Programmed cell death protein 2, C-terminal putative domain family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Programmed cell death protein 2, C-terminal putative domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X8B9_LEIDO

TriTrypDb:

LdBPK_343330.1 , LdCL_340042700 , LDHU3_34.5510

Length:

408

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A0A3S7X8B9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8B9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	212	216	PF00656	0.515
CLV_NRD_NRD_1	95	97	PF00675	0.577
CLV_PCSK_KEX2_1	95	97	PF00082	0.520
CLV_PCSK_SKI1_1	16	20	PF00082	0.563
CLV_PCSK_SKI1_1	232	236	PF00082	0.502
CLV_PCSK_SKI1_1	239	243	PF00082	0.447
DEG_SCF_FBW7_1	318	325	PF00400	0.324
DEG_SPOP_SBC_1	111	115	PF00917	0.480
DOC_CKS1_1	11	16	PF01111	0.385
DOC_CYCLIN_yCln2_LP_2	354	360	PF00134	0.264
DOC_MAPK_gen_1	258	265	PF00069	0.595
DOC_MAPK_MEF2A_6	324	332	PF00069	0.384
DOC_PP2B_LxvP_1	337	340	PF13499	0.455
DOC_PP2B_LxvP_1	354	357	PF13499	0.240
DOC_PP4_FxxP_1	57	60	PF00568	0.319
DOC_USP7_MATH_1	126	130	PF00917	0.534
DOC_USP7_MATH_1	136	140	PF00917	0.256
DOC_USP7_MATH_1	228	232	PF00917	0.512
DOC_USP7_MATH_1	26	30	PF00917	0.431
DOC_USP7_MATH_1	271	275	PF00917	0.500
DOC_USP7_MATH_1	66	70	PF00917	0.436
DOC_USP7_MATH_1	99	103	PF00917	0.622
DOC_WW_Pin1_4	10	15	PF00397	0.368
DOC_WW_Pin1_4	199	204	PF00397	0.736
DOC_WW_Pin1_4	217	222	PF00397	0.669
DOC_WW_Pin1_4	306	311	PF00397	0.449
DOC_WW_Pin1_4	318	323	PF00397	0.195
LIG_14-3-3_CanoR_1	128	134	PF00244	0.534
LIG_14-3-3_CanoR_1	232	237	PF00244	0.539
LIG_14-3-3_CanoR_1	324	332	PF00244	0.293
LIG_14-3-3_CanoR_1	98	104	PF00244	0.597
LIG_APCC_ABBA_1	249	254	PF00400	0.385
LIG_BIR_II_1	1	5	PF00653	0.507
LIG_BRCT_BRCA1_1	138	142	PF00533	0.303
LIG_BRCT_BRCA1_1	53	57	PF00533	0.442
LIG_deltaCOP1_diTrp_1	179	189	PF00928	0.664
LIG_FHA_1	233	239	PF00498	0.521
LIG_FHA_1	242	248	PF00498	0.390
LIG_FHA_1	26	32	PF00498	0.331
LIG_FHA_1	323	329	PF00498	0.314
LIG_FHA_1	353	359	PF00498	0.265
LIG_FHA_1	361	367	PF00498	0.251
LIG_FHA_1	63	69	PF00498	0.404
LIG_FHA_2	160	166	PF00498	0.638
LIG_FHA_2	17	23	PF00498	0.496
LIG_FHA_2	218	224	PF00498	0.646
LIG_LIR_Apic_2	250	255	PF02991	0.421
LIG_LIR_Apic_2	54	60	PF02991	0.332
LIG_LIR_Gen_1	145	154	PF02991	0.491
LIG_LIR_Gen_1	400	408	PF02991	0.290
LIG_LIR_Gen_1	79	88	PF02991	0.298
LIG_LIR_Nem_3	145	150	PF02991	0.449
LIG_LIR_Nem_3	400	404	PF02991	0.299
LIG_LIR_Nem_3	79	84	PF02991	0.327
LIG_MLH1_MIPbox_1	53	57	PF16413	0.456
LIG_PDZ_Class_3	403	408	PF00595	0.394
LIG_SH2_CRK	81	85	PF00017	0.291
LIG_SH2_NCK_1	252	256	PF00017	0.494
LIG_SH2_PTP2	401	404	PF00017	0.392
LIG_SH2_SRC	252	255	PF00017	0.548
LIG_SH2_STAP1	27	31	PF00017	0.351
LIG_SH2_STAP1	81	85	PF00017	0.291
LIG_SH2_STAT5	146	149	PF00017	0.450
LIG_SH2_STAT5	243	246	PF00017	0.504
LIG_SH2_STAT5	27	30	PF00017	0.359
LIG_SH2_STAT5	361	364	PF00017	0.305
LIG_SH2_STAT5	37	40	PF00017	0.334
LIG_SH2_STAT5	382	385	PF00017	0.308
LIG_SH2_STAT5	397	400	PF00017	0.291
LIG_SH2_STAT5	401	404	PF00017	0.231
LIG_SH2_STAT5	56	59	PF00017	0.440
LIG_SH2_STAT5	86	89	PF00017	0.262
LIG_SH3_1	200	206	PF00018	0.625
LIG_SH3_1	222	228	PF00018	0.415
LIG_SH3_3	104	110	PF00018	0.560
LIG_SH3_3	200	206	PF00018	0.722
LIG_SH3_3	222	228	PF00018	0.535
LIG_SH3_3	336	342	PF00018	0.288
LIG_SH3_3	393	399	PF00018	0.404
LIG_SH3_3	71	77	PF00018	0.373
LIG_SUMO_SIM_par_1	247	254	PF11976	0.414
LIG_SUMO_SIM_par_1	76	82	PF11976	0.323
LIG_SxIP_EBH_1	324	334	PF03271	0.216
LIG_TRAF2_1	264	267	PF00917	0.580
MOD_CDK_SPK_2	217	222	PF00069	0.486
MOD_CDK_SPxK_1	10	16	PF00069	0.436
MOD_CDK_SPxK_1	318	324	PF00069	0.324
MOD_CK1_1	117	123	PF00069	0.722
MOD_CK1_1	129	135	PF00069	0.405
MOD_CK2_1	159	165	PF00069	0.632
MOD_CK2_1	217	223	PF00069	0.616
MOD_CK2_1	261	267	PF00069	0.558
MOD_CK2_1	282	288	PF00069	0.536
MOD_CK2_1	40	46	PF00069	0.493
MOD_CK2_1	99	105	PF00069	0.626
MOD_GlcNHglycan	1	4	PF01048	0.614
MOD_GlcNHglycan	119	122	PF01048	0.674
MOD_GlcNHglycan	244	247	PF01048	0.468
MOD_GlcNHglycan	278	281	PF01048	0.637
MOD_GlcNHglycan	283	287	PF01048	0.649
MOD_GlcNHglycan	48	51	PF01048	0.467
MOD_GSK3_1	110	117	PF00069	0.522
MOD_GSK3_1	136	143	PF00069	0.403
MOD_GSK3_1	21	28	PF00069	0.393
MOD_GSK3_1	228	235	PF00069	0.550
MOD_GSK3_1	271	278	PF00069	0.599
MOD_GSK3_1	318	325	PF00069	0.383
MOD_GSK3_1	62	69	PF00069	0.428
MOD_GSK3_1	99	106	PF00069	0.625
MOD_N-GLC_1	140	145	PF02516	0.457
MOD_N-GLC_1	332	337	PF02516	0.276
MOD_NEK2_1	103	108	PF00069	0.652
MOD_NEK2_1	112	117	PF00069	0.456
MOD_NEK2_1	242	247	PF00069	0.483
MOD_NEK2_1	275	280	PF00069	0.617
MOD_NEK2_1	282	287	PF00069	0.667
MOD_NEK2_1	323	328	PF00069	0.283
MOD_NEK2_1	352	357	PF00069	0.244
MOD_NEK2_1	374	379	PF00069	0.287
MOD_NEK2_1	380	385	PF00069	0.283
MOD_NEK2_1	40	45	PF00069	0.515
MOD_NEK2_2	271	276	PF00069	0.503
MOD_NEK2_2	99	104	PF00069	0.443
MOD_PIKK_1	136	142	PF00454	0.312
MOD_PIKK_1	16	22	PF00454	0.518
MOD_PIKK_1	308	314	PF00454	0.249
MOD_PK_1	261	267	PF00069	0.623
MOD_PKA_2	159	165	PF00069	0.519
MOD_PKA_2	323	329	PF00069	0.293
MOD_PKA_2	94	100	PF00069	0.561
MOD_Plk_1	261	267	PF00069	0.610
MOD_Plk_1	294	300	PF00069	0.259
MOD_Plk_2-3	188	194	PF00069	0.772
MOD_Plk_4	271	277	PF00069	0.550
MOD_Plk_4	66	72	PF00069	0.300
MOD_ProDKin_1	10	16	PF00069	0.385
MOD_ProDKin_1	199	205	PF00069	0.737
MOD_ProDKin_1	217	223	PF00069	0.667
MOD_ProDKin_1	306	312	PF00069	0.449
MOD_ProDKin_1	318	324	PF00069	0.195
MOD_SUMO_rev_2	163	168	PF00179	0.477
MOD_SUMO_rev_2	365	372	PF00179	0.311
TRG_ENDOCYTIC_2	37	40	PF00928	0.376
TRG_ENDOCYTIC_2	401	404	PF00928	0.283
TRG_ENDOCYTIC_2	75	78	PF00928	0.298
TRG_ENDOCYTIC_2	81	84	PF00928	0.279
TRG_ER_diArg_1	95	98	PF00400	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYV7	Leptomonas seymouri	63%	100%
A0A0S4JQH8	Bodo saltans	30%	100%
A0A1X0PA07	Trypanosomatidae	35%	100%
A0A3R7N1R1	Trypanosoma rangeli	35%	100%
A4HB73	Leishmania braziliensis	75%	98%
A4IAC1	Leishmania infantum	100%	100%
C9ZLX1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9B5E4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q2I9	Leishmania major	91%	100%
Q8C5N5	Mus musculus	26%	100%
V5DMW4	Trypanosoma cruzi	34%	100%