anti_2	212	217	PF11976	0.654
LIG_TRAF2_1	39	42	PF00917	0.641
LIG_UBA3_1	264	269	PF00899	0.511
MOD_CK1_1	105	111	PF00069	0.597
MOD_CK1_1	138	144	PF00069	0.632
MOD_CK2_1	165	171	PF00069	0.623
MOD_CK2_1	176	182	PF00069	0.586
MOD_CK2_1	222	228	PF00069	0.549
MOD_Cter_Amidation	111	114	PF01082	0.532
MOD_GSK3_1	249	256	PF00069	0.632
MOD_NEK2_1	133	138	PF00069	0.590
MOD_NEK2_1	188	193	PF00069	0.628
MOD_NEK2_2	118	123	PF00069	0.650
MOD_NEK2_2	263	268	PF00069	0.538
MOD_PIKK_1	158	164	PF00454	0.549
MOD_PIKK_1	271	277	PF00454	0.616
MOD_PIKK_1	97	103	PF00454	0.687
MOD_PKA_2	133	139	PF00069	0.666
MOD_PKA_2	222	228	PF00069	0.543
MOD_Plk_1	138	144	PF00069	0.537
MOD_Plk_1	165	171	PF00069	0.635
MOD_Plk_2-3	176	182	PF00069	0.635
MOD_Plk_2-3	2	8	PF00069	0.761
MOD_Plk_4	165	171	PF00069	0.611
MOD_Plk_4	188	194	PF00069	0.614
MOD_SUMO_rev_2	149	155	PF00179	0.618
MOD_SUMO_rev_2	156	161	PF00179	0.598
MOD_SUMO_rev_2	31	39	PF00179	0.661
MOD_SUMO_rev_2	63	69	PF00179	0.700
TRG_DiLeu_BaEn_4	64	70	PF01217	0.596
TRG_ENDOCYTIC_2	231	234	PF00928	0.553
TRG_ENDOCYTIC_2	235	238	PF00928	0.544
TRG_ER_diArg_1	32	34	PF00400	0.611
TRG_ER_diArg_1	43	46	PF00400	0.548
TRG_NES_CRM1_1	127	139	PF08389	0.557
TRG_NLS_Bipartite_1	43	62	PF00514	0.706
TRG_NLS_MonoCore_2	57	62	PF00514	0.719
TRG_NLS_MonoExtC_3	57	63	PF00514	0.721
TRG_NLS_MonoExtN_4	57	62	PF00514	0.719
TRG_Pf-PMV_PEXEL_1	123	127	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	32	36	PF00026	0.635

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA36	Leptomonas seymouri	78%	100%
A0A0S4IQB1	Bodo saltans	59%	98%
A0A1X0PAJ9	Trypanosomatidae	66%	99%
A0A422NJ26	Trypanosoma rangeli	61%	99%
A1L4T4	Oryza sativa subsp. japonica	29%	100%
A2Z7C4	Oryza sativa subsp. indica	29%	100%
A4HBG6	Leishmania braziliensis	93%	100%
A4IAL2	Leishmania infantum	100%	100%
A9SCJ6	Physcomitrium patens	32%	100%
A9SS00	Physcomitrium patens	34%	100%
C9ZLM6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9B5N7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
F6HDT7	Vitis vinifera	29%	100%
O48707	Arabidopsis thaliana	30%	100%
Q4Q281	Leishmania major	96%	100%
Q8W108	Arabidopsis thaliana	27%	100%
V5B654	Trypanosoma cruzi	63%	99%