DNA polymerase delta subunit 3

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X8I7_LEIDO

TriTrypDb:

LdBPK_344040.1 , LdCL_340049800 , LDHU3_34.6350

Length:

488

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X8I7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8I7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	55	59	PF00656	0.622
CLV_NRD_NRD_1	247	249	PF00675	0.803
CLV_NRD_NRD_1	436	438	PF00675	0.821
CLV_NRD_NRD_1	66	68	PF00675	0.725
CLV_PCSK_KEX2_1	209	211	PF00082	0.750
CLV_PCSK_KEX2_1	247	249	PF00082	0.803
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.741
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.667
CLV_PCSK_SKI1_1	12	16	PF00082	0.650
CLV_PCSK_SKI1_1	195	199	PF00082	0.664
CLV_PCSK_SKI1_1	229	233	PF00082	0.703
CLV_Separin_Metazoa	169	173	PF03568	0.744
DEG_Nend_UBRbox_3	1	3	PF02207	0.448
DEG_SCF_FBW7_1	332	338	PF00400	0.704
DOC_CKS1_1	332	337	PF01111	0.814
DOC_CYCLIN_RxL_1	9	19	PF00134	0.586
DOC_USP7_MATH_1	148	152	PF00917	0.745
DOC_USP7_MATH_1	243	247	PF00917	0.667
DOC_USP7_MATH_1	440	444	PF00917	0.772
DOC_USP7_MATH_1	57	61	PF00917	0.677
DOC_USP7_UBL2_3	215	219	PF12436	0.750
DOC_USP7_UBL2_3	228	232	PF12436	0.782
DOC_WW_Pin1_4	153	158	PF00397	0.754
DOC_WW_Pin1_4	171	176	PF00397	0.839
DOC_WW_Pin1_4	188	193	PF00397	0.755
DOC_WW_Pin1_4	250	255	PF00397	0.671
DOC_WW_Pin1_4	328	333	PF00397	0.736
DOC_WW_Pin1_4	431	436	PF00397	0.699
DOC_WW_Pin1_4	443	448	PF00397	0.639
DOC_WW_Pin1_4	471	476	PF00397	0.780
LIG_14-3-3_CanoR_1	12	22	PF00244	0.593
LIG_14-3-3_CanoR_1	121	127	PF00244	0.686
LIG_14-3-3_CanoR_1	400	410	PF00244	0.616
LIG_14-3-3_CanoR_1	437	444	PF00244	0.699
LIG_BIR_III_2	317	321	PF00653	0.619
LIG_BRCT_BRCA1_1	264	268	PF00533	0.741
LIG_BRCT_BRCA1_1	363	367	PF00533	0.585
LIG_EVH1_1	329	333	PF00568	0.672
LIG_EVH1_2	319	323	PF00568	0.649
LIG_FHA_1	234	240	PF00498	0.657
LIG_FHA_1	404	410	PF00498	0.566
LIG_FHA_1	48	54	PF00498	0.653
LIG_FHA_1	60	66	PF00498	0.565
LIG_FHA_2	138	144	PF00498	0.829
LIG_FHA_2	14	20	PF00498	0.643
LIG_LIR_Gen_1	76	87	PF02991	0.691
LIG_LIR_Nem_3	76	82	PF02991	0.687
LIG_LYPXL_yS_3	110	113	PF13949	0.713
LIG_MLH1_MIPbox_1	363	367	PF16413	0.585
LIG_PCNA_PIPBox_1	360	369	PF02747	0.601
LIG_PCNA_yPIPBox_3	2	12	PF02747	0.446
LIG_PDZ_Class_1	483	488	PF00595	0.611
LIG_PTB_Apo_2	387	394	PF02174	0.534
LIG_REV1ctd_RIR_1	480	488	PF16727	0.666
LIG_SH2_CRK	46	50	PF00017	0.603
LIG_SH2_CRK	79	83	PF00017	0.692
LIG_SH2_STAT5	378	381	PF00017	0.532
LIG_SH2_STAT5	46	49	PF00017	0.550
LIG_SH3_2	221	226	PF14604	0.713
LIG_SH3_3	154	160	PF00018	0.652
LIG_SH3_3	177	183	PF00018	0.764
LIG_SH3_3	218	224	PF00018	0.715
LIG_SH3_3	300	306	PF00018	0.782
LIG_SH3_3	322	328	PF00018	0.720
LIG_SH3_3	329	335	PF00018	0.744
LIG_SH3_3	441	447	PF00018	0.784
LIG_SH3_4	219	226	PF00018	0.823
LIG_SUMO_SIM_par_1	3	11	PF11976	0.600
LIG_SUMO_SIM_par_1	80	85	PF11976	0.692
LIG_TRAF2_1	293	296	PF00917	0.666
LIG_TRAF2_1	467	470	PF00917	0.639
LIG_TRAF2_1	52	55	PF00917	0.697
LIG_UBA3_1	198	203	PF00899	0.693
LIG_WRC_WIRS_1	363	368	PF05994	0.663
LIG_WRC_WIRS_1	479	484	PF05994	0.649
LIG_WW_3	169	173	PF00397	0.744
LIG_WW_3	219	223	PF00397	0.609
MOD_CDK_SPK_2	190	195	PF00069	0.732
MOD_CDK_SPxK_1	333	339	PF00069	0.772
MOD_CDK_SPxK_1	431	437	PF00069	0.676
MOD_CDK_SPxK_1	471	477	PF00069	0.637
MOD_CDK_SPxxK_3	188	195	PF00069	0.638
MOD_CDK_SPxxK_3	333	340	PF00069	0.774
MOD_CDK_SPxxK_3	431	438	PF00069	0.785
MOD_CK1_1	153	159	PF00069	0.763
MOD_CK1_1	173	179	PF00069	0.617
MOD_CK1_1	250	256	PF00069	0.774
MOD_CK1_1	282	288	PF00069	0.746
MOD_CK1_1	331	337	PF00069	0.821
MOD_CK1_1	443	449	PF00069	0.758
MOD_CK1_1	458	464	PF00069	0.719
MOD_CK1_1	88	94	PF00069	0.686
MOD_CK2_1	113	119	PF00069	0.668
MOD_CK2_1	13	19	PF00069	0.628
MOD_CK2_1	137	143	PF00069	0.830
MOD_CK2_1	277	283	PF00069	0.684
MOD_CK2_1	284	290	PF00069	0.688
MOD_CK2_1	305	311	PF00069	0.698
MOD_CK2_1	408	414	PF00069	0.492
MOD_CK2_1	49	55	PF00069	0.643
MOD_GlcNHglycan	152	155	PF01048	0.739
MOD_GlcNHglycan	249	252	PF01048	0.783
MOD_GlcNHglycan	348	351	PF01048	0.723
MOD_GlcNHglycan	403	406	PF01048	0.455
MOD_GlcNHglycan	438	441	PF01048	0.730
MOD_GlcNHglycan	58	62	PF01048	0.735
MOD_GlcNHglycan	90	93	PF01048	0.643
MOD_GSK3_1	184	191	PF00069	0.708
MOD_GSK3_1	230	237	PF00069	0.702
MOD_GSK3_1	243	250	PF00069	0.643
MOD_GSK3_1	254	261	PF00069	0.744
MOD_GSK3_1	273	280	PF00069	0.728
MOD_GSK3_1	282	289	PF00069	0.643
MOD_GSK3_1	331	338	PF00069	0.702
MOD_GSK3_1	34	41	PF00069	0.601
MOD_GSK3_1	342	349	PF00069	0.581
MOD_GSK3_1	436	443	PF00069	0.799
MOD_GSK3_1	458	465	PF00069	0.745
MOD_GSK3_1	471	478	PF00069	0.562
MOD_N-GLC_1	234	239	PF02516	0.654
MOD_N-GLC_1	88	93	PF02516	0.704
MOD_NEK2_1	422	427	PF00069	0.670
MOD_NEK2_1	482	487	PF00069	0.668
MOD_NEK2_1	8	13	PF00069	0.573
MOD_NEK2_1	82	87	PF00069	0.673
MOD_NEK2_1	90	95	PF00069	0.700
MOD_NEK2_2	475	480	PF00069	0.660
MOD_PIKK_1	424	430	PF00454	0.546
MOD_PKA_1	184	190	PF00069	0.612
MOD_PKA_1	247	253	PF00069	0.642
MOD_PKA_2	243	249	PF00069	0.726
MOD_PKA_2	436	442	PF00069	0.699
MOD_PKA_2	458	464	PF00069	0.737
MOD_Plk_1	103	109	PF00069	0.704
MOD_Plk_1	234	240	PF00069	0.651
MOD_Plk_1	74	80	PF00069	0.722
MOD_Plk_2-3	408	414	PF00069	0.476
MOD_Plk_4	362	368	PF00069	0.574
MOD_Plk_4	44	50	PF00069	0.549
MOD_Plk_4	478	484	PF00069	0.604
MOD_ProDKin_1	153	159	PF00069	0.753
MOD_ProDKin_1	171	177	PF00069	0.838
MOD_ProDKin_1	188	194	PF00069	0.751
MOD_ProDKin_1	250	256	PF00069	0.671
MOD_ProDKin_1	328	334	PF00069	0.738
MOD_ProDKin_1	431	437	PF00069	0.705
MOD_ProDKin_1	443	449	PF00069	0.640
MOD_ProDKin_1	471	477	PF00069	0.775
MOD_SUMO_for_1	183	186	PF00179	0.783
MOD_SUMO_for_1	231	234	PF00179	0.683
MOD_SUMO_for_1	293	296	PF00179	0.666
MOD_SUMO_for_1	386	389	PF00179	0.533
MOD_SUMO_rev_2	138	148	PF00179	0.709
MOD_SUMO_rev_2	381	388	PF00179	0.574
TRG_DiLeu_BaEn_2	388	394	PF01217	0.663
TRG_DiLeu_BaLyEn_6	10	15	PF01217	0.678
TRG_ENDOCYTIC_2	110	113	PF00928	0.624
TRG_ENDOCYTIC_2	46	49	PF00928	0.567
TRG_ENDOCYTIC_2	79	82	PF00928	0.636
TRG_NLS_MonoCore_2	208	213	PF00514	0.711
TRG_NLS_MonoExtC_3	208	214	PF00514	0.711
TRG_NLS_MonoExtN_4	244	251	PF00514	0.632
TRG_Pf-PMV_PEXEL_1	267	271	PF00026	0.727

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYZ0	Leptomonas seymouri	46%	95%
A0A1X0PAH9	Trypanosomatidae	28%	93%
A4HBE4	Leishmania braziliensis	64%	99%
A4IAJ2	Leishmania infantum	100%	100%
E9B5L6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q2C0	Leishmania major	87%	100%