LeishMANIAdb
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Cell differentiation protein-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Cell differentiation protein-like protein
Gene product:
cell differentiation protein-like protein
Species:
Leishmania donovani
UniProt:
A0A3S7X8L0_LEIDO
TriTrypDb:
LdBPK_344180.1 , LdCL_340051900 , LDHU3_34.6560
Length:
358

Annotations

LeishMANIAdb annotations

A conserved Eukaryotic protein. Certainly not TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0030014 CCR4-NOT complex 3 10
GO:0032991 protein-containing complex 1 11
GO:0140535 intracellular protein-containing complex 2 11
GO:0000932 P-body 5 1
GO:0005737 cytoplasm 2 1
GO:0030015 CCR4-NOT core complex 3 1
GO:0035770 ribonucleoprotein granule 3 1
GO:0036464 cytoplasmic ribonucleoprotein granule 4 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0099080 supramolecular complex 2 1
GO:0110165 cellular anatomical entity 1 3
GO:0016020 membrane 2 2

Expansion

Sequence features

A0A3S7X8L0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8L0

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 11
GO:0006401 RNA catabolic process 5 11
GO:0006402 mRNA catabolic process 6 11
GO:0006725 cellular aromatic compound metabolic process 3 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0009056 catabolic process 2 11
GO:0009057 macromolecule catabolic process 4 11
GO:0009892 negative regulation of metabolic process 4 11
GO:0009987 cellular process 1 11
GO:0010468 regulation of gene expression 5 11
GO:0010605 negative regulation of macromolecule metabolic process 5 11
GO:0010629 negative regulation of gene expression 6 11
GO:0016070 RNA metabolic process 5 11
GO:0016071 mRNA metabolic process 6 11
GO:0019222 regulation of metabolic process 3 11
GO:0019439 aromatic compound catabolic process 4 11
GO:0034641 cellular nitrogen compound metabolic process 3 11
GO:0034655 nucleobase-containing compound catabolic process 4 11
GO:0043170 macromolecule metabolic process 3 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0044248 cellular catabolic process 3 11
GO:0044260 obsolete cellular macromolecule metabolic process 3 11
GO:0044265 obsolete cellular macromolecule catabolic process 4 11
GO:0044270 cellular nitrogen compound catabolic process 4 11
GO:0046483 heterocycle metabolic process 3 11
GO:0046700 heterocycle catabolic process 4 11
GO:0048519 negative regulation of biological process 3 11
GO:0050789 regulation of biological process 2 11
GO:0060255 regulation of macromolecule metabolic process 4 11
GO:0065007 biological regulation 1 11
GO:0071704 organic substance metabolic process 2 11
GO:0090304 nucleic acid metabolic process 4 11
GO:1901360 organic cyclic compound metabolic process 3 11
GO:1901361 organic cyclic compound catabolic process 4 11
GO:1901575 organic substance catabolic process 3 11
GO:0006417 regulation of translation 6 1
GO:0009889 regulation of biosynthetic process 4 1
GO:0009890 negative regulation of biosynthetic process 5 1
GO:0010556 regulation of macromolecule biosynthetic process 5 1
GO:0010558 negative regulation of macromolecule biosynthetic process 6 1
GO:0010608 post-transcriptional regulation of gene expression 6 1
GO:0017148 negative regulation of translation 7 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031324 negative regulation of cellular metabolic process 5 1
GO:0031326 regulation of cellular biosynthetic process 5 1
GO:0031327 negative regulation of cellular biosynthetic process 6 1
GO:0034248 regulation of amide metabolic process 5 1
GO:0034249 negative regulation of amide metabolic process 6 1
GO:0048523 negative regulation of cellular process 4 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051172 negative regulation of nitrogen compound metabolic process 5 1
GO:0051246 regulation of protein metabolic process 5 1
GO:0051248 negative regulation of protein metabolic process 6 1
GO:0080090 regulation of primary metabolic process 4 1
GO:2000112 obsolete regulation of cellular macromolecule biosynthetic process 6 1
GO:2000113 obsolete negative regulation of cellular macromolecule biosynthetic process 7 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 142 148 PF00089 0.556
CLV_NRD_NRD_1 163 165 PF00675 0.491
CLV_NRD_NRD_1 331 333 PF00675 0.575
CLV_NRD_NRD_1 348 350 PF00675 0.555
CLV_PCSK_KEX2_1 163 165 PF00082 0.556
CLV_PCSK_KEX2_1 348 350 PF00082 0.699
CLV_PCSK_KEX2_1 99 101 PF00082 0.391
CLV_PCSK_PC1ET2_1 99 101 PF00082 0.391
CLV_PCSK_SKI1_1 286 290 PF00082 0.565
CLV_PCSK_SKI1_1 305 309 PF00082 0.450
CLV_PCSK_SKI1_1 333 337 PF00082 0.536
CLV_PCSK_SKI1_1 74 78 PF00082 0.370
CLV_PCSK_SKI1_1 91 95 PF00082 0.259
CLV_Separin_Metazoa 188 192 PF03568 0.391
DEG_APCC_DBOX_1 304 312 PF00400 0.391
DEG_APCC_DBOX_1 331 339 PF00400 0.357
DEG_APCC_DBOX_1 73 81 PF00400 0.587
DEG_Nend_UBRbox_2 1 3 PF02207 0.760
DOC_CDC14_PxL_1 173 181 PF14671 0.299
DOC_CKS1_1 131 136 PF01111 0.331
DOC_MAPK_FxFP_2 174 177 PF00069 0.299
DOC_MAPK_gen_1 332 340 PF00069 0.299
DOC_MAPK_gen_1 89 96 PF00069 0.522
DOC_MAPK_MEF2A_6 332 340 PF00069 0.290
DOC_MAPK_NFAT4_5 333 341 PF00069 0.299
DOC_PP4_FxxP_1 174 177 PF00568 0.299
DOC_USP7_MATH_1 184 188 PF00917 0.395
DOC_USP7_MATH_2 9 15 PF00917 0.721
DOC_USP7_UBL2_3 98 102 PF12436 0.556
DOC_WW_Pin1_4 130 135 PF00397 0.313
DOC_WW_Pin1_4 179 184 PF00397 0.391
LIG_14-3-3_CanoR_1 145 150 PF00244 0.331
LIG_14-3-3_CanoR_1 191 196 PF00244 0.296
LIG_14-3-3_CanoR_1 260 268 PF00244 0.322
LIG_14-3-3_CanoR_1 317 322 PF00244 0.356
LIG_14-3-3_CanoR_1 91 97 PF00244 0.540
LIG_Actin_WH2_2 284 299 PF00022 0.289
LIG_CtBP_PxDLS_1 313 317 PF00389 0.356
LIG_EH1_1 238 246 PF00400 0.289
LIG_FHA_1 236 242 PF00498 0.289
LIG_FHA_2 180 186 PF00498 0.391
LIG_FHA_2 318 324 PF00498 0.340
LIG_LIR_Gen_1 101 110 PF02991 0.513
LIG_LIR_Gen_1 259 268 PF02991 0.331
LIG_LIR_Nem_3 101 106 PF02991 0.489
LIG_LIR_Nem_3 109 114 PF02991 0.325
LIG_LIR_Nem_3 126 131 PF02991 0.221
LIG_LIR_Nem_3 259 264 PF02991 0.309
LIG_LIR_Nem_3 320 324 PF02991 0.357
LIG_LIR_Nem_3 67 72 PF02991 0.673
LIG_LYPXL_S_1 127 131 PF13949 0.489
LIG_LYPXL_S_1 175 179 PF13949 0.489
LIG_LYPXL_yS_3 128 131 PF13949 0.289
LIG_LYPXL_yS_3 176 179 PF13949 0.289
LIG_LYPXL_yS_3 69 72 PF13949 0.659
LIG_NRBOX 334 340 PF00104 0.289
LIG_Pex14_2 174 178 PF04695 0.299
LIG_PTB_Apo_2 315 322 PF02174 0.299
LIG_SH2_STAT3 22 25 PF00017 0.750
LIG_SH2_STAT3 253 256 PF00017 0.331
LIG_SH2_STAT5 212 215 PF00017 0.289
LIG_SH2_STAT5 295 298 PF00017 0.309
LIG_SH2_STAT5 324 327 PF00017 0.391
LIG_SH3_3 135 141 PF00018 0.391
LIG_SH3_3 279 285 PF00018 0.340
LIG_SH3_3 34 40 PF00018 0.795
LIG_SH3_3 42 48 PF00018 0.830
LIG_SUMO_SIM_anti_2 147 154 PF11976 0.301
LIG_SUMO_SIM_par_1 92 97 PF11976 0.585
LIG_TRAF2_1 320 323 PF00917 0.340
LIG_TRAF2_1 9 12 PF00917 0.759
LIG_TRAF2_2 66 71 PF00917 0.695
LIG_UBA3_1 218 224 PF00899 0.331
LIG_UBA3_1 93 99 PF00899 0.568
LIG_WRC_WIRS_1 236 241 PF05994 0.289
MOD_CDK_SPxxK_3 179 186 PF00069 0.391
MOD_CK1_1 148 154 PF00069 0.316
MOD_CK1_1 259 265 PF00069 0.340
MOD_CK2_1 179 185 PF00069 0.391
MOD_CK2_1 296 302 PF00069 0.404
MOD_CK2_1 317 323 PF00069 0.367
MOD_GlcNHglycan 135 138 PF01048 0.591
MOD_GSK3_1 106 113 PF00069 0.469
MOD_GSK3_1 144 151 PF00069 0.303
MOD_GSK3_1 230 237 PF00069 0.395
MOD_N-GLC_1 317 322 PF02516 0.513
MOD_N-GLC_2 170 172 PF02516 0.591
MOD_NEK2_1 110 115 PF00069 0.270
MOD_NEK2_1 166 171 PF00069 0.334
MOD_NEK2_1 190 195 PF00069 0.315
MOD_NEK2_1 94 99 PF00069 0.549
MOD_PIKK_1 64 70 PF00454 0.675
MOD_PK_1 145 151 PF00069 0.313
MOD_PKA_1 348 354 PF00069 0.417
MOD_PKA_2 144 150 PF00069 0.313
MOD_PKA_2 190 196 PF00069 0.305
MOD_PKA_2 259 265 PF00069 0.328
MOD_PKA_2 296 302 PF00069 0.289
MOD_PKA_2 348 354 PF00069 0.417
MOD_Plk_1 317 323 PF00069 0.331
MOD_Plk_2-3 11 17 PF00069 0.678
MOD_Plk_4 106 112 PF00069 0.460
MOD_Plk_4 123 129 PF00069 0.340
MOD_Plk_4 145 151 PF00069 0.299
MOD_Plk_4 235 241 PF00069 0.305
MOD_ProDKin_1 130 136 PF00069 0.313
MOD_ProDKin_1 179 185 PF00069 0.391
TRG_DiLeu_BaEn_1 101 106 PF01217 0.591
TRG_DiLeu_BaLyEn_6 126 131 PF01217 0.289
TRG_DiLeu_BaLyEn_6 283 288 PF01217 0.289
TRG_ENDOCYTIC_2 128 131 PF00928 0.289
TRG_ENDOCYTIC_2 176 179 PF00928 0.289
TRG_ENDOCYTIC_2 295 298 PF00928 0.330
TRG_ENDOCYTIC_2 32 35 PF00928 0.840
TRG_ENDOCYTIC_2 69 72 PF00928 0.663
TRG_ER_diArg_1 163 165 PF00400 0.356
TRG_ER_diArg_1 348 350 PF00400 0.499
TRG_NES_CRM1_1 231 242 PF08389 0.313
TRG_Pf-PMV_PEXEL_1 310 314 PF00026 0.513
TRG_Pf-PMV_PEXEL_1 348 352 PF00026 0.631

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1Y3 Leptomonas seymouri 91% 100%
A0A0S4ITM9 Bodo saltans 57% 100%
A0A1X0PA96 Trypanosomatidae 54% 100%
A0A3R7N5E2 Trypanosoma rangeli 53% 100%
A4HBG1 Leishmania braziliensis 94% 100%
A4IAK7 Leishmania infantum 100% 100%
A7MB47 Bos taurus 48% 100%
C9ZLN4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 56% 100%
E9B5N2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
P53829 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 47% 96%
Q4Q286 Leishmania major 98% 100%
Q4R347 Macaca fascicularis 48% 100%
Q5PQL2 Rattus norvegicus 48% 100%
Q5R6Z6 Pongo abelii 48% 100%
Q6IP65 Xenopus laevis 48% 100%
Q6NWL4 Danio rerio 50% 100%
Q6P819 Xenopus tropicalis 48% 100%
Q92368 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 50% 100%
Q92600 Homo sapiens 48% 100%
Q9JKY0 Mus musculus 48% 100%
V5BLQ5 Trypanosoma cruzi 54% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS