CAP10 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1193), putative

Species:

Leishmania donovani

UniProt:

A0A3S7X8K5_LEIDO

TriTrypDb:

LdBPK_344010.1 , LdCL_340049500 , LDHU3_34.6320

Length:

584

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A0A3S7X8K5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8K5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	52	56	PF00656	0.415
CLV_NRD_NRD_1	11	13	PF00675	0.418
CLV_NRD_NRD_1	277	279	PF00675	0.561
CLV_NRD_NRD_1	387	389	PF00675	0.556
CLV_NRD_NRD_1	494	496	PF00675	0.505
CLV_NRD_NRD_1	535	537	PF00675	0.585
CLV_NRD_NRD_1	70	72	PF00675	0.629
CLV_PCSK_FUR_1	492	496	PF00082	0.499
CLV_PCSK_KEX2_1	11	13	PF00082	0.426
CLV_PCSK_KEX2_1	136	138	PF00082	0.772
CLV_PCSK_KEX2_1	402	404	PF00082	0.600
CLV_PCSK_KEX2_1	494	496	PF00082	0.512
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.622
CLV_PCSK_PC1ET2_1	402	404	PF00082	0.600
CLV_PCSK_SKI1_1	175	179	PF00082	0.698
CLV_PCSK_SKI1_1	243	247	PF00082	0.522
CLV_PCSK_SKI1_1	256	260	PF00082	0.447
CLV_PCSK_SKI1_1	415	419	PF00082	0.462
DEG_APCC_DBOX_1	402	410	PF00400	0.328
DEG_SPOP_SBC_1	100	104	PF00917	0.509
DOC_CYCLIN_yCln2_LP_2	376	382	PF00134	0.292
DOC_MAPK_gen_1	11	21	PF00069	0.432
DOC_MAPK_gen_1	136	143	PF00069	0.551
DOC_MAPK_gen_1	536	542	PF00069	0.370
DOC_MAPK_JIP1_4	15	21	PF00069	0.450
DOC_MAPK_MEF2A_6	12	21	PF00069	0.443
DOC_MAPK_MEF2A_6	301	310	PF00069	0.303
DOC_PP1_RVXF_1	293	300	PF00149	0.292
DOC_PP2B_LxvP_1	376	379	PF13499	0.288
DOC_PP4_FxxP_1	562	565	PF00568	0.292
DOC_SPAK_OSR1_1	331	335	PF12202	0.391
DOC_USP7_MATH_1	110	114	PF00917	0.577
DOC_USP7_MATH_1	247	251	PF00917	0.306
DOC_USP7_MATH_1	57	61	PF00917	0.476
DOC_USP7_UBL2_3	270	274	PF12436	0.253
DOC_USP7_UBL2_3	456	460	PF12436	0.320
DOC_WW_Pin1_4	130	135	PF00397	0.512
DOC_WW_Pin1_4	146	151	PF00397	0.477
DOC_WW_Pin1_4	319	324	PF00397	0.295
DOC_WW_Pin1_4	71	76	PF00397	0.534
LIG_14-3-3_CanoR_1	111	120	PF00244	0.556
LIG_14-3-3_CanoR_1	15	20	PF00244	0.516
LIG_14-3-3_CanoR_1	213	219	PF00244	0.405
LIG_14-3-3_CanoR_1	220	225	PF00244	0.411
LIG_14-3-3_CanoR_1	301	307	PF00244	0.268
LIG_14-3-3_CanoR_1	351	358	PF00244	0.359
LIG_14-3-3_CanoR_1	41	50	PF00244	0.523
LIG_14-3-3_CanoR_1	492	501	PF00244	0.312
LIG_14-3-3_CanoR_1	553	562	PF00244	0.405
LIG_Actin_WH2_2	255	272	PF00022	0.415
LIG_BIR_II_1	1	5	PF00653	0.630
LIG_BRCT_BRCA1_1	2	6	PF00533	0.692
LIG_BRCT_BRCA1_1	321	325	PF00533	0.284
LIG_CtBP_PxDLS_1	16	20	PF00389	0.295
LIG_deltaCOP1_diTrp_1	287	293	PF00928	0.293
LIG_DLG_GKlike_1	15	22	PF00625	0.450
LIG_EH_1	478	482	PF12763	0.361
LIG_FHA_1	34	40	PF00498	0.644
LIG_FHA_1	348	354	PF00498	0.353
LIG_FHA_1	358	364	PF00498	0.205
LIG_FHA_2	119	125	PF00498	0.573
LIG_FHA_2	213	219	PF00498	0.361
LIG_FHA_2	555	561	PF00498	0.376
LIG_FHA_2	576	582	PF00498	0.479
LIG_IRF3_LxIS_1	138	144	PF10401	0.418
LIG_KLC1_Yacidic_2	204	209	PF13176	0.313
LIG_LIR_Apic_2	560	565	PF02991	0.311
LIG_LIR_Gen_1	185	193	PF02991	0.356
LIG_LIR_Gen_1	298	307	PF02991	0.309
LIG_LIR_Gen_1	313	321	PF02991	0.261
LIG_LIR_Gen_1	326	336	PF02991	0.366
LIG_LIR_Gen_1	373	382	PF02991	0.309
LIG_LIR_Gen_1	416	422	PF02991	0.308
LIG_LIR_Gen_1	496	505	PF02991	0.302
LIG_LIR_Gen_1	566	573	PF02991	0.428
LIG_LIR_Gen_1	64	75	PF02991	0.372
LIG_LIR_Nem_3	185	191	PF02991	0.352
LIG_LIR_Nem_3	286	291	PF02991	0.269
LIG_LIR_Nem_3	298	302	PF02991	0.270
LIG_LIR_Nem_3	30	35	PF02991	0.368
LIG_LIR_Nem_3	304	310	PF02991	0.217
LIG_LIR_Nem_3	313	317	PF02991	0.222
LIG_LIR_Nem_3	326	332	PF02991	0.329
LIG_LIR_Nem_3	373	378	PF02991	0.273
LIG_LIR_Nem_3	416	421	PF02991	0.300
LIG_LIR_Nem_3	496	501	PF02991	0.302
LIG_LIR_Nem_3	566	570	PF02991	0.376
LIG_LIR_Nem_3	64	70	PF02991	0.434
LIG_LYPXL_yS_3	512	515	PF13949	0.345
LIG_MYND_1	150	154	PF01753	0.464
LIG_MYND_1	91	95	PF01753	0.572
LIG_Pex14_1	289	293	PF04695	0.294
LIG_Pex14_1	328	332	PF04695	0.276
LIG_Pex14_2	325	329	PF04695	0.300
LIG_PTB_Apo_2	337	344	PF02174	0.310
LIG_PTB_Apo_2	476	483	PF02174	0.408
LIG_SH2_CRK	162	166	PF00017	0.381
LIG_SH2_CRK	321	325	PF00017	0.314
LIG_SH2_CRK	567	571	PF00017	0.431
LIG_SH2_GRB2like	338	341	PF00017	0.312
LIG_SH2_NCK_1	282	286	PF00017	0.357
LIG_SH2_SRC	391	394	PF00017	0.334
LIG_SH2_SRC	461	464	PF00017	0.343
LIG_SH2_STAP1	162	166	PF00017	0.408
LIG_SH2_STAP1	349	353	PF00017	0.426
LIG_SH2_STAT3	349	352	PF00017	0.391
LIG_SH2_STAT5	207	210	PF00017	0.412
LIG_SH2_STAT5	235	238	PF00017	0.282
LIG_SH2_STAT5	314	317	PF00017	0.341
LIG_SH2_STAT5	338	341	PF00017	0.315
LIG_SH2_STAT5	349	352	PF00017	0.324
LIG_SH2_STAT5	38	41	PF00017	0.455
LIG_SH2_STAT5	391	394	PF00017	0.288
LIG_SH2_STAT5	463	466	PF00017	0.335
LIG_SH2_STAT5	556	559	PF00017	0.418
LIG_SH3_1	178	184	PF00018	0.446
LIG_SH3_2	106	111	PF14604	0.565
LIG_SH3_2	131	136	PF14604	0.415
LIG_SH3_2	181	186	PF14604	0.452
LIG_SH3_3	103	109	PF00018	0.559
LIG_SH3_3	128	134	PF00018	0.487
LIG_SH3_3	178	184	PF00018	0.362
LIG_SH3_3	196	202	PF00018	0.238
LIG_SH3_3	303	309	PF00018	0.254
LIG_SH3_3	567	573	PF00018	0.366
LIG_SH3_3	79	85	PF00018	0.585
LIG_SH3_3	88	94	PF00018	0.583
LIG_SUMO_SIM_anti_2	96	104	PF11976	0.432
LIG_SUMO_SIM_par_1	25	30	PF11976	0.324
LIG_TYR_ITIM	312	317	PF00017	0.297
LIG_WRC_WIRS_1	372	377	PF05994	0.292
LIG_WW_3	108	112	PF00397	0.567
MOD_CDC14_SPxK_1	133	136	PF00782	0.413
MOD_CDK_SPxK_1	130	136	PF00069	0.418
MOD_CDK_SPxxK_3	130	137	PF00069	0.419
MOD_CK1_1	104	110	PF00069	0.542
MOD_CK1_1	113	119	PF00069	0.510
MOD_CK1_1	144	150	PF00069	0.525
MOD_CK1_1	354	360	PF00069	0.326
MOD_CK1_1	42	48	PF00069	0.560
MOD_CK1_1	441	447	PF00069	0.353
MOD_CK1_1	469	475	PF00069	0.323
MOD_CK1_1	530	536	PF00069	0.355
MOD_CK1_1	62	68	PF00069	0.500
MOD_CK2_1	118	124	PF00069	0.609
MOD_CK2_1	469	475	PF00069	0.323
MOD_CK2_1	493	499	PF00069	0.338
MOD_CK2_1	554	560	PF00069	0.353
MOD_GlcNHglycan	103	106	PF01048	0.716
MOD_GlcNHglycan	138	141	PF01048	0.760
MOD_GlcNHglycan	146	149	PF01048	0.755
MOD_GlcNHglycan	440	443	PF01048	0.622
MOD_GSK3_1	100	107	PF00069	0.528
MOD_GSK3_1	110	117	PF00069	0.485
MOD_GSK3_1	142	149	PF00069	0.526
MOD_GSK3_1	150	157	PF00069	0.403
MOD_GSK3_1	319	326	PF00069	0.261
MOD_GSK3_1	347	354	PF00069	0.350
MOD_GSK3_1	39	46	PF00069	0.488
MOD_GSK3_1	422	429	PF00069	0.405
MOD_GSK3_1	465	472	PF00069	0.293
MOD_LATS_1	13	19	PF00433	0.450
MOD_N-GLC_1	220	225	PF02516	0.642
MOD_N-GLC_1	336	341	PF02516	0.524
MOD_N-GLC_1	42	47	PF02516	0.631
MOD_N-GLC_2	550	552	PF02516	0.488
MOD_NEK2_1	141	146	PF00069	0.588
MOD_NEK2_1	260	265	PF00069	0.384
MOD_NEK2_1	27	32	PF00069	0.374
MOD_NEK2_1	398	403	PF00069	0.408
MOD_NEK2_1	413	418	PF00069	0.317
MOD_NEK2_1	493	498	PF00069	0.322
MOD_NEK2_2	33	38	PF00069	0.474
MOD_PIKK_1	273	279	PF00454	0.281
MOD_PIKK_1	323	329	PF00454	0.261
MOD_PIKK_1	59	65	PF00454	0.497
MOD_PKA_1	136	142	PF00069	0.420
MOD_PKA_1	494	500	PF00069	0.295
MOD_PKA_2	110	116	PF00069	0.524
MOD_PKA_2	136	142	PF00069	0.597
MOD_PKA_2	212	218	PF00069	0.388
MOD_PKA_2	426	432	PF00069	0.460
MOD_PKA_2	486	492	PF00069	0.343
MOD_PKA_2	493	499	PF00069	0.287
MOD_PKB_1	492	500	PF00069	0.279
MOD_Plk_1	154	160	PF00069	0.368
MOD_Plk_1	220	226	PF00069	0.405
MOD_Plk_1	354	360	PF00069	0.296
MOD_Plk_1	382	388	PF00069	0.398
MOD_Plk_1	413	419	PF00069	0.327
MOD_Plk_1	42	48	PF00069	0.507
MOD_Plk_1	518	524	PF00069	0.393
MOD_Plk_1	575	581	PF00069	0.441
MOD_Plk_2-3	560	566	PF00069	0.361
MOD_Plk_2-3	575	581	PF00069	0.432
MOD_Plk_4	268	274	PF00069	0.267
MOD_Plk_4	302	308	PF00069	0.327
MOD_Plk_4	33	39	PF00069	0.571
MOD_Plk_4	371	377	PF00069	0.280
MOD_Plk_4	382	388	PF00069	0.271
MOD_Plk_4	466	472	PF00069	0.296
MOD_Plk_4	530	536	PF00069	0.342
MOD_Plk_4	62	68	PF00069	0.410
MOD_ProDKin_1	130	136	PF00069	0.513
MOD_ProDKin_1	146	152	PF00069	0.466
MOD_ProDKin_1	319	325	PF00069	0.293
MOD_ProDKin_1	71	77	PF00069	0.538
TRG_DiLeu_BaEn_4	574	580	PF01217	0.448
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.438
TRG_DiLeu_BaLyEn_6	510	515	PF01217	0.377
TRG_ENDOCYTIC_2	162	165	PF00928	0.402
TRG_ENDOCYTIC_2	282	285	PF00928	0.305
TRG_ENDOCYTIC_2	314	317	PF00928	0.283
TRG_ENDOCYTIC_2	321	324	PF00928	0.298
TRG_ENDOCYTIC_2	461	464	PF00928	0.265
TRG_ENDOCYTIC_2	512	515	PF00928	0.320
TRG_ENDOCYTIC_2	567	570	PF00928	0.353
TRG_ER_diArg_1	10	12	PF00400	0.625
TRG_ER_diArg_1	403	406	PF00400	0.400
TRG_ER_diArg_1	493	495	PF00400	0.286
TRG_ER_diArg_1	551	554	PF00400	0.409
TRG_NES_CRM1_1	156	169	PF08389	0.375
TRG_NES_CRM1_1	411	426	PF08389	0.300
TRG_NLS_Bipartite_1	388	406	PF00514	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5V7	Leptomonas seymouri	64%	100%
A0A0S4IP10	Bodo saltans	25%	100%
A0A0S4KMJ1	Bodo saltans	49%	100%
A0A1X0PB74	Trypanosomatidae	52%	100%
A0A3S5IRZ3	Trypanosoma rangeli	51%	100%
A4HBE1	Leishmania braziliensis	82%	100%
A4IAI9	Leishmania infantum	99%	100%
C9ZLP9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
C9ZS63	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	90%
E9B5L3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q2C3	Leishmania major	93%	100%
V5BRE4	Trypanosoma cruzi	53%	100%