LeishMANIAdb
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Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical_protein_conserved
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7X8J4_LEIDO
TriTrypDb:
LdBPK_344060.1 , LdCL_340050000 , LDHU3_34.6370
Length:
98

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3S7X8J4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8J4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 77 81 PF00656 0.414
CLV_PCSK_KEX2_1 62 64 PF00082 0.406
CLV_PCSK_KEX2_1 90 92 PF00082 0.347
CLV_PCSK_PC1ET2_1 62 64 PF00082 0.373
CLV_PCSK_PC1ET2_1 90 92 PF00082 0.347
CLV_PCSK_SKI1_1 40 44 PF00082 0.354
CLV_PCSK_SKI1_1 62 66 PF00082 0.470
DEG_SPOP_SBC_1 21 25 PF00917 0.409
DOC_MAPK_gen_1 62 68 PF00069 0.348
LIG_14-3-3_CanoR_1 63 67 PF00244 0.387
LIG_BIR_II_1 1 5 PF00653 0.438
LIG_BRCT_BRCA1_1 31 35 PF00533 0.313
LIG_BRCT_BRCA1_1 51 55 PF00533 0.455
LIG_BRCT_BRCA1_2 51 57 PF00533 0.331
LIG_FHA_2 75 81 PF00498 0.422
LIG_LIR_Gen_1 65 75 PF02991 0.369
LIG_LIR_Nem_3 65 71 PF02991 0.390
LIG_SH2_CRK 45 49 PF00017 0.439
LIG_SH2_CRK 85 89 PF00017 0.437
LIG_SH2_NCK_1 45 49 PF00017 0.299
LIG_SH2_SRC 45 48 PF00017 0.380
LIG_SH2_STAT5 73 76 PF00017 0.296
LIG_SUMO_SIM_anti_2 2 9 PF11976 0.498
LIG_TYR_ITIM 43 48 PF00017 0.433
MOD_CK1_1 2 8 PF00069 0.434
MOD_GlcNHglycan 24 27 PF01048 0.395
MOD_GlcNHglycan 30 34 PF01048 0.308
MOD_GlcNHglycan 51 54 PF01048 0.392
MOD_GlcNHglycan 80 83 PF01048 0.507
MOD_GSK3_1 74 81 PF00069 0.359
MOD_GSK3_1 90 97 PF00069 0.591
MOD_NEK2_1 22 27 PF00069 0.518
MOD_PKA_1 62 68 PF00069 0.398
MOD_PKA_1 90 96 PF00069 0.451
MOD_PKA_2 62 68 PF00069 0.398
MOD_PKA_2 90 96 PF00069 0.460
MOD_Plk_4 2 8 PF00069 0.437
MOD_SUMO_for_1 56 59 PF00179 0.565
TRG_ENDOCYTIC_2 45 48 PF00928 0.401
TRG_ENDOCYTIC_2 85 88 PF00928 0.438

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PE77 Leptomonas seymouri 82% 100%
A0A0S4KJ18 Bodo saltans 47% 100%
A0A1X0PB28 Trypanosomatidae 52% 98%
A0A3R7MX32 Trypanosoma rangeli 57% 98%
A4HBE6 Leishmania braziliensis 90% 100%
A4IAJ4 Leishmania infantum 100% 100%
C9ZLP6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 49% 68%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS