Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X8B8_LEIDO

TriTrypDb:

LdBPK_343120.1 , LdCL_340040100 , LDHU3_34.5290

Length:

727

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X8B8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8B8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	261	265	PF00656	0.489
CLV_C14_Caspase3-7	504	508	PF00656	0.583
CLV_C14_Caspase3-7	576	580	PF00656	0.521
CLV_NRD_NRD_1	162	164	PF00675	0.585
CLV_NRD_NRD_1	200	202	PF00675	0.608
CLV_NRD_NRD_1	436	438	PF00675	0.644
CLV_NRD_NRD_1	543	545	PF00675	0.605
CLV_NRD_NRD_1	563	565	PF00675	0.558
CLV_NRD_NRD_1	573	575	PF00675	0.570
CLV_NRD_NRD_1	645	647	PF00675	0.626
CLV_PCSK_KEX2_1	162	164	PF00082	0.629
CLV_PCSK_KEX2_1	182	184	PF00082	0.385
CLV_PCSK_KEX2_1	35	37	PF00082	0.689
CLV_PCSK_KEX2_1	436	438	PF00082	0.644
CLV_PCSK_KEX2_1	457	459	PF00082	0.639
CLV_PCSK_KEX2_1	468	470	PF00082	0.557
CLV_PCSK_KEX2_1	543	545	PF00082	0.647
CLV_PCSK_KEX2_1	563	565	PF00082	0.558
CLV_PCSK_KEX2_1	573	575	PF00082	0.570
CLV_PCSK_KEX2_1	644	646	PF00082	0.591
CLV_PCSK_PC1ET2_1	182	184	PF00082	0.506
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.674
CLV_PCSK_PC1ET2_1	457	459	PF00082	0.541
CLV_PCSK_PC1ET2_1	468	470	PF00082	0.513
CLV_PCSK_SKI1_1	102	106	PF00082	0.545
CLV_PCSK_SKI1_1	182	186	PF00082	0.517
CLV_PCSK_SKI1_1	320	324	PF00082	0.637
CLV_PCSK_SKI1_1	437	441	PF00082	0.646
CLV_PCSK_SKI1_1	458	462	PF00082	0.565
CLV_PCSK_SKI1_1	563	567	PF00082	0.545
CLV_PCSK_SKI1_1	63	67	PF00082	0.564
CLV_PCSK_SKI1_1	673	677	PF00082	0.515
DEG_Nend_UBRbox_3	1	3	PF02207	0.556
DOC_CDC14_PxL_1	331	339	PF14671	0.485
DOC_CKS1_1	559	564	PF01111	0.579
DOC_CKS1_1	76	81	PF01111	0.568
DOC_CYCLIN_RxL_1	561	569	PF00134	0.566
DOC_CYCLIN_yCln2_LP_2	66	69	PF00134	0.604
DOC_MAPK_gen_1	457	463	PF00069	0.625
DOC_MAPK_gen_1	596	606	PF00069	0.494
DOC_MAPK_gen_1	644	653	PF00069	0.486
DOC_MAPK_gen_1	98	107	PF00069	0.524
DOC_MAPK_MEF2A_6	610	618	PF00069	0.605
DOC_MAPK_MEF2A_6	646	655	PF00069	0.478
DOC_PP1_RVXF_1	562	569	PF00149	0.522
DOC_PP1_RVXF_1	581	587	PF00149	0.515
DOC_PP2B_LxvP_1	274	277	PF13499	0.434
DOC_PP2B_LxvP_1	478	481	PF13499	0.618
DOC_PP2B_LxvP_1	66	69	PF13499	0.604
DOC_PP4_FxxP_1	65	68	PF00568	0.611
DOC_USP7_MATH_1	203	207	PF00917	0.640
DOC_USP7_MATH_1	27	31	PF00917	0.609
DOC_USP7_MATH_1	369	373	PF00917	0.574
DOC_USP7_MATH_1	383	387	PF00917	0.588
DOC_USP7_MATH_1	390	394	PF00917	0.600
DOC_USP7_MATH_1	420	424	PF00917	0.612
DOC_USP7_MATH_1	46	50	PF00917	0.627
DOC_USP7_MATH_1	495	499	PF00917	0.575
DOC_WW_Pin1_4	114	119	PF00397	0.634
DOC_WW_Pin1_4	168	173	PF00397	0.605
DOC_WW_Pin1_4	41	46	PF00397	0.621
DOC_WW_Pin1_4	481	486	PF00397	0.627
DOC_WW_Pin1_4	502	507	PF00397	0.540
DOC_WW_Pin1_4	521	526	PF00397	0.579
DOC_WW_Pin1_4	558	563	PF00397	0.573
DOC_WW_Pin1_4	605	610	PF00397	0.580
DOC_WW_Pin1_4	75	80	PF00397	0.597
LIG_14-3-3_CanoR_1	108	118	PF00244	0.606
LIG_14-3-3_CanoR_1	20	24	PF00244	0.626
LIG_14-3-3_CanoR_1	201	211	PF00244	0.523
LIG_14-3-3_CanoR_1	376	382	PF00244	0.644
LIG_14-3-3_CanoR_1	543	551	PF00244	0.625
LIG_14-3-3_CanoR_1	644	650	PF00244	0.587
LIG_14-3-3_CterR_2	723	727	PF00244	0.459
LIG_Actin_WH2_2	169	184	PF00022	0.543
LIG_Actin_WH2_2	5	22	PF00022	0.619
LIG_BIR_III_2	264	268	PF00653	0.597
LIG_BRCT_BRCA1_1	496	500	PF00533	0.499
LIG_BRCT_BRCA1_1	688	692	PF00533	0.549
LIG_BRCT_BRCA1_2	688	694	PF00533	0.547
LIG_Clathr_ClatBox_1	81	85	PF01394	0.591
LIG_deltaCOP1_diTrp_1	219	227	PF00928	0.550
LIG_FHA_1	183	189	PF00498	0.555
LIG_FHA_1	219	225	PF00498	0.656
LIG_FHA_1	35	41	PF00498	0.579
LIG_FHA_1	50	56	PF00498	0.578
LIG_FHA_1	589	595	PF00498	0.538
LIG_FHA_1	634	640	PF00498	0.642
LIG_FHA_1	646	652	PF00498	0.496
LIG_FHA_1	69	75	PF00498	0.541
LIG_FHA_1	76	82	PF00498	0.595
LIG_FHA_1	9	15	PF00498	0.582
LIG_FHA_2	231	237	PF00498	0.470
LIG_FHA_2	259	265	PF00498	0.560
LIG_FHA_2	537	543	PF00498	0.611
LIG_LIR_Apic_2	353	359	PF02991	0.559
LIG_LIR_Apic_2	380	385	PF02991	0.621
LIG_LIR_Gen_1	125	134	PF02991	0.572
LIG_LIR_Gen_1	147	154	PF02991	0.569
LIG_LIR_Gen_1	328	337	PF02991	0.499
LIG_LIR_Gen_1	456	467	PF02991	0.585
LIG_LIR_Gen_1	497	506	PF02991	0.483
LIG_LIR_Gen_1	647	657	PF02991	0.591
LIG_LIR_Gen_1	689	699	PF02991	0.542
LIG_LIR_Nem_3	125	131	PF02991	0.580
LIG_LIR_Nem_3	147	151	PF02991	0.567
LIG_LIR_Nem_3	328	334	PF02991	0.510
LIG_LIR_Nem_3	456	462	PF02991	0.631
LIG_LIR_Nem_3	497	503	PF02991	0.487
LIG_LIR_Nem_3	647	652	PF02991	0.543
LIG_LIR_Nem_3	689	695	PF02991	0.586
LIG_MAD2	599	607	PF02301	0.495
LIG_Pex14_1	496	500	PF04695	0.499
LIG_SH2_CRK	331	335	PF00017	0.495
LIG_SH2_CRK	459	463	PF00017	0.616
LIG_SH2_STAP1	254	258	PF00017	0.573
LIG_SH2_STAP1	459	463	PF00017	0.616
LIG_SH2_STAT3	640	643	PF00017	0.645
LIG_SH3_2	24	29	PF14604	0.555
LIG_SH3_3	21	27	PF00018	0.551
LIG_SH3_3	287	293	PF00018	0.486
LIG_SH3_3	591	597	PF00018	0.621
LIG_SH3_3	601	607	PF00018	0.546
LIG_SH3_3	73	79	PF00018	0.579
LIG_SUMO_SIM_anti_2	171	177	PF11976	0.608
LIG_SUMO_SIM_par_1	103	109	PF11976	0.543
LIG_SUMO_SIM_par_1	80	85	PF11976	0.588
LIG_TRFH_1	65	69	PF08558	0.569
MOD_CDK_SPK_2	558	563	PF00069	0.529
MOD_CDK_SPK_2	605	610	PF00069	0.621
MOD_CDK_SPxK_1	558	564	PF00069	0.574
MOD_CK1_1	109	115	PF00069	0.642
MOD_CK1_1	116	122	PF00069	0.620
MOD_CK1_1	171	177	PF00069	0.557
MOD_CK1_1	206	212	PF00069	0.545
MOD_CK1_1	361	367	PF00069	0.650
MOD_CK1_1	386	392	PF00069	0.754
MOD_CK1_1	44	50	PF00069	0.660
MOD_CK1_1	502	508	PF00069	0.504
MOD_CK1_1	546	552	PF00069	0.630
MOD_CK1_1	621	627	PF00069	0.513
MOD_CK1_1	668	674	PF00069	0.586
MOD_CK1_1	70	76	PF00069	0.634
MOD_CK2_1	413	419	PF00069	0.622
MOD_CK2_1	536	542	PF00069	0.639
MOD_CK2_1	77	83	PF00069	0.650
MOD_Cter_Amidation	160	163	PF01082	0.576
MOD_Cter_Amidation	33	36	PF01082	0.626
MOD_GlcNHglycan	108	111	PF01048	0.602
MOD_GlcNHglycan	113	116	PF01048	0.599
MOD_GlcNHglycan	140	144	PF01048	0.587
MOD_GlcNHglycan	312	315	PF01048	0.588
MOD_GlcNHglycan	331	334	PF01048	0.577
MOD_GlcNHglycan	350	353	PF01048	0.529
MOD_GlcNHglycan	371	374	PF01048	0.621
MOD_GlcNHglycan	388	391	PF01048	0.571
MOD_GlcNHglycan	402	405	PF01048	0.692
MOD_GlcNHglycan	415	418	PF01048	0.528
MOD_GlcNHglycan	465	468	PF01048	0.536
MOD_GlcNHglycan	470	473	PF01048	0.577
MOD_GlcNHglycan	48	51	PF01048	0.627
MOD_GlcNHglycan	497	500	PF01048	0.709
MOD_GlcNHglycan	546	549	PF01048	0.528
MOD_GlcNHglycan	620	623	PF01048	0.531
MOD_GlcNHglycan	631	634	PF01048	0.702
MOD_GSK3_1	109	116	PF00069	0.595
MOD_GSK3_1	149	156	PF00069	0.589
MOD_GSK3_1	202	209	PF00069	0.627
MOD_GSK3_1	243	250	PF00069	0.562
MOD_GSK3_1	254	261	PF00069	0.500
MOD_GSK3_1	357	364	PF00069	0.666
MOD_GSK3_1	386	393	PF00069	0.634
MOD_GSK3_1	40	47	PF00069	0.652
MOD_GSK3_1	470	477	PF00069	0.634
MOD_GSK3_1	49	56	PF00069	0.578
MOD_GSK3_1	490	497	PF00069	0.474
MOD_GSK3_1	517	524	PF00069	0.653
MOD_GSK3_1	573	580	PF00069	0.735
MOD_GSK3_1	629	636	PF00069	0.549
MOD_GSK3_1	661	668	PF00069	0.547
MOD_N-GLC_1	386	391	PF02516	0.657
MOD_NEK2_1	106	111	PF00069	0.558
MOD_NEK2_1	19	24	PF00069	0.615
MOD_NEK2_1	410	415	PF00069	0.623
MOD_NEK2_1	618	623	PF00069	0.520
MOD_NEK2_1	675	680	PF00069	0.606
MOD_NEK2_1	8	13	PF00069	0.576
MOD_NEK2_2	243	248	PF00069	0.493
MOD_NEK2_2	254	259	PF00069	0.448
MOD_NEK2_2	420	425	PF00069	0.610
MOD_PIKK_1	203	209	PF00454	0.590
MOD_PIKK_1	27	33	PF00454	0.635
MOD_PIKK_1	346	352	PF00454	0.594
MOD_PIKK_1	665	671	PF00454	0.506
MOD_PK_1	162	168	PF00069	0.525
MOD_PKA_1	162	168	PF00069	0.580
MOD_PKA_1	182	188	PF00069	0.371
MOD_PKA_1	468	474	PF00069	0.566
MOD_PKA_1	543	549	PF00069	0.592
MOD_PKA_1	573	579	PF00069	0.512
MOD_PKA_1	644	650	PF00069	0.621
MOD_PKA_2	138	144	PF00069	0.593
MOD_PKA_2	149	155	PF00069	0.481
MOD_PKA_2	162	168	PF00069	0.510
MOD_PKA_2	182	188	PF00069	0.469
MOD_PKA_2	19	25	PF00069	0.671
MOD_PKA_2	247	253	PF00069	0.510
MOD_PKA_2	468	474	PF00069	0.599
MOD_PKA_2	543	549	PF00069	0.592
MOD_PKA_2	573	579	PF00069	0.527
MOD_PKA_2	644	650	PF00069	0.622
MOD_PKB_1	137	145	PF00069	0.593
MOD_Plk_1	139	145	PF00069	0.597
MOD_Plk_1	218	224	PF00069	0.605
MOD_Plk_1	302	308	PF00069	0.627
MOD_Plk_1	490	496	PF00069	0.602
MOD_Plk_2-3	77	83	PF00069	0.529
MOD_Plk_4	171	177	PF00069	0.682
MOD_Plk_4	302	308	PF00069	0.627
MOD_Plk_4	377	383	PF00069	0.632
MOD_Plk_4	546	552	PF00069	0.749
MOD_Plk_4	655	661	PF00069	0.613
MOD_Plk_4	77	83	PF00069	0.587
MOD_ProDKin_1	114	120	PF00069	0.635
MOD_ProDKin_1	168	174	PF00069	0.601
MOD_ProDKin_1	41	47	PF00069	0.620
MOD_ProDKin_1	481	487	PF00069	0.622
MOD_ProDKin_1	502	508	PF00069	0.531
MOD_ProDKin_1	521	527	PF00069	0.582
MOD_ProDKin_1	558	564	PF00069	0.574
MOD_ProDKin_1	605	611	PF00069	0.577
MOD_ProDKin_1	75	81	PF00069	0.590
MOD_SUMO_rev_2	324	332	PF00179	0.514
TRG_DiLeu_BaEn_1	77	82	PF01217	0.536
TRG_DiLeu_BaEn_2	426	432	PF01217	0.611
TRG_DiLeu_BaLyEn_6	611	616	PF01217	0.525
TRG_ENDOCYTIC_2	331	334	PF00928	0.501
TRG_ENDOCYTIC_2	459	462	PF00928	0.626
TRG_ER_diArg_1	562	564	PF00400	0.570
TRG_ER_diArg_1	572	574	PF00400	0.557
TRG_ER_diArg_1	644	646	PF00400	0.515
TRG_NES_CRM1_1	5	18	PF08389	0.582
TRG_Pf-PMV_PEXEL_1	563	567	PF00026	0.673
TRG_Pf-PMV_PEXEL_1	637	642	PF00026	0.598
TRG_Pf-PMV_PEXEL_1	708	712	PF00026	0.589

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Q0	Leptomonas seymouri	34%	89%
A4HB53	Leishmania braziliensis	62%	99%
E9AHT9	Leishmania infantum	100%	100%
E9B5C3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q2L0	Leishmania major	87%	100%