LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7X8E8_LEIDO
TriTrypDb:
LdBPK_343420.1 , LdCL_340043600 , LDHU3_34.5640
Length:
162

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 6
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 2, no: 7
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

A0A3S7X8E8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8E8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 102 104 PF00675 0.540
CLV_NRD_NRD_1 4 6 PF00675 0.566
CLV_NRD_NRD_1 95 97 PF00675 0.563
CLV_PCSK_KEX2_1 102 104 PF00082 0.540
CLV_PCSK_KEX2_1 95 97 PF00082 0.563
DEG_SCF_FBW7_2 85 92 PF00400 0.785
DEG_SPOP_SBC_1 23 27 PF00917 0.593
DOC_MAPK_gen_1 65 73 PF00069 0.753
DOC_PP1_RVXF_1 73 79 PF00149 0.761
DOC_USP7_MATH_1 138 142 PF00917 0.864
DOC_USP7_MATH_1 151 155 PF00917 0.866
DOC_WW_Pin1_4 85 90 PF00397 0.791
LIG_BIR_II_1 1 5 PF00653 0.747
LIG_CtBP_PxDLS_1 33 37 PF00389 0.543
LIG_eIF4E_1 57 63 PF01652 0.680
LIG_FHA_1 40 46 PF00498 0.491
LIG_GBD_Chelix_1 51 59 PF00786 0.515
LIG_LIR_Gen_1 70 78 PF02991 0.749
LIG_LIR_Nem_3 58 63 PF02991 0.592
LIG_LIR_Nem_3 70 76 PF02991 0.718
LIG_SH2_STAT5 57 60 PF00017 0.671
LIG_SH3_3 121 127 PF00018 0.737
LIG_SH3_3 154 160 PF00018 0.828
LIG_SUMO_SIM_anti_2 42 48 PF11976 0.491
MOD_CDK_SPK_2 85 90 PF00069 0.760
MOD_CDK_SPxK_1 85 91 PF00069 0.716
MOD_CK2_1 71 77 PF00069 0.668
MOD_GlcNHglycan 108 111 PF01048 0.766
MOD_GlcNHglycan 67 70 PF01048 0.782
MOD_GSK3_1 151 158 PF00069 0.814
MOD_GSK3_1 65 72 PF00069 0.753
MOD_N-GLC_1 85 90 PF02516 0.712
MOD_NEK2_1 47 52 PF00069 0.493
MOD_NEK2_1 55 60 PF00069 0.608
MOD_NEK2_1 71 76 PF00069 0.704
MOD_PIKK_1 122 128 PF00454 0.726
MOD_PIKK_1 138 144 PF00454 0.777
MOD_Plk_1 151 157 PF00069 0.816
MOD_Plk_1 69 75 PF00069 0.675
MOD_Plk_4 47 53 PF00069 0.544
MOD_Plk_4 55 61 PF00069 0.303
MOD_ProDKin_1 85 91 PF00069 0.716
MOD_SUMO_for_1 89 92 PF00179 0.811
TRG_DiLeu_BaLyEn_6 58 63 PF01217 0.561
TRG_ER_diArg_1 64 67 PF00400 0.604

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PA23 Leptomonas seymouri 46% 88%
A0A3Q8ILG5 Leishmania donovani 76% 100%
A4HB82 Leishmania braziliensis 67% 70%
A4IAD0 Leishmania infantum 99% 100%
A4IAD1 Leishmania infantum 68% 93%
E9B5F3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
E9B5F5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4Q2I0 Leishmania major 87% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS