LicD_family_putative/Pfam:PF04991

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

LicD family, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X8D8_LEIDO

TriTrypDb:

LdBPK_343320.1 , LdCL_340042600 , LDHU3_34.5500

Length:

224

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Phosphorylation

Amastigote: 21

Expansion

Sequence features

A0A3S7X8D8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8D8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	151	153	PF00675	0.477
CLV_PCSK_KEX2_1	140	142	PF00082	0.518
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.602
CLV_PCSK_PC7_1	136	142	PF00082	0.559
CLV_PCSK_SKI1_1	101	105	PF00082	0.490
CLV_PCSK_SKI1_1	141	145	PF00082	0.583
CLV_PCSK_SKI1_1	77	81	PF00082	0.594
DEG_SCF_FBW7_1	1	8	PF00400	0.637
DOC_PP1_RVXF_1	99	106	PF00149	0.280
DOC_PP2B_LxvP_1	216	219	PF13499	0.334
DOC_USP7_MATH_1	116	120	PF00917	0.382
DOC_USP7_MATH_1	143	147	PF00917	0.445
DOC_USP7_MATH_1	186	190	PF00917	0.391
DOC_USP7_UBL2_3	80	84	PF12436	0.282
DOC_WW_Pin1_4	1	6	PF00397	0.741
DOC_WW_Pin1_4	114	119	PF00397	0.392
LIG_BIR_II_1	1	5	PF00653	0.753
LIG_BRCT_BRCA1_1	181	185	PF00533	0.349
LIG_FHA_1	153	159	PF00498	0.279
LIG_FHA_1	163	169	PF00498	0.280
LIG_FHA_1	215	221	PF00498	0.291
LIG_FHA_2	11	17	PF00498	0.652
LIG_LIR_Gen_1	161	168	PF02991	0.323
LIG_LIR_Gen_1	214	223	PF02991	0.331
LIG_LIR_Gen_1	50	56	PF02991	0.337
LIG_LIR_Nem_3	214	218	PF02991	0.326
LIG_LIR_Nem_3	50	54	PF02991	0.337
LIG_SH2_STAP1	163	167	PF00017	0.279
LIG_SH2_STAT3	206	209	PF00017	0.364
LIG_SH2_STAT5	206	209	PF00017	0.289
LIG_SH2_STAT5	56	59	PF00017	0.369
LIG_SH2_STAT5	61	64	PF00017	0.310
LIG_SH3_3	110	116	PF00018	0.355
LIG_SUMO_SIM_par_1	44	50	PF11976	0.365
LIG_UBA3_1	184	188	PF00899	0.364
MOD_CDK_SPK_2	1	6	PF00069	0.694
MOD_CK1_1	10	16	PF00069	0.775
MOD_CK1_1	117	123	PF00069	0.380
MOD_CK1_1	179	185	PF00069	0.352
MOD_CK1_1	50	56	PF00069	0.436
MOD_GlcNHglycan	124	127	PF01048	0.583
MOD_GlcNHglycan	168	171	PF01048	0.615
MOD_GlcNHglycan	192	195	PF01048	0.576
MOD_GlcNHglycan	20	23	PF01048	0.347
MOD_GlcNHglycan	65	68	PF01048	0.571
MOD_GlcNHglycan	9	12	PF01048	0.486
MOD_GSK3_1	1	8	PF00069	0.678
MOD_GSK3_1	162	169	PF00069	0.371
MOD_GSK3_1	186	193	PF00069	0.389
MOD_GSK3_1	89	96	PF00069	0.278
MOD_N-GLC_1	18	23	PF02516	0.413
MOD_N-GLC_1	89	94	PF02516	0.487
MOD_NEK2_1	162	167	PF00069	0.291
MOD_NEK2_1	35	40	PF00069	0.306
MOD_NEK2_1	89	94	PF00069	0.311
MOD_PKA_1	152	158	PF00069	0.331
MOD_PKA_2	63	69	PF00069	0.358
MOD_Plk_1	28	34	PF00069	0.599
MOD_Plk_4	162	168	PF00069	0.303
MOD_Plk_4	89	95	PF00069	0.282
MOD_ProDKin_1	1	7	PF00069	0.741
MOD_ProDKin_1	114	120	PF00069	0.390
TRG_DiLeu_BaLyEn_6	216	221	PF01217	0.333
TRG_ENDOCYTIC_2	163	166	PF00928	0.218
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P990	Leptomonas seymouri	64%	100%
A0A0S4JMC1	Bodo saltans	38%	100%
A0A1X0PAV6	Trypanosomatidae	55%	100%
A0A422MZF8	Trypanosoma rangeli	51%	100%
A4HB72	Leishmania braziliensis	79%	100%
A4IAC0	Leishmania infantum	100%	100%
C9ZLX2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9B5E3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q2J0	Leishmania major	95%	100%