Dolichol phosphate-mannose biosynthesis regulatory protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X8J1_LEIDO

TriTrypDb:

LdBPK_343780.1 , LdCL_340047200 , LDHU3_34.6060

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

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Expansion

Sequence features

A0A3S7X8J1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8J1

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	38	42	PF00082	0.521
DEG_Nend_Nbox_1	1	3	PF02207	0.798
DEG_SPOP_SBC_1	54	58	PF00917	0.311
DOC_MAPK_MEF2A_6	8	15	PF00069	0.745
DOC_PP2B_LxvP_1	2	5	PF13499	0.772
DOC_WW_Pin1_4	45	50	PF00397	0.359
LIG_DCNL_PONY_1	1	4	PF03556	0.789
LIG_eIF4E_1	7	13	PF01652	0.694
LIG_FHA_1	55	61	PF00498	0.389
LIG_FHA_1	81	87	PF00498	0.489

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A4HBB7	Leishmania braziliensis	74%	100%
A4IAG6	Leishmania infantum	99%	100%
E9B5J0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q2E6	Leishmania major	93%	100%

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