NLI interacting factor-like phosphatase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NLI interacting factor-like phosphatase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X8G2_LEIDO

TriTrypDb:

LdBPK_343730.1 , LdCL_340046700 , LDHU3_34.6000

Length:

531

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X8G2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8G2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004721	phosphoprotein phosphatase activity	3	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.709
CLV_C14_Caspase3-7	233	237	PF00656	0.681
CLV_C14_Caspase3-7	421	425	PF00656	0.718
CLV_C14_Caspase3-7	53	57	PF00656	0.648
CLV_C14_Caspase3-7	85	89	PF00656	0.768
CLV_NRD_NRD_1	147	149	PF00675	0.726
CLV_NRD_NRD_1	155	157	PF00675	0.731
CLV_NRD_NRD_1	201	203	PF00675	0.682
CLV_NRD_NRD_1	204	206	PF00675	0.666
CLV_NRD_NRD_1	208	210	PF00675	0.646
CLV_NRD_NRD_1	216	218	PF00675	0.614
CLV_NRD_NRD_1	238	240	PF00675	0.657
CLV_NRD_NRD_1	306	308	PF00675	0.411
CLV_NRD_NRD_1	38	40	PF00675	0.675
CLV_PCSK_FUR_1	316	320	PF00082	0.411
CLV_PCSK_KEX2_1	147	149	PF00082	0.730
CLV_PCSK_KEX2_1	154	156	PF00082	0.737
CLV_PCSK_KEX2_1	201	203	PF00082	0.767
CLV_PCSK_KEX2_1	208	210	PF00082	0.648
CLV_PCSK_KEX2_1	216	218	PF00082	0.643
CLV_PCSK_KEX2_1	238	240	PF00082	0.650
CLV_PCSK_KEX2_1	306	308	PF00082	0.411
CLV_PCSK_KEX2_1	318	320	PF00082	0.411
CLV_PCSK_KEX2_1	38	40	PF00082	0.675
CLV_PCSK_PC1ET2_1	318	320	PF00082	0.399
CLV_PCSK_PC7_1	234	240	PF00082	0.515
CLV_PCSK_SKI1_1	156	160	PF00082	0.705
CLV_PCSK_SKI1_1	378	382	PF00082	0.380
CLV_PCSK_SKI1_1	423	427	PF00082	0.714
CLV_Separin_Metazoa	270	274	PF03568	0.511
DEG_SPOP_SBC_1	175	179	PF00917	0.699
DEG_SPOP_SBC_1	63	67	PF00917	0.666
DEG_SPOP_SBC_1	72	76	PF00917	0.504
DOC_CYCLIN_RxL_1	375	385	PF00134	0.467
DOC_CYCLIN_RxL_1	483	493	PF00134	0.531
DOC_CYCLIN_yCln2_LP_2	219	222	PF00134	0.533
DOC_MAPK_MEF2A_6	273	282	PF00069	0.411
DOC_PP2B_LxvP_1	219	222	PF13499	0.589
DOC_PP4_FxxP_1	3	6	PF00568	0.709
DOC_USP7_MATH_1	158	162	PF00917	0.718
DOC_USP7_MATH_1	173	177	PF00917	0.710
DOC_USP7_MATH_1	210	214	PF00917	0.639
DOC_USP7_MATH_1	29	33	PF00917	0.714
DOC_USP7_MATH_1	353	357	PF00917	0.511
DOC_USP7_MATH_1	370	374	PF00917	0.411
DOC_USP7_MATH_1	392	396	PF00917	0.627
DOC_USP7_MATH_1	425	429	PF00917	0.598
DOC_USP7_MATH_1	432	436	PF00917	0.730
DOC_USP7_MATH_1	437	441	PF00917	0.520
DOC_USP7_MATH_1	510	514	PF00917	0.674
DOC_USP7_MATH_1	518	522	PF00917	0.517
DOC_WW_Pin1_4	414	419	PF00397	0.758
DOC_WW_Pin1_4	490	495	PF00397	0.478
DOC_WW_Pin1_4	6	11	PF00397	0.727
LIG_14-3-3_CanoR_1	172	182	PF00244	0.761
LIG_14-3-3_CanoR_1	322	331	PF00244	0.358
LIG_14-3-3_CanoR_1	383	387	PF00244	0.381
LIG_14-3-3_CanoR_1	393	397	PF00244	0.529
LIG_14-3-3_CanoR_1	42	50	PF00244	0.694
LIG_ActinCP_TwfCPI_2	3	12	PF01115	0.732
LIG_BIR_II_1	1	5	PF00653	0.704
LIG_Clathr_ClatBox_1	341	345	PF01394	0.511
LIG_EH1_1	455	463	PF00400	0.504
LIG_eIF4E_1	91	97	PF01652	0.602
LIG_FHA_1	177	183	PF00498	0.676
LIG_FHA_1	428	434	PF00498	0.754
LIG_FHA_1	491	497	PF00498	0.563
LIG_FHA_1	74	80	PF00498	0.552
LIG_FHA_2	419	425	PF00498	0.737
LIG_GBD_Chelix_1	246	254	PF00786	0.411
LIG_LIR_Apic_2	2	6	PF02991	0.707
LIG_LIR_Apic_2	215	221	PF02991	0.583
LIG_LIR_Apic_2	289	295	PF02991	0.511
LIG_LIR_Apic_2	362	367	PF02991	0.511
LIG_LIR_Gen_1	92	101	PF02991	0.522
LIG_LIR_Nem_3	521	525	PF02991	0.497
LIG_LIR_Nem_3	88	94	PF02991	0.604
LIG_MYND_1	494	498	PF01753	0.566
LIG_MYND_3	438	442	PF01753	0.525
LIG_NRBOX	356	362	PF00104	0.511
LIG_NRBOX	376	382	PF00104	0.423
LIG_Pex14_2	124	128	PF04695	0.775
LIG_Pex14_2	244	248	PF04695	0.411
LIG_SH2_CRK	259	263	PF00017	0.399
LIG_SH2_CRK	492	496	PF00017	0.595
LIG_SH2_CRK	522	526	PF00017	0.502
LIG_SH2_CRK	94	98	PF00017	0.675
LIG_SH2_GRB2like	292	295	PF00017	0.411
LIG_SH2_GRB2like	78	81	PF00017	0.671
LIG_SH2_NCK_1	94	98	PF00017	0.675
LIG_SH2_PTP2	292	295	PF00017	0.511
LIG_SH2_SRC	292	295	PF00017	0.411
LIG_SH2_STAP1	388	392	PF00017	0.521
LIG_SH2_STAP1	68	72	PF00017	0.579
LIG_SH2_STAP1	73	77	PF00017	0.484
LIG_SH2_STAT5	292	295	PF00017	0.411
LIG_SH2_STAT5	364	367	PF00017	0.352
LIG_SH2_STAT5	492	495	PF00017	0.584
LIG_SH2_STAT5	73	76	PF00017	0.572
LIG_SH2_STAT5	78	81	PF00017	0.548
LIG_SH3_1	492	498	PF00018	0.618
LIG_SH3_2	37	42	PF14604	0.707
LIG_SH3_3	131	137	PF00018	0.587
LIG_SH3_3	34	40	PF00018	0.695
LIG_SH3_3	49	55	PF00018	0.626
LIG_SH3_3	492	498	PF00018	0.573
LIG_SH3_3	524	530	PF00018	0.611
LIG_SUMO_SIM_anti_2	371	379	PF11976	0.507
LIG_SUMO_SIM_anti_2	440	445	PF11976	0.546
LIG_SUMO_SIM_par_1	339	345	PF11976	0.411
LIG_SUMO_SIM_par_1	371	379	PF11976	0.397
LIG_TRAF2_1	404	407	PF00917	0.695
LIG_UBA3_1	374	378	PF00899	0.511
MOD_CDC14_SPxK_1	9	12	PF00782	0.730
MOD_CDK_SPK_2	414	419	PF00069	0.758
MOD_CDK_SPxK_1	6	12	PF00069	0.730
MOD_CK1_1	108	114	PF00069	0.668
MOD_CK1_1	163	169	PF00069	0.689
MOD_CK1_1	176	182	PF00069	0.679
MOD_CK1_1	224	230	PF00069	0.553
MOD_CK1_1	428	434	PF00069	0.601
MOD_CK1_1	521	527	PF00069	0.497
MOD_CK1_1	89	95	PF00069	0.623
MOD_CK2_1	396	402	PF00069	0.587
MOD_CK2_1	84	90	PF00069	0.624
MOD_Cter_Amidation	236	239	PF01082	0.663
MOD_Cter_Amidation	304	307	PF01082	0.411
MOD_GlcNHglycan	212	215	PF01048	0.699
MOD_GlcNHglycan	223	226	PF01048	0.516
MOD_GlcNHglycan	349	352	PF01048	0.511
MOD_GlcNHglycan	402	406	PF01048	0.637
MOD_GlcNHglycan	435	438	PF01048	0.519
MOD_GlcNHglycan	84	87	PF01048	0.751
MOD_GSK3_1	105	112	PF00069	0.765
MOD_GSK3_1	158	165	PF00069	0.651
MOD_GSK3_1	171	178	PF00069	0.646
MOD_GSK3_1	180	187	PF00069	0.781
MOD_GSK3_1	224	231	PF00069	0.582
MOD_GSK3_1	392	399	PF00069	0.655
MOD_GSK3_1	414	421	PF00069	0.777
MOD_GSK3_1	423	430	PF00069	0.700
MOD_GSK3_1	433	440	PF00069	0.513
MOD_GSK3_1	6	13	PF00069	0.735
MOD_GSK3_1	62	69	PF00069	0.710
MOD_GSK3_1	82	89	PF00069	0.705
MOD_N-GLC_2	325	327	PF02516	0.402
MOD_NEK2_1	1	6	PF00069	0.710
MOD_NEK2_1	14	19	PF00069	0.712
MOD_NEK2_1	250	255	PF00069	0.380
MOD_NEK2_1	271	276	PF00069	0.459
MOD_NEK2_1	396	401	PF00069	0.549
MOD_NEK2_1	41	46	PF00069	0.754
MOD_NEK2_2	10	15	PF00069	0.740
MOD_NEK2_2	418	423	PF00069	0.731
MOD_NEK2_2	481	486	PF00069	0.546
MOD_PKA_1	147	153	PF00069	0.715
MOD_PKA_1	201	207	PF00069	0.724
MOD_PKA_2	14	20	PF00069	0.759
MOD_PKA_2	146	152	PF00069	0.725
MOD_PKA_2	171	177	PF00069	0.769
MOD_PKA_2	201	207	PF00069	0.766
MOD_PKA_2	21	27	PF00069	0.704
MOD_PKA_2	29	35	PF00069	0.691
MOD_PKA_2	382	388	PF00069	0.425
MOD_PKA_2	392	398	PF00069	0.633
MOD_PKA_2	41	47	PF00069	0.701
MOD_PKA_2	412	418	PF00069	0.718
MOD_PKA_2	428	434	PF00069	0.527
MOD_PKA_2	505	511	PF00069	0.689
MOD_Plk_1	250	256	PF00069	0.411
MOD_Plk_1	370	376	PF00069	0.411
MOD_Plk_2-3	109	115	PF00069	0.781
MOD_Plk_4	177	183	PF00069	0.691
MOD_Plk_4	250	256	PF00069	0.399
MOD_Plk_4	370	376	PF00069	0.511
MOD_Plk_4	465	471	PF00069	0.506
MOD_ProDKin_1	414	420	PF00069	0.760
MOD_ProDKin_1	490	496	PF00069	0.489
MOD_ProDKin_1	6	12	PF00069	0.730
TRG_DiLeu_BaEn_1	215	220	PF01217	0.690
TRG_DiLeu_BaEn_1	474	479	PF01217	0.537
TRG_DiLeu_BaLyEn_6	337	342	PF01217	0.384
TRG_DiLeu_BaLyEn_6	492	497	PF01217	0.575
TRG_ENDOCYTIC_2	259	262	PF00928	0.399
TRG_ENDOCYTIC_2	522	525	PF00928	0.458
TRG_ENDOCYTIC_2	94	97	PF00928	0.580
TRG_ER_diArg_1	146	148	PF00400	0.738
TRG_ER_diArg_1	154	156	PF00400	0.745
TRG_ER_diArg_1	216	218	PF00400	0.610
TRG_ER_diArg_1	37	39	PF00400	0.756
TRG_NES_CRM1_1	240	252	PF08389	0.511
TRG_NES_CRM1_1	270	281	PF08389	0.411
TRG_NES_CRM1_1	333	345	PF08389	0.511
TRG_NLS_MonoExtC_3	204	209	PF00514	0.721
TRG_NLS_MonoExtN_4	202	209	PF00514	0.722
TRG_Pf-PMV_PEXEL_1	340	345	PF00026	0.333
TRG_Pf-PMV_PEXEL_1	378	382	PF00026	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCT0	Leptomonas seymouri	54%	100%
A4HBB3	Leishmania braziliensis	73%	100%
A4IAG1	Leishmania infantum	100%	100%
E9B5I5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q2F0	Leishmania major	90%	99%