LeishMANIAdb
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Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical_protein_conserved
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7X8G4_LEIDO
TriTrypDb:
LdBPK_343610.1 , LdCL_340045500 , LDHU3_34.5860
Length:
197

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

A0A3S7X8G4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8G4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 139 141 PF00675 0.589
CLV_PCSK_KEX2_1 139 141 PF00082 0.655
CLV_PCSK_KEX2_1 39 41 PF00082 0.422
CLV_PCSK_PC1ET2_1 139 141 PF00082 0.655
CLV_PCSK_PC1ET2_1 39 41 PF00082 0.480
CLV_PCSK_SKI1_1 158 162 PF00082 0.640
CLV_PCSK_SKI1_1 74 78 PF00082 0.641
DOC_MAPK_gen_1 9 17 PF00069 0.607
DOC_PP1_RVXF_1 124 130 PF00149 0.520
DOC_PP1_RVXF_1 180 187 PF00149 0.514
LIG_14-3-3_CanoR_1 11 16 PF00244 0.567
LIG_14-3-3_CterR_2 194 197 PF00244 0.522
LIG_BIR_II_1 1 5 PF00653 0.587
LIG_FHA_1 12 18 PF00498 0.579
LIG_GBD_Chelix_1 56 64 PF00786 0.310
LIG_LIR_Gen_1 168 177 PF02991 0.496
LIG_LIR_Gen_1 2 12 PF02991 0.572
LIG_LIR_Nem_3 130 134 PF02991 0.464
LIG_LIR_Nem_3 2 8 PF02991 0.633
LIG_LIR_Nem_3 35 41 PF02991 0.673
LIG_LYPXL_S_1 68 72 PF13949 0.496
LIG_LYPXL_yS_3 100 103 PF13949 0.415
LIG_LYPXL_yS_3 69 72 PF13949 0.383
LIG_SH2_CRK 5 9 PF00017 0.613
LIG_SH2_STAT5 71 74 PF00017 0.445
LIG_SH2_STAT5 75 78 PF00017 0.444
LIG_SH3_3 31 37 PF00018 0.602
LIG_SUMO_SIM_par_1 13 18 PF11976 0.660
LIG_TYR_ITIM 67 72 PF00017 0.470
LIG_UBA3_1 159 164 PF00899 0.541
LIG_WRC_WIRS_1 20 25 PF05994 0.603
MOD_CK1_1 32 38 PF00069 0.514
MOD_GlcNHglycan 112 115 PF01048 0.728
MOD_GlcNHglycan 167 170 PF01048 0.597
MOD_GlcNHglycan 31 34 PF01048 0.449
MOD_N-GLC_1 118 123 PF02516 0.622
MOD_NEK2_1 10 15 PF00069 0.439
MOD_NEK2_1 29 34 PF00069 0.444
MOD_PIKK_1 118 124 PF00454 0.611
MOD_PKA_2 10 16 PF00069 0.450
MOD_Plk_1 118 124 PF00069 0.621
MOD_Plk_1 152 158 PF00069 0.488
MOD_Plk_4 51 57 PF00069 0.424
MOD_SUMO_for_1 162 165 PF00179 0.643
MOD_SUMO_for_1 45 48 PF00179 0.607
TRG_DiLeu_BaEn_1 180 185 PF01217 0.624
TRG_DiLeu_BaLyEn_6 62 67 PF01217 0.410
TRG_ENDOCYTIC_2 100 103 PF00928 0.518
TRG_ENDOCYTIC_2 170 173 PF00928 0.698
TRG_ENDOCYTIC_2 5 8 PF00928 0.554
TRG_ENDOCYTIC_2 69 72 PF00928 0.474
TRG_ER_diArg_1 186 189 PF00400 0.628
TRG_ER_diArg_1 88 91 PF00400 0.503

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6S8 Leptomonas seymouri 61% 100%
A0A0S4KIP5 Bodo saltans 37% 99%
A0A1X0PAY8 Trypanosomatidae 46% 100%
A4HBA1 Leishmania braziliensis 85% 100%
A4IAE9 Leishmania infantum 100% 100%
C9ZLU5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 100%
E9B5H3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
Q4Q2G2 Leishmania major 96% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS