Ribosomal protein L7Ae/L30e/S12e/Gadd45 family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleolar protein family a member-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7X8I5_LEIDO

TriTrypDb:

LdBPK_343810.1 , LdCL_340047500 , LDHU3_34.6110

Length:

148

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	6
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	7
GO:0043228	non-membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043232	intracellular non-membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7
GO:1990904	ribonucleoprotein complex	2	11
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0005732	sno(s)RNA-containing ribonucleoprotein complex	3	1
GO:0031429	box H/ACA snoRNP complex	3	1
GO:0072588	box H/ACA RNP complex	4	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A0A3S7X8I5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8I5

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	11
GO:0022613	ribonucleoprotein complex biogenesis	4	9
GO:0042254	ribosome biogenesis	5	9
GO:0044085	cellular component biogenesis	3	9
GO:0071840	cellular component organization or biogenesis	2	9
GO:0000154	rRNA modification	6	1
GO:0000469	cleavage involved in rRNA processing	7	1
GO:0000470	maturation of LSU-rRNA	9	1
GO:0001522	pseudouridine synthesis	6	1
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009451	RNA modification	5	1
GO:0016070	RNA metabolic process	5	2
GO:0016072	rRNA metabolic process	7	1
GO:0016073	snRNA metabolic process	7	1
GO:0031118	rRNA pseudouridine synthesis	7	1
GO:0031120	snRNA pseudouridine synthesis	7	1
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0040031	snRNA modification	6	1
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0090501	RNA phosphodiester bond hydrolysis	6	1
GO:1901360	organic cyclic compound metabolic process	3	2
GO:0006399	tRNA metabolic process	7	1
GO:0006412	translation	4	1
GO:0006518	peptide metabolic process	4	1
GO:0008033	tRNA processing	8	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0019538	protein metabolic process	3	1
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	1
GO:0043043	peptide biosynthetic process	5	1
GO:0043603	amide metabolic process	3	1
GO:0043604	amide biosynthetic process	4	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	2
GO:0030515	snoRNA binding	5	1
GO:0034513	box H/ACA snoRNA binding	6	1
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2
GO:0003735	structural constituent of ribosome	2	1
GO:0005198	structural molecule activity	1	1
GO:0019843	rRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	66	68	PF00675	0.357
CLV_PCSK_KEX2_1	116	118	PF00082	0.345
CLV_PCSK_KEX2_1	52	54	PF00082	0.405
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.357
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.405
CLV_PCSK_SKI1_1	116	120	PF00082	0.356
CLV_PCSK_SKI1_1	136	140	PF00082	0.320
CLV_PCSK_SKI1_1	45	49	PF00082	0.365
CLV_PCSK_SKI1_1	57	61	PF00082	0.340
CLV_PCSK_SKI1_1	71	75	PF00082	0.224
DOC_MAPK_gen_1	116	124	PF00069	0.557
DOC_MAPK_gen_1	67	76	PF00069	0.557
DOC_MAPK_MEF2A_6	117	126	PF00069	0.637
DOC_USP7_MATH_1	27	31	PF00917	0.566
DOC_USP7_UBL2_3	34	38	PF12436	0.545
DOC_USP7_UBL2_3	60	64	PF12436	0.594
DOC_WW_Pin1_4	78	83	PF00397	0.557
LIG_14-3-3_CanoR_1	117	122	PF00244	0.555
LIG_14-3-3_CanoR_1	21	27	PF00244	0.559
LIG_BIR_III_2	79	83	PF00653	0.571
LIG_CSL_BTD_1	101	104	PF09270	0.557
LIG_FHA_1	117	123	PF00498	0.557
LIG_FHA_1	34	40	PF00498	0.530
LIG_FHA_1	61	67	PF00498	0.557
LIG_LIR_Apic_2	18	23	PF02991	0.642
LIG_LIR_Gen_1	132	141	PF02991	0.519
LIG_LIR_Gen_1	81	91	PF02991	0.557
LIG_LIR_Nem_3	132	137	PF02991	0.522
LIG_LIR_Nem_3	81	86	PF02991	0.557
LIG_SH2_CRK	134	138	PF00017	0.572
LIG_SH2_CRK	20	24	PF00017	0.555
LIG_SH2_CRK	40	44	PF00017	0.529
LIG_SH2_CRK	83	87	PF00017	0.571
LIG_SH2_NCK_1	83	87	PF00017	0.571
LIG_SH2_PTP2	100	103	PF00017	0.557
LIG_SH2_STAP1	134	138	PF00017	0.499
LIG_SH2_STAP1	15	19	PF00017	0.608
LIG_SH2_STAT5	100	103	PF00017	0.557
LIG_SH3_3	98	104	PF00018	0.557
LIG_SUMO_SIM_anti_2	119	125	PF11976	0.557
LIG_SUMO_SIM_par_1	137	143	PF11976	0.546
LIG_TRAF2_1	9	12	PF00917	0.743
LIG_TYR_ITIM	98	103	PF00017	0.557
MOD_GSK3_1	22	29	PF00069	0.553
MOD_PIKK_1	110	116	PF00454	0.557
MOD_PK_1	117	123	PF00069	0.557
MOD_PKA_1	116	122	PF00069	0.557
MOD_PKA_2	116	122	PF00069	0.555
MOD_Plk_4	117	123	PF00069	0.553
MOD_Plk_4	38	44	PF00069	0.517
MOD_ProDKin_1	78	84	PF00069	0.557
MOD_SUMO_rev_2	128	133	PF00179	0.600
MOD_SUMO_rev_2	94	99	PF00179	0.571
TRG_ENDOCYTIC_2	100	103	PF00928	0.557
TRG_ENDOCYTIC_2	134	137	PF00928	0.502
TRG_ENDOCYTIC_2	40	43	PF00928	0.492
TRG_ENDOCYTIC_2	83	86	PF00928	0.571
TRG_NLS_Bipartite_1	37	55	PF00514	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HQX1	Leptomonas seymouri	30%	69%
A0A0N1I8X8	Leptomonas seymouri	93%	100%
A0A0S4JKB4	Bodo saltans	28%	100%
A0A0S4KMG7	Bodo saltans	76%	100%
A0A1X0NU51	Trypanosomatidae	30%	100%
A0A1X0PA41	Trypanosomatidae	82%	100%
A0A3Q8IDI1	Leishmania donovani	30%	100%
A0A3R7MN38	Trypanosoma rangeli	88%	99%
A0A3R7NA40	Trypanosoma rangeli	30%	100%
A2BK92	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	32%	100%
A4H8B5	Leishmania braziliensis	30%	100%
A4HBC1	Leishmania braziliensis	93%	100%
A4HWN5	Leishmania infantum	30%	100%
A4IAG9	Leishmania infantum	99%	100%
A4YIL9	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	28%	100%
B8D6E8	Desulfurococcus amylolyticus (strain DSM 18924 / JCM 16383 / VKM B-2413 / 1221n)	35%	100%
C3MJN1	Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)	33%	100%
C3MYY9	Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)	33%	100%
C3N038	Sulfolobus islandicus (strain M.16.27)	33%	100%
C3N8Q2	Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)	33%	100%
C3NMR6	Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)	33%	100%
C4KJ77	Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)	33%	100%
C9ZLS2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	76%	100%
C9ZXQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AQE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B5J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
O29494	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	31%	100%
O74690	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
P0CQ52	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	28%	100%
P0CQ53	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	28%	100%
P32495	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	95%
P55858	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	31%	100%
P62426	Methanococcus maripaludis (strain S2 / LL)	32%	100%
P62427	Nanoarchaeum equitans (strain Kin4-M)	29%	100%
Q21568	Caenorhabditis elegans	31%	100%
Q4J8P1	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	35%	100%
Q4P0K3	Ustilago maydis (strain 521 / FGSC 9021)	31%	100%
Q4Q2E3	Leishmania major	97%	100%
Q4QF32	Leishmania major	30%	100%
Q54ST0	Dictyostelium discoideum	31%	100%
Q5ANL6	Candida albicans (strain SC5314 / ATCC MYA-2876)	26%	100%
Q5E950	Bos taurus	43%	97%
Q5RC65	Pongo abelii	41%	97%
Q5XH16	Xenopus laevis	33%	100%
Q60YI3	Caenorhabditis briggsae	40%	91%
Q6BLQ3	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	25%	100%
Q6KZI7	Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)	32%	100%
Q6NTV9	Xenopus laevis	41%	99%
Q6P8C4	Xenopus tropicalis	42%	99%
Q6P8E9	Xenopus tropicalis	31%	100%
Q6PBV6	Danio rerio	39%	99%
Q6XIP0	Drosophila yakuba	37%	92%
Q8I7X7	Branchiostoma belcheri	46%	93%
Q971C9	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	35%	100%
Q97BK8	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	34%	100%
Q9CRB2	Mus musculus	40%	97%
Q9LEY9	Arabidopsis thaliana	43%	95%
Q9NX24	Homo sapiens	42%	97%
Q9P7H0	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	96%
Q9U3Z7	Drosophila melanogaster	32%	100%
Q9V3U2	Drosophila melanogaster	38%	92%
Q9XXD4	Caenorhabditis elegans	41%	91%