Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X8J0_LEIDO

TriTrypDb:

LdBPK_344050.1 , LdCL_340049900 , LDHU3_34.6360

Length:

203

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X8J0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8J0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	115	117	PF00675	0.572
CLV_NRD_NRD_1	195	197	PF00675	0.624
CLV_PCSK_FUR_1	129	133	PF00082	0.591
CLV_PCSK_KEX2_1	114	116	PF00082	0.559
CLV_PCSK_KEX2_1	131	133	PF00082	0.448
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.630
CLV_PCSK_SKI1_1	154	158	PF00082	0.453
CLV_PCSK_SKI1_1	20	24	PF00082	0.322
CLV_PCSK_SKI1_1	3	7	PF00082	0.560
DOC_MAPK_gen_1	168	176	PF00069	0.478
DOC_PP4_FxxP_1	162	165	PF00568	0.482
DOC_USP7_MATH_1	92	96	PF00917	0.519
DOC_USP7_UBL2_3	197	201	PF12436	0.539
DOC_WW_Pin1_4	195	200	PF00397	0.550
LIG_Actin_WH2_2	34	50	PF00022	0.515
LIG_APCC_ABBA_1	24	29	PF00400	0.391
LIG_APCC_ABBAyCdc20_2	23	29	PF00400	0.361
LIG_BIR_II_1	1	5	PF00653	0.628
LIG_FHA_1	62	68	PF00498	0.477
LIG_FHA_2	44	50	PF00498	0.379
LIG_Integrin_RGD_1	58	60	PF01839	0.507
LIG_LIR_Gen_1	183	193	PF02991	0.539
LIG_LIR_Nem_3	183	189	PF02991	0.523
LIG_LIR_Nem_3	97	103	PF02991	0.572
LIG_PTB_Apo_2	136	143	PF02174	0.518
LIG_PTB_Phospho_1	136	142	PF10480	0.518
LIG_SH2_STAT5	186	189	PF00017	0.535
LIG_SH2_STAT5	35	38	PF00017	0.518
LIG_SH3_3	99	105	PF00018	0.502
LIG_TRAF2_1	180	183	PF00917	0.444
MOD_CDK_SPK_2	195	200	PF00069	0.518
MOD_CDK_SPxK_1	195	201	PF00069	0.523
MOD_CK2_1	177	183	PF00069	0.453
MOD_CK2_1	43	49	PF00069	0.383
MOD_Cter_Amidation	129	132	PF01082	0.550
MOD_N-GLC_1	125	130	PF02516	0.663
MOD_N-GLC_1	92	97	PF02516	0.497
MOD_NEK2_1	125	130	PF00069	0.663
MOD_NEK2_1	81	86	PF00069	0.497
MOD_Plk_1	177	183	PF00069	0.453
MOD_Plk_1	43	49	PF00069	0.516
MOD_Plk_2-3	177	183	PF00069	0.453
MOD_ProDKin_1	195	201	PF00069	0.555
TRG_DiLeu_BaLyEn_6	86	91	PF01217	0.524
TRG_ENDOCYTIC_2	142	145	PF00928	0.512
TRG_ENDOCYTIC_2	186	189	PF00928	0.535
TRG_ENDOCYTIC_2	78	81	PF00928	0.484
TRG_ER_diArg_1	113	116	PF00400	0.615
TRG_ER_diArg_1	170	173	PF00400	0.460
TRG_ER_diArg_1	87	90	PF00400	0.528
TRG_ER_diLys_1	200	203	PF00400	0.555
TRG_NES_CRM1_1	16	29	PF08389	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILH1	Leptomonas seymouri	93%	100%
A0A0S4KPQ6	Bodo saltans	61%	99%
A0A1X0PA75	Trypanosomatidae	74%	100%
A4HBE5	Leishmania braziliensis	97%	100%
A4IAJ3	Leishmania infantum	100%	100%
C9ZLP7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	100%
E9B5L7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
Q4Q2B9	Leishmania major	98%	100%
V5BLR3	Trypanosoma cruzi	74%	82%