GRIP domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GRIP domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X8J7_LEIDO

TriTrypDb:

LdBPK_343920.1 , LdCL_340048600 , LDHU3_34.6220

Length:

423

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X8J7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8J7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	212	216	PF00656	0.636
CLV_C14_Caspase3-7	308	312	PF00656	0.686
CLV_NRD_NRD_1	137	139	PF00675	0.546
CLV_NRD_NRD_1	333	335	PF00675	0.554
CLV_NRD_NRD_1	353	355	PF00675	0.499
CLV_NRD_NRD_1	360	362	PF00675	0.678
CLV_PCSK_KEX2_1	112	114	PF00082	0.603
CLV_PCSK_KEX2_1	136	138	PF00082	0.541
CLV_PCSK_KEX2_1	333	335	PF00082	0.615
CLV_PCSK_KEX2_1	353	355	PF00082	0.389
CLV_PCSK_KEX2_1	360	362	PF00082	0.566
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.591
CLV_PCSK_SKI1_1	19	23	PF00082	0.615
CLV_PCSK_SKI1_1	397	401	PF00082	0.378
CLV_PCSK_SKI1_1	419	423	PF00082	0.610
CLV_PCSK_SKI1_1	95	99	PF00082	0.624
DEG_APCC_DBOX_1	135	143	PF00400	0.401
DEG_APCC_DBOX_1	396	404	PF00400	0.410
DEG_Nend_UBRbox_1	1	4	PF02207	0.651
DOC_CYCLIN_RxL_1	16	25	PF00134	0.573
DOC_CYCLIN_RxL_1	394	404	PF00134	0.408
DOC_MAPK_DCC_7	28	37	PF00069	0.635
DOC_MAPK_DCC_7	397	405	PF00069	0.434
DOC_MAPK_gen_1	353	359	PF00069	0.600
DOC_MAPK_gen_1	394	402	PF00069	0.442
DOC_MAPK_MEF2A_6	28	37	PF00069	0.635
DOC_MAPK_MEF2A_6	397	405	PF00069	0.434
DOC_MIT_MIM_1	134	142	PF04212	0.570
DOC_PP1_RVXF_1	337	343	PF00149	0.545
DOC_WW_Pin1_4	226	231	PF00397	0.666
DOC_WW_Pin1_4	75	80	PF00397	0.756
LIG_14-3-3_CanoR_1	339	343	PF00244	0.545
LIG_Actin_WH2_2	392	410	PF00022	0.420
LIG_Actin_WH2_2	90	107	PF00022	0.607
LIG_BRCT_BRCA1_1	39	43	PF00533	0.630
LIG_CaM_IQ_9	206	221	PF13499	0.522
LIG_CaM_IQ_9	90	105	PF13499	0.642
LIG_FHA_1	120	126	PF00498	0.551
LIG_FHA_1	302	308	PF00498	0.702
LIG_FHA_1	323	329	PF00498	0.687
LIG_FHA_1	56	62	PF00498	0.562
LIG_FHA_1	7	13	PF00498	0.543
LIG_FHA_1	88	94	PF00498	0.547
LIG_FHA_2	174	180	PF00498	0.601
LIG_FHA_2	240	246	PF00498	0.561
LIG_FHA_2	306	312	PF00498	0.727
LIG_FHA_2	408	414	PF00498	0.451
LIG_FHA_2	86	92	PF00498	0.678
LIG_FHA_2	94	100	PF00498	0.510
LIG_GBD_Chelix_1	382	390	PF00786	0.480
LIG_LIR_Gen_1	245	255	PF02991	0.536
LIG_LIR_Gen_1	316	326	PF02991	0.584
LIG_LIR_Gen_1	341	350	PF02991	0.544
LIG_LIR_Nem_3	245	251	PF02991	0.509
LIG_LIR_Nem_3	316	322	PF02991	0.603
LIG_LIR_Nem_3	341	345	PF02991	0.615
LIG_NRBOX	282	288	PF00104	0.584
LIG_NRBOX	402	408	PF00104	0.335
LIG_RPA_C_Fungi	348	360	PF08784	0.561
LIG_SH2_SRC	45	48	PF00017	0.570
LIG_SH2_STAP1	45	49	PF00017	0.556
LIG_SH2_STAT3	36	39	PF00017	0.655
LIG_SH2_STAT5	248	251	PF00017	0.608
LIG_SH2_STAT5	36	39	PF00017	0.634
LIG_SH2_STAT5	378	381	PF00017	0.335
LIG_SUMO_SIM_par_1	4	9	PF11976	0.544
LIG_SUMO_SIM_par_1	57	62	PF11976	0.465
LIG_TRAF2_1	165	168	PF00917	0.590
LIG_TRAF2_1	265	268	PF00917	0.623
LIG_TRAF2_2	68	73	PF00917	0.643
LIG_UBA3_1	399	408	PF00899	0.447
MOD_CDC14_SPxK_1	78	81	PF00782	0.610
MOD_CDK_SPxK_1	75	81	PF00069	0.619
MOD_CK1_1	182	188	PF00069	0.569
MOD_CK1_1	87	93	PF00069	0.655
MOD_CK2_1	173	179	PF00069	0.545
MOD_CK2_1	349	355	PF00069	0.626
MOD_CK2_1	85	91	PF00069	0.688
MOD_GlcNHglycan	288	291	PF01048	0.669
MOD_GlcNHglycan	296	299	PF01048	0.745
MOD_GlcNHglycan	371	374	PF01048	0.660
MOD_GlcNHglycan	63	66	PF01048	0.654
MOD_GSK3_1	301	308	PF00069	0.692
MOD_GSK3_1	318	325	PF00069	0.456
MOD_GSK3_1	55	62	PF00069	0.571
MOD_GSK3_1	71	78	PF00069	0.749
MOD_GSK3_1	81	88	PF00069	0.601
MOD_GSK3_1	89	96	PF00069	0.456
MOD_N-GLC_1	145	150	PF02516	0.591
MOD_N-GLC_1	226	231	PF02516	0.516
MOD_N-GLC_1	299	304	PF02516	0.647
MOD_NEK2_1	12	17	PF00069	0.503
MOD_NEK2_1	173	178	PF00069	0.585
MOD_NEK2_1	22	27	PF00069	0.552
MOD_NEK2_1	286	291	PF00069	0.617
MOD_NEK2_1	322	327	PF00069	0.610
MOD_NEK2_1	349	354	PF00069	0.497
MOD_NEK2_1	386	391	PF00069	0.420
MOD_NEK2_1	55	60	PF00069	0.502
MOD_NEK2_1	61	66	PF00069	0.570
MOD_NEK2_1	85	90	PF00069	0.669
MOD_NEK2_1	93	98	PF00069	0.555
MOD_NEK2_2	145	150	PF00069	0.578
MOD_PIKK_1	182	188	PF00454	0.615
MOD_PIKK_1	263	269	PF00454	0.515
MOD_PIKK_1	310	316	PF00454	0.712
MOD_PIKK_1	37	43	PF00454	0.552
MOD_PKA_1	112	118	PF00069	0.621
MOD_PKA_2	112	118	PF00069	0.591
MOD_PKA_2	182	188	PF00069	0.498
MOD_PKA_2	268	274	PF00069	0.468
MOD_PKA_2	27	33	PF00069	0.502
MOD_PKA_2	338	344	PF00069	0.476
MOD_Plk_1	145	151	PF00069	0.519
MOD_Plk_1	22	28	PF00069	0.640
MOD_Plk_4	228	234	PF00069	0.684
MOD_Plk_4	401	407	PF00069	0.358
MOD_Plk_4	55	61	PF00069	0.542
MOD_ProDKin_1	226	232	PF00069	0.670
MOD_ProDKin_1	75	81	PF00069	0.753
MOD_SUMO_rev_2	155	165	PF00179	0.637
MOD_SUMO_rev_2	250	258	PF00179	0.498
TRG_DiLeu_BaEn_1	275	280	PF01217	0.597
TRG_DiLeu_BaEn_1	282	287	PF01217	0.613
TRG_ENDOCYTIC_2	248	251	PF00928	0.497
TRG_ENDOCYTIC_2	255	258	PF00928	0.463
TRG_ER_diArg_1	135	138	PF00400	0.531
TRG_ER_diArg_1	175	178	PF00400	0.571
TRG_ER_diArg_1	332	334	PF00400	0.611
TRG_ER_diArg_1	359	361	PF00400	0.679
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	19	23	PF00026	0.644
TRG_Pf-PMV_PEXEL_1	281	285	PF00026	0.578
TRG_Pf-PMV_PEXEL_1	333	337	PF00026	0.589

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF68	Leptomonas seymouri	40%	90%
A0A0S4KIU3	Bodo saltans	28%	91%
A0A1X0PB65	Trypanosomatidae	24%	92%
A4HBD2	Leishmania braziliensis	66%	100%
A4IAI0	Leishmania infantum	99%	100%
C9ZLQ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	92%
E9B5K4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q2D2	Leishmania major	84%	100%
V5BW28	Trypanosoma cruzi	29%	89%