Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X8G3_LEIDO

TriTrypDb:

LdBPK_343760.1 , LdCL_340047000 , LDHU3_34.6040

Length:

270

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0020016	ciliary pocket	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X8G3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8G3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.477
CLV_C14_Caspase3-7	20	24	PF00656	0.614
CLV_NRD_NRD_1	161	163	PF00675	0.554
CLV_NRD_NRD_1	206	208	PF00675	0.531
CLV_NRD_NRD_1	66	68	PF00675	0.443
CLV_NRD_NRD_1	7	9	PF00675	0.522
CLV_NRD_NRD_1	73	75	PF00675	0.474
CLV_NRD_NRD_1	81	83	PF00675	0.543
CLV_PCSK_FUR_1	204	208	PF00082	0.530
CLV_PCSK_KEX2_1	160	162	PF00082	0.546
CLV_PCSK_KEX2_1	206	208	PF00082	0.531
CLV_PCSK_KEX2_1	66	68	PF00082	0.442
CLV_PCSK_KEX2_1	7	9	PF00082	0.522
CLV_PCSK_KEX2_1	81	83	PF00082	0.555
CLV_PCSK_SKI1_1	161	165	PF00082	0.518
CLV_PCSK_SKI1_1	173	177	PF00082	0.434
CLV_PCSK_SKI1_1	209	213	PF00082	0.589
CLV_PCSK_SKI1_1	217	221	PF00082	0.544
CLV_PCSK_SKI1_1	75	79	PF00082	0.512
DOC_ANK_TNKS_1	81	88	PF00023	0.544
DOC_CYCLIN_RxL_1	69	79	PF00134	0.511
DOC_MAPK_gen_1	160	172	PF00069	0.476
DOC_MAPK_MEF2A_6	165	172	PF00069	0.572
DOC_MAPK_RevD_3	51	67	PF00069	0.498
DOC_PP4_FxxP_1	114	117	PF00568	0.586
DOC_USP7_MATH_1	153	157	PF00917	0.627
DOC_USP7_MATH_1	18	22	PF00917	0.703
DOC_USP7_MATH_1	237	241	PF00917	0.636
DOC_USP7_MATH_1	243	247	PF00917	0.732
DOC_WW_Pin1_4	14	19	PF00397	0.636
DOC_WW_Pin1_4	164	169	PF00397	0.578
DOC_WW_Pin1_4	247	252	PF00397	0.549
DOC_WW_Pin1_4	254	259	PF00397	0.510
LIG_14-3-3_CanoR_1	105	114	PF00244	0.635
LIG_14-3-3_CanoR_1	136	142	PF00244	0.571
LIG_14-3-3_CanoR_1	39	49	PF00244	0.646
LIG_14-3-3_CanoR_1	7	15	PF00244	0.555
LIG_14-3-3_CterR_2	265	270	PF00244	0.546
LIG_APCC_ABBA_1	49	54	PF00400	0.542
LIG_BIR_II_1	1	5	PF00653	0.721
LIG_FHA_1	107	113	PF00498	0.642
LIG_FHA_1	165	171	PF00498	0.566
LIG_FHA_1	236	242	PF00498	0.580
LIG_FHA_1	88	94	PF00498	0.624
LIG_FHA_2	18	24	PF00498	0.579
LIG_LIR_Apic_2	10	16	PF02991	0.624
LIG_LIR_Apic_2	113	117	PF02991	0.586
LIG_LIR_Gen_1	257	267	PF02991	0.597
LIG_LIR_Nem_3	205	211	PF02991	0.482
LIG_LIR_Nem_3	257	263	PF02991	0.606
LIG_SH2_CRK	260	264	PF00017	0.560
LIG_SH2_SRC	142	145	PF00017	0.539
LIG_SH2_STAT5	218	221	PF00017	0.471
LIG_SH2_STAT5	256	259	PF00017	0.572
LIG_SH3_3	12	18	PF00018	0.610
LIG_WRC_WIRS_1	188	193	PF05994	0.545
LIG_WW_3	265	269	PF00397	0.629
MOD_CDK_SPK_2	254	259	PF00069	0.561
MOD_CK1_1	106	112	PF00069	0.603
MOD_CK1_1	17	23	PF00069	0.692
MOD_CK1_1	261	267	PF00069	0.555
MOD_CK1_1	96	102	PF00069	0.676
MOD_CK2_1	153	159	PF00069	0.478
MOD_Cter_Amidation	79	82	PF01082	0.519
MOD_GlcNHglycan	1	4	PF01048	0.651
MOD_GlcNHglycan	109	112	PF01048	0.485
MOD_GlcNHglycan	127	130	PF01048	0.637
MOD_GlcNHglycan	220	223	PF01048	0.599
MOD_GlcNHglycan	241	244	PF01048	0.695
MOD_GlcNHglycan	245	248	PF01048	0.596
MOD_GlcNHglycan	93	96	PF01048	0.626
MOD_GSK3_1	103	110	PF00069	0.742
MOD_GSK3_1	116	123	PF00069	0.619
MOD_GSK3_1	14	21	PF00069	0.704
MOD_GSK3_1	235	242	PF00069	0.567
MOD_GSK3_1	243	250	PF00069	0.675
MOD_GSK3_1	254	261	PF00069	0.568
MOD_GSK3_1	35	42	PF00069	0.601
MOD_GSK3_1	87	94	PF00069	0.626
MOD_N-GLC_1	230	235	PF02516	0.627
MOD_NEK2_1	187	192	PF00069	0.652
MOD_NEK2_1	230	235	PF00069	0.711
MOD_PIKK_1	21	27	PF00454	0.602
MOD_PIKK_1	245	251	PF00454	0.620
MOD_PKA_2	135	141	PF00069	0.664
MOD_PKA_2	21	27	PF00069	0.677
MOD_PKA_2	258	264	PF00069	0.636
MOD_PKA_2	38	44	PF00069	0.545
MOD_PKA_2	6	12	PF00069	0.664
MOD_Plk_1	182	188	PF00069	0.598
MOD_Plk_4	137	143	PF00069	0.675
MOD_Plk_4	182	188	PF00069	0.551
MOD_ProDKin_1	14	20	PF00069	0.636
MOD_ProDKin_1	164	170	PF00069	0.569
MOD_ProDKin_1	247	253	PF00069	0.554
MOD_ProDKin_1	254	260	PF00069	0.515
MOD_SUMO_for_1	45	48	PF00179	0.543
TRG_DiLeu_BaEn_1	159	164	PF01217	0.603
TRG_DiLeu_BaLyEn_6	207	212	PF01217	0.548
TRG_DiLeu_LyEn_5	159	164	PF01217	0.524
TRG_ENDOCYTIC_2	260	263	PF00928	0.565
TRG_ER_diArg_1	160	162	PF00400	0.553
TRG_ER_diArg_1	206	208	PF00400	0.497
TRG_ER_diArg_1	6	8	PF00400	0.521
TRG_Pf-PMV_PEXEL_1	209	214	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	58	62	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	75	79	PF00026	0.459

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P700	Leptomonas seymouri	48%	100%
A0A0S4JIE0	Bodo saltans	33%	100%
A0A1X0PA42	Trypanosomatidae	35%	100%
A0A3R7M3X3	Trypanosoma rangeli	38%	100%
A4HBB6	Leishmania braziliensis	69%	100%
A4IAG4	Leishmania infantum	100%	100%
E9B5I8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q2E7	Leishmania major	90%	100%