Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X8E4_LEIDO

TriTrypDb:

LdBPK_343600.1 , LdCL_340045400 , LDHU3_34.5850

Length:

355

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X8E4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8E4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.502
CLV_C14_Caspase3-7	223	227	PF00656	0.653
CLV_C14_Caspase3-7	31	35	PF00656	0.483
CLV_MEL_PAP_1	66	72	PF00089	0.535
CLV_NRD_NRD_1	146	148	PF00675	0.555
CLV_NRD_NRD_1	315	317	PF00675	0.525
CLV_NRD_NRD_1	4	6	PF00675	0.660
CLV_PCSK_FUR_1	2	6	PF00082	0.672
CLV_PCSK_KEX2_1	146	148	PF00082	0.578
CLV_PCSK_KEX2_1	302	304	PF00082	0.521
CLV_PCSK_KEX2_1	32	34	PF00082	0.493
CLV_PCSK_KEX2_1	4	6	PF00082	0.612
CLV_PCSK_KEX2_1	59	61	PF00082	0.376
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.566
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.493
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.432
CLV_PCSK_SKI1_1	118	122	PF00082	0.485
CLV_PCSK_SKI1_1	205	209	PF00082	0.442
CLV_PCSK_SKI1_1	278	282	PF00082	0.489
CLV_PCSK_SKI1_1	302	306	PF00082	0.508
CLV_PCSK_SKI1_1	349	353	PF00082	0.449
DEG_Nend_UBRbox_1	1	4	PF02207	0.573
DOC_CYCLIN_RxL_1	202	211	PF00134	0.515
DOC_CYCLIN_yCln2_LP_2	315	321	PF00134	0.516
DOC_MAPK_gen_1	316	327	PF00069	0.539
DOC_MAPK_gen_1	32	39	PF00069	0.563
DOC_MAPK_HePTP_8	29	41	PF00069	0.569
DOC_MAPK_MEF2A_6	194	203	PF00069	0.394
DOC_MAPK_MEF2A_6	32	41	PF00069	0.573
DOC_MAPK_RevD_3	17	33	PF00069	0.400
DOC_PP2B_LxvP_1	207	210	PF13499	0.501
DOC_PP2B_LxvP_1	54	57	PF13499	0.385
DOC_PP4_FxxP_1	76	79	PF00568	0.532
DOC_USP7_MATH_1	3	7	PF00917	0.656
DOC_USP7_MATH_1	345	349	PF00917	0.516
DOC_USP7_MATH_1	55	59	PF00917	0.443
DOC_WW_Pin1_4	125	130	PF00397	0.429
DOC_WW_Pin1_4	75	80	PF00397	0.506
LIG_14-3-3_CanoR_1	155	165	PF00244	0.454
LIG_14-3-3_CanoR_1	2	12	PF00244	0.538
LIG_14-3-3_CanoR_1	320	327	PF00244	0.510
LIG_14-3-3_CanoR_1	60	70	PF00244	0.406
LIG_APCC_ABBA_1	246	251	PF00400	0.357
LIG_BRCT_BRCA1_1	5	9	PF00533	0.508
LIG_BRCT_BRCA1_1	57	61	PF00533	0.443
LIG_FHA_1	13	19	PF00498	0.404
LIG_FHA_1	157	163	PF00498	0.455
LIG_FHA_1	25	31	PF00498	0.401
LIG_FHA_1	279	285	PF00498	0.529
LIG_FHA_1	333	339	PF00498	0.426
LIG_FHA_1	49	55	PF00498	0.375
LIG_FHA_1	61	67	PF00498	0.172
LIG_FHA_2	223	229	PF00498	0.698
LIG_FHA_2	26	32	PF00498	0.533
LIG_FHA_2	269	275	PF00498	0.503
LIG_FHA_2	338	344	PF00498	0.474
LIG_LIR_Apic_2	328	332	PF02991	0.539
LIG_LIR_Apic_2	74	79	PF02991	0.565
LIG_LIR_Gen_1	14	24	PF02991	0.398
LIG_LIR_Gen_1	307	318	PF02991	0.406
LIG_LIR_Nem_3	109	115	PF02991	0.390
LIG_LIR_Nem_3	128	134	PF02991	0.264
LIG_LIR_Nem_3	14	19	PF02991	0.399
LIG_LIR_Nem_3	307	313	PF02991	0.399
LIG_LIR_Nem_3	348	353	PF02991	0.503
LIG_LIR_Nem_3	6	12	PF02991	0.466
LIG_PCNA_PIPBox_1	99	108	PF02747	0.503
LIG_PDZ_Class_2	350	355	PF00595	0.369
LIG_Pex14_2	76	80	PF04695	0.535
LIG_SH2_CRK	180	184	PF00017	0.554
LIG_SH2_STAT5	12	15	PF00017	0.413
LIG_SH2_STAT5	165	168	PF00017	0.441
LIG_SH2_STAT5	310	313	PF00017	0.458
LIG_SH2_STAT5	42	45	PF00017	0.446
LIG_SH3_3	250	256	PF00018	0.521
LIG_SUMO_SIM_par_1	51	58	PF11976	0.371
LIG_TRAF2_1	139	142	PF00917	0.494
LIG_TRAF2_1	321	324	PF00917	0.419
LIG_WRC_WIRS_1	102	107	PF05994	0.491
MOD_CDC14_SPxK_1	78	81	PF00782	0.505
MOD_CDK_SPxK_1	75	81	PF00069	0.501
MOD_CK1_1	104	110	PF00069	0.476
MOD_CK1_1	136	142	PF00069	0.472
MOD_CK1_1	272	278	PF00069	0.481
MOD_CK1_1	65	71	PF00069	0.398
MOD_CK1_1	75	81	PF00069	0.464
MOD_CK1_1	88	94	PF00069	0.646
MOD_CK2_1	136	142	PF00069	0.466
MOD_CK2_1	222	228	PF00069	0.717
MOD_CK2_1	25	31	PF00069	0.548
MOD_CK2_1	268	274	PF00069	0.487
MOD_CK2_1	337	343	PF00069	0.434
MOD_DYRK1A_RPxSP_1	125	129	PF00069	0.438
MOD_GlcNHglycan	88	91	PF01048	0.672
MOD_GSK3_1	218	225	PF00069	0.705
MOD_GSK3_1	268	275	PF00069	0.523
MOD_GSK3_1	333	340	PF00069	0.431
MOD_GSK3_1	61	68	PF00069	0.454
MOD_GSK3_1	71	78	PF00069	0.476
MOD_GSK3_1	81	88	PF00069	0.359
MOD_N-GLC_1	221	226	PF02516	0.703
MOD_NEK2_1	106	111	PF00069	0.425
MOD_NEK2_1	220	225	PF00069	0.711
MOD_NEK2_1	304	309	PF00069	0.503
MOD_NEK2_1	311	316	PF00069	0.484
MOD_NEK2_1	61	66	PF00069	0.427
MOD_NEK2_1	72	77	PF00069	0.431
MOD_NEK2_2	3	8	PF00069	0.597
MOD_PIKK_1	107	113	PF00454	0.491
MOD_PIKK_1	178	184	PF00454	0.472
MOD_PKA_2	3	9	PF00069	0.634
MOD_PKA_2	319	325	PF00069	0.512
MOD_PKB_1	171	179	PF00069	0.546
MOD_Plk_1	173	179	PF00069	0.509
MOD_Plk_4	101	107	PF00069	0.461
MOD_Plk_4	157	163	PF00069	0.504
MOD_Plk_4	25	31	PF00069	0.405
MOD_Plk_4	62	68	PF00069	0.452
MOD_ProDKin_1	125	131	PF00069	0.431
MOD_ProDKin_1	75	81	PF00069	0.516
MOD_SUMO_rev_2	296	304	PF00179	0.572
TRG_DiLeu_BaEn_1	300	305	PF01217	0.445
TRG_DiLeu_LyEn_5	300	305	PF01217	0.517
TRG_ENDOCYTIC_2	16	19	PF00928	0.414
TRG_ENDOCYTIC_2	180	183	PF00928	0.474
TRG_ENDOCYTIC_2	310	313	PF00928	0.466
TRG_ER_diArg_1	1	4	PF00400	0.698
TRG_ER_diArg_1	169	172	PF00400	0.475
TRG_Pf-PMV_PEXEL_1	278	282	PF00026	0.353
TRG_Pf-PMV_PEXEL_1	302	306	PF00026	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P771	Leptomonas seymouri	58%	95%
A0A0S4KPS3	Bodo saltans	30%	100%
A0A1X0PA34	Trypanosomatidae	40%	100%
A0A422NT02	Trypanosoma rangeli	39%	100%
A4HBA0	Leishmania braziliensis	80%	100%
A4IAE8	Leishmania infantum	100%	100%
C9ZLU6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B5H2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q2G3	Leishmania major	96%	100%
V5DMU4	Trypanosoma cruzi	41%	100%