DnaJ domain family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X8J5_LEIDO

TriTrypDb:

LdBPK_343910.1 , LdCL_340048500 , LDHU3_34.6210

Length:

266

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3S7X8J5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8J5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	107	109	PF00675	0.421
CLV_NRD_NRD_1	218	220	PF00675	0.616
CLV_NRD_NRD_1	3	5	PF00675	0.415
CLV_PCSK_KEX2_1	107	109	PF00082	0.421
CLV_PCSK_KEX2_1	211	213	PF00082	0.558
CLV_PCSK_KEX2_1	218	220	PF00082	0.556
CLV_PCSK_KEX2_1	3	5	PF00082	0.415
CLV_PCSK_KEX2_1	49	51	PF00082	0.329
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.565
CLV_PCSK_PC1ET2_1	218	220	PF00082	0.550
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.329
CLV_PCSK_SKI1_1	211	215	PF00082	0.604
CLV_PCSK_SKI1_1	45	49	PF00082	0.376
CLV_PCSK_SKI1_1	53	57	PF00082	0.382
CLV_PCSK_SKI1_1	93	97	PF00082	0.534
DEG_Nend_Nbox_1	1	3	PF02207	0.705
DEG_SCF_FBW7_1	224	231	PF00400	0.439
DOC_CKS1_1	225	230	PF01111	0.400
DOC_CYCLIN_yCln2_LP_2	186	192	PF00134	0.408
DOC_MAPK_gen_1	197	205	PF00069	0.427
DOC_MAPK_gen_1	3	9	PF00069	0.669
DOC_MAPK_gen_1	48	58	PF00069	0.544
DOC_MAPK_MEF2A_6	49	58	PF00069	0.572
DOC_USP7_MATH_1	228	232	PF00917	0.402
DOC_USP7_MATH_1	251	255	PF00917	0.476
DOC_USP7_UBL2_3	44	48	PF12436	0.534
DOC_USP7_UBL2_3	49	53	PF12436	0.525
DOC_WW_Pin1_4	224	229	PF00397	0.436
DOC_WW_Pin1_4	254	259	PF00397	0.402
LIG_14-3-3_CanoR_1	120	126	PF00244	0.617
LIG_14-3-3_CanoR_1	163	169	PF00244	0.397
LIG_BIR_III_2	221	225	PF00653	0.327
LIG_CSL_BTD_1	186	189	PF09270	0.406
LIG_deltaCOP1_diTrp_1	184	190	PF00928	0.490
LIG_FHA_1	113	119	PF00498	0.585
LIG_FHA_1	259	265	PF00498	0.371
LIG_FHA_2	41	47	PF00498	0.573
LIG_LIR_Gen_1	135	143	PF02991	0.300
LIG_LIR_Gen_1	66	75	PF02991	0.526
LIG_LIR_Nem_3	135	139	PF02991	0.309
LIG_LIR_Nem_3	66	72	PF02991	0.530
LIG_PDZ_Class_2	261	266	PF00595	0.372
LIG_SH2_CRK	111	115	PF00017	0.636
LIG_SH2_GRB2like	111	114	PF00017	0.620
LIG_SH2_STAP1	155	159	PF00017	0.364
LIG_SH2_STAP1	168	172	PF00017	0.453
LIG_SH2_STAT5	150	153	PF00017	0.404
LIG_SH2_STAT5	155	158	PF00017	0.323
LIG_SH2_STAT5	226	229	PF00017	0.445
LIG_SH3_3	222	228	PF00018	0.385
LIG_SH3_3	242	248	PF00018	0.470
LIG_SUMO_SIM_anti_2	201	207	PF11976	0.434
LIG_WW_1	223	226	PF00397	0.476
MOD_CK1_1	164	170	PF00069	0.388
MOD_CK1_1	254	260	PF00069	0.501
MOD_CK2_1	164	170	PF00069	0.387
MOD_CMANNOS	187	190	PF00535	0.600
MOD_GlcNHglycan	18	21	PF01048	0.454
MOD_GlcNHglycan	230	233	PF01048	0.647
MOD_GlcNHglycan	253	256	PF01048	0.712
MOD_GlcNHglycan	4	7	PF01048	0.490
MOD_GSK3_1	224	231	PF00069	0.434
MOD_GSK3_1	253	260	PF00069	0.434
MOD_N-GLC_1	112	117	PF02516	0.412
MOD_NEK2_1	114	119	PF00069	0.599
MOD_NEK2_1	2	7	PF00069	0.627
MOD_NEK2_1	206	211	PF00069	0.344
MOD_NEK2_1	78	83	PF00069	0.568
MOD_PKA_2	119	125	PF00069	0.590
MOD_PKA_2	164	170	PF00069	0.375
MOD_PKA_2	2	8	PF00069	0.612
MOD_Plk_4	29	35	PF00069	0.510
MOD_ProDKin_1	224	230	PF00069	0.435
MOD_ProDKin_1	254	260	PF00069	0.400
MOD_SUMO_for_1	95	98	PF00179	0.678
TRG_DiLeu_BaEn_1	74	79	PF01217	0.518
TRG_ENDOCYTIC_2	11	14	PF00928	0.596
TRG_ENDOCYTIC_2	111	114	PF00928	0.594
TRG_ER_diArg_1	106	108	PF00400	0.627
TRG_ER_diArg_1	162	165	PF00400	0.381
TRG_ER_diArg_1	2	4	PF00400	0.621
TRG_NLS_MonoExtN_4	45	52	PF00514	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILG9	Leptomonas seymouri	73%	100%
A0A0S4KRJ1	Bodo saltans	43%	100%
A0A1X0PA98	Trypanosomatidae	54%	100%
A0A422NVC0	Trypanosoma rangeli	54%	100%
A4HBD1	Leishmania braziliensis	84%	100%
A4IAH9	Leishmania infantum	100%	100%
C9ZLR0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9B5K3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q2D3	Leishmania major	93%	100%