Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DHHC palmitoyltransferase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X8K2_LEIDO

TriTrypDb:

LdBPK_344130.1 , LdCL_340050700 , LDHU3_34.6460

Length:

266

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S7X8K2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8K2

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	1
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018198	peptidyl-cysteine modification	6	1
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	1
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	1
GO:0018345	protein palmitoylation	6	1
GO:0019538	protein metabolic process	3	1
GO:0033036	macromolecule localization	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016409	palmitoyltransferase activity	5	11
GO:0016417	S-acyltransferase activity	5	11
GO:0016740	transferase activity	2	11
GO:0016746	acyltransferase activity	3	11
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	11
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	11
GO:0019707	protein-cysteine S-acyltransferase activity	3	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	18	20	PF00675	0.384
CLV_NRD_NRD_1	229	231	PF00675	0.319
CLV_PCSK_FUR_1	16	20	PF00082	0.332
CLV_PCSK_FUR_1	226	230	PF00082	0.332
CLV_PCSK_KEX2_1	15	17	PF00082	0.383
CLV_PCSK_KEX2_1	18	20	PF00082	0.342
CLV_PCSK_KEX2_1	226	228	PF00082	0.283
CLV_PCSK_KEX2_1	229	231	PF00082	0.291
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.332
CLV_PCSK_SKI1_1	246	250	PF00082	0.419
DEG_Nend_UBRbox_3	1	3	PF02207	0.609
DOC_CDC14_PxL_1	37	45	PF14671	0.394
DOC_CKS1_1	52	57	PF01111	0.345
DOC_CYCLIN_RxL_1	186	197	PF00134	0.212
DOC_MAPK_gen_1	186	196	PF00069	0.310
DOC_MAPK_MEF2A_6	186	195	PF00069	0.381
DOC_PP2B_LxvP_1	185	188	PF13499	0.212
DOC_PP4_FxxP_1	253	256	PF00568	0.582
DOC_SPAK_OSR1_1	230	234	PF12202	0.497
DOC_USP7_MATH_1	262	266	PF00917	0.582
DOC_WW_Pin1_4	51	56	PF00397	0.358
LIG_14-3-3_CanoR_1	104	112	PF00244	0.517
LIG_14-3-3_CanoR_1	213	217	PF00244	0.482
LIG_14-3-3_CanoR_1	246	256	PF00244	0.665
LIG_Actin_WH2_2	198	215	PF00022	0.313
LIG_BRCT_BRCA1_1	237	241	PF00533	0.582
LIG_BRCT_BRCA1_1	249	253	PF00533	0.598
LIG_eIF4E_1	133	139	PF01652	0.404
LIG_FHA_1	3	9	PF00498	0.728
LIG_FHA_1	63	69	PF00498	0.278
LIG_FHA_2	108	114	PF00498	0.467
LIG_GBD_Chelix_1	174	182	PF00786	0.396
LIG_LIR_Apic_2	250	256	PF02991	0.571
LIG_LIR_Gen_1	170	178	PF02991	0.307
LIG_LIR_Gen_1	208	217	PF02991	0.432
LIG_LIR_Gen_1	73	83	PF02991	0.333
LIG_LIR_Gen_1	91	101	PF02991	0.565
LIG_LIR_Nem_3	170	174	PF02991	0.310
LIG_LIR_Nem_3	208	212	PF02991	0.407
LIG_LIR_Nem_3	215	219	PF02991	0.482
LIG_LIR_Nem_3	91	97	PF02991	0.590
LIG_NRBOX	67	73	PF00104	0.248
LIG_NRBOX	82	88	PF00104	0.378
LIG_Pex14_2	241	245	PF04695	0.521
LIG_Pex14_2	249	253	PF04695	0.543
LIG_PTB_Apo_2	149	156	PF02174	0.404
LIG_SH2_CRK	214	218	PF00017	0.482
LIG_SH2_CRK	219	223	PF00017	0.449
LIG_SH2_CRK	258	262	PF00017	0.664
LIG_SH2_STAP1	214	218	PF00017	0.482
LIG_SH2_STAT5	133	136	PF00017	0.404
LIG_SH2_STAT5	214	217	PF00017	0.470
LIG_SH3_3	49	55	PF00018	0.410
LIG_SH3_3	86	92	PF00018	0.377
LIG_SUMO_SIM_par_1	192	197	PF11976	0.493
LIG_SUMO_SIM_par_1	4	11	PF11976	0.553
LIG_SUMO_SIM_par_1	64	69	PF11976	0.297
LIG_SUMO_SIM_par_1	85	91	PF11976	0.353
LIG_TYR_ITIM	212	217	PF00017	0.378
LIG_WRC_WIRS_1	206	211	PF05994	0.469
MOD_CK1_1	170	176	PF00069	0.323
MOD_Cter_Amidation	13	16	PF01082	0.443
MOD_GlcNHglycan	232	236	PF01048	0.318
MOD_GSK3_1	2	9	PF00069	0.722
MOD_GSK3_1	231	238	PF00069	0.553
MOD_GSK3_1	99	106	PF00069	0.583
MOD_N-GLC_2	130	132	PF02516	0.331
MOD_NEK2_1	177	182	PF00069	0.381
MOD_NEK2_1	194	199	PF00069	0.449
MOD_NEK2_1	212	217	PF00069	0.251
MOD_NEK2_1	231	236	PF00069	0.575
MOD_NEK2_1	241	246	PF00069	0.530
MOD_NEK2_2	221	226	PF00069	0.539
MOD_PKA_2	103	109	PF00069	0.517
MOD_PKA_2	164	170	PF00069	0.335
MOD_PKA_2	17	23	PF00069	0.620
MOD_PKA_2	212	218	PF00069	0.335
MOD_Plk_4	177	183	PF00069	0.286
MOD_Plk_4	205	211	PF00069	0.397
MOD_Plk_4	212	218	PF00069	0.323
MOD_Plk_4	62	68	PF00069	0.324
MOD_ProDKin_1	51	57	PF00069	0.353
TRG_ENDOCYTIC_2	133	136	PF00928	0.397
TRG_ENDOCYTIC_2	214	217	PF00928	0.492
TRG_ENDOCYTIC_2	219	222	PF00928	0.492
TRG_ENDOCYTIC_2	258	261	PF00928	0.667
TRG_ER_diArg_1	16	19	PF00400	0.555
TRG_ER_diArg_1	225	228	PF00400	0.495
TRG_ER_diArg_1	229	231	PF00400	0.435
TRG_NLS_MonoExtC_3	14	19	PF00514	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0L0	Leptomonas seymouri	51%	100%
A0A0S4KJ92	Bodo saltans	33%	96%
A0A1X0PBJ7	Trypanosomatidae	29%	100%
A0A3R7M6T4	Trypanosoma rangeli	24%	100%
A4HBF2	Leishmania braziliensis	71%	100%
A4IAK1	Leishmania infantum	100%	100%
E9B5M5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q2B1	Leishmania major	92%	100%
V5BW09	Trypanosoma cruzi	26%	100%