Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X8F7_LEIDO

TriTrypDb:

LdBPK_343170.1 , LdCL_340040600 , LDHU3_34.5340

Length:

729

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X8F7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8F7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	572	576	PF00656	0.751
CLV_C14_Caspase3-7	61	65	PF00656	0.475
CLV_NRD_NRD_1	241	243	PF00675	0.757
CLV_NRD_NRD_1	523	525	PF00675	0.497
CLV_NRD_NRD_1	653	655	PF00675	0.609
CLV_NRD_NRD_1	71	73	PF00675	0.605
CLV_PCSK_KEX2_1	118	120	PF00082	0.505
CLV_PCSK_KEX2_1	241	243	PF00082	0.757
CLV_PCSK_KEX2_1	29	31	PF00082	0.562
CLV_PCSK_KEX2_1	525	527	PF00082	0.548
CLV_PCSK_KEX2_1	652	654	PF00082	0.662
CLV_PCSK_KEX2_1	71	73	PF00082	0.605
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.505
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.562
CLV_PCSK_PC1ET2_1	525	527	PF00082	0.527
CLV_PCSK_PC7_1	649	655	PF00082	0.643
CLV_PCSK_SKI1_1	138	142	PF00082	0.461
CLV_PCSK_SKI1_1	202	206	PF00082	0.621
CLV_PCSK_SKI1_1	307	311	PF00082	0.559
CLV_PCSK_SKI1_1	35	39	PF00082	0.547
CLV_PCSK_SKI1_1	42	46	PF00082	0.521
CLV_PCSK_SKI1_1	584	588	PF00082	0.588
CLV_PCSK_SKI1_1	642	646	PF00082	0.541
CLV_Separin_Metazoa	39	43	PF03568	0.651
CLV_Separin_Metazoa	608	612	PF03568	0.664
DEG_APCC_DBOX_1	34	42	PF00400	0.537
DEG_APCC_DBOX_1	651	659	PF00400	0.651
DEG_APCC_KENBOX_2	335	339	PF00400	0.686
DEG_Nend_Nbox_1	1	3	PF02207	0.609
DEG_SCF_FBW7_1	372	378	PF00400	0.719
DEG_SCF_FBW7_2	685	691	PF00400	0.672
DEG_SPOP_SBC_1	700	704	PF00917	0.592
DOC_CKS1_1	372	377	PF01111	0.713
DOC_CKS1_1	408	413	PF01111	0.675
DOC_CKS1_1	682	687	PF01111	0.665
DOC_CYCLIN_RxL_1	135	144	PF00134	0.508
DOC_CYCLIN_yCln2_LP_2	692	698	PF00134	0.600
DOC_MAPK_gen_1	642	650	PF00069	0.506
DOC_MAPK_gen_1	652	660	PF00069	0.473
DOC_MAPK_HePTP_8	650	662	PF00069	0.663
DOC_MAPK_MEF2A_6	653	662	PF00069	0.576
DOC_PP1_RVXF_1	482	489	PF00149	0.555
DOC_PP2B_LxvP_1	409	412	PF13499	0.608
DOC_PP2B_LxvP_1	692	695	PF13499	0.646
DOC_PP2B_LxvP_1	720	723	PF13499	0.696
DOC_PP2B_PxIxI_1	264	270	PF00149	0.578
DOC_PP4_FxxP_1	488	491	PF00568	0.513
DOC_PP4_FxxP_1	84	87	PF00568	0.437
DOC_USP7_MATH_1	173	177	PF00917	0.601
DOC_USP7_MATH_1	273	277	PF00917	0.737
DOC_USP7_MATH_1	31	35	PF00917	0.517
DOC_USP7_MATH_1	375	379	PF00917	0.732
DOC_USP7_MATH_1	535	539	PF00917	0.615
DOC_USP7_MATH_1	630	634	PF00917	0.668
DOC_USP7_MATH_1	65	69	PF00917	0.543
DOC_USP7_MATH_1	700	704	PF00917	0.728
DOC_USP7_MATH_1	723	727	PF00917	0.666
DOC_WW_Pin1_4	103	108	PF00397	0.471
DOC_WW_Pin1_4	152	157	PF00397	0.476
DOC_WW_Pin1_4	246	251	PF00397	0.779
DOC_WW_Pin1_4	296	301	PF00397	0.655
DOC_WW_Pin1_4	312	317	PF00397	0.370
DOC_WW_Pin1_4	371	376	PF00397	0.773
DOC_WW_Pin1_4	407	412	PF00397	0.665
DOC_WW_Pin1_4	602	607	PF00397	0.665
DOC_WW_Pin1_4	681	686	PF00397	0.754
DOC_WW_Pin1_4	701	706	PF00397	0.790
DOC_WW_Pin1_4	709	714	PF00397	0.696
LIG_14-3-3_CanoR_1	223	228	PF00244	0.612
LIG_14-3-3_CanoR_1	30	38	PF00244	0.527
LIG_14-3-3_CanoR_1	555	560	PF00244	0.592
LIG_14-3-3_CanoR_1	611	617	PF00244	0.677
LIG_APCC_ABBA_1	207	212	PF00400	0.435
LIG_APCC_ABBAyCdc20_2	291	297	PF00400	0.672
LIG_Clathr_ClatBox_1	195	199	PF01394	0.579
LIG_Clathr_ClatBox_1	207	211	PF01394	0.416
LIG_deltaCOP1_diTrp_1	674	680	PF00928	0.798
LIG_eIF4E_1	110	116	PF01652	0.419
LIG_FAT_LD_1	15	23	PF03623	0.485
LIG_FHA_1	153	159	PF00498	0.562
LIG_FHA_1	184	190	PF00498	0.445
LIG_FHA_1	199	205	PF00498	0.522
LIG_FHA_1	264	270	PF00498	0.745
LIG_FHA_1	508	514	PF00498	0.635
LIG_FHA_1	549	555	PF00498	0.697
LIG_FHA_1	594	600	PF00498	0.527
LIG_FHA_1	617	623	PF00498	0.647
LIG_FHA_1	685	691	PF00498	0.651
LIG_FHA_1	715	721	PF00498	0.707
LIG_FHA_2	273	279	PF00498	0.779
LIG_FHA_2	437	443	PF00498	0.706
LIG_FHA_2	450	456	PF00498	0.606
LIG_FHA_2	475	481	PF00498	0.579
LIG_FHA_2	568	574	PF00498	0.579
LIG_Integrin_isoDGR_2	338	340	PF01839	0.700
LIG_Integrin_isoDGR_2	502	504	PF01839	0.563
LIG_IRF3_LxIS_1	137	144	PF10401	0.454
LIG_LIR_Apic_2	186	190	PF02991	0.543
LIG_LIR_Gen_1	111	120	PF02991	0.481
LIG_LIR_Gen_1	131	142	PF02991	0.381
LIG_LIR_Gen_1	177	188	PF02991	0.474
LIG_LIR_Gen_1	283	292	PF02991	0.653
LIG_LIR_Gen_1	494	501	PF02991	0.515
LIG_LIR_Gen_1	646	655	PF02991	0.534
LIG_LIR_Gen_1	679	688	PF02991	0.700
LIG_LIR_Nem_3	131	137	PF02991	0.499
LIG_LIR_Nem_3	152	157	PF02991	0.578
LIG_LIR_Nem_3	177	183	PF02991	0.492
LIG_LIR_Nem_3	283	288	PF02991	0.667
LIG_LIR_Nem_3	302	308	PF02991	0.311
LIG_LIR_Nem_3	494	500	PF02991	0.508
LIG_LIR_Nem_3	565	571	PF02991	0.673
LIG_LIR_Nem_3	646	650	PF02991	0.528
LIG_LIR_Nem_3	679	683	PF02991	0.710
LIG_NRBOX	14	20	PF00104	0.492
LIG_NRBOX	226	232	PF00104	0.552
LIG_PCNA_yPIPBox_3	359	367	PF02747	0.497
LIG_PDZ_Class_2	724	729	PF00595	0.750
LIG_Pex14_1	617	621	PF04695	0.588
LIG_Pex14_2	324	328	PF04695	0.533
LIG_Pex14_2	9	13	PF04695	0.522
LIG_PTB_Apo_2	148	155	PF02174	0.493
LIG_PTB_Phospho_1	148	154	PF10480	0.595
LIG_RPA_C_Fungi	649	661	PF08784	0.660
LIG_SH2_CRK	120	124	PF00017	0.587
LIG_SH2_CRK	134	138	PF00017	0.353
LIG_SH2_CRK	154	158	PF00017	0.219
LIG_SH2_CRK	187	191	PF00017	0.550
LIG_SH2_CRK	497	501	PF00017	0.530
LIG_SH2_GRB2like	366	369	PF00017	0.534
LIG_SH2_GRB2like	629	632	PF00017	0.649
LIG_SH2_NCK_1	187	191	PF00017	0.550
LIG_SH2_NCK_1	497	501	PF00017	0.509
LIG_SH2_NCK_1	629	633	PF00017	0.731
LIG_SH2_SRC	629	632	PF00017	0.649
LIG_SH2_STAP1	55	59	PF00017	0.531
LIG_SH2_STAT5	154	157	PF00017	0.553
LIG_SH2_STAT5	2	5	PF00017	0.674
LIG_SH2_STAT5	216	219	PF00017	0.478
LIG_SH2_STAT5	308	311	PF00017	0.510
LIG_SH2_STAT5	366	369	PF00017	0.556
LIG_SH2_STAT5	519	522	PF00017	0.625
LIG_SH2_STAT5	647	650	PF00017	0.505
LIG_SH2_STAT5	83	86	PF00017	0.443
LIG_SH3_3	197	203	PF00018	0.607
LIG_SH3_3	391	397	PF00018	0.775
LIG_SH3_3	417	423	PF00018	0.798
LIG_SH3_3	635	641	PF00018	0.647
LIG_SH3_3	666	672	PF00018	0.766
LIG_SH3_3	679	685	PF00018	0.656
LIG_SUMO_SIM_anti_2	556	561	PF11976	0.587
LIG_SUMO_SIM_par_1	265	272	PF11976	0.657
LIG_SUMO_SIM_par_1	585	591	PF11976	0.626
LIG_SUMO_SIM_par_1	686	693	PF11976	0.543
LIG_TRAF2_1	275	278	PF00917	0.700
LIG_TRAF2_1	570	573	PF00917	0.580
LIG_TRAF2_1	605	608	PF00917	0.570
LIG_TRAF2_2	316	321	PF00917	0.572
LIG_TRFH_1	497	501	PF08558	0.530
LIG_WRC_WIRS_1	10	15	PF05994	0.573
LIG_WRC_WIRS_1	59	64	PF05994	0.477
LIG_WW_3	423	427	PF00397	0.749
MOD_CDC14_SPxK_1	254	257	PF00782	0.633
MOD_CDK_SPxK_1	251	257	PF00069	0.630
MOD_CK1_1	152	158	PF00069	0.571
MOD_CK1_1	229	235	PF00069	0.698
MOD_CK1_1	249	255	PF00069	0.464
MOD_CK1_1	272	278	PF00069	0.700
MOD_CK1_1	378	384	PF00069	0.703
MOD_CK1_1	602	608	PF00069	0.664
MOD_CK2_1	272	278	PF00069	0.786
MOD_CK2_1	296	302	PF00069	0.542
MOD_CK2_1	436	442	PF00069	0.674
MOD_CK2_1	460	466	PF00069	0.630
MOD_CK2_1	474	480	PF00069	0.494
MOD_CK2_1	567	573	PF00069	0.583
MOD_CK2_1	602	608	PF00069	0.599
MOD_CK2_1	700	706	PF00069	0.724
MOD_GlcNHglycan	143	146	PF01048	0.540
MOD_GlcNHglycan	251	254	PF01048	0.702
MOD_GlcNHglycan	261	264	PF01048	0.683
MOD_GlcNHglycan	271	274	PF01048	0.625
MOD_GlcNHglycan	389	393	PF01048	0.778
MOD_GlcNHglycan	433	436	PF01048	0.704
MOD_GlcNHglycan	530	533	PF01048	0.650
MOD_GlcNHglycan	536	540	PF01048	0.628
MOD_GlcNHglycan	545	548	PF01048	0.745
MOD_GSK3_1	198	205	PF00069	0.584
MOD_GSK3_1	225	232	PF00069	0.644
MOD_GSK3_1	259	266	PF00069	0.690
MOD_GSK3_1	268	275	PF00069	0.651
MOD_GSK3_1	371	378	PF00069	0.688
MOD_GSK3_1	427	434	PF00069	0.686
MOD_GSK3_1	456	463	PF00069	0.662
MOD_GSK3_1	5	12	PF00069	0.573
MOD_GSK3_1	543	550	PF00069	0.704
MOD_GSK3_1	588	595	PF00069	0.526
MOD_GSK3_1	616	623	PF00069	0.649
MOD_N-GLC_1	150	155	PF02516	0.603
MOD_N-GLC_1	378	383	PF02516	0.733
MOD_N-GLC_1	5	10	PF02516	0.590
MOD_N-GLC_1	630	635	PF02516	0.672
MOD_NEK2_1	149	154	PF00069	0.589
MOD_NEK2_1	183	188	PF00069	0.549
MOD_NEK2_1	230	235	PF00069	0.601
MOD_NEK2_1	599	604	PF00069	0.540
MOD_NEK2_1	9	14	PF00069	0.525
MOD_NEK2_2	449	454	PF00069	0.627
MOD_NEK2_2	55	60	PF00069	0.536
MOD_PIKK_1	126	132	PF00454	0.630
MOD_PIKK_1	167	173	PF00454	0.602
MOD_PIKK_1	314	320	PF00454	0.662
MOD_PIKK_1	404	410	PF00454	0.668
MOD_PIKK_1	436	442	PF00454	0.620
MOD_PIKK_1	44	50	PF00454	0.559
MOD_PIKK_1	466	472	PF00454	0.599
MOD_PIKK_1	610	616	PF00454	0.677
MOD_PIKK_1	721	727	PF00454	0.712
MOD_PK_1	555	561	PF00069	0.590
MOD_PK_1	654	660	PF00069	0.661
MOD_PKA_2	474	480	PF00069	0.562
MOD_PKA_2	610	616	PF00069	0.636
MOD_PKB_1	223	231	PF00069	0.512
MOD_PKB_1	652	660	PF00069	0.663
MOD_Plk_1	150	156	PF00069	0.595
MOD_Plk_1	320	326	PF00069	0.667
MOD_Plk_1	456	462	PF00069	0.636
MOD_Plk_1	5	11	PF00069	0.585
MOD_Plk_2-3	588	594	PF00069	0.630
MOD_Plk_4	14	20	PF00069	0.441
MOD_Plk_4	175	181	PF00069	0.600
MOD_Plk_4	226	232	PF00069	0.654
MOD_Plk_4	456	462	PF00069	0.690
MOD_Plk_4	5	11	PF00069	0.630
MOD_Plk_4	555	561	PF00069	0.590
MOD_Plk_4	643	649	PF00069	0.525
MOD_ProDKin_1	103	109	PF00069	0.465
MOD_ProDKin_1	152	158	PF00069	0.469
MOD_ProDKin_1	246	252	PF00069	0.782
MOD_ProDKin_1	296	302	PF00069	0.644
MOD_ProDKin_1	312	318	PF00069	0.376
MOD_ProDKin_1	371	377	PF00069	0.781
MOD_ProDKin_1	407	413	PF00069	0.663
MOD_ProDKin_1	602	608	PF00069	0.664
MOD_ProDKin_1	681	687	PF00069	0.754
MOD_ProDKin_1	701	707	PF00069	0.791
MOD_ProDKin_1	709	715	PF00069	0.695
MOD_SUMO_rev_2	521	527	PF00179	0.557
TRG_DiLeu_BaEn_2	336	342	PF01217	0.705
TRG_DiLeu_BaLyEn_6	646	651	PF01217	0.626
TRG_ENDOCYTIC_2	110	113	PF00928	0.468
TRG_ENDOCYTIC_2	120	123	PF00928	0.488
TRG_ENDOCYTIC_2	134	137	PF00928	0.384
TRG_ENDOCYTIC_2	154	157	PF00928	0.223
TRG_ENDOCYTIC_2	216	219	PF00928	0.478
TRG_ENDOCYTIC_2	497	500	PF00928	0.493
TRG_ENDOCYTIC_2	568	571	PF00928	0.655
TRG_ENDOCYTIC_2	647	650	PF00928	0.468
TRG_ENDOCYTIC_2	83	86	PF00928	0.443
TRG_ER_diArg_1	240	242	PF00400	0.732
TRG_ER_diArg_1	310	313	PF00400	0.535
TRG_ER_diArg_1	524	527	PF00400	0.503
TRG_ER_diArg_1	651	654	PF00400	0.647
TRG_Pf-PMV_PEXEL_1	365	369	PF00026	0.581
TRG_Pf-PMV_PEXEL_1	462	466	PF00026	0.598

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I561	Leptomonas seymouri	44%	99%
A4HB58	Leishmania braziliensis	80%	100%
A4IAA5	Leishmania infantum	100%	100%
E9B5C8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q2K5	Leishmania major	93%	100%